BR9714272A - Taxóide, composição farmacêutica tendo atividade de inversão de resistência a medicamento, e, processo para tratar tumores - Google Patents
Taxóide, composição farmacêutica tendo atividade de inversão de resistência a medicamento, e, processo para tratar tumoresInfo
- Publication number
- BR9714272A BR9714272A BR9714272-7A BR9714272A BR9714272A BR 9714272 A BR9714272 A BR 9714272A BR 9714272 A BR9714272 A BR 9714272A BR 9714272 A BR9714272 A BR 9714272A
- Authority
- BR
- Brazil
- Prior art keywords
- taxoid
- pharmaceutical composition
- drug resistance
- treat tumors
- resistance inversion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"TAXóIDE, COMPOSIçãO FARMACêUTICA TENDO ATIVIDADE DE INVERSãO DE RESISTêNCIA A MEDICAMENTO, E, PROCESSO PARA TRATAR TUMORES". A presente invenção é dirigida a novos taxóides possuindo fortes atividades de inversão para resistência a medicamento, associados com agentes anti-câncer, à preparação destes agentes de inversão e suas composições farmacêuticas. Os novos taxóides da presente invenção têm a fórmula (I):
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/780,633 US5811452A (en) | 1997-01-08 | 1997-01-08 | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
PCT/US1997/024020 WO1998030553A1 (en) | 1997-01-08 | 1997-12-29 | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9714272A true BR9714272A (pt) | 2000-04-18 |
Family
ID=25120175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9714272-7A BR9714272A (pt) | 1997-01-08 | 1997-12-29 | Taxóide, composição farmacêutica tendo atividade de inversão de resistência a medicamento, e, processo para tratar tumores |
Country Status (12)
Country | Link |
---|---|
US (1) | US5811452A (pt) |
EP (1) | EP0966456B1 (pt) |
JP (1) | JP2001509150A (pt) |
KR (1) | KR20000069887A (pt) |
AT (1) | ATE236143T1 (pt) |
AU (1) | AU738536B2 (pt) |
BR (1) | BR9714272A (pt) |
CA (1) | CA2276483A1 (pt) |
DE (1) | DE69720535T2 (pt) |
ES (1) | ES2196393T3 (pt) |
IL (1) | IL130669A0 (pt) |
WO (1) | WO1998030553A1 (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6005120A (en) | 1993-07-20 | 1999-12-21 | Florida State University | Tricyclic and tetracyclic taxanes |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
US6020507A (en) * | 1998-03-02 | 2000-02-01 | Bristol-Myers Squibb Company | Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile |
NZ517772A (en) * | 1999-11-24 | 2004-03-26 | Immunogen Inc | Cytotoxic agents comprising taxanes and their therapeutic use |
NZ514407A (en) * | 2000-02-02 | 2004-12-24 | Univ Florida State Res Found | C10 carbamoyloxy substituted taxanes as antitumor agents |
CN1362876A (zh) * | 2000-02-02 | 2002-08-07 | 佛罗里达州立大学研究基金有限公司 | C10杂取代的乙酸基紫衫烷抗肿瘤剂 |
PT1165549E (pt) * | 2000-02-02 | 2008-06-20 | Univ Florida State Res Found | Taxanos substituídos em c7 por carbamoíloxi como agentes anti-tumorais |
JP2003522170A (ja) * | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのc7カーボネート置換タキサン |
JP2003522171A (ja) | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのc10カーボネート置換タキサン |
AR030188A1 (es) | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
CN1362957A (zh) | 2000-02-02 | 2002-08-07 | 佛罗里达州立大学研究基金有限公司 | 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷 |
WO2002022159A1 (en) | 2000-09-11 | 2002-03-21 | Therapro Technologies, Inc. | Thionin as an antineoplastic and immunostimulant |
ITMI20012186A1 (it) * | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato |
ITMI20012185A1 (it) | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato |
AU2003256847A1 (en) * | 2002-07-26 | 2004-02-16 | Advanced Research And Technology Institute At Indiana University | Method of treating cancer |
US7390898B2 (en) * | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
CA2494074A1 (en) * | 2002-08-02 | 2004-02-12 | Immunogen, Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
ITMI20021921A1 (it) * | 2002-09-10 | 2004-03-11 | Indena Spa | Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali. |
AU2003273671A1 (en) * | 2002-10-09 | 2004-05-04 | Phytogen Life Sciences, Inc. | Novel taxanes and methods related to use and preparation thereof |
WO2004032923A1 (en) * | 2002-10-11 | 2004-04-22 | Dana-Farber Cancer Institute Inc | Epothilone derivatives for the treatment of multiple myeloma |
US7064980B2 (en) * | 2003-09-17 | 2006-06-20 | Sandisk Corporation | Non-volatile memory and method with bit line coupled compensation |
US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
HN2005000054A (es) * | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
WO2005087222A1 (en) | 2004-03-05 | 2005-09-22 | Florida State University Research Foundation, Inc. | C7 lactyloxy-substituted taxanes |
AU2006214498A1 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
PL1871753T3 (pl) * | 2005-03-31 | 2012-12-31 | Accord Healthcare Inc | Wytwarzanie taksanów z 9-dihydro-13-acetylobakatyny iii |
ES2389518T3 (es) | 2008-01-18 | 2012-10-26 | Indena S.P.A. | Formas sólidas de ortataxel |
JP2011517455A (ja) * | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | C(10)エチルエステルおよびc(10)シクロプロピルエステル置換タキサン |
KR20210100223A (ko) | 2008-04-30 | 2021-08-13 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
PT3122757T (pt) | 2014-02-28 | 2023-11-03 | Hangzhou Dac Biotech Co Ltd | Ligantes carregados e as suas utilizações em conjugação |
EP3319936A4 (en) | 2015-07-12 | 2019-02-06 | Suzhou M-conj Biotech Co., Ltd. | PLACES OF CONDUCT FOR THE CONJUGATION OF CELL BINDING MOLECULES |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
JP7138350B2 (ja) | 2016-11-14 | 2022-09-16 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ. | 共役連結体、該連結体を含有する細胞結合分子-薬物共役体、並びに該共役体及び連結体の使用及び製造方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284864A (en) * | 1991-09-23 | 1994-02-08 | Florida State University | Butenyl substituted taxanes and pharmaceutical compositions containing them |
US5283253A (en) * | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5350866A (en) * | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
ZA94128B (en) * | 1993-02-01 | 1994-08-19 | Univ New York State Res Found | Process for the preparation of taxane derivatives and betalactam intermediates therefor |
US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
MA23823A1 (fr) * | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
-
1997
- 1997-01-08 US US08/780,633 patent/US5811452A/en not_active Expired - Lifetime
- 1997-12-29 KR KR1019997006080A patent/KR20000069887A/ko not_active Application Discontinuation
- 1997-12-29 AU AU59037/98A patent/AU738536B2/en not_active Ceased
- 1997-12-29 AT AT97954636T patent/ATE236143T1/de not_active IP Right Cessation
- 1997-12-29 IL IL13066997A patent/IL130669A0/xx unknown
- 1997-12-29 WO PCT/US1997/024020 patent/WO1998030553A1/en not_active Application Discontinuation
- 1997-12-29 ES ES97954636T patent/ES2196393T3/es not_active Expired - Lifetime
- 1997-12-29 BR BR9714272-7A patent/BR9714272A/pt not_active IP Right Cessation
- 1997-12-29 DE DE69720535T patent/DE69720535T2/de not_active Expired - Fee Related
- 1997-12-29 JP JP53093598A patent/JP2001509150A/ja not_active Ceased
- 1997-12-29 EP EP97954636A patent/EP0966456B1/en not_active Expired - Lifetime
- 1997-12-29 CA CA002276483A patent/CA2276483A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0966456A1 (en) | 1999-12-29 |
WO1998030553A1 (en) | 1998-07-16 |
KR20000069887A (ko) | 2000-11-25 |
US5811452A (en) | 1998-09-22 |
AU5903798A (en) | 1998-08-03 |
IL130669A0 (en) | 2000-06-01 |
AU738536B2 (en) | 2001-09-20 |
ATE236143T1 (de) | 2003-04-15 |
JP2001509150A (ja) | 2001-07-10 |
DE69720535T2 (de) | 2004-03-04 |
DE69720535D1 (de) | 2003-05-08 |
ES2196393T3 (es) | 2003-12-16 |
CA2276483A1 (en) | 1998-07-16 |
EP0966456A4 (en) | 2000-07-26 |
EP0966456B1 (en) | 2003-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A , 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1865 DE 03/10/2006. |