BR9708772A - "comprimidos famacêuticos de liberação controlada que contém um veìculo à base de amilose reticulada e hidróxi propil metil celulose" - Google Patents
"comprimidos famacêuticos de liberação controlada que contém um veìculo à base de amilose reticulada e hidróxi propil metil celulose"Info
- Publication number
- BR9708772A BR9708772A BR9708772-6A BR9708772A BR9708772A BR 9708772 A BR9708772 A BR 9708772A BR 9708772 A BR9708772 A BR 9708772A BR 9708772 A BR9708772 A BR 9708772A
- Authority
- BR
- Brazil
- Prior art keywords
- cross
- linked amylose
- controlled
- methyl cellulose
- vehicle based
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<B>COMPRIMIDOS FARMACêUTICOS DE LIBERAçãO CONTROLADA QUE CONTêM UM VEìCULO à BASE DE AMILOSE RETICULADA E HIDRóXI PROPIL METIL CELULOSE<D>, ou seja, um comprimido farmacêutico de liberação controlada que contém um ingrediente ativo em combinação com um veículo formado por amilose reticulada no qual hidróxi propil metil celulose (HPMC) com uma viscosidade igual ou maior do que 4.000 cps é adicionada como adjuvante. A adição da HPMC ao comprimido permite controlar o efeito das enzimas, e mais particularmente da alfa-amilase, presentes no meio intestinal, sobre a amilose reticulada usada como veículo e, desse modo, reduzir a dependência da cinética de liberação na concentração de enzimas presentes no meio.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002173818A CA2173818A1 (fr) | 1996-04-10 | 1996-04-10 | Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose |
PCT/CA1997/000229 WO1997037639A1 (fr) | 1996-04-10 | 1997-04-04 | Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9708772A true BR9708772A (pt) | 2000-01-04 |
Family
ID=4157953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9708772-6A BR9708772A (pt) | 1996-04-10 | 1997-04-04 | "comprimidos famacêuticos de liberação controlada que contém um veìculo à base de amilose reticulada e hidróxi propil metil celulose" |
Country Status (22)
Country | Link |
---|---|
US (1) | US5885615A (pt) |
EP (1) | EP0954290B1 (pt) |
JP (1) | JP4166278B2 (pt) |
KR (1) | KR100439614B1 (pt) |
CN (1) | CN1218396A (pt) |
AT (1) | ATE240719T1 (pt) |
AU (1) | AU711089B2 (pt) |
BR (1) | BR9708772A (pt) |
CA (1) | CA2173818A1 (pt) |
CZ (1) | CZ294342B6 (pt) |
DE (1) | DE69722247T2 (pt) |
DK (1) | DK0954290T3 (pt) |
ES (1) | ES2200166T3 (pt) |
IL (1) | IL126477A (pt) |
MY (1) | MY115535A (pt) |
NO (1) | NO321862B1 (pt) |
NZ (1) | NZ332576A (pt) |
PL (1) | PL187764B1 (pt) |
PT (1) | PT954290E (pt) |
TR (1) | TR199802034T2 (pt) |
WO (1) | WO1997037639A1 (pt) |
ZA (1) | ZA973054B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
US6197339B1 (en) | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
US6284273B1 (en) * | 1998-02-24 | 2001-09-04 | Vincent Lenaerts | Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds |
WO2000033818A1 (en) | 1998-12-11 | 2000-06-15 | Nostrum Pharmaceuticals, Inc. | Sustained release tablet containing hydrocolloid and cellulose ether |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
EP1174127A1 (en) * | 2000-07-21 | 2002-01-23 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Composition for targeted release of an actvie substance and process for producing such a composition |
US6673369B2 (en) * | 2001-08-29 | 2004-01-06 | Ranbaxy Laboratories Limited | Controlled release formulation |
WO2003077897A1 (en) * | 2002-03-15 | 2003-09-25 | Cypress Bioscience, Inc. | Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes |
TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
MY142195A (en) * | 2002-10-25 | 2010-10-15 | Labopharm Inc | Controlled-release compositions |
US20040132826A1 (en) * | 2002-10-25 | 2004-07-08 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
US20060003004A1 (en) * | 2002-10-25 | 2006-01-05 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
JP2006507276A (ja) * | 2002-10-25 | 2006-03-02 | ラボファーマ インコーポレイテッド | 放出制御組成物 |
EP1578281A2 (en) * | 2002-11-25 | 2005-09-28 | Boston Scientific Limited | Injection device for treating mammalian body |
EP1592453A1 (en) * | 2003-01-28 | 2005-11-09 | Collegium Pharmaceutical, Inc. | Multiparticulate compositions of milnacipran for oral administration |
US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
AR051654A1 (es) * | 2004-11-04 | 2007-01-31 | Astrazeneca Ab | Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones |
CA2491665A1 (fr) * | 2004-12-24 | 2006-06-24 | Louis Cartilier | Formulation de comprime pour liberation soutenue de principe actif |
JP5269595B2 (ja) * | 2005-09-09 | 2013-08-21 | アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー | 1日1回投与用トラゾドン組成物 |
ATE543522T1 (de) * | 2005-09-21 | 2012-02-15 | Surmodics Inc | In vivo geformte matrizen mit natürlichen biologisch abbaubaren polysacchariden und ihre ophthalmischen verwendungen |
CN101309709A (zh) * | 2005-09-21 | 2008-11-19 | 苏尔莫迪克斯公司 | 包含天然生物可降解的多糖的涂层和物品 |
EP1946780B1 (en) * | 2005-11-11 | 2012-01-11 | Asahi Kasei Chemicals Corporation | Controlled release solid preparation |
US20080154241A1 (en) * | 2006-12-07 | 2008-06-26 | Burkstrand Michael J | Latent stabilization of bioactive agents releasable from implantable medical articles |
WO2009137689A2 (en) | 2008-05-07 | 2009-11-12 | Surmodics, Inc. | Delivery of nucleic acid complexes from particles |
US20100056540A1 (en) * | 2008-09-04 | 2010-03-04 | Bristol-Myers Squibb Company | Stable pharmaceutical composition for optimized delivery of an hiv attachment inhibitor |
ES2582779T3 (es) * | 2008-10-27 | 2016-09-15 | Alza Corporation | Forma de dosificación oral de acetaminofeno/tramadol de liberación prolongada |
US20100260842A1 (en) * | 2009-04-06 | 2010-10-14 | Rashmi Nair | Pseudoephedrine pharmaceutical formulations |
US8901092B2 (en) | 2010-12-29 | 2014-12-02 | Surmodics, Inc. | Functionalized polysaccharides for active agent delivery |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3065143A (en) * | 1960-04-19 | 1962-11-20 | Richardson Merrell Inc | Sustained release tablet |
US4167558A (en) * | 1976-02-13 | 1979-09-11 | Hoffmann-La Roche Inc. | Novel sustained release tablet formulations |
US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
US4610870A (en) * | 1984-10-05 | 1986-09-09 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
US4734285A (en) * | 1985-10-28 | 1988-03-29 | The Dow Chemical Company | Sustained release compositions |
US4704285A (en) * | 1985-11-18 | 1987-11-03 | The Dow Chemical Company | Sustained release compositions comprising hydroxypropyl cellulose ethers |
US4775535A (en) * | 1986-04-04 | 1988-10-04 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
US4855143A (en) * | 1986-04-04 | 1989-08-08 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
US5603956A (en) * | 1990-11-27 | 1997-02-18 | Labopharm Inc. | Cross-linked enzymatically controlled drug release |
CA2041774C (en) * | 1990-11-27 | 1994-04-19 | Mircea A. Mateescu | Use of cross-linked amylose as a matrix for the slow release of biologically active compounds |
NL9201196A (nl) * | 1992-07-03 | 1994-02-01 | Tno | Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat. |
CA2140032C (en) * | 1992-07-24 | 1999-01-26 | Mircea A. Mateescu | Cross-linked amylose material for enzymatically controlled drug release |
US5616343A (en) * | 1993-03-25 | 1997-04-01 | Labopharm, Inc. | Cross-linked amylose as a binder/disintegrant in tablets |
IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
-
1996
- 1996-04-10 CA CA002173818A patent/CA2173818A1/fr not_active Abandoned
- 1996-08-19 US US08/699,611 patent/US5885615A/en not_active Expired - Lifetime
-
1997
- 1997-04-04 ES ES97915220T patent/ES2200166T3/es not_active Expired - Lifetime
- 1997-04-04 WO PCT/CA1997/000229 patent/WO1997037639A1/fr active IP Right Grant
- 1997-04-04 JP JP53470597A patent/JP4166278B2/ja not_active Expired - Fee Related
- 1997-04-04 EP EP97915220A patent/EP0954290B1/fr not_active Expired - Lifetime
- 1997-04-04 DE DE69722247T patent/DE69722247T2/de not_active Expired - Lifetime
- 1997-04-04 DK DK97915220T patent/DK0954290T3/da active
- 1997-04-04 KR KR10-1998-0708056A patent/KR100439614B1/ko not_active IP Right Cessation
- 1997-04-04 IL IL12647797A patent/IL126477A/en not_active IP Right Cessation
- 1997-04-04 BR BR9708772-6A patent/BR9708772A/pt not_active IP Right Cessation
- 1997-04-04 NZ NZ332576A patent/NZ332576A/xx not_active IP Right Cessation
- 1997-04-04 PL PL32928597A patent/PL187764B1/pl unknown
- 1997-04-04 PT PT97915220T patent/PT954290E/pt unknown
- 1997-04-04 AU AU22832/97A patent/AU711089B2/en not_active Ceased
- 1997-04-04 TR TR1998/02034T patent/TR199802034T2/xx unknown
- 1997-04-04 AT AT97915220T patent/ATE240719T1/de active
- 1997-04-04 CZ CZ19983254A patent/CZ294342B6/cs not_active IP Right Cessation
- 1997-04-04 CN CN97194638A patent/CN1218396A/zh active Pending
- 1997-04-10 MY MYPI97001576A patent/MY115535A/en unknown
- 1997-04-10 ZA ZA9703054A patent/ZA973054B/xx unknown
-
1998
- 1998-10-08 NO NO19984703A patent/NO321862B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0954290T3 (da) | 2003-09-22 |
CA2173818A1 (fr) | 1997-10-11 |
NO984703L (no) | 1998-12-08 |
US5885615A (en) | 1999-03-23 |
PT954290E (pt) | 2003-10-31 |
IL126477A (en) | 2001-10-31 |
CN1218396A (zh) | 1999-06-02 |
NO321862B1 (no) | 2006-07-17 |
DE69722247D1 (de) | 2003-06-26 |
CZ325498A3 (cs) | 1999-03-17 |
WO1997037639A1 (fr) | 1997-10-16 |
CZ294342B6 (cs) | 2004-12-15 |
AU711089B2 (en) | 1999-10-07 |
MY115535A (en) | 2003-07-31 |
PL329285A1 (en) | 1999-03-15 |
EP0954290B1 (fr) | 2003-05-21 |
EP0954290A1 (fr) | 1999-11-10 |
DE69722247T2 (de) | 2004-04-01 |
AU2283297A (en) | 1997-10-29 |
ZA973054B (en) | 1998-06-01 |
PL187764B1 (pl) | 2004-10-29 |
KR20000005337A (ko) | 2000-01-25 |
IL126477A0 (en) | 1999-08-17 |
NO984703D0 (no) | 1998-10-08 |
KR100439614B1 (ko) | 2004-10-14 |
TR199802034T2 (xx) | 1999-02-22 |
NZ332576A (en) | 2000-03-27 |
JP4166278B2 (ja) | 2008-10-15 |
ATE240719T1 (de) | 2003-06-15 |
ES2200166T3 (es) | 2004-03-01 |
JP2000507561A (ja) | 2000-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/04/1997, OBSERVADAS AS CONDICOES LEGAIS. |
|
B24H | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi) | ||
B24F | Patent annual fee: publication cancelled |
Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE AS 16A, 17A, 18A, 19A E 20A ANUIDADES. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |