BR112023018802A2 - Uso de hormônio de crescimento de ação prolongada para o tratamento de doenças induzidas por inflamação - Google Patents
Uso de hormônio de crescimento de ação prolongada para o tratamento de doenças induzidas por inflamaçãoInfo
- Publication number
- BR112023018802A2 BR112023018802A2 BR112023018802A BR112023018802A BR112023018802A2 BR 112023018802 A2 BR112023018802 A2 BR 112023018802A2 BR 112023018802 A BR112023018802 A BR 112023018802A BR 112023018802 A BR112023018802 A BR 112023018802A BR 112023018802 A2 BR112023018802 A2 BR 112023018802A2
- Authority
- BR
- Brazil
- Prior art keywords
- inflammation
- long
- growth hormone
- treatment
- acting growth
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 4
- 108010051696 Growth Hormone Proteins 0.000 title abstract 4
- 239000000122 growth hormone Substances 0.000 title abstract 4
- 206010061218 Inflammation Diseases 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
uso de hormônio de crescimento de ação prolongada para o tratamento de doenças induzidas por inflamação. a presente invenção refere-se a um hormônio de crescimento de ação prolongada (gh) para uso no tratamento de uma doença induzida por inflamação.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21166699 | 2021-04-01 | ||
PCT/EP2022/058584 WO2022207798A1 (en) | 2021-04-01 | 2022-03-31 | Use of long-acting growth hormone for treating inflammation-induced diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023018802A2 true BR112023018802A2 (pt) | 2023-10-31 |
Family
ID=75362497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023018802A BR112023018802A2 (pt) | 2021-04-01 | 2022-03-31 | Uso de hormônio de crescimento de ação prolongada para o tratamento de doenças induzidas por inflamação |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP4314035A1 (pt) |
JP (1) | JP2024514095A (pt) |
KR (1) | KR20230164709A (pt) |
CN (1) | CN117396497A (pt) |
AU (1) | AU2022246997A1 (pt) |
BR (1) | BR112023018802A2 (pt) |
CA (1) | CA3212417A1 (pt) |
IL (1) | IL307192A (pt) |
MX (1) | MX2023011059A (pt) |
WO (1) | WO2022207798A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115845032A (zh) * | 2022-10-28 | 2023-03-28 | 深圳科兴药业有限公司 | 生长激素fc融合蛋白注射液及其用途 |
Family Cites Families (34)
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US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
CA2521784C (en) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
US7690003B2 (en) | 2003-08-29 | 2010-03-30 | Fuller Jeffrey C | System and method for increasing data throughput using thread scheduling |
JP4949838B2 (ja) | 2003-09-19 | 2012-06-13 | ノヴォ ノルディスク アー/エス | 新規glp−1誘導体 |
HUE045882T2 (hu) | 2004-03-23 | 2020-01-28 | Ascendis Pharma Gmbh | Polimer prodrug önmagát lehasító linkerrel |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
WO2008034122A2 (en) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
ATE502114T1 (de) | 2007-06-21 | 2011-04-15 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
JP2010533202A (ja) | 2007-07-11 | 2010-10-21 | エンゾン ファーマシューティカルズ,インコーポレーテッド | 多置換芳香族部分を含むポリマー性薬剤送達システム |
CN101980725B (zh) | 2008-02-01 | 2013-06-12 | 阿森迪斯药物股份有限公司 | 包含可自裂解的连接体的前药 |
TW201004648A (en) | 2008-05-23 | 2010-02-01 | Enzon Pharmaceuticals Inc | Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides |
KR101544245B1 (ko) | 2009-02-03 | 2015-08-12 | 아뮤닉스 오퍼레이팅 인코포레이티드 | 연장된 재조합 폴리펩티드 및 이를 포함하는 조성물 |
AU2010277556B2 (en) | 2009-07-31 | 2014-10-09 | Ascendis Pharma As | Biodegradable polyethylene glycol based water-insoluble hydrogels |
WO2011082368A2 (en) | 2009-12-31 | 2011-07-07 | Enzon Pharmaceuticals, Inc | Polymeric conjugates of aromatic amine containing compounds including releasable urea linker |
WO2011123813A2 (en) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
JP5977229B2 (ja) | 2010-05-05 | 2016-08-24 | プロリンクス リミテッド ライアビリティ カンパニー | 巨大分子共役体からの徐放 |
US8946405B2 (en) | 2010-05-05 | 2015-02-03 | Prolynx Llc | Controlled release from solid supports |
DK2571510T3 (en) | 2010-05-21 | 2018-11-19 | Xl Protein Gmbh | BIOSYNTHETIC PROLIN / ALANIN-RANDOM COIL POLYPEPTIDES AND THEIR APPLICATIONS |
EP2741778A1 (en) | 2011-08-12 | 2014-06-18 | Ascendis Pharma A/S | Polymeric hyperbranched carrier-linked prodrugs |
AU2012296951B2 (en) | 2011-08-12 | 2016-09-15 | Ascendis Pharma A/S | Protein carrier-linked prodrugs |
WO2013024047A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | High-loading water-soluble carrier-linked prodrugs |
WO2013036857A1 (en) | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
CA2848142C (en) | 2011-09-07 | 2021-05-18 | Prolynx Llc | Hydrogels with biodegradable crosslinking |
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WO2014060512A1 (en) | 2012-10-17 | 2014-04-24 | Novo Nordisk Health Care Ag | Fatty acid acylated amino acids for growth hormone delivery |
WO2016020373A1 (en) | 2014-08-06 | 2016-02-11 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
HUE053855T2 (hu) | 2014-11-18 | 2021-07-28 | Ascendis Pharma Endocrinology Div A/S | Új polimer hGH prodrogok |
AR111190A1 (es) | 2017-03-22 | 2019-06-12 | Genentech Inc | Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados |
JP2022502403A (ja) | 2018-09-26 | 2022-01-11 | アセンディス ファーマ エー/エス | 分解性ヒアルロン酸ヒドロゲル |
CN112770781A (zh) | 2018-09-26 | 2021-05-07 | 阿森迪斯药物股份有限公司 | 新的水凝胶缀合物 |
BR112021020023A2 (pt) | 2019-04-05 | 2021-12-07 | Prolynx Llc | Ligantes de conjugação melhorados |
US20220289812A1 (en) | 2019-08-09 | 2022-09-15 | Phasebio Pharmaceuticals, Inc. | Elp fusion proteins comprising parathyroid hormone for controlled and sustained release |
-
2022
- 2022-03-31 KR KR1020237037345A patent/KR20230164709A/ko unknown
- 2022-03-31 JP JP2023560478A patent/JP2024514095A/ja active Pending
- 2022-03-31 IL IL307192A patent/IL307192A/en unknown
- 2022-03-31 CA CA3212417A patent/CA3212417A1/en active Pending
- 2022-03-31 EP EP22713687.6A patent/EP4314035A1/en active Pending
- 2022-03-31 CN CN202280038557.7A patent/CN117396497A/zh active Pending
- 2022-03-31 MX MX2023011059A patent/MX2023011059A/es unknown
- 2022-03-31 AU AU2022246997A patent/AU2022246997A1/en active Pending
- 2022-03-31 WO PCT/EP2022/058584 patent/WO2022207798A1/en active Application Filing
- 2022-03-31 BR BR112023018802A patent/BR112023018802A2/pt unknown
Also Published As
Publication number | Publication date |
---|---|
JP2024514095A (ja) | 2024-03-28 |
CA3212417A1 (en) | 2022-10-06 |
IL307192A (en) | 2023-11-01 |
CN117396497A (zh) | 2024-01-12 |
AU2022246997A9 (en) | 2024-01-25 |
AU2022246997A1 (en) | 2023-09-28 |
KR20230164709A (ko) | 2023-12-04 |
MX2023011059A (es) | 2023-09-29 |
WO2022207798A1 (en) | 2022-10-06 |
EP4314035A1 (en) | 2024-02-07 |
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