BR112022026397A2 - Métodos para tratar câncer usando derivados de amida de heteroaril-bifenila - Google Patents
Métodos para tratar câncer usando derivados de amida de heteroaril-bifenilaInfo
- Publication number
- BR112022026397A2 BR112022026397A2 BR112022026397A BR112022026397A BR112022026397A2 BR 112022026397 A2 BR112022026397 A2 BR 112022026397A2 BR 112022026397 A BR112022026397 A BR 112022026397A BR 112022026397 A BR112022026397 A BR 112022026397A BR 112022026397 A2 BR112022026397 A2 BR 112022026397A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- heteroaryl
- amide derivatives
- cancer
- treatting
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
MÉTODOS PARA TRATAR CÂNCER USANDO DERIVADOS DE AMIDA DE HETEROARIL-BIFENILA. São fornecidos no presente documento métodos de tratamento de certos cânceres que compreendem administrar ao sujeito que precisa dos mesmos uma quantidade eficaz de um composto da Fórmula (I) incluindo estereoisômeros e sais farmaceuticamente aceitáveis dos mesmos, em que R1, R2, R3, R4, Ra e Rb são conforme definidos no presente documento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063042807P | 2020-06-23 | 2020-06-23 | |
PCT/US2021/038339 WO2021262627A1 (en) | 2020-06-23 | 2021-06-22 | Methods of treating cancer using heteroaryl-biphenyl amide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022026397A2 true BR112022026397A2 (pt) | 2023-03-14 |
Family
ID=79022859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022026397A BR112022026397A2 (pt) | 2020-06-23 | 2021-06-22 | Métodos para tratar câncer usando derivados de amida de heteroaril-bifenila |
Country Status (14)
Country | Link |
---|---|
US (2) | US20210393759A1 (pt) |
EP (1) | EP4167991A1 (pt) |
JP (1) | JP2023531970A (pt) |
KR (1) | KR20230040993A (pt) |
CN (1) | CN116472045A (pt) |
AU (1) | AU2021297216A1 (pt) |
BR (1) | BR112022026397A2 (pt) |
CA (1) | CA3187605A1 (pt) |
CL (1) | CL2022003716A1 (pt) |
CO (1) | CO2023000703A2 (pt) |
IL (1) | IL299206A (pt) |
MX (1) | MX2022016554A (pt) |
TW (1) | TW202216694A (pt) |
WO (1) | WO2021262627A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111225665B (zh) | 2017-08-08 | 2023-12-08 | 凯莫森特里克斯股份有限公司 | 大环免疫调节剂 |
WO2019165043A2 (en) | 2018-02-22 | 2019-08-29 | Chemocentryx, Inc. | Indane-amines as pd-l1 antagonists |
US11872217B2 (en) | 2019-07-10 | 2024-01-16 | Chemocentryx, Inc. | Indanes as PD-L1 inhibitors |
KR20220084119A (ko) * | 2019-10-16 | 2022-06-21 | 케모센트릭스, 인크. | Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아미드 |
JP2022551972A (ja) | 2019-10-16 | 2022-12-14 | ケモセントリックス,インコーポレイティド | Pd-l1疾患の治療のためのヘテロアリール-ビフェニルアミン |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201402004YA (en) * | 2011-11-14 | 2014-05-29 | Cephalon Inc | Uracil derivatives as axl and c-met kinase inhibitors |
WO2013085802A1 (en) * | 2011-12-06 | 2013-06-13 | Merck Sharp & Dohme Corp. | Pyrrolopyrimidines as janus kinase inhibitors |
CN106674136B (zh) * | 2016-12-23 | 2019-07-02 | 中国医科大学 | 嘧啶类抗肿瘤化合物及其制备方法 |
WO2020232256A1 (en) * | 2019-05-15 | 2020-11-19 | Chemocentryx, Inc. | Triaryl compounds for treatment of pd-l1 diseases |
KR20220084119A (ko) * | 2019-10-16 | 2022-06-21 | 케모센트릭스, 인크. | Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아미드 |
-
2021
- 2021-06-22 JP JP2022579736A patent/JP2023531970A/ja active Pending
- 2021-06-22 AU AU2021297216A patent/AU2021297216A1/en active Pending
- 2021-06-22 WO PCT/US2021/038339 patent/WO2021262627A1/en active Application Filing
- 2021-06-22 BR BR112022026397A patent/BR112022026397A2/pt unknown
- 2021-06-22 CA CA3187605A patent/CA3187605A1/en active Pending
- 2021-06-22 TW TW110122725A patent/TW202216694A/zh unknown
- 2021-06-22 MX MX2022016554A patent/MX2022016554A/es unknown
- 2021-06-22 US US17/354,003 patent/US20210393759A1/en not_active Abandoned
- 2021-06-22 EP EP21829047.6A patent/EP4167991A1/en active Pending
- 2021-06-22 KR KR1020237001820A patent/KR20230040993A/ko unknown
- 2021-06-22 IL IL299206A patent/IL299206A/en unknown
- 2021-06-22 CN CN202180059142.3A patent/CN116472045A/zh active Pending
-
2022
- 2022-12-22 CL CL2022003716A patent/CL2022003716A1/es unknown
-
2023
- 2023-01-20 CO CONC2023/0000703A patent/CO2023000703A2/es unknown
- 2023-11-15 US US18/509,667 patent/US20240115682A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CO2023000703A2 (es) | 2023-01-26 |
CL2022003716A1 (es) | 2023-06-30 |
IL299206A (en) | 2023-02-01 |
EP4167991A1 (en) | 2023-04-26 |
WO2021262627A1 (en) | 2021-12-30 |
TW202216694A (zh) | 2022-05-01 |
JP2023531970A (ja) | 2023-07-26 |
MX2022016554A (es) | 2023-04-10 |
AU2021297216A1 (en) | 2023-02-02 |
US20210393759A1 (en) | 2021-12-23 |
US20240115682A1 (en) | 2024-04-11 |
CN116472045A (zh) | 2023-07-21 |
CA3187605A1 (en) | 2021-12-30 |
KR20230040993A (ko) | 2023-03-23 |
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