EA202090959A1 - Аминзамещенные гетероциклические соединения в качестве ингибиторов ehmt2, их соли и способы их синтеза - Google Patents
Аминзамещенные гетероциклические соединения в качестве ингибиторов ehmt2, их соли и способы их синтезаInfo
- Publication number
- EA202090959A1 EA202090959A1 EA202090959A EA202090959A EA202090959A1 EA 202090959 A1 EA202090959 A1 EA 202090959A1 EA 202090959 A EA202090959 A EA 202090959A EA 202090959 A EA202090959 A EA 202090959A EA 202090959 A1 EA202090959 A1 EA 202090959A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- amine
- substituted heterocyclic
- methods
- synthesis
- salts
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102100035042 Histone-lysine N-methyltransferase EHMT2 Human genes 0.000 title 1
- 101000877312 Homo sapiens Histone-lysine N-methyltransferase EHMT2 Proteins 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Настоящее изобретение относится к аминзамещенным гетероциклическим соединениям. Настоящее изобретение также относится к фармацевтическим композициям, содержащим данные соединения, и к способам лечения нарушения (например, рака), осуществляемым путем введения аминзамещенного гетероциклического соединения, раскрытого в данном документе, или фармацевтической композиции на его основе нуждающимся в этом субъектам. Настоящее изобретение также относится к применению таких соединений в исследовательских или других целях, отличных от терапевтических.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762573917P | 2017-10-18 | 2017-10-18 | |
PCT/US2018/056428 WO2019079540A1 (en) | 2017-10-18 | 2018-10-18 | AMINO-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF EHMT2, SALTS THEREOF, AND METHODS OF SYNTHESIS THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090959A1 true EA202090959A1 (ru) | 2020-07-13 |
Family
ID=66173899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090959A EA202090959A1 (ru) | 2017-10-18 | 2018-10-18 | Аминзамещенные гетероциклические соединения в качестве ингибиторов ehmt2, их соли и способы их синтеза |
Country Status (16)
Country | Link |
---|---|
US (2) | US20200247790A1 (ru) |
EP (1) | EP3697762A4 (ru) |
JP (2) | JP2021500334A (ru) |
KR (1) | KR20200101330A (ru) |
CN (1) | CN111417628A (ru) |
AU (2) | AU2018353122B2 (ru) |
BR (1) | BR112020007632A2 (ru) |
CA (1) | CA3079273A1 (ru) |
CL (1) | CL2020001009A1 (ru) |
CO (1) | CO2020005944A2 (ru) |
EA (1) | EA202090959A1 (ru) |
IL (2) | IL301746A (ru) |
MA (1) | MA50418A (ru) |
MX (1) | MX2020007152A (ru) |
SG (1) | SG11202003225YA (ru) |
WO (1) | WO2019079540A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019016775A2 (pt) | 2017-02-17 | 2020-03-31 | Trevena, Inc. | Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos |
WO2018195450A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
LT3697789T (lt) | 2017-10-18 | 2021-12-10 | Incyte Corporation | Kondensuoti imidazolo dariniai, pakeisti tretinėmis hidroksigrupėmis, kaip pi3k-gama inhibitoriai |
CN114249785B (zh) * | 2020-09-23 | 2024-04-05 | 常州方圆制药有限公司 | 一种2-腺苷n-吡唑的衍生物瑞加德松的制备方法 |
WO2022093904A1 (en) * | 2020-10-27 | 2022-05-05 | Trevena, Inc. | Crystalline and amorphous forms of a delta-opioid modulator |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026130A1 (en) * | 2003-09-18 | 2005-03-24 | Novartis Ag | 2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
MY167260A (en) * | 2005-11-01 | 2018-08-14 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
US9284272B2 (en) * | 2014-03-28 | 2016-03-15 | Abbvie Inc. | Inhibitors of histone methyltransferase G9a |
US9840500B2 (en) * | 2014-06-16 | 2017-12-12 | Fundación Para La Investigación Médica Aplicada | Compounds as dual inhibitors of histone methyltransferases and DNA methyltransferases |
CN106456627A (zh) * | 2014-06-23 | 2017-02-22 | 基因泰克公司 | 治疗癌症和预防癌症耐药性的方法 |
CN109153650A (zh) * | 2016-04-15 | 2019-01-04 | Epizyme股份有限公司 | 作为ehmt1和ehmt2抑制剂的胺取代的芳基或杂芳基化合物 |
EP4285906A3 (en) * | 2016-12-19 | 2024-03-13 | Epizyme, Inc. | Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof |
-
2018
- 2018-10-18 EA EA202090959A patent/EA202090959A1/ru unknown
- 2018-10-18 WO PCT/US2018/056428 patent/WO2019079540A1/en unknown
- 2018-10-18 CN CN201880077022.4A patent/CN111417628A/zh active Pending
- 2018-10-18 BR BR112020007632-5A patent/BR112020007632A2/pt unknown
- 2018-10-18 SG SG11202003225YA patent/SG11202003225YA/en unknown
- 2018-10-18 EP EP18869308.9A patent/EP3697762A4/en active Pending
- 2018-10-18 MX MX2020007152A patent/MX2020007152A/es unknown
- 2018-10-18 JP JP2020521599A patent/JP2021500334A/ja not_active Withdrawn
- 2018-10-18 US US16/756,565 patent/US20200247790A1/en not_active Abandoned
- 2018-10-18 KR KR1020207013781A patent/KR20200101330A/ko not_active Application Discontinuation
- 2018-10-18 MA MA050418A patent/MA50418A/fr unknown
- 2018-10-18 AU AU2018353122A patent/AU2018353122B2/en active Active
- 2018-10-18 IL IL301746A patent/IL301746A/en unknown
- 2018-10-18 CA CA3079273A patent/CA3079273A1/en active Pending
-
2020
- 2020-04-15 CL CL2020001009A patent/CL2020001009A1/es unknown
- 2020-04-16 IL IL273974A patent/IL273974B2/en unknown
- 2020-05-15 CO CONC2020/0005944A patent/CO2020005944A2/es unknown
-
2022
- 2022-03-24 US US17/703,155 patent/US20220324851A1/en active Pending
-
2023
- 2023-01-11 JP JP2023002371A patent/JP2023036991A/ja active Pending
-
2024
- 2024-02-22 AU AU2024201165A patent/AU2024201165A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL301746A (en) | 2023-05-01 |
AU2018353122A1 (en) | 2020-06-04 |
EP3697762A1 (en) | 2020-08-26 |
IL273974B1 (en) | 2023-04-01 |
AU2018353122B2 (en) | 2023-11-23 |
EP3697762A4 (en) | 2021-04-07 |
CL2020001009A1 (es) | 2020-12-18 |
MA50418A (fr) | 2021-04-07 |
IL273974A (en) | 2020-05-31 |
SG11202003225YA (en) | 2020-05-28 |
US20200247790A1 (en) | 2020-08-06 |
IL273974B2 (en) | 2023-08-01 |
CO2020005944A2 (es) | 2020-07-31 |
US20220324851A1 (en) | 2022-10-13 |
BR112020007632A2 (pt) | 2020-09-29 |
JP2021500334A (ja) | 2021-01-07 |
WO2019079540A1 (en) | 2019-04-25 |
JP2023036991A (ja) | 2023-03-14 |
MX2020007152A (es) | 2020-12-10 |
CN111417628A (zh) | 2020-07-14 |
KR20200101330A (ko) | 2020-08-27 |
CA3079273A1 (en) | 2019-04-25 |
AU2024201165A1 (en) | 2024-03-14 |
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