BR112022022524A2 - Proteínas imunomoduladoras inibidoras de april e baff com e sem uma proteína inibidora de células t e métodos de uso das mesmas - Google Patents
Proteínas imunomoduladoras inibidoras de april e baff com e sem uma proteína inibidora de células t e métodos de uso das mesmasInfo
- Publication number
- BR112022022524A2 BR112022022524A2 BR112022022524A BR112022022524A BR112022022524A2 BR 112022022524 A2 BR112022022524 A2 BR 112022022524A2 BR 112022022524 A BR112022022524 A BR 112022022524A BR 112022022524 A BR112022022524 A BR 112022022524A BR 112022022524 A2 BR112022022524 A2 BR 112022022524A2
- Authority
- BR
- Brazil
- Prior art keywords
- baff
- april
- immunomodulatory
- cell
- proteins
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 9
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 6
- 230000002401 inhibitory effect Effects 0.000 title abstract 4
- 230000020385 T cell costimulation Effects 0.000 abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 2
- 230000011748 cell maturation Effects 0.000 abstract 1
- 230000036755 cellular response Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROTEÍNAS IMUNOMODULADORAS INIBIDORAS DE APRIL E BAFF COM E SEM UMA PROTEÍNA INIBIDORA DE CÉLULAS T E MÉTODOS DE USO DAS MESMAS. A presente invenção refere-se a proteínas imunomoduladoras que exibem atividade neutralizante de BAFF e APRIL (ou heterotrímeros BAFF/APRIL) sozinhos, ou também acopladas à inibição da coestimulação de células T. As proteínas imunomoduladoras fornecidas no presente documento incluem domínios variantes do antígeno de maturação de células B (BCMA) sozinho ou proteína imunomoduladora de múltiplos domínios que inibem respostas de células B e também podem inibir a coestimulação de células T. Também são fornecidas moléculas de ácidos nucleicos que codificam as proteínas imunomoduladoras. As proteínas imunomoduladoras fornecem utilidade terapêutica para uma variedade de doenças ou condições imunológicas. Também são fornecidas composições e métodos para fazer e usar tais proteínas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063022373P | 2020-05-08 | 2020-05-08 | |
US202063034361P | 2020-06-03 | 2020-06-03 | |
US202063080643P | 2020-09-18 | 2020-09-18 | |
PCT/US2021/031432 WO2021226553A2 (en) | 2020-05-08 | 2021-05-07 | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022022524A2 true BR112022022524A2 (pt) | 2022-12-13 |
Family
ID=76270049
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022022433A BR112022022433A2 (pt) | 2020-05-08 | 2021-05-07 | Proteínas imunomoduladoras inibitórias april e baff e métodos de uso das mesmas |
BR112022022524A BR112022022524A2 (pt) | 2020-05-08 | 2021-05-07 | Proteínas imunomoduladoras inibidoras de april e baff com e sem uma proteína inibidora de células t e métodos de uso das mesmas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022022433A BR112022022433A2 (pt) | 2020-05-08 | 2021-05-07 | Proteínas imunomoduladoras inibitórias april e baff e métodos de uso das mesmas |
Country Status (15)
Country | Link |
---|---|
US (4) | US20210388054A1 (pt) |
EP (2) | EP4146684A2 (pt) |
JP (2) | JP2023525033A (pt) |
KR (2) | KR20230029622A (pt) |
CN (4) | CN116903727A (pt) |
AU (2) | AU2021268033A1 (pt) |
BR (2) | BR112022022433A2 (pt) |
CA (2) | CA3178885A1 (pt) |
CL (1) | CL2022003104A1 (pt) |
CO (1) | CO2022017780A2 (pt) |
IL (2) | IL297981A (pt) |
MX (2) | MX2022013999A (pt) |
PE (1) | PE20230494A1 (pt) |
TW (1) | TW202208414A (pt) |
WO (2) | WO2021226551A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA50360A (fr) | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences Inc | Protéines immunomodulatrices de variants de ctla-4 et leurs utilisations |
JP2022539785A (ja) * | 2019-12-24 | 2022-09-13 | レメゲン シーオー.,エルティーディー. | TACI-Fc融合タンパク質及びその用途 |
EP4333869A1 (en) * | 2021-05-07 | 2024-03-13 | Alpine Immune Sciences, Inc. | Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein |
WO2023089500A1 (en) * | 2021-11-17 | 2023-05-25 | Aurinia Pharmaceuticals Inc. | B cell activating factor (baff)-a proliferation inducing ligand (april) dual inhibitors |
CA3236667A1 (en) * | 2022-06-08 | 2023-12-14 | Jianmin Fang | Method for treating myasthenia gravis with taci-fc fusion protein |
WO2024044721A1 (en) * | 2022-08-25 | 2024-02-29 | University Of Washington | Injectable recombinant protein-based hydrogels for therapeutic delivery |
WO2024077018A2 (en) * | 2022-10-04 | 2024-04-11 | Alpine Immune Sciences, Inc. | Methods and uses of taci-fc fusion immunomodulatory protein |
WO2024120458A1 (zh) * | 2022-12-07 | 2024-06-13 | 荣昌生物制药(烟台)股份有限公司 | TACI-Fc融合蛋白液体药物制剂 |
Family Cites Families (137)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
US5443964A (en) | 1987-08-10 | 1995-08-22 | Duke University | Poxvirus insertion/expression vector |
US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
US6410010B1 (en) | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
ATE248924T1 (de) | 1991-05-06 | 2003-09-15 | Us Gov Health & Human Serv | Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung |
CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
US5262522A (en) | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
DE69534702T2 (de) | 1994-09-23 | 2006-08-24 | The University Of British Columbia, Vancouver | Verfahren zur erhöhung der expression von endogenen peptiden tragenden mhc klasse i molekulen |
PT784483E (pt) | 1994-10-03 | 2001-05-31 | Us Gov Health & Human Serv | Composicao que compreende um virus recombinante que exprime um antigenio e um virus recombinante que exprime uma molecula imunoestimuladora |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
KR20050004269A (ko) | 1996-10-25 | 2005-01-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 뉴트로킨 알파 |
US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
DE69830901T2 (de) | 1997-05-02 | 2006-05-24 | Genentech Inc., San Francisco | ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
JP2002510481A (ja) | 1998-04-02 | 2002-04-09 | ジェネンテック・インコーポレーテッド | 抗体変異体及びその断片 |
GB2337755B (en) | 1998-05-29 | 2003-10-29 | Secr Defence | Virus vaccine |
US6375952B1 (en) | 1998-08-07 | 2002-04-23 | University Of Washington | Immunological herpes simplex virus antigens and methods for use thereof |
US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
US20060067933A1 (en) | 1999-01-07 | 2006-03-30 | Gross Jane A | Soluble receptor BR43x2 and methods of using |
WO2000040716A2 (en) | 1999-01-07 | 2000-07-13 | Zymogenetics, Inc. | Soluble receptor br43x2 and methods of using them for therapy |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
JP4827353B2 (ja) | 1999-08-09 | 2011-11-30 | ターゲティッド ジェネティクス コーポレイション | 鎖内塩基対を形成するような配列の設計による、組換えウイルスベクターからの一本鎖の異種ヌクレオチド配列の発現の増大 |
DE60028830T2 (de) | 2000-02-16 | 2007-01-18 | Genentech, Inc., South San Francisco | Anti-april antikörper und hybridomazellen |
EP1746106A3 (en) | 2000-04-27 | 2007-03-14 | Biogen Idec MA Inc. | Use of TACI as an anti-tumor agent |
AU2001253920B2 (en) | 2000-04-27 | 2006-03-16 | Apoxis Sa | Use of taci as an anti-tumor agent |
US20040013674A1 (en) | 2001-04-27 | 2004-01-22 | Christine Ambrose | Taci as an anti-tumor agent |
CA2408617A1 (en) | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
AU2001282856A1 (en) | 2000-06-15 | 2001-12-24 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
WO2002066516A2 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
KR20040030628A (ko) | 2001-05-24 | 2004-04-09 | 지모제넥틱스, 인코포레이티드 | Taci-면역글로불린 융합 단백질 |
CA2446734A1 (en) | 2001-05-24 | 2002-11-28 | Human Genome Sciences, Inc. | Antibodies against tumor necrosis factor delta (april) |
PL377119A1 (pl) | 2001-08-03 | 2006-01-23 | Genentech, Inc. | Peptydy TACIs i BR3 i ich zastosowanie |
DK1461073T3 (da) | 2001-11-30 | 2010-03-29 | Us Gov Health & Human Serv | Peptidagonister til prostataspecifikt antigen og anvendelser heraf |
US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
AU2003256836A1 (en) | 2002-07-25 | 2004-02-16 | Genentech, Inc. | Taci antibodies and uses thereof |
WO2004033486A2 (en) | 2002-10-11 | 2004-04-22 | Zymogenetics, Inc. | Production of homotrimeric fusion proteins |
US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
TWI335821B (en) | 2002-12-16 | 2011-01-11 | Genentech Inc | Immunoglobulin variants and uses thereof |
EP1578782A4 (en) | 2002-12-30 | 2007-09-12 | Amgen Inc | COSTIMULATING FACTORIAL THERAPY |
US20050163775A1 (en) | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
EP1629001A2 (en) | 2003-06-05 | 2006-03-01 | Genentech, Inc. | Blys antagonists and uses thereof |
BRPI0415709A (pt) | 2003-10-20 | 2006-12-19 | Biogen Idec Inc | esquemas terapêuticos para antagonistas de baff |
PL1718677T3 (pl) | 2003-12-19 | 2012-09-28 | Genentech Inc | Jednowartościowe fragmenty przeciwciała stosowane jako środki lecznicze |
ES2403055T3 (es) | 2004-04-13 | 2013-05-13 | F. Hoffmann-La Roche Ag | Anticuerpos anti-P-selectina |
CN101987870B (zh) | 2004-07-15 | 2013-07-03 | 赞科股份有限公司 | 优化的Fc变体 |
TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ox40l抗體 |
ES2387312T3 (es) | 2004-09-22 | 2012-09-20 | Kyowa Hakko Kirin Co., Ltd. | Anticuerpos IgG4 humanos estabilizados |
MX2007005378A (es) | 2004-11-04 | 2008-02-14 | Genentech Inc | Polipeptidos que ligan a baff y/o april. |
US7550296B2 (en) | 2004-12-01 | 2009-06-23 | Bayer Schering Pharma Ag | Generation of replication competent viruses for therapeutic use |
EA200701211A1 (ru) * | 2004-12-31 | 2007-12-28 | Дженентек, Инк. | Полипептиды, которые связываются с br3, и их применение |
EP3623473A1 (en) | 2005-03-31 | 2020-03-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
JP2009507777A (ja) | 2005-08-09 | 2009-02-26 | ザイモジェネティクス,インコーポレイティド | TACI−Ig融合分子を用いたB細胞性腫瘍の処置方法 |
EP1922079A2 (en) | 2005-08-09 | 2008-05-21 | ZymoGenetics, Inc. | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
EP1924286A4 (en) | 2005-08-12 | 2010-01-13 | Garvan Inst Med Res | PROPHYLACTIC AND / OR THERAPEUTIC METHOD FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
US7655439B2 (en) | 2005-09-09 | 2010-02-02 | Zymogenetics, Inc. | Trimerizing polypeptides |
US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
CA2626082C (en) | 2005-10-13 | 2017-04-11 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
US8784812B2 (en) | 2006-05-15 | 2014-07-22 | Zymogenetics, Inc. | Methods for treating autoimmune diseases using a TACI-Ig fusion molecule |
CA2661872A1 (en) | 2006-08-28 | 2008-03-06 | Ares Trading S.A. | Process for the purification of fc-fusion proteins |
FI2061803T4 (fi) | 2006-08-28 | 2023-03-14 | Process for the purification of fc-containing proteins | |
JP2010501622A (ja) | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Fc−融合タンパク質の精製法 |
WO2008092117A2 (en) | 2007-01-25 | 2008-07-31 | Xencor, Inc. | Immunoglobulins with modifications in the fcr binding region |
JP2010516744A (ja) | 2007-01-26 | 2010-05-20 | メルク セローノ ソシエテ アノニム | 油体技術を用いたFc−融合タンパク質の精製 |
US8852591B2 (en) | 2007-03-27 | 2014-10-07 | Zymogenetics, Inc. | Combination of BLyS and/or APRIL inhibition and immunosuppressants for treatment of autoimmune disease |
SG182191A1 (en) * | 2007-06-13 | 2012-07-30 | Zymogenetics Inc | Use of taci-ig fusion protein such as atacicept for the manufacture of a medicament for treating lupus erythematosus |
CN101323643B (zh) | 2007-06-15 | 2010-12-01 | 烟台荣昌生物工程有限公司 | 优化的TACI-Fc融合蛋白 |
SI2173890T1 (sl) | 2007-06-21 | 2011-06-30 | Univ Muenchen Tech | Biološko aktivni proteini, ki imajo povečano in vivo in/ali in vitro stabilnost |
DK2233149T3 (en) | 2007-10-16 | 2016-05-17 | Zymogenetics Inc | COMBINATION OF TRANSMEMBRANAKTIVATOR AND CALCIUM MODULATOR AND cyclophilin-LIGAND INTERAKTOR (TACI) AND ANTI-CD20 MEANS FOR TREATMENT OF AUTO-IMMUNE DISEASE |
EP2203465A1 (en) | 2007-10-22 | 2010-07-07 | Merck Serono S.A. | Method for purifying an fc-containing protein |
PL2219675T3 (pl) | 2007-11-12 | 2014-04-30 | Ares Trading Sa | Formulacja dla białek fuzyjnych TACI-immunoglobulina |
US20100239580A1 (en) | 2007-11-12 | 2010-09-23 | Area Trading S.A. | Taci-immunoglobulin fusion proteins for treatment of optic neuritis |
EP2219673A1 (en) | 2007-11-12 | 2010-08-25 | Ares Trading S.A. | Taci-immunoglobulin fusion proteins for treatment of relapsing multiple sclerosis |
DK2222861T3 (en) | 2007-12-11 | 2018-02-05 | Univ North Carolina Chapel Hill | POLYPURIN-TRACT MODIFIED RETROVIRAL VECTORS |
CA2720682A1 (en) | 2008-04-25 | 2009-10-29 | Zymogenetics, Inc. | Levels of bcma protein expression on b cells and use in diagnostic methods |
US8003335B2 (en) | 2008-04-30 | 2011-08-23 | Universite Paris-SUD11 | Levels of APRIL in serum and use in diagnostic methods |
CA2720651C (en) | 2008-05-01 | 2020-03-10 | Zymogenetics, Inc. | Levels of blys/april heterotrimers in serum and use in diagnostic methods |
EP2540740B1 (en) | 2008-06-17 | 2014-09-10 | Apogenix GmbH | Multimeric TNF receptors |
EP2435477A1 (en) | 2009-05-28 | 2012-04-04 | Glaxo Group Limited | Antigen-binding proteins |
WO2011109280A1 (en) * | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Methods and compositions to treat immune-mediated disorders |
CN101851278B (zh) | 2010-05-26 | 2013-03-13 | 石药集团中奇制药技术(石家庄)有限公司 | B细胞激活因子拮抗剂及其制备方法与用途 |
US20110311548A1 (en) | 2010-06-18 | 2011-12-22 | Human Genome Sciences, Inc. | Use of b lymphocyte stimulator protein antagonists to treat asthma and other allergic and inflammatory conditions of the respiratory system |
JP6267512B2 (ja) | 2010-09-10 | 2018-01-24 | ティゲニクス、エセ、ア、ウTiGenix,S.A.U. | 幹細胞培養培地および方法 |
CN102085368B (zh) | 2011-01-19 | 2013-06-12 | 烟台荣昌生物工程有限公司 | 优化的TACI-Fc融合蛋白用于制备治疗***性红斑狼疮药物的应用 |
CA2830254C (en) | 2011-03-16 | 2019-09-10 | Amgen Inc. | Fc variants |
AU2012243039B2 (en) | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
WO2013041029A1 (en) * | 2011-09-23 | 2013-03-28 | Igenimed Pharmaceuticals Inc. | Novel soluble ctla4 variants |
TWI476001B (zh) | 2011-12-26 | 2015-03-11 | Ind Tech Res Inst | 三倍體Fc融合蛋白及其用途 |
MX366864B (es) | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Composiciones de conjugados de xten y métodos para realizarlas. |
US10065987B2 (en) | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
EP3744728A1 (en) | 2013-02-12 | 2020-12-02 | Bristol-Myers Squibb Company | Tangential flow filtration based protein refolding methods |
CN105392801A (zh) | 2013-03-15 | 2016-03-09 | 比奥根Ma公司 | 使用抗αvβ5抗体治疗和预防急性肾损伤 |
CN110903398B (zh) | 2014-01-15 | 2023-08-15 | 豪夫迈·罗氏有限公司 | 具有修饰的FCRN和保持的蛋白A结合性质的Fc区变体 |
US10562954B2 (en) * | 2014-05-12 | 2020-02-18 | Shanghai Kanda Biotechnology Co., Ltd. | Fusion protein inhibiting TACI-BAFF complex formation and preparation method therefor and use thereof |
JP2017522312A (ja) | 2014-07-15 | 2017-08-10 | イミューン デザイン コーポレイション | Tlr4アゴニストアジュバント及びレンチウイルスベクターを用いたプライム・ブーストレジメン |
CA2990177A1 (en) | 2015-06-25 | 2016-12-29 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
BR112018011781A2 (pt) * | 2015-12-14 | 2018-12-04 | Macrogenics Inc | molécula biespecífica possuindo um ou mais sítios de ligação a epítopo capazes de ligação imunoespecífica a (um) epítopo(s) de pd-1 e um ou mais sítios de ligação a epítopo capazes de ligação imunoespecífica a (um) epítopo(s) de ctla-4, e composição farmacêutica |
EP3443000A2 (en) | 2016-04-15 | 2019-02-20 | Alpine Immune Sciences, Inc. | Cd80 variant immunomodulatory proteins and uses thereof |
EP3442999A2 (en) | 2016-04-15 | 2019-02-20 | Alpine Immune Sciences, Inc. | Icos ligand variant immunomodulatory proteins and uses thereof |
EP3452101A2 (en) | 2016-05-04 | 2019-03-13 | CureVac AG | Rna encoding a therapeutic protein |
CA3029197A1 (en) | 2016-06-24 | 2017-12-28 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
EP3491013A1 (en) | 2016-07-28 | 2019-06-05 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
KR20190099194A (ko) | 2016-10-20 | 2019-08-26 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 분비가능한 변이체 면역조절 단백질 및 조작된 세포 치료 |
EP3596116B1 (en) | 2017-03-16 | 2023-09-06 | Alpine Immune Sciences, Inc. | Pd-l1 variant immunomodulatory proteins and uses thereof |
AU2018235838B2 (en) | 2017-03-16 | 2023-12-14 | Alpine Immune Sciences, Inc. | CD80 variant immunomodulatory proteins and uses thereof |
WO2018170023A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Pd-l2 variant immunomodulatory proteins and uses thereof |
WO2018236995A2 (en) | 2017-06-20 | 2018-12-27 | Dana-Farber Cancer Institute, Inc. | METHODS FOR MODULATING REGULATORY T LYMPHOCYTES, REGULATORY B LYMPHOCYTES AND IMMUNE RESPONSES USING AVRIL-TACI INTERACTION MODULATORS |
AU2018326805B2 (en) | 2017-09-01 | 2023-11-30 | Dana-Farber Cancer Institute, Inc. | Immunogenic peptides specific to BCMA and TACI antigens for treatment of cancer |
MA50360A (fr) * | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences Inc | Protéines immunomodulatrices de variants de ctla-4 et leurs utilisations |
CA3078517A1 (en) | 2017-10-18 | 2019-04-25 | Alpine Immune Sciences, Inc. | Variant icos ligand immunomodulatory proteins and related compositions and methods |
GB201720426D0 (en) | 2017-12-07 | 2018-01-24 | Hummingbird Bioscience Pte Ltd | CD47 and BCMA antigen-binding molecules |
US20230101432A1 (en) | 2018-01-03 | 2023-03-30 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
MX2020009051A (es) | 2018-03-02 | 2020-12-03 | Allogene Therapeutics Inc | Receptores de citocina quimericos inducibles. |
CN110522908A (zh) | 2018-05-25 | 2019-12-03 | 荣昌生物制药(烟台)有限公司 | TACI-Fc融合蛋白用于制备治疗视神经脊髓炎谱系疾病和多发性硬化之药物中的应用 |
US20210363219A1 (en) | 2018-06-15 | 2021-11-25 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
WO2020028572A2 (en) | 2018-08-01 | 2020-02-06 | Unum Therapeutics Inc. | ANTIBODY-COUPLED T CELL RECEPTORS (ACTRs) IN COMBINATION WITH TRANS CO-STIMULATORY MOLECULES AND THERAPEUTIC USES THEREOF |
WO2020047329A1 (en) * | 2018-08-29 | 2020-03-05 | Shattuck Labs, Inc. | Chimeric proteins comprising extracellular domains and uses thereof |
JP2022501361A (ja) | 2018-09-19 | 2022-01-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | バリアントcd80融合タンパク質および関連構築物の方法および使用 |
CA3117978A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
JP2022510276A (ja) | 2018-11-30 | 2022-01-26 | アルパイン イミューン サイエンシズ インコーポレイテッド | Cd86バリアント免疫調節タンパク質およびその使用 |
WO2020214867A1 (en) | 2019-04-17 | 2020-10-22 | Alpine Immune Sciences, Inc. | Methods and uses of variant icos ligand (icosl) fusion proteins |
CN114728040A (zh) | 2019-06-14 | 2022-07-08 | 科优基因公司 | 新型白介素-2变体及其双功能融合分子 |
EP4056232A4 (en) | 2019-09-13 | 2023-09-13 | Kyowa Kirin Co., Ltd. | DCR3 VARIANT |
BR112021025458A2 (pt) | 2019-12-10 | 2022-06-21 | Remegen Co Ltd | Formulação farmacêutica, método de preparação e uso da mesma |
JP2022539785A (ja) | 2019-12-24 | 2022-09-13 | レメゲン シーオー.,エルティーディー. | TACI-Fc融合タンパク質及びその用途 |
-
2021
- 2021-05-07 AU AU2021268033A patent/AU2021268033A1/en active Pending
- 2021-05-07 KR KR1020227043140A patent/KR20230029622A/ko active Search and Examination
- 2021-05-07 IL IL297981A patent/IL297981A/en unknown
- 2021-05-07 US US17/315,168 patent/US20210388054A1/en active Pending
- 2021-05-07 WO PCT/US2021/031430 patent/WO2021226551A1/en unknown
- 2021-05-07 WO PCT/US2021/031432 patent/WO2021226553A2/en unknown
- 2021-05-07 BR BR112022022433A patent/BR112022022433A2/pt unknown
- 2021-05-07 IL IL297980A patent/IL297980A/en unknown
- 2021-05-07 EP EP21730004.5A patent/EP4146684A2/en active Pending
- 2021-05-07 EP EP21730003.7A patent/EP4146683A1/en active Pending
- 2021-05-07 US US17/923,208 patent/US20230241168A1/en active Pending
- 2021-05-07 MX MX2022013999A patent/MX2022013999A/es unknown
- 2021-05-07 AU AU2021267276A patent/AU2021267276A1/en active Pending
- 2021-05-07 KR KR1020227043139A patent/KR20230029621A/ko active Search and Examination
- 2021-05-07 MX MX2022013998A patent/MX2022013998A/es unknown
- 2021-05-07 CN CN202310582491.4A patent/CN116903727A/zh active Pending
- 2021-05-07 TW TW110116616A patent/TW202208414A/zh unknown
- 2021-05-07 PE PE2022002607A patent/PE20230494A1/es unknown
- 2021-05-07 BR BR112022022524A patent/BR112022022524A2/pt unknown
- 2021-05-07 CN CN202180047833.1A patent/CN115812077A/zh active Pending
- 2021-05-07 CN CN202311249622.3A patent/CN117736297A/zh active Pending
- 2021-05-07 CA CA3178885A patent/CA3178885A1/en active Pending
- 2021-05-07 CN CN202180047593.5A patent/CN116194467A/zh active Pending
- 2021-05-07 CA CA3178882A patent/CA3178882A1/en active Pending
- 2021-05-07 JP JP2022567473A patent/JP2023525033A/ja active Pending
- 2021-05-07 JP JP2022567472A patent/JP2023525032A/ja active Pending
- 2021-06-11 US US17/346,095 patent/US11274140B2/en active Active
-
2022
- 2022-11-08 CL CL2022003104A patent/CL2022003104A1/es unknown
- 2022-12-07 CO CONC2022/0017780A patent/CO2022017780A2/es unknown
-
2023
- 2023-03-17 US US18/186,098 patent/US20240218045A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TW202208414A (zh) | 2022-03-01 |
CN116903727A (zh) | 2023-10-20 |
JP2023525032A (ja) | 2023-06-14 |
CA3178882A1 (en) | 2021-11-11 |
WO2021226553A3 (en) | 2022-04-28 |
CL2022003104A1 (es) | 2023-07-14 |
US20210388054A1 (en) | 2021-12-16 |
US11274140B2 (en) | 2022-03-15 |
MX2022013998A (es) | 2023-02-16 |
IL297980A (en) | 2023-01-01 |
BR112022022433A2 (pt) | 2022-12-13 |
PE20230494A1 (es) | 2023-03-23 |
MX2022013999A (es) | 2023-02-16 |
CN116194467A (zh) | 2023-05-30 |
EP4146683A1 (en) | 2023-03-15 |
CA3178885A1 (en) | 2021-11-11 |
WO2021226551A1 (en) | 2021-11-11 |
IL297981A (en) | 2023-01-01 |
US20210363223A1 (en) | 2021-11-25 |
US20230241168A1 (en) | 2023-08-03 |
AU2021268033A1 (en) | 2022-12-15 |
WO2021226553A2 (en) | 2021-11-11 |
JP2023525033A (ja) | 2023-06-14 |
KR20230029621A (ko) | 2023-03-03 |
CO2022017780A2 (es) | 2023-03-17 |
AU2021267276A1 (en) | 2022-12-15 |
US20240218045A1 (en) | 2024-07-04 |
CN117736297A (zh) | 2024-03-22 |
KR20230029622A (ko) | 2023-03-03 |
EP4146684A2 (en) | 2023-03-15 |
CN115812077A (zh) | 2023-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022022524A2 (pt) | Proteínas imunomoduladoras inibidoras de april e baff com e sem uma proteína inibidora de células t e métodos de uso das mesmas | |
Grange et al. | Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-κB and MAPK pathways | |
BR112017020961A2 (pt) | muteína, molécula de ácido nucleico, célula hospedeira, método de produção de uma muteína e método de ligação | |
CL2018000537A1 (es) | Anticuerpo anti-factor d del complemento; polinucleótido codificante; vector que comprende dicho polinucleótido; célula húesped que comprende dicho vector; método de fabricación de anticuerpo; composición farmacéutica que lo comprende; uso del anticuerpo para tratar trastornos inflamatorios o trastornos oculares (divisional de cl 1001-2009). | |
BR112021005769A2 (pt) | proteínas de ligação a dll3 e métodos de uso | |
Terragni et al. | Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine | |
Secor et al. | Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression | |
Heruth et al. | RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis | |
ECSP088262A (es) | Proteínas de fusión de albúmina | |
NO20076059L (no) | 2,4-Diamino-pyrimidiner anvendt som aurorainhibitorer | |
BRPI0415613A (pt) | novos compostos de diazaspiroalcanos e seu uso no tratamento de doenças mediadas por ccr8 | |
BR112012027034A2 (pt) | inibidores da arginase e suas aplicações terapêuticas | |
BR112014004560A2 (pt) | compostos e composições como inibidores de c-kit quinase | |
EA201170635A1 (ru) | Композиции, способы получения и применение каркаса на основе домена фибронектина типа iii | |
NO20061292L (no) | Heterosyldiske forbindelser og fremgangsmater for fremstilling og anvendelse derav | |
BRPI0606803A2 (pt) | axmi-018, axmi-020 e axmi-021, uma famìlia de genes de delta-endotoxina e métodos para seu uso | |
BRPI0409173A (pt) | compostos e composições como inibidores de proteìna quinase | |
EA201201661A1 (ru) | Новые аминопиразолохиназолины | |
EA201200515A1 (ru) | Полипептиды и их применение | |
BR112012010333A2 (pt) | peptídeos terapêuticos | |
HK1134283A1 (en) | Arylsulfonamide compounds | |
BRPI0512352A (pt) | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas | |
CL2021000207A1 (es) | Nuevas proteínas de fusión específicas para cd137 y pd-l1 | |
DE602006020501D1 (de) | Synthetische mecp2-sequenz für die proteinersatztherapie | |
BRPI0714844B8 (pt) | molécula de ácido nucleico e seus usos, composição farmaceutica e complexo |