BR112022021789A2 - Bibliotecas de ácido nucléico variantes para coronavírus - Google Patents
Bibliotecas de ácido nucléico variantes para coronavírusInfo
- Publication number
- BR112022021789A2 BR112022021789A2 BR112022021789A BR112022021789A BR112022021789A2 BR 112022021789 A2 BR112022021789 A2 BR 112022021789A2 BR 112022021789 A BR112022021789 A BR 112022021789A BR 112022021789 A BR112022021789 A BR 112022021789A BR 112022021789 A2 BR112022021789 A2 BR 112022021789A2
- Authority
- BR
- Brazil
- Prior art keywords
- libraries
- nucleic acid
- acid libraries
- variant nucleic
- coronavirus variant
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 6
- 108020004707 nucleic acids Proteins 0.000 title abstract 6
- 150000007523 nucleic acids Chemical class 0.000 title abstract 6
- 241000711573 Coronaviridae Species 0.000 title abstract 2
- 102000053723 Angiotensin-converting enzyme 2 Human genes 0.000 abstract 1
- 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 abstract 1
- 241001678559 COVID-19 virus Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
BIBLIOTECAS DE ÁCIDO NUCLÉICO VARIANTES PARA CORONAVÍRUS. São fornecidos neste documento métodos e composições relacionados a bibliotecas de anticorpos otimizados com ácidos nucleicos que codificam para um anticorpo compreendendo sequências modificadas. As bibliotecas aqui descritas compreendem ácidos nucleicos que codificam anticorpos SARS-CoV-2 ou ACE2. Ainda aqui descritas são bibliotecas de proteínas geradas quando as bibliotecas de ácidos nucleicos são traduzidas. Ainda descritas neste documento são bibliotecas de células que expressam bibliotecas de ácidos nucleicos variegadas descritas neste documento.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063016254P | 2020-04-27 | 2020-04-27 | |
US202063034896P | 2020-06-04 | 2020-06-04 | |
US202063069665P | 2020-08-24 | 2020-08-24 | |
US202063073362P | 2020-09-01 | 2020-09-01 | |
US202063104465P | 2020-10-22 | 2020-10-22 | |
US202063115568P | 2020-11-18 | 2020-11-18 | |
PCT/US2021/029485 WO2021222315A2 (en) | 2020-04-27 | 2021-04-27 | Variant nucleic acid libraries for coronavirus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022021789A2 true BR112022021789A2 (pt) | 2023-03-07 |
Family
ID=78374237
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022021780A BR112022021780A2 (pt) | 2020-04-27 | 2021-04-27 | Bibliotecas de ácido nucléico variantes para coronavírus |
BR112022021789A BR112022021789A2 (pt) | 2020-04-27 | 2021-04-27 | Bibliotecas de ácido nucléico variantes para coronavírus |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022021780A BR112022021780A2 (pt) | 2020-04-27 | 2021-04-27 | Bibliotecas de ácido nucléico variantes para coronavírus |
Country Status (11)
Country | Link |
---|---|
US (2) | US20210395344A1 (pt) |
EP (2) | EP4142739A2 (pt) |
JP (2) | JP2023523336A (pt) |
KR (2) | KR20230016184A (pt) |
CN (2) | CN116113420A (pt) |
AU (2) | AU2021263755A1 (pt) |
BR (2) | BR112022021780A2 (pt) |
CA (2) | CA3177030A1 (pt) |
IL (2) | IL297701A (pt) |
MX (2) | MX2022013513A (pt) |
WO (2) | WO2021222316A2 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2533173A (en) | 2013-08-05 | 2016-06-15 | Twist Bioscience Corp | De Novo synthesized gene libraries |
US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
IL258164B (en) | 2015-09-18 | 2022-09-01 | Twist Bioscience Corp | Methods to regulate the activity of proteins and cells and a method for the production of nucleic acids |
KR20180058772A (ko) | 2015-09-22 | 2018-06-01 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
JP6871364B2 (ja) | 2016-09-21 | 2021-05-12 | ツイスト バイオサイエンス コーポレーション | 核酸に基づくデータ保存 |
CA3054303A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
AU2018284227B2 (en) | 2017-06-12 | 2024-05-02 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
EA202090562A1 (ru) | 2017-09-11 | 2020-08-10 | Твист Байосайенс Корпорейшн | Связывающие gpcr белки и их синтез |
US10894242B2 (en) | 2017-10-20 | 2021-01-19 | Twist Bioscience Corporation | Heated nanowells for polynucleotide synthesis |
SG11202011467RA (en) | 2018-05-18 | 2020-12-30 | Twist Bioscience Corp | Polynucleotides, reagents, and methods for nucleic acid hybridization |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
CN113766930A (zh) | 2019-02-26 | 2021-12-07 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
MX2022013513A (es) * | 2020-04-27 | 2023-01-16 | Twist Bioscience Corp | Bibliotecas de ácidos nucleicos variantes para coronavirus. |
WO2022086866A1 (en) | 2020-10-19 | 2022-04-28 | Twist Bioscience Corporation | Methods of synthesizing oligonucleotides using tethered nucleotides |
WO2022204316A2 (en) * | 2021-03-24 | 2022-09-29 | Twist Bioscience Corporation | Variant nucleic acid libraries for cd3 |
CA3238160A1 (en) * | 2021-11-18 | 2023-05-25 | Aaron Sato | Dickkopf-1 variant antibodies and methods of use |
WO2023102034A2 (en) * | 2021-12-01 | 2023-06-08 | Twist Bioscience Corporation | Neuropilin-1 variant antibodies and methods of use |
WO2023130123A2 (en) * | 2022-01-03 | 2023-07-06 | Twist Bioscience Corporation | Bispecific sars-cov-2 antibodies and methods of use |
WO2023235827A2 (en) * | 2022-06-03 | 2023-12-07 | The Rockefeller University | Coronavirus-inhibiting antibodies |
Family Cites Families (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
ATE262374T1 (de) | 1991-11-22 | 2004-04-15 | Affymetrix Inc | Kombinatorische strategien für polymersynthese |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5368823A (en) | 1993-02-11 | 1994-11-29 | University Of Georgia Research Foundation, Inc. | Automated synthesis of oligonucleotides |
US7135312B2 (en) | 1993-04-15 | 2006-11-14 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
US5455239A (en) | 1993-08-05 | 1995-10-03 | Merck & Co. Inc. | 3-aryl of heteroaryl-7-heteroaralkylamido cephalosporin compounds, compositions and methods of use |
US6893816B1 (en) | 1993-10-28 | 2005-05-17 | Houston Advanced Research Center | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
PT725682E (pt) | 1993-10-28 | 2002-09-30 | Houston Advanced Res Ct | Dispositivo poroso microfabricado de escoamento |
US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
AU6646398A (en) | 1996-12-31 | 1998-07-31 | Genometrix Incorporated | Multiplexed molecular analysis apparatus and method |
US6419883B1 (en) | 1998-01-16 | 2002-07-16 | University Of Washington | Chemical synthesis using solvent microdroplets |
US6028189A (en) | 1997-03-20 | 2000-02-22 | University Of Washington | Solvent for oligonucleotide synthesis and methods of use |
IL131978A0 (en) | 1997-03-20 | 2001-03-19 | Univ Washington | Solvent for biopolymer synthesis solvent microdots and methods of use |
EP0991930B1 (en) | 1997-06-26 | 2004-06-16 | Perseptive Biosystems, Inc. | High density sample holder for analysis of biological samples |
JP2002538790A (ja) | 1999-03-08 | 2002-11-19 | プロトジーン・ラボラトリーズ・インコーポレーテッド | 長いdna配列を経済的に合成し、そして組み立てるための方法および組成物 |
US6472147B1 (en) | 1999-05-25 | 2002-10-29 | The Scripps Research Institute | Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries |
US20020025561A1 (en) | 2000-04-17 | 2002-02-28 | Hodgson Clague Pitman | Vectors for gene-self-assembly |
US7163660B2 (en) | 2000-05-31 | 2007-01-16 | Infineon Technologies Ag | Arrangement for taking up liquid analytes |
US6716629B2 (en) | 2000-10-10 | 2004-04-06 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
US6905816B2 (en) | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
US20020164824A1 (en) | 2001-02-16 | 2002-11-07 | Jianming Xiao | Method and apparatus based on bundled capillaries for high throughput screening |
US7211654B2 (en) | 2001-03-14 | 2007-05-01 | Regents Of The University Of Michigan | Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports |
US20040161741A1 (en) | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
WO2003057924A1 (en) | 2002-01-04 | 2003-07-17 | Board Of Regents, The University Of Texas System | Proofreading, error deletion, and ligation method for synthesis of high-fidelity polynucleotide sequences |
US20070275411A1 (en) | 2006-05-25 | 2007-11-29 | Mcgall Glenn H | Silane mixtures |
US7563600B2 (en) | 2002-09-12 | 2009-07-21 | Combimatrix Corporation | Microarray synthesis and assembly of gene-length polynucleotides |
US20070059692A1 (en) | 2002-10-28 | 2007-03-15 | Xiaolian Gao | Array oligomer synthesis and use |
US7422911B2 (en) | 2002-10-31 | 2008-09-09 | Agilent Technologies, Inc. | Composite flexible array substrate having flexible support |
US7879580B2 (en) | 2002-12-10 | 2011-02-01 | Massachusetts Institute Of Technology | Methods for high fidelity production of long nucleic acid molecules |
US7932025B2 (en) | 2002-12-10 | 2011-04-26 | Massachusetts Institute Of Technology | Methods for high fidelity production of long nucleic acid molecules with error control |
WO2004058945A2 (en) | 2002-12-23 | 2004-07-15 | Agilent Technologies, Inc. | Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same |
US7202264B2 (en) | 2003-01-31 | 2007-04-10 | Isis Pharmaceuticals, Inc. | Supports for oligomer synthesis |
JP2004268394A (ja) | 2003-03-07 | 2004-09-30 | Canon Inc | インクジェット記録装置及びその制御方法 |
AU2004251256B2 (en) | 2003-05-30 | 2009-05-28 | The Board Of Trustees Of The University Of Illinois | Gene expression profiles that identify genetically elite ungulate mammals |
US8133670B2 (en) | 2003-06-13 | 2012-03-13 | Cold Spring Harbor Laboratory | Method for making populations of defined nucleic acid molecules |
CA2531684C (en) * | 2003-07-22 | 2014-03-11 | Crucell Holland B.V. | Binding molecules against sars-coronavirus and uses thereof |
WO2005060520A2 (en) | 2003-11-25 | 2005-07-07 | Dana-Farber Cancer Institute, Inc. | ANTIBODIES AGAINST SARS-CoV AND METHODS OF USE THEREOF |
PL1697507T3 (pl) | 2003-12-02 | 2013-03-29 | Pasteur Institut | Zastosowanie białek i peptydów kodowanych przez genom nowego szczepu koronawirusa związanego z SARS |
EP1733055A4 (en) | 2004-02-27 | 2009-03-11 | Harvard College | polynucleotide |
US8825411B2 (en) | 2004-05-04 | 2014-09-02 | Dna Twopointo, Inc. | Design, synthesis and assembly of synthetic nucleic acids |
JP2008525020A (ja) | 2004-12-22 | 2008-07-17 | ナショナル ユニバーシティ オブ シンガポール | 新規ヘビ毒素 |
EP2361933A3 (en) * | 2005-01-26 | 2012-05-02 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
US20070196834A1 (en) | 2005-09-09 | 2007-08-23 | Francesco Cerrina | Method and system for the generation of large double stranded DNA fragments |
CN101277758A (zh) | 2005-09-14 | 2008-10-01 | Illumina公司 | 连续聚合物合成器 |
EP1939621B1 (en) | 2005-09-16 | 2014-11-19 | Azbil Corporation | Method for manufacturing substrate for biochip, and method for manufacturing biochip |
EP4105644A3 (en) | 2006-03-31 | 2022-12-28 | Illumina, Inc. | Systems and devices for sequence by synthesis analysis |
EP2007907A2 (en) | 2006-04-19 | 2008-12-31 | Applera Corporation | Reagents, methods, and libraries for gel-free bead-based sequencing |
WO2008054543A2 (en) | 2006-05-20 | 2008-05-08 | Codon Devices, Inc. | Oligonucleotides for multiplex nucleic acid assembly |
DE102006039479A1 (de) | 2006-08-23 | 2008-03-06 | Febit Biotech Gmbh | Programmierbare Oligonukleotidsynthese |
EP2078077A2 (en) | 2006-10-04 | 2009-07-15 | Codon Devices, Inc | Nucleic acid libraries and their design and assembly |
US20080085511A1 (en) | 2006-10-05 | 2008-04-10 | Peck Bill J | Preparation of biopolymer arrays |
US20080085514A1 (en) | 2006-10-10 | 2008-04-10 | Peck Bill J | Methods and devices for array synthesis |
WO2008063135A1 (en) | 2006-11-24 | 2008-05-29 | Agency For Science, Technology And Research | Apparatus for processing a sample in a liquid droplet and method of using the same |
NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
KR100827449B1 (ko) | 2007-02-07 | 2008-05-07 | 삼성전자주식회사 | 광분해성 화합물과 상기 화합물이 커플링된 올리고머프로브 어레이용 기판, 올리고머 프로브 어레이 및 이의제조 방법 |
JP4582224B2 (ja) | 2008-05-02 | 2010-11-17 | ソニー株式会社 | マイクロビーズ作製方法及びマイクロビーズ |
JP4667490B2 (ja) | 2008-07-09 | 2011-04-13 | 三菱電機株式会社 | 加熱調理器 |
US8808986B2 (en) | 2008-08-27 | 2014-08-19 | Gen9, Inc. | Methods and devices for high fidelity polynucleotide synthesis |
JP2012504416A (ja) | 2008-09-30 | 2012-02-23 | アボット・ラボラトリーズ | 改良抗体ライブラリー |
US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
WO2010053443A1 (en) | 2008-11-06 | 2010-05-14 | Agency For Science, Technology And Research | Apparatus for biopolymer synthesis |
JP2012508017A (ja) * | 2008-11-07 | 2012-04-05 | ファブラス エルエルシー | 抗dll4抗体及びその使用 |
US20110286916A1 (en) | 2008-11-20 | 2011-11-24 | Jose Miguel Aste-Amezaga | Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use |
US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
EP2398915B1 (en) | 2009-02-20 | 2016-08-24 | Synthetic Genomics, Inc. | Synthesis of sequence-verified nucleic acids |
WO2010115122A2 (en) | 2009-04-03 | 2010-10-07 | Illumina, Inc. | Generation of uniform fragments of nucleic acids using patterned substrates |
EP3279215B1 (en) | 2009-11-24 | 2020-02-12 | MedImmune Limited | Targeted binding agents against b7-h1 |
US8716467B2 (en) | 2010-03-03 | 2014-05-06 | Gen9, Inc. | Methods and devices for nucleic acid synthesis |
WO2011109031A1 (en) | 2010-03-05 | 2011-09-09 | Synthetic Genomics, Inc. | Methods for cloning and manipulating genomes |
WO2012033987A2 (en) | 2010-09-09 | 2012-03-15 | Purdue Research Foundation | Anti-human folate receptor beta antibodies and methods of use |
US20140045728A1 (en) | 2010-10-22 | 2014-02-13 | President And Fellows Of Harvard College | Orthogonal Amplification and Assembly of Nucleic Acid Sequences |
JP6118725B2 (ja) | 2010-11-12 | 2017-04-19 | ジェン9・インコーポレイテッドGen9,INC. | 核酸合成のための方法およびデバイス |
US9487807B2 (en) | 2010-12-27 | 2016-11-08 | Ibis Biosciences, Inc. | Compositions and methods for producing single-stranded circular DNA |
CN103597068A (zh) | 2011-03-30 | 2014-02-19 | 独立行政法人国立长寿医疗研究中心 | 膜分选培养器、膜分选培养试剂盒、和使用其的干细胞分选方法、以及分离膜 |
ES2844529T3 (es) | 2011-09-01 | 2021-07-22 | Genome Compiler Corp | Sistema de diseño, visualización y transacciones de construcciones polinucleotídicas para fabricar las mismas |
US8840981B2 (en) | 2011-09-09 | 2014-09-23 | Eastman Kodak Company | Microfluidic device with multilayer coating |
WO2013049227A2 (en) | 2011-09-26 | 2013-04-04 | Geneart Ag | High efficiency, small volume nucleic acid synthesis |
US8987174B2 (en) | 2011-10-28 | 2015-03-24 | Prognosys Biosciences, Inc. | Methods for manufacturing molecular arrays |
WO2013096692A1 (en) | 2011-12-21 | 2013-06-27 | Illumina, Inc. | Apparatus and methods for kinetic analysis and determination of nucleic acid sequences |
AU2013229488B2 (en) | 2012-03-08 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof |
SI2852615T1 (sl) | 2012-05-22 | 2019-02-28 | Bristol-Myers Squibb Company | IL-17A/F IL-23 bispecifična protitelesa in njihova uporaba |
WO2014021938A1 (en) | 2012-08-02 | 2014-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and apparatus for nucleic acid synthesis using oligo-templated polymerization |
KR20140048733A (ko) | 2012-10-16 | 2014-04-24 | 삼성전자주식회사 | 다중 웰 플레이트 및 상기 다중 웰 플레이트를 이용한 표적 물질 분석 방법 |
GB2533173A (en) | 2013-08-05 | 2016-06-15 | Twist Bioscience Corp | De Novo synthesized gene libraries |
US20150145336A1 (en) | 2013-11-27 | 2015-05-28 | Solantro Semiconductor Corp. | Modular power conversion system and method |
WO2016022557A1 (en) | 2014-08-05 | 2016-02-11 | Twist Bioscience Corporation | Cell free cloning of nucleic acids |
EP3191604B1 (en) | 2014-09-09 | 2021-04-14 | Igenomx International Genomics Corporation | Methods and compositions for rapid nucleic acid library preparation |
JP6859259B2 (ja) | 2014-11-19 | 2021-04-14 | ジェネンテック, インコーポレイテッド | BACElに対する抗体及び神経疾患免疫療法のためのその使用 |
TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
AU2016206457B2 (en) | 2015-01-16 | 2021-11-11 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ROR1 |
WO2016126987A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
US10669304B2 (en) | 2015-02-04 | 2020-06-02 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
US20160333340A1 (en) | 2015-05-11 | 2016-11-17 | Twist Bioscience Corporation | Compositions and methods for nucleic acid amplification |
IL258164B (en) | 2015-09-18 | 2022-09-01 | Twist Bioscience Corp | Methods to regulate the activity of proteins and cells and a method for the production of nucleic acids |
KR20180058772A (ko) | 2015-09-22 | 2018-06-01 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
CA2997444A1 (en) | 2015-09-29 | 2017-04-06 | Amgen Inc. | Asgr inhibitors for reducing cholesterol levels |
MA43053A (fr) | 2015-09-30 | 2018-08-08 | Janssen Biotech Inc | Anticorps antagonistes se liant spécifiquement au cd40 humain et procédés d'utilisation |
CN108603307A (zh) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | 功能化表面及其制备 |
US20170357752A1 (en) | 2016-06-10 | 2017-12-14 | Twist Bioscience Corporation | Systems and methods for automated annotation and screening of biological sequences |
WO2018026920A1 (en) | 2016-08-03 | 2018-02-08 | Twist Bioscience Corporation | Textured surfaces for polynucleotide synthesis |
JP6854340B2 (ja) | 2016-08-22 | 2021-04-07 | ツイスト バイオサイエンス コーポレーション | デノボ合成された核酸ライブラリ |
JP6871364B2 (ja) | 2016-09-21 | 2021-05-12 | ツイスト バイオサイエンス コーポレーション | 核酸に基づくデータ保存 |
WO2018094263A1 (en) | 2016-11-18 | 2018-05-24 | Twist Bioscience Corporation | Polynucleotide libraries having controlled stoichiometry and synthesis thereof |
US10907274B2 (en) | 2016-12-16 | 2021-02-02 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
EP3565839A4 (en) * | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | CHECKPOINT REGULATOR ANTAGONISTS |
MX2019008197A (es) | 2017-01-06 | 2019-09-11 | Scholar Rock Inc | Inhibidores de tgfb1 permisivos del contexto, espicificos de isoformas y uso de los mismos. |
CA3054303A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
AU2018234624B2 (en) | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
CN110913865A (zh) | 2017-03-15 | 2020-03-24 | 特韦斯特生物科学公司 | 免疫突触的变体文库及其合成 |
SG10201912494TA (en) * | 2017-05-08 | 2020-02-27 | Adimab Llc | Anti-cd3-binding domains and antibodies comprising them, and methods for their generation and use |
WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
AU2018284227B2 (en) | 2017-06-12 | 2024-05-02 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
EA202090562A1 (ru) | 2017-09-11 | 2020-08-10 | Твист Байосайенс Корпорейшн | Связывающие gpcr белки и их синтез |
US10111883B1 (en) | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
US10894242B2 (en) | 2017-10-20 | 2021-01-19 | Twist Bioscience Corporation | Heated nanowells for polynucleotide synthesis |
WO2019084500A1 (en) | 2017-10-27 | 2019-05-02 | Twist Bioscience Corporation | SYSTEMS AND METHODS FOR CLASSIFYING POLYNUCLEOTIDES |
EP3735459A4 (en) | 2018-01-04 | 2021-10-06 | Twist Bioscience Corporation | DNA-BASED DIGITAL INFORMATION STORAGE |
SG11202011467RA (en) | 2018-05-18 | 2020-12-30 | Twist Bioscience Corp | Polynucleotides, reagents, and methods for nucleic acid hybridization |
US10969965B2 (en) | 2018-12-24 | 2021-04-06 | Western Digital Technologies, Inc. | Dynamic performance density tuning for data storage device |
CA3124980A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
JP2022521766A (ja) | 2019-02-25 | 2022-04-12 | ツイスト バイオサイエンス コーポレーション | 次世代シーケンシングのための組成物および方法 |
SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
CN113766930A (zh) | 2019-02-26 | 2021-12-07 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
US20220243195A1 (en) | 2019-06-21 | 2022-08-04 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
CA3148245A1 (en) | 2019-07-22 | 2021-01-28 | Igenomx International Genomics Corporation | Methods and compositions for high throughput sample preparation using double unique dual indexing |
KR20220069046A (ko) | 2019-09-23 | 2022-05-26 | 트위스트 바이오사이언스 코포레이션 | 단일 도메인 항체에 대한 변이체 핵산 라이브러리 |
KR20220066151A (ko) | 2019-09-23 | 2022-05-23 | 트위스트 바이오사이언스 코포레이션 | Crth2에 대한 변이체 핵산 라이브러리 |
EP4073296A4 (en) | 2019-12-09 | 2024-05-22 | Twist Bioscience Corporation | NUCLEIC ACID VARIANT LIBRARIES FOR ADENOSINE RECEPTORS |
AU2021220847A1 (en) | 2020-02-11 | 2022-09-01 | Vanderbilt University | Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) |
CN111592594B (zh) | 2020-03-13 | 2022-05-10 | 北京大学 | 一种抗新型冠状病毒的单克隆抗体及其应用 |
WO2021195326A1 (en) | 2020-03-26 | 2021-09-30 | Vanderbilt University | Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) |
WO2021195385A1 (en) | 2020-03-26 | 2021-09-30 | Vanderbilt University | HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-GoV-2) |
CR20220545A (es) | 2020-03-26 | 2023-01-09 | Univ Vanderbilt | ANTICUERPOS MONOCLONALES HUMANOS DIRIGIDOS CONTRA EL CORONAVIRUS 2 DEL SÍNDROME RESPIRATORIO AGUDO GRAVE (SARS-CoV-2) |
US20230122364A1 (en) | 2020-03-27 | 2023-04-20 | Vanderbilt University | HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2) |
CN115916496A (zh) | 2020-04-14 | 2023-04-04 | 奥西利姆生物技术公司 | 通过数字光刻***和方法的动态微加工 |
MX2022013513A (es) * | 2020-04-27 | 2023-01-16 | Twist Bioscience Corp | Bibliotecas de ácidos nucleicos variantes para coronavirus. |
WO2022010934A2 (en) | 2020-07-07 | 2022-01-13 | Twist Bioscience Corporation | Devices and methods for light-directed polymer synthesis |
US20220106586A1 (en) | 2020-08-25 | 2022-04-07 | Twist Bioscience Corporation | Compositions and methods for library sequencing |
US20220064313A1 (en) | 2020-08-26 | 2022-03-03 | Twist Bioscience Corporation | Methods and compositions relating to glp1r variants |
WO2022047076A1 (en) | 2020-08-28 | 2022-03-03 | Twist Bioscience Corporation | Devices and methods for synthesis |
EP4225912A1 (en) | 2020-10-05 | 2023-08-16 | Twist Bioscience Corporation | Hybridization methods and reagents |
WO2022086866A1 (en) | 2020-10-19 | 2022-04-28 | Twist Bioscience Corporation | Methods of synthesizing oligonucleotides using tethered nucleotides |
WO2022087293A1 (en) | 2020-10-22 | 2022-04-28 | Twist Bioscience Corporation | Methods and systems for detecting coronavirus |
US20220135965A1 (en) | 2020-10-26 | 2022-05-05 | Twist Bioscience Corporation | Libraries for next generation sequencing |
WO2022098662A2 (en) | 2020-11-03 | 2022-05-12 | Twist Bioscience Corporation | Methods and compositions relating to chemokine receptor variants |
EP4281112A1 (en) | 2021-01-21 | 2023-11-29 | Twist Bioscience Corporation | Methods and compositions relating to adenosine receptors |
US20220277808A1 (en) | 2021-02-19 | 2022-09-01 | Twist Bioscience Corporation | Libraries for identification of genomic variants |
EP4314074A1 (en) | 2021-03-24 | 2024-02-07 | Twist Bioscience Corporation | Variant nucleic acid libraries for tigit |
WO2022204316A2 (en) | 2021-03-24 | 2022-09-29 | Twist Bioscience Corporation | Variant nucleic acid libraries for cd3 |
US20220323924A1 (en) | 2021-03-24 | 2022-10-13 | Twist Bioscience Corporation | Electrochemical polynucleotide synthesis |
US20220356463A1 (en) | 2021-04-09 | 2022-11-10 | Twist Bioscience Corporation | Libraries for mutational analysis |
US20220356468A1 (en) | 2021-05-03 | 2022-11-10 | Twist Bioscience Corporation | Variant nucleic acid libraries for ion channels |
EP4334515A1 (en) | 2021-05-03 | 2024-03-13 | Twist Bioscience Corporation | Variant nucleic acid libraries for glycans |
WO2022271884A2 (en) | 2021-06-22 | 2022-12-29 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
-
2021
- 2021-04-27 MX MX2022013513A patent/MX2022013513A/es unknown
- 2021-04-27 JP JP2022565726A patent/JP2023523336A/ja active Pending
- 2021-04-27 CA CA3177030A patent/CA3177030A1/en active Pending
- 2021-04-27 US US17/242,179 patent/US20210395344A1/en not_active Abandoned
- 2021-04-27 MX MX2022013499A patent/MX2022013499A/es unknown
- 2021-04-27 EP EP21796107.7A patent/EP4142739A2/en not_active Withdrawn
- 2021-04-27 IL IL297701A patent/IL297701A/en unknown
- 2021-04-27 EP EP21797661.2A patent/EP4142784A2/en active Pending
- 2021-04-27 CN CN202180045891.0A patent/CN116113420A/zh active Pending
- 2021-04-27 CN CN202180045924.1A patent/CN116209463A/zh active Pending
- 2021-04-27 AU AU2021263755A patent/AU2021263755A1/en active Pending
- 2021-04-27 KR KR1020227041294A patent/KR20230016184A/ko unknown
- 2021-04-27 US US17/242,170 patent/US12018065B2/en active Active
- 2021-04-27 AU AU2021263756A patent/AU2021263756A1/en active Pending
- 2021-04-27 KR KR1020227041289A patent/KR20230017781A/ko unknown
- 2021-04-27 JP JP2022565725A patent/JP2023523335A/ja active Pending
- 2021-04-27 WO PCT/US2021/029486 patent/WO2021222316A2/en active Application Filing
- 2021-04-27 BR BR112022021780A patent/BR112022021780A2/pt not_active Application Discontinuation
- 2021-04-27 CA CA3177029A patent/CA3177029A1/en active Pending
- 2021-04-27 IL IL297700A patent/IL297700A/en unknown
- 2021-04-27 WO PCT/US2021/029485 patent/WO2021222315A2/en active Application Filing
- 2021-04-27 BR BR112022021789A patent/BR112022021789A2/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN116113420A (zh) | 2023-05-12 |
US20210355194A1 (en) | 2021-11-18 |
CA3177030A1 (en) | 2021-11-04 |
EP4142784A2 (en) | 2023-03-08 |
US20210395344A1 (en) | 2021-12-23 |
JP2023523335A (ja) | 2023-06-02 |
MX2022013513A (es) | 2023-01-16 |
JP2023523336A (ja) | 2023-06-02 |
WO2021222316A3 (en) | 2021-12-09 |
CA3177029A1 (en) | 2021-11-04 |
AU2021263756A1 (en) | 2022-12-15 |
MX2022013499A (es) | 2023-01-16 |
BR112022021780A2 (pt) | 2023-03-07 |
CN116209463A (zh) | 2023-06-02 |
KR20230016184A (ko) | 2023-02-01 |
US12018065B2 (en) | 2024-06-25 |
IL297700A (en) | 2022-12-01 |
EP4142739A2 (en) | 2023-03-08 |
IL297701A (en) | 2022-12-01 |
WO2021222315A3 (en) | 2021-12-09 |
WO2021222316A2 (en) | 2021-11-04 |
KR20230017781A (ko) | 2023-02-06 |
WO2021222315A2 (en) | 2021-11-04 |
AU2021263755A1 (en) | 2022-12-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022021789A2 (pt) | Bibliotecas de ácido nucléico variantes para coronavírus | |
WO2022271884A3 (en) | Methods and compositions relating to covid antibody epitopes | |
WO2023023190A3 (en) | Single domain antibodies for sars-cov-2 | |
WO2023023183A3 (en) | Sars-cov-2 antibodies and related compositions and methods of use | |
EA201990861A1 (ru) | Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения | |
BR112022011235A2 (pt) | Bibliotecas de variantes de ácido nucleico para receptores de adenosina | |
BR112015000836A2 (pt) | método para identificar um polipeptídeo tendo uma funcionalidade ou especificidade de ligação desejadas, biblioteca de moléculas de polinucleotídeo, método para gerar uma biblioteca de polinucleotídeos, vetor, célula hospedeira, anticorpo e método para gerar uma população de células hospedeiras | |
UY35286A (es) | Construcciones de anticuerpos para CDH19 y CD3 | |
BR112019005316A2 (pt) | anticorpos monoclonais para morte programada 1 (pd-1) | |
CR9969A (es) | Anticuerpos anti-globulomero ab, porciones de union a antigeno de estos, hibridomas correspondientes, acidos nucleicos, vectores, celulas huesped, metodos para producir dichos anticuerpos, composiciones que comprenden dichos anticuerpos | |
SV2006002513A (es) | Anticuerpos anti-il-6, composiciones, metodos y usos ref. docket cen5094svnp | |
CL2009000082A1 (es) | Acido nucleico que codifica anticuerpos anti cd79a o anti cd79b para el tratamiento de tumores hematopoyeticos; vector y células huésped que los comprenden; polipeptido codificado por dicho acido nucleico, inmunoconjugado con el cuerpo. | |
CL2011000308A1 (es) | Anticuerpo monoclonal que se une al gen 3 de la activacion linfocitaria (lag-3) humana; composicion que comprende dicho anticuerpo; molecula de acido nucleico que lo codifica; vector de expresion y celula huesped que lo comprende; metodo de preparacion; y su uso para estimular la respuesta inmune. | |
PE20130205A1 (es) | Proteinas de union a il-1 | |
BRPI0812091A2 (pt) | Método para fabricar uma proteína policlonal recombinante | |
CY1109230T1 (el) | Ισομεραση συζευγμενου λινελαϊκου οξεος και μια διαδικασια για την παρασκευη συζευγμενου λινελαϊκου οξεος | |
CL2011002611A1 (es) | Anticuerpo aislado anti-cadherina-17; molecula de acido nucleico que lo codifica; vector; celula huesped; metodo de produccion; inmunoconjugado que lo comprende; composicion que lo comprende; y su uso para tratar o prevenir una enfermedad asociada con celulas objetivo que expresan cadherina-17. | |
BR112022022503A2 (pt) | Anticorpos neutralizantes que se ligam à proteína s de sars-cov-2 | |
MX2019009045A (es) | Nuevas luciferasas y metodos para su uso. | |
AR103794A1 (es) | Producción de alquenos | |
BR112021019701A2 (pt) | Anticorpos multiespecíficos para antígeno de câncer de bomba de efluxo e composições, reagentes, kits e métodos relacionados aos mesmos | |
Gupta et al. | Mapping of post-translational modifications of transition proteins, TP1 and TP2, and identification of protein arginine methyltransferase 4 and lysine methyltransferase 7 as methyltransferase for TP2 | |
BR112022008075A2 (pt) | Métodos de seqüênciamento de proteínas de célula única e de ácido nucleico | |
EA202190892A1 (ru) | Клеточные анализы клостридиальных нейротоксинов | |
AR070146A1 (es) | Gen de bacillus thuringiensis (bt) con actividad contra coleopteros |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2775 DE 12-03-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |