BR112022005595A2 - Composto, medicamento, métodos para inibir histona deacetilase 6 e para profilaxia ou tratamento de doença de alzheimer ou paralisia supranuclear progressiva em um mamífero, e, uso de composto - Google Patents

Composto, medicamento, métodos para inibir histona deacetilase 6 e para profilaxia ou tratamento de doença de alzheimer ou paralisia supranuclear progressiva em um mamífero, e, uso de composto

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Publication number
BR112022005595A2
BR112022005595A2 BR112022005595A BR112022005595A BR112022005595A2 BR 112022005595 A2 BR112022005595 A2 BR 112022005595A2 BR 112022005595 A BR112022005595 A BR 112022005595A BR 112022005595 A BR112022005595 A BR 112022005595A BR 112022005595 A2 BR112022005595 A2 BR 112022005595A2
Authority
BR
Brazil
Prior art keywords
compound
treatment
prophylaxis
alzheimer
mammal
Prior art date
Application number
BR112022005595A
Other languages
English (en)
Inventor
Ito Masahiro
Sugiyama Hideyuki
Yamamoto Takashi
Kakegawa Keiko
Li Jinxing
Wang Junsi
Kasahara Takahito
Yoshikawa Masato
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of BR112022005595A2 publication Critical patent/BR112022005595A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

COMPOSTO, MEDICAMENTO, MÉTODOS PARA INIBIR HISTONA DEACETILASE 6 E PARA PROFILAXIA OU TRATAMENTO DE DOENÇA DE ALZHEIMER OU PARALISIA SUPRANUCLEAR PROGRESSIVA EM UM MAMÍFERO, E, USO DE COMPOSTO. A presente invenção provê um composto heterocíclico com uma ação inibidora de HDAC6, que é útil para o tratamento de doenças do sistema nervoso central, incluindo doenças neurodegenerativas e semelhantes, e um medicamento compreendendo o composto. A presente invenção refere-se a um composto representado pela fórmula (I): em que cada símbolo é como definido na descrição, ou um sal do mesmo.
BR112022005595A 2019-09-27 2020-09-24 Composto, medicamento, métodos para inibir histona deacetilase 6 e para profilaxia ou tratamento de doença de alzheimer ou paralisia supranuclear progressiva em um mamífero, e, uso de composto BR112022005595A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019177815 2019-09-27
PCT/JP2020/037386 WO2021060567A1 (en) 2019-09-27 2020-09-24 2-isoindol-1,3,4-oxadiazole derivatives useful as hdac6 inhibitors

Publications (1)

Publication Number Publication Date
BR112022005595A2 true BR112022005595A2 (pt) 2022-07-19

Family

ID=73040188

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005595A BR112022005595A2 (pt) 2019-09-27 2020-09-24 Composto, medicamento, métodos para inibir histona deacetilase 6 e para profilaxia ou tratamento de doença de alzheimer ou paralisia supranuclear progressiva em um mamífero, e, uso de composto

Country Status (18)

Country Link
US (2) US11453661B2 (pt)
EP (1) EP4034536A1 (pt)
JP (1) JP2022552444A (pt)
KR (1) KR20220070465A (pt)
CN (1) CN114846012B (pt)
AR (1) AR120040A1 (pt)
AU (1) AU2020353984A1 (pt)
BR (1) BR112022005595A2 (pt)
CA (1) CA3156060A1 (pt)
CL (1) CL2022000763A1 (pt)
CO (1) CO2022005059A2 (pt)
EC (1) ECSP22026524A (pt)
IL (1) IL291413A (pt)
MX (1) MX2022003490A (pt)
PE (1) PE20220711A1 (pt)
TW (1) TW202126643A (pt)
WO (1) WO2021060567A1 (pt)
ZA (1) ZA202204666B (pt)

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CO2022005059A2 (es) 2022-07-08
TW202126643A (zh) 2021-07-16
CL2022000763A1 (es) 2023-01-20
PE20220711A1 (es) 2022-05-04
EP4034536A1 (en) 2022-08-03
CN114846012B (zh) 2024-01-26
US11453661B2 (en) 2022-09-27
CN114846012A (zh) 2022-08-02
US11958845B2 (en) 2024-04-16
IL291413A (en) 2022-05-01
ECSP22026524A (es) 2022-05-31
AU2020353984A2 (en) 2022-08-04
MX2022003490A (es) 2022-04-25
US20230183227A1 (en) 2023-06-15
AR120040A1 (es) 2022-01-26
JP2022552444A (ja) 2022-12-15
WO2021060567A1 (en) 2021-04-01
ZA202204666B (en) 2023-11-29
KR20220070465A (ko) 2022-05-31
CA3156060A1 (en) 2021-04-01
AU2020353984A1 (en) 2022-04-21
US20210094944A1 (en) 2021-04-01

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