BR112021022778A2 - Compostos e métodos para o tratamento de covid-19 - Google Patents
Compostos e métodos para o tratamento de covid-19Info
- Publication number
- BR112021022778A2 BR112021022778A2 BR112021022778A BR112021022778A BR112021022778A2 BR 112021022778 A2 BR112021022778 A2 BR 112021022778A2 BR 112021022778 A BR112021022778 A BR 112021022778A BR 112021022778 A BR112021022778 A BR 112021022778A BR 112021022778 A2 BR112021022778 A2 BR 112021022778A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- methods
- covid
- treatment
- cov
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 208000025721 COVID-19 Diseases 0.000 title abstract 3
- 241001678559 COVID-19 virus Species 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
COMPOSTOS E MÉTODOS PARA O TRATAMENTO DE COVID-19. A presente invenção refere-se aos compostos de fórmula I em que R1, R2 e ----- são como aqui definidos, composições farmacêuticas compreendendo os compostos e métodos de tratamento de COVID-19 em um paciente através da administração de quantidades terapeuticamente eficazes dos compostos, e métodos de inibição ou prevenção da replicação de SARS-CoV-2 com os compostos.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063005407P | 2020-04-05 | 2020-04-05 | |
US202063038454P | 2020-06-12 | 2020-06-12 | |
US202063061628P | 2020-08-05 | 2020-08-05 | |
US202063065658P | 2020-08-14 | 2020-08-14 | |
US202063073145P | 2020-09-01 | 2020-09-01 | |
US202063114289P | 2020-11-16 | 2020-11-16 | |
US202163163635P | 2021-03-19 | 2021-03-19 | |
PCT/IB2021/052741 WO2021205298A1 (en) | 2020-04-05 | 2021-04-01 | Compounds and methods for the treatment of covid-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021022778A2 true BR112021022778A2 (pt) | 2022-11-22 |
Family
ID=75478095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021022778A BR112021022778A2 (pt) | 2020-04-05 | 2021-04-01 | Compostos e métodos para o tratamento de covid-19 |
Country Status (18)
Country | Link |
---|---|
US (1) | US11926642B2 (pt) |
EP (1) | EP3953361A1 (pt) |
JP (1) | JP2023519035A (pt) |
KR (1) | KR20210151949A (pt) |
CN (1) | CN114641485A (pt) |
AU (1) | AU2021253796B2 (pt) |
BR (1) | BR112021022778A2 (pt) |
CA (1) | CA3140164A1 (pt) |
CO (1) | CO2021015318A2 (pt) |
CR (1) | CR20210563A (pt) |
EC (1) | ECSP21080535A (pt) |
IL (1) | IL288061A (pt) |
MX (1) | MX2021013934A (pt) |
PE (1) | PE20220765A1 (pt) |
TW (1) | TWI807291B (pt) |
UY (1) | UY39149A (pt) |
WO (1) | WO2021205298A1 (pt) |
ZA (1) | ZA202109010B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11124497B1 (en) | 2020-04-17 | 2021-09-21 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
US11174231B1 (en) | 2020-06-09 | 2021-11-16 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
US11351149B2 (en) * | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
US20220204476A1 (en) * | 2020-12-21 | 2022-06-30 | The Governors Of The University Of Alberta | Rna virus inhibitor compounds and uses thereof |
AU2022210132A1 (en) * | 2021-01-20 | 2023-08-31 | National University Corporation Hokkaido University | Anti-viral agent |
CN115073431B (zh) | 2021-04-14 | 2023-09-05 | 盐野义制药株式会社 | 具有病毒增殖抑制作用的三嗪衍生物及含有其的药物组合物 |
WO2022266363A1 (en) * | 2021-06-16 | 2022-12-22 | The Scripps Research Institute | Protease inhibitors for the treatment of coronavirus infections |
TW202320793A (zh) | 2021-09-28 | 2023-06-01 | 日商塩野義製藥股份有限公司 | 含有三嗪衍生物之醫藥組合物 |
EP4289432A1 (en) | 2021-11-24 | 2023-12-13 | Shionogi & Co., Ltd | Preparation for oral administration containing triazine derivative |
WO2023095860A1 (ja) * | 2021-11-26 | 2023-06-01 | 塩野義製薬株式会社 | 3clプロテアーゼ阻害剤及びcovid-19治療用薬剤を組み合わせることを特徴とするcovid-19治療用医薬 |
KR20230140401A (ko) * | 2022-03-25 | 2023-10-06 | 주식회사 미토이뮨테라퓨틱스 | 항바이러스용 약학적 조성물 및 이의 용도 |
WO2023196412A1 (en) * | 2022-04-06 | 2023-10-12 | Nobias Therapeutics, Inc. | Liquid formulations comprising mitogen-activated protein kinase kinase (mek) inhibitors and methods using same |
CN114773405B (zh) * | 2022-06-21 | 2022-09-23 | 和鼎(南京)医药技术有限公司 | 一种莫那比拉韦的制备方法 |
CN115054593B (zh) * | 2022-07-15 | 2023-02-03 | 深圳市人民医院 | 防治新型冠状病毒肺炎或检测新冠病毒及突变株的药物及应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007513881A (ja) | 2003-11-20 | 2007-05-31 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Xi因子の治療学的使用 |
WO2005113580A1 (en) | 2004-05-21 | 2005-12-01 | Pfizer Inc. | Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
WO2006061714A2 (en) | 2004-12-09 | 2006-06-15 | Pfizer Inc. | Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
MX2011013824A (es) | 2009-07-07 | 2012-01-30 | Boehringer Ingelheim Int | Composicion farmaceutica para un inhibidor de proteasa del virus de la hepatitis c. |
DK3077397T3 (da) * | 2013-12-06 | 2019-12-16 | Vertex Pharma | 2-amino-6-fluor-n-[5-fluor-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamidforbindelse anvendelig som atr-kinase-inhibitor, dens fremstilling, forskellige faste former og radiomarkerede derivater deraf |
TW201623265A (zh) | 2014-05-09 | 2016-07-01 | 奇尼塔公司 | 抗病毒化合物、醫藥組合物及其使用方法 |
WO2018085476A1 (en) | 2016-11-02 | 2018-05-11 | Centrexion Therapeutics Corporation | Stable aqueous capsaicin injectable formulations and medical uses thereof |
US10316021B2 (en) * | 2016-11-28 | 2019-06-11 | Pfizer Inc. | Heteroarylphenoxy benzamide kappa opioid ligands |
-
2021
- 2021-04-01 BR BR112021022778A patent/BR112021022778A2/pt not_active Application Discontinuation
- 2021-04-01 EP EP21718202.1A patent/EP3953361A1/en active Pending
- 2021-04-01 KR KR1020217037131A patent/KR20210151949A/ko unknown
- 2021-04-01 WO PCT/IB2021/052741 patent/WO2021205298A1/en unknown
- 2021-04-01 MX MX2021013934A patent/MX2021013934A/es unknown
- 2021-04-01 JP JP2021567925A patent/JP2023519035A/ja active Pending
- 2021-04-01 CA CA3140164A patent/CA3140164A1/en active Pending
- 2021-04-01 CN CN202180003337.6A patent/CN114641485A/zh active Pending
- 2021-04-01 PE PE2021001897A patent/PE20220765A1/es unknown
- 2021-04-01 CR CR20210563A patent/CR20210563A/es unknown
- 2021-04-01 AU AU2021253796A patent/AU2021253796B2/en active Active
- 2021-04-01 TW TW110112267A patent/TWI807291B/zh active
- 2021-04-05 UY UY0001039149A patent/UY39149A/es unknown
- 2021-07-01 US US17/365,213 patent/US11926642B2/en active Active
- 2021-11-12 CO CONC2021/0015318A patent/CO2021015318A2/es unknown
- 2021-11-12 ZA ZA2021/09010A patent/ZA202109010B/en unknown
- 2021-11-12 IL IL288061A patent/IL288061A/en unknown
- 2021-11-12 EC ECSENADI202180535A patent/ECSP21080535A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL288061A (en) | 2022-01-01 |
US20220017548A1 (en) | 2022-01-20 |
CR20210563A (es) | 2022-01-24 |
TWI807291B (zh) | 2023-07-01 |
KR20210151949A (ko) | 2021-12-14 |
US11926642B2 (en) | 2024-03-12 |
AU2021253796A1 (en) | 2021-12-09 |
CN114641485A (zh) | 2022-06-17 |
CA3140164A1 (en) | 2021-10-14 |
CO2021015318A2 (es) | 2021-11-19 |
TW202202148A (zh) | 2022-01-16 |
PE20220765A1 (es) | 2022-05-16 |
EP3953361A1 (en) | 2022-02-16 |
UY39149A (es) | 2021-10-29 |
ECSP21080535A (es) | 2022-03-31 |
WO2021205298A1 (en) | 2021-10-14 |
JP2023519035A (ja) | 2023-05-10 |
MX2021013934A (es) | 2021-12-15 |
AU2021253796B2 (en) | 2023-06-01 |
ZA202109010B (en) | 2023-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112021022778A2 (pt) | Compostos e métodos para o tratamento de covid-19 | |
BR112021022419A2 (pt) | Compostos antivirais contendo nitrila | |
BR112020017090A8 (pt) | Imunoterapias relacionadas com microbioma | |
BR112015028879A8 (pt) | compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos | |
BR112019008431A2 (pt) | aplicação de (s)-norcetamina e sal da mesma como fármaco | |
BR112018067930A8 (pt) | Composto, sal de ácido trifluoroacético, composição farmacêutica, método para tratamento de uma infecção bacteriana, e, uso de um composto. | |
BRPI0807749B8 (pt) | composto, composição farmacêutica, e, método para a prevenção, tratamento ou melhora de doenças ou condições dérmicas, ou distúrbios de ferida cutânea agudos ou crônicos | |
BR112020006381A8 (pt) | Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica | |
BR112012006010A2 (pt) | composto de glicina | |
BR112021022758A2 (pt) | Compostos de 1-oxo-isoindolina-5-carboxamida substituídos, suas composições e métodos de tratamento com os mesmos | |
BR112015003729A2 (pt) | composto de fórmula estrutural i; composição farmacêutica; método de tratamento de uma doença mediada por caminho do hif; método de tratamento de uma doença causada por proliferação anormal de células; e método para alcançar um efeito em um paciente | |
BR112022024597A2 (pt) | Compostos de 4-oxo-3,4-di-hidroquinazolinona para o tratamento de doenças e distúrbios associados com braf | |
BR112014017985A8 (pt) | Combinação de um inibidor de rtk com um antiestrogênio e uso da mesma para o tratamento de cancer | |
BR112021025764A2 (pt) | Derivado de pirimidina que inibe o crescimento de células cancerígenas e uso medicinal do mesmo | |
BR112023002573A2 (pt) | Composto, composição farmacêutica, método de tratamento ou prevenção de infecção viral e distúrbio respiratório e método de inibição de protease viral | |
BR112022014968A2 (pt) | Composto, composição farmacêutica e métodos de inibição do nível de brd9 em uma célula, de inibição da atividade de brd9 em uma célula, de tratamento de um distúrbio, de tratamento de um câncer em um sujeito em necessidade e de tratamento de infecção em um sujeito em necessidade | |
BR112019000614A2 (pt) | derivados de quinazolinona inovadores de inibição de pi3k e composição farmacêutica contendo os mesmos | |
BR112021026820A2 (pt) | Inibidores heterocíclicos de monoacilglicerol lipase (magl) | |
BR112022022599A2 (pt) | Métodos de tratamento de covid-19 usando bardoxolona metil ou análogos da mesma | |
BR112022021957A2 (pt) | Imidazopirimidinas como moduladores de il -17 | |
BR112023017367A2 (pt) | Composições e métodos para inibição de ceto-hexoquinase (khk) | |
BR112022025946A2 (pt) | Composto, composição farmacêutica e método de tratamento de uma doença | |
BR112014002885A2 (pt) | uso de composto orgânico para o tratamento da síndrome de noonan | |
BR112023016958A2 (pt) | Compostos para uso no tratamento de uma infecção por vírus envelopado | |
BR112023017040A2 (pt) | Derivados de indolina como inibidores de ddr1 e ddr2 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved |
Owner name: PFIZER INC. (US) |
|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing |