BR112021019039A2 - Composição anestésica e método de anestesia do olho - Google Patents
Composição anestésica e método de anestesia do olhoInfo
- Publication number
- BR112021019039A2 BR112021019039A2 BR112021019039A BR112021019039A BR112021019039A2 BR 112021019039 A2 BR112021019039 A2 BR 112021019039A2 BR 112021019039 A BR112021019039 A BR 112021019039A BR 112021019039 A BR112021019039 A BR 112021019039A BR 112021019039 A2 BR112021019039 A2 BR 112021019039A2
- Authority
- BR
- Brazil
- Prior art keywords
- articaine
- anesthetic
- composition
- eye
- anesthesia
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 8
- 230000003444 anaesthetic effect Effects 0.000 title abstract 5
- 206010002091 Anaesthesia Diseases 0.000 title abstract 3
- 230000037005 anaesthesia Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- QTGIAADRBBLJGA-UHFFFAOYSA-N Articaine Chemical compound CCCNC(C)C(=O)NC=1C(C)=CSC=1C(=O)OC QTGIAADRBBLJGA-UHFFFAOYSA-N 0.000 abstract 4
- 229960003831 articaine Drugs 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 2
- 239000000872 buffer Substances 0.000 abstract 2
- 229960001855 mannitol Drugs 0.000 abstract 2
- 230000000699 topical effect Effects 0.000 abstract 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
composição anestésica e método de anestesia do olho. a presente invenção refere-se a uma composição anestésica oftálmica tópica que inclui uma formulação com uma quantidade de articaína para fornecer propriedades anestésicas quando aplicada topicamente ao olho e um ph, viscosidade, osmolalidade, constante de dissociação, e aditivos tais como antioxidantes, tampões, metil celulose, para alcançar eficácia e segurança. a composição pode conter articaína em quantidades de cerca de 4,0% p / v a cerca de 12,0% p / v e pode ter um ph de cerca de ph 3,5 a ph 7,0. o tampão pode ser o complexo borato / manitol obtido a partir de ácido bórico ou sal do mesmo e d-manitol. as formulações de articaína podem atingir anestesia adequada do aspecto interno da parede ocular por aplicação tópica, sem o uso de um anestésico injetável. implementações exemplificativas da descrição incluem formulações que incluem articaína em uma quantidade de pelo menos 7,0% p / v, onde a formulação é uma solução aquosa, um gel, uma pomada, ou em uma forma encapsulada.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962824207P | 2019-03-26 | 2019-03-26 | |
| PCT/US2019/024239 WO2019191200A1 (en) | 2018-03-27 | 2019-03-27 | Method and formulation for producing anesthesia of internal aspect of eye wall by topical application |
| US16/811,798 US11096922B2 (en) | 2018-03-27 | 2020-03-06 | Anesthetic composition and method of anesthetizing the eye |
| PCT/US2020/022915 WO2020197816A1 (en) | 2019-03-26 | 2020-03-16 | Anesthetic composition and method of anesthetizing the eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021019039A2 true BR112021019039A2 (pt) | 2021-11-30 |
Family
ID=72609654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021019039A BR112021019039A2 (pt) | 2019-03-26 | 2020-03-16 | Composição anestésica e método de anestesia do olho |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3946311A4 (pt) |
| JP (1) | JP2022527621A (pt) |
| KR (1) | KR20210143254A (pt) |
| CN (1) | CN114072139A (pt) |
| AU (1) | AU2020245203A1 (pt) |
| BR (1) | BR112021019039A2 (pt) |
| CA (1) | CA3134531A1 (pt) |
| IL (1) | IL286624A (pt) |
| MX (1) | MX2021011589A (pt) |
| SG (1) | SG11202110423UA (pt) |
| WO (1) | WO2020197816A1 (pt) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2132826C (en) * | 1992-05-06 | 1999-01-05 | Masood Chowhan | Use of borate-polyol complexes in ophthalmic compositions |
| ATE547122T1 (de) * | 2001-11-21 | 2012-03-15 | Novartis Pharma Gmbh | Zusammensetzung zur stabilisierung von hyaluronsäure |
| CN101695488B (zh) * | 2009-11-05 | 2012-05-02 | 蚌埠丰原涂山制药有限公司 | 复方阿替卡因注射用冻干制剂及其制备方法 |
| CN101721407B (zh) * | 2009-11-23 | 2013-04-10 | 蚌埠丰原涂山制药有限公司 | 复方盐酸阿替卡因注射液及其制备方法 |
| FR2968996B1 (fr) * | 2010-12-17 | 2013-04-12 | Anteis Sa | Formulation aqueuse injectable sterile utilisee en ophtalmologie |
| FR3036035B1 (fr) * | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
| JP2018526423A (ja) * | 2015-09-08 | 2018-09-13 | ビューポイント セラピューティクス， インコーポレイテッド | 眼科疾患を処置するための化合物および製剤 |
| WO2018220283A1 (fr) * | 2017-05-29 | 2018-12-06 | Kh Medtech Sarl | Composition injectable sterile contenant de l'acide hyaluronique reticule et de l'articaine |
-
2020
- 2020-03-16 AU AU2020245203A patent/AU2020245203A1/en active Pending
- 2020-03-16 JP JP2021560140A patent/JP2022527621A/ja active Pending
- 2020-03-16 EP EP20776365.7A patent/EP3946311A4/en active Pending
- 2020-03-16 KR KR1020217034148A patent/KR20210143254A/ko unknown
- 2020-03-16 CA CA3134531A patent/CA3134531A1/en active Pending
- 2020-03-16 SG SG11202110423UA patent/SG11202110423UA/en unknown
- 2020-03-16 MX MX2021011589A patent/MX2021011589A/es unknown
- 2020-03-16 WO PCT/US2020/022915 patent/WO2020197816A1/en active Application Filing
- 2020-03-16 BR BR112021019039A patent/BR112021019039A2/pt unknown
- 2020-03-16 CN CN202080033483.9A patent/CN114072139A/zh active Pending
-
2021
- 2021-09-23 IL IL286624A patent/IL286624A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL286624A (en) | 2021-10-31 |
| JP2022527621A (ja) | 2022-06-02 |
| MX2021011589A (es) | 2021-12-15 |
| AU2020245203A1 (en) | 2021-11-11 |
| EP3946311A1 (en) | 2022-02-09 |
| WO2020197816A1 (en) | 2020-10-01 |
| KR20210143254A (ko) | 2021-11-26 |
| SG11202110423UA (en) | 2021-10-28 |
| EP3946311A4 (en) | 2022-12-28 |
| CN114072139A (zh) | 2022-02-18 |
| CA3134531A1 (en) | 2020-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |