BR112015019794A2 - composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto - Google Patents

composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto

Info

Publication number
BR112015019794A2
BR112015019794A2 BR112015019794A BR112015019794A BR112015019794A2 BR 112015019794 A2 BR112015019794 A2 BR 112015019794A2 BR 112015019794 A BR112015019794 A BR 112015019794A BR 112015019794 A BR112015019794 A BR 112015019794A BR 112015019794 A2 BR112015019794 A2 BR 112015019794A2
Authority
BR
Brazil
Prior art keywords
compound
sphingosine
pharmaceutical composition
phosphate receptor
receptor agonist
Prior art date
Application number
BR112015019794A
Other languages
English (en)
Other versions
BR112015019794B1 (pt
BR112015019794A8 (pt
Inventor
Seong Park Deok
Yup Paek Seung
Bae Lee Sung
Hyung Lee Won
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of BR112015019794A2 publication Critical patent/BR112015019794A2/pt
Publication of BR112015019794A8 publication Critical patent/BR112015019794A8/pt
Publication of BR112015019794B1 publication Critical patent/BR112015019794B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

1 / 1 resumo “composto, composiã‡ãƒo farmacãšutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto” a presente invenã§ã£o refere-se a novos compostos da fã³rmula 1 como agonistas do receptor de esfingosina-1-fosfato que podem ser eficazmente usados para o tratamento de doenã§as autoimunes, um mã©todo para preparar os mesmos e uma composiã§ã£o farmacãªutica compreendendo os mesmos como um componente ativo. os compostos de acordo com a presente invenã§ã£o sã£o eficazes nas doenã§as autoimunes extensivas e doenã§as inflamatã³rias crã´nicas incluindo a esclerose mãºltipla remitente-recorrente e tambã©m podem ser usados para tratar ou prevenir distãºrbios de imunorregulagem.
BR112015019794-9A 2013-02-20 2014-02-19 Composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto BR112015019794B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20130018293 2013-02-20
KR10-2013-0018293 2013-02-20
PCT/KR2014/001336 WO2014129796A1 (en) 2013-02-20 2014-02-19 Sphingosine-1-phosphate receptor agonists, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent

Publications (3)

Publication Number Publication Date
BR112015019794A2 true BR112015019794A2 (pt) 2017-07-18
BR112015019794A8 BR112015019794A8 (pt) 2018-08-14
BR112015019794B1 BR112015019794B1 (pt) 2022-09-13

Family

ID=51391525

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015019794-9A BR112015019794B1 (pt) 2013-02-20 2014-02-19 Composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto

Country Status (17)

Country Link
US (1) US9540362B2 (pt)
EP (1) EP2958913B1 (pt)
JP (1) JP6294359B2 (pt)
KR (1) KR101939657B1 (pt)
CN (1) CN105051037B (pt)
AU (1) AU2014219575B2 (pt)
BR (1) BR112015019794B1 (pt)
DK (1) DK2958913T3 (pt)
ES (1) ES2698359T3 (pt)
HU (1) HUE039931T2 (pt)
MX (1) MX370032B (pt)
PL (1) PL2958913T3 (pt)
PT (1) PT2958913T (pt)
RU (1) RU2654483C2 (pt)
SI (1) SI2958913T1 (pt)
TW (1) TWI582073B (pt)
WO (1) WO2014129796A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI692469B (zh) * 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物
KR102644587B1 (ko) * 2015-12-24 2024-03-07 (주)아모레퍼시픽 유사 세라마이드 화합물 및 그 제조방법
ES2975689T3 (es) * 2016-01-29 2024-07-11 Ono Pharmaceutical Co Derivado de tetrahidronaftaleno
CA3034796A1 (en) * 2016-07-22 2018-01-25 Shijiazhuang Sagacity New Drug Development Co., Ltd. S1p1 agonist and application thereof
CN114874209A (zh) 2017-03-07 2022-08-09 豪夫迈·罗氏有限公司 噁二唑瞬时受体电位通道抑制剂
CN107382965A (zh) * 2017-08-14 2017-11-24 河南科技大学第附属医院 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法
KR101891051B1 (ko) * 2018-01-29 2018-08-31 주식회사 세종바이오메드 스핑고신-1-포스페이트 유사체 및 이의 합성 방법
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
AU2020206036A1 (en) 2019-01-11 2021-08-05 Naegis Pharmaceuticals Inc. Leukotriene synthesis inhibitors
CN110240537B (zh) * 2019-05-22 2022-06-21 成都阿奇生物医药科技有限公司 一种茚氧乙酸类化合物及其制备方法和用途
MX2022006326A (es) 2019-12-03 2022-06-22 Lg Chemical Ltd Agonista del receptor de esfingosina-1-fosfato, metodo de preparacion para el mismo, y composicion farmaceutica que lo contiene como ingrediente activo.
KR20210073998A (ko) 2019-12-11 2021-06-21 주식회사 엘지화학 다발성 경화증 예방 또는 치료용 약제학적 조성물
TW202220651A (zh) * 2020-09-28 2022-06-01 南韓商Ｌｇ化學股份有限公司 神經鞘胺醇－１－磷酸受體促效劑的用途
WO2022065939A1 (ko) 2020-09-28 2022-03-31 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 용도
CN116490490A (zh) * 2020-10-13 2023-07-25 株式会社Lg化学 制备用于合成鞘氨醇-1-磷酸酯受体激动剂的中间体的方法
WO2022080812A1 (ko) * 2020-10-13 2022-04-21 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조 방법
KR20220142376A (ko) * 2021-04-14 2022-10-21 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제를 포함하는 직접 타정용 약제학적 조성물
TW202302538A (zh) * 2021-04-14 2023-01-16 南韓商Ｌｇ化學股份有限公司 製備用於合成鞘胺醇—１—磷酸酯受體促效劑之中間體的方法
WO2022220598A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 결정형
WO2022220595A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제를 포함하는 고형 제제의 제조 방법
CN117177964A (zh) * 2021-04-14 2023-12-05 株式会社Lg化学 制备鞘氨醇-1-磷酸酯受体激动剂的新方法
KR20220142377A (ko) 2021-04-14 2022-10-21 주식회사 엘지화학 입도가 조절된 스핑고신-1-인산 수용체 효능제를 포함하는 약제학적 조성물
CN117203197A (zh) 2021-04-14 2023-12-08 株式会社Lg化学 鞘氨醇-1-磷酸酯受体激动剂的药学上可接受的盐及其结晶形式
EP4324826A1 (en) 2021-04-14 2024-02-21 Lg Chem, Ltd. Crystalline form of sphingosine-1-phosphate receptor agonist
CN117203189A (zh) * 2021-04-14 2023-12-08 株式会社Lg化学 制备用于合成鞘氨醇-1-磷酸酯受体激动剂的中间体的方法
WO2022220600A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 결정형
WO2022220613A1 (ko) 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 신규한 제조방법
US20240228441A1 (en) 2021-04-14 2024-07-11 Lg Chem, Ltd. Method for preparing intermediate for synthesis of sphingosine-1-phosphate receptor agonist
WO2022220596A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 습식과립법에 의한 스핑고신-1-인산 수용체 효능제를 포함하는 경구용 고형 제제의 제조 방법
KR20220142382A (ko) * 2021-04-14 2022-10-21 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 결정형

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011255A1 (fr) * 1997-08-28 1999-03-11 Ono Pharmaceutical Co., Ltd. Regulateurs du recepteur active par les agents de proliferation des peroxysomes
AU2003261935A1 (en) 2002-09-06 2004-03-29 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
CA2509202A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Fused heterocyclic derivatives as ppar modulators
WO2004092116A1 (en) 2003-04-10 2004-10-28 Amgen, Inc. Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof
JP5315611B2 (ja) 2004-06-23 2013-10-16 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその用途
PT1826197E (pt) 2004-12-13 2012-03-06 Ono Pharmaceutical Co Derivado de ácido aminocarboxílico e sua utilização medicinal
ES2336243T3 (es) 2005-01-26 2010-04-09 Schering Corporation Derivados de 3-(indazol-5-il)-(1,2,4)triazina y composiciones similares como inhibidores de proteina quinasa para el tratamiento del cancer.
WO2007103759A2 (en) 2006-03-02 2007-09-13 Smithkline Beecham Corporation Thiazolones for use as pi3 kinase inhibitors
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
JP2009269819A (ja) * 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk アミン化合物
WO2008064320A2 (en) * 2006-11-21 2008-05-29 University Of Virginia Patent Foundation Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity
US20110207704A1 (en) 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
AR064420A1 (es) 2006-12-21 2009-04-01 Alcon Mfg Ltd Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop).
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
CA2692713A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Heterocyclic modulators of pkb
JP4792126B2 (ja) 2007-08-01 2011-10-12 ファイザー・インク ピラゾール化合物およびＲａｆ阻害剤としてのその使用
GB0725101D0 (en) 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
PT2913326T (pt) 2008-05-14 2020-08-24 Scripps Research Inst Novos moduladores de recetores de fosfato de esfingosina
US8153103B2 (en) 2008-07-01 2012-04-10 Board Of Regents, The University Of Texas System Conjugates of photo-activatable dyes
US9181182B2 (en) 2008-10-17 2015-11-10 Akaal Pharma Pty Ltd S1P receptors modulators
JP5855942B2 (ja) 2008-12-18 2016-02-09 メルク セローノ ソシエテ アノニム 多発性硬化症の治療に有用なオキサジアゾール縮合複素環式誘導体
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
US20100174539A1 (en) 2009-01-06 2010-07-08 Qualcomm Incorporated Method and apparatus for vector quantization codebook search
WO2010093191A2 (en) 2009-02-13 2010-08-19 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
EP2241558A1 (en) 2009-04-03 2010-10-20 Merck Serono SA Oxadiazole derivatives
BRPI1014956B8 (pt) 2009-04-22 2021-05-25 Resverlogix Corp agentes anti-inflamatórios
GB0910674D0 (en) 2009-06-19 2009-08-05 Glaxo Group Ltd Novel compounds
US20120101134A1 (en) 2009-06-26 2012-04-26 Glaxo Group Limited 5-membered heteroaryl derivatives used as sphingosine 1-phosphate receptor agonists
MY160907A (en) 2009-11-13 2017-03-31 Receptos Inc Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
AU2010319982B2 (en) 2009-11-13 2016-02-04 Receptos Llc Selective heterocyclic sphingosine 1 phosphate receptor modulators
IN2012DN05171A (pt) 2009-11-24 2015-10-23 Allergan Inc
EP2390252A1 (en) * 2010-05-19 2011-11-30 Almirall, S.A. New pyrazole derivatives
JP2013543892A (ja) * 2010-11-24 2013-12-09 アラーガン インコーポレイテッド Ｓ１ｐ受容体調節剤としてのインドール誘導体
TWI692469B (zh) * 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物

Also Published As

Publication number Publication date
AU2014219575A1 (en) 2015-08-20
KR20140104376A (ko) 2014-08-28
MX370032B (es) 2019-11-28
HUE039931T2 (hu) 2019-02-28
TW201444794A (zh) 2014-12-01
TWI582073B (zh) 2017-05-11
PT2958913T (pt) 2018-12-03
AU2014219575B2 (en) 2017-07-06
JP2016513126A (ja) 2016-05-12
CN105051037A (zh) 2015-11-11
RU2654483C2 (ru) 2018-05-21
SI2958913T1 (sl) 2018-12-31
EP2958913A1 (en) 2015-12-30
KR101939657B1 (ko) 2019-01-17
ES2698359T3 (es) 2019-02-04
JP6294359B2 (ja) 2018-03-14
BR112015019794B1 (pt) 2022-09-13
EP2958913B1 (en) 2018-10-03
DK2958913T3 (en) 2018-11-05
US9540362B2 (en) 2017-01-10
BR112015019794A8 (pt) 2018-08-14
CN105051037B (zh) 2018-05-18
US20150376173A1 (en) 2015-12-31
EP2958913A4 (en) 2016-10-05
RU2015139594A (ru) 2017-03-27
PL2958913T3 (pl) 2019-03-29
WO2014129796A1 (en) 2014-08-28
MX2015009986A (es) 2015-10-05

Similar Documents

Publication Publication Date Title
BR112015019794A2 (pt) composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto
BR112015001847A8 (pt) Composições e tratamento para doenças e distúrbios nos olhos
AU2018236800B2 (en) DNA-PK inhibitors
BR112017012327A8 (pt) benzamidas substituídas por 1,3-tiazol-2-il.
BR112015022566A2 (pt) composto e composição farmacêutica
CU20130115A7 (es) Compuestos y composiciones como inhibidores de trk
BR112015031903A8 (pt) composto, sal farmaceuticamente aceitável, composição farmacêutica e uso de um composto
EA201591403A1 (ru) Спиролактамные модуляторы рецептора nmda и их применение
BR112018015273A2 (pt) derivados de benzimidazol como moduladores de ror-gama
BR112015007183A2 (pt) composições, uso de uma composição, método para o combate dos fungos e semente
UY33597A (es) Compuestos y composiciones como inhibidores de la trk
BR112015027282A2 (pt) fenfluramina para uso no tratamento de síndrome de dravet
BR112016003201A2 (pt) inibidores de grp94 seletivos e usos dos mesmos
BR112015028605A8 (pt) uso de uma composição e uso de um imunossupressor e uma composição
EA201591405A1 (ru) Спиролактамные модуляторы nmda-рецептора и их применение
BR112015015870A2 (pt) composição farmacêutica
BR112015029240A2 (pt) composto, composição e método de evitar ou tratar inflamação associada com inflamassoma nrlp3 em um indivíduo
BR112014028017A2 (pt) composto, composição farmacêutica, método para tratar um distúrbio, método para reduzir a quantidade il-17 em um indivíduo e método para inibir a atividade de ror
BR112015030385A8 (pt) composto, composto para uso e composição farmacêutica
BR112015027563A2 (pt) métodos para melhorar a regeneração do músculo envelhecido
BR112015026238A8 (pt) composto dihidropirazino-pirazina, composição farmacêutica que o compreende, uso do composto, métodos para inibir ou medir a fosforilação e para inibir a atividade da proteína quinase, bem como kit
BR112016021648A2 (pt) novos compostos
MX2022001796A (es) Metodos y composiciones para inhibir los sintomas asociados con la veisalgia.
BR112016009062A2 (pt) Composição antibacteriana, método para a preparação de uma composição, método para prever ou determinar a eficácia de uma terapia de bacteriófago em um indivíduo, método para selecionar um indivíduo ou determinar se um indivíduo é susceptível de se beneficiar de uma terapia com bacteriófagos, bacteriófago, ácido nucleico isolado, e, polipeptídeo isolado
NI201600070A (es) Inhibidores tetracíclicos de autotaxina

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: LG CHEM, LTD (KR)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/02/2014, OBSERVADAS AS CONDICOES LEGAIS