CA2284131A1
(en)
|
1997-03-07 |
1998-09-11 |
Human Genome Sciences, Inc. |
70 human secreted proteins
|
US6878687B1
(en)
|
1997-03-07 |
2005-04-12 |
Human Genome Sciences, Inc. |
Protein HMAAD57
|
AU4834999A
(en)
|
1998-06-26 |
2000-01-17 |
Incyte Pharmaceuticals, Inc. |
Human signal peptide-containing proteins
|
AUPQ873300A0
(en)
|
2000-07-12 |
2000-08-03 |
Medvet Science Pty. Ltd. |
A binding motif of a receptor (2)
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
JP2004522742A
(ja)
|
2000-12-08 |
2004-07-29 |
ベイラー カレッジ オブ メディシン |
免疫応答の改変において使用するためのtrem−1スプライス改変体
|
CA2342376C
(en)
|
2001-03-20 |
2013-11-12 |
Marco Colonna |
A receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
US8981061B2
(en)
|
2001-03-20 |
2015-03-17 |
Novo Nordisk A/S |
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
|
US8231878B2
(en)
|
2001-03-20 |
2012-07-31 |
Cosmo Research & Development S.P.A. |
Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
ATE423571T1
(de)
|
2001-10-12 |
2009-03-15 |
Schering Corp |
Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten
|
US20060263770A1
(en)
|
2002-03-22 |
2006-11-23 |
Marco Colonna |
Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
|
EP1508340A4
(en)
|
2002-05-24 |
2009-07-01 |
Takeda Pharmaceutical |
MEANS FOR IMPROVING INSULIN RESISTANCE
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
GB0401730D0
(en)
|
2004-01-27 |
2004-03-03 |
Bioxell Spa |
Diagnosis method
|
EP1749029B1
(en)
|
2004-05-27 |
2011-03-09 |
Crucell Holland B.V. |
Binding molecules capable of neutralizing rabies virus and uses thereof
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
US8101345B1
(en)
|
2005-03-25 |
2012-01-24 |
Isis Pharmaceuticals, Inc. |
Proinflammatory nucleic acids
|
KR20060135280A
(ko)
|
2005-06-24 |
2006-12-29 |
전남대학교산학협력단 |
선천성 면역에 관여하는 트렘-2의 클로닝
|
AU2006265113A1
(en)
|
2005-07-01 |
2007-01-11 |
The Johns Hopkins University |
Compositions and methods for the treatment or prevention of disorders relating to oxidative stress
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
DE202006007499U1
(de)
|
2006-05-11 |
2007-01-11 |
Osaka University |
Verwendung einer Zusammensetzung, die Plexin-A1-DAP12-Interaktion inhibiert, zur Behandlung von Entzündungs-, Autoimmun- oder Knochenresorptionserkrankungen
|
RU2487888C2
(ru)
|
2006-06-12 |
2013-07-20 |
ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ, ЭлЭлСи |
Одноцепочечные мультивалентные связывающие белки с эффекторной функцией
|
CA2551163A1
(en)
|
2006-07-17 |
2008-01-17 |
Boehringer Ingelheim International Gmbh |
Methods for treating inflammatory, autoimmune or bone resorption diseases
|
US7553936B2
(en)
|
2006-12-04 |
2009-06-30 |
The United States of America as represented by Secretary Department of Health and Human Services |
Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions
|
CA2675583A1
(en)
|
2007-01-16 |
2008-07-24 |
Wyeth |
Inflammation treatment, detection and monitoring via trem-1
|
GR1007327B
(el)
|
2007-08-08 |
2011-06-27 |
Ευαγγελος Γιαμαρελλος-Μπουρμπουλης |
Ο διαλυτος υποδοχεας ενεργοποιησης των μυελοκυτταρων (strem-1) ως δεικτης αποτελεσματικοτητας της θεραπειας του πεπτικου ελκους
|
TW200918553A
(en)
*
|
2007-09-18 |
2009-05-01 |
Amgen Inc |
Human GM-CSF antigen binding proteins
|
KR100960684B1
(ko)
|
2008-02-22 |
2010-05-31 |
전남대학교산학협력단 |
Ga733-2 발현 억제제로서의 trem-2 유전자, 및 이를포함하는 형질전환 동물 및 이의 사용방법
|
WO2010045479A1
(en)
|
2008-10-15 |
2010-04-22 |
The Board Of Trustees Of The University Of Illinois |
Phospholipid micellar and liposomal compositions and uses thereof
|
EP2424977B1
(en)
|
2009-04-28 |
2013-06-12 |
Life & Brain GmbH |
Microglial precursor cells for the treatment of malignant neoplasms of the central nervous system
|
WO2010132370A2
(en)
|
2009-05-11 |
2010-11-18 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Soluble tlt-1 for the treatment and diagnosis of sepsis
|
EP2711018A1
(en)
|
2009-06-22 |
2014-03-26 |
MedImmune, LLC |
Engineered Fc regions for site-specific conjugation
|
WO2011047097A2
(en)
|
2009-10-13 |
2011-04-21 |
Sigalov Alexander B |
Inhibition of trem receptor signaling with peptide variants
|
CN102038698A
(zh)
|
2009-10-14 |
2011-05-04 |
山东绿叶天然药物研究开发有限公司 |
莫诺苷的新用途
|
JO3244B1
(ar)
*
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
CN102127168A
(zh)
|
2010-01-19 |
2011-07-20 |
中国人民解放军第二军医大学 |
一种髓样细胞表达激发受体-1的重组融合蛋白及其应用
|
KR20110086460A
(ko)
|
2010-01-22 |
2011-07-28 |
한국교원대학교산학협력단 |
수용성 수용체 라이브러리 및 이를 이용한 사이토카인 발현 조절 유전자의 스크리닝 방법
|
JP5918750B2
(ja)
|
2010-04-08 |
2016-05-18 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
Trem様転写物1(tlt−1)から誘導された阻害性ペプチドおよびその使用
|
CN104402997A
(zh)
|
2010-04-30 |
2015-03-11 |
阿雷克森制药公司 |
在人中具有降低的免疫原性的抗体
|
WO2012016333A1
(en)
|
2010-08-06 |
2012-02-09 |
University Health Network |
Biomarkers for malaria
|
US20130130354A1
(en)
|
2010-09-28 |
2013-05-23 |
CTI Salud S.A. |
Novel genes and uses thereof, expression profile of colon, gastric and pancreatic cancer
|
US20120201746A1
(en)
|
2010-12-22 |
2012-08-09 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
WO2012088290A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
WO2012125495A2
(en)
*
|
2011-03-11 |
2012-09-20 |
Amgen Inc. |
Method of correlated mutational analysis to improve therapeutic antibodies
|
KR20120112973A
(ko)
|
2011-04-04 |
2012-10-12 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 예방 또는 치료용 조성물
|
US20130058947A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc |
Novel Modulators and Methods of Use
|
ES2682081T3
(es)
|
2011-10-11 |
2018-09-18 |
F. Hoffmann-La Roche Ag |
Ensamblaje mejorado de anticuerpos biespecíficos
|
RU2014120465A
(ru)
|
2011-10-21 |
2015-11-27 |
Стемдженикс, Инк |
Функционализированные наночастицы для внутриклеточной доставки биологически активных молекул
|
JP6326371B2
(ja)
|
2011-11-04 |
2018-05-16 |
ザイムワークス,インコーポレイテッド |
Fcドメインにおける変異を有する安定なヘテロ二量体抗体デザイン
|
WO2013070565A1
(en)
|
2011-11-07 |
2013-05-16 |
Medimmune, Llc |
Multispecific and multivalent binding proteins and uses thereof
|
CA3111357A1
(en)
|
2011-12-23 |
2013-06-27 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
CN102517287B
(zh)
|
2012-01-10 |
2013-09-11 |
广西大学 |
抑制水牛TREM1基因表达的shRNA、慢病毒表达载体及其构建方法和应用
|
KR20130114951A
(ko)
|
2012-04-10 |
2013-10-21 |
한양대학교 산학협력단 |
폴리감마글루탐산을 포함하는 Th17 매개성 질환 예방 또는 치료용 조성물
|
CN104837865B
(zh)
|
2012-09-07 |
2019-09-24 |
国立健康与医学研究所 |
衍生自髓样细胞触发受体-1(trem-1)trem-样转录物1(tlt-1)的抑制肽及其用途
|
JP6461800B2
(ja)
*
|
2012-10-04 |
2019-01-30 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
ヒトモノクローナル抗pd−l1抗体および使用方法
|
CA2887825A1
(en)
|
2012-10-23 |
2014-05-01 |
The Board Of Regents Of The University Of Texas System |
Engineered igg fc domains
|
WO2014074942A1
(en)
|
2012-11-08 |
2014-05-15 |
Illumina, Inc. |
Risk variants of alzheimer's disease
|
US9066928B1
(en)
*
|
2012-12-04 |
2015-06-30 |
University Of Kentucky Research Foundation |
Method, composition, and kit useful for treatment of alzheimer's disease
|
US9546203B2
(en)
|
2013-03-14 |
2017-01-17 |
Amgen Inc. |
Aglycosylated Fc-containing polypeptides with cysteine substitutions
|
KR20150010326A
(ko)
|
2013-07-19 |
2015-01-28 |
전남대학교산학협력단 |
비만 및 제 2형 당뇨 또는 지방간의 예방 또는 치료용 바이아릴아마이드를 포함한 유도체 화합물
|
KR101402921B1
(ko)
|
2013-08-28 |
2014-06-02 |
전남대학교산학협력단 |
비만 또는 제 2형 당뇨의 치료를 위한 레스베라톨 유도체의 이용
|
CA2825821A1
(en)
|
2013-08-28 |
2015-02-28 |
Chiesi Farmaceutici S.P.A. |
1-phenylalkanecarboxylic acid derivatives for the treatment of alzheimer's disease and multiple sclerosis
|
WO2015037000A1
(en)
|
2013-09-11 |
2015-03-19 |
Compugen Ltd |
Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases
|
CN103555829B
(zh)
|
2013-10-12 |
2015-10-21 |
厦门人瑞生物医药科技有限公司 |
一种检测trem2基因r47h突变的探针、试剂盒和方法
|
WO2015103594A1
(en)
|
2014-01-06 |
2015-07-09 |
Children's Medical Center Corporation |
Biomarkers for dementia and dementia related neurological disorders
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
CN103866041A
(zh)
|
2014-04-04 |
2014-06-18 |
厦门大学 |
帕金森病和脑白质疏松症的突变检测试剂盒及其检测方法
|
CN106459205B
(zh)
|
2014-04-11 |
2021-04-09 |
免疫医疗有限责任公司 |
包含半胱氨酸工程化抗体的轭合化合物
|
CN105218669A
(zh)
|
2014-06-10 |
2016-01-06 |
河北翰林生物科技有限公司 |
制备抗人r47h-trem2突变体的人单克隆抗体的方法
|
WO2016004389A2
(en)
|
2014-07-03 |
2016-01-07 |
Abbvie Inc. |
Monovalent binding proteins
|
JP6738316B2
(ja)
|
2014-07-17 |
2020-08-12 |
ノヴォ ノルディスク アクティーゼルスカブ |
粘度を低下させるためのtrem−1抗体の部位特異的変異誘発
|
US20170240631A1
(en)
|
2014-08-08 |
2017-08-24 |
Alector Llc |
Anti-trem2 antibodies and methods of use thereof
|
KR101756417B1
(ko)
|
2014-08-21 |
2017-07-10 |
한국유나이티드제약 주식회사 |
금제제를 포함하는 간 섬유화 또는 간 경화의 예방 또는 치료용 약학적 조성물
|
KR102506663B1
(ko)
|
2014-09-28 |
2023-03-08 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
자극성 및 비자극성 골수성 세포의 조절
|
WO2016064895A1
(en)
|
2014-10-20 |
2016-04-28 |
The Brigham And Women's Hospital, Inc. |
Targeting apolipoprotein e (apoe) in neurologic disease
|
US10081792B2
(en)
|
2014-12-31 |
2018-09-25 |
Wisconsin Alumni Research Foundation |
Derivation of human microglia from pluripotent stem cells
|
SI3283508T1
(sl)
|
2015-04-17 |
2021-09-30 |
Alpine Immune Sciences, Inc. |
Imunomodulirajoči proteini z nastavljivimi afinitetami
|
CN107847504A
(zh)
|
2015-05-18 |
2018-03-27 |
斯奈普泰克发展有限责任公司 |
淀粉状蛋白β的加兰他敏清除
|
EP3307779A2
(en)
|
2015-06-12 |
2018-04-18 |
Alector LLC |
Anti-cd33 antibodies and methods of use thereof
|
CN107922480B
(zh)
|
2015-06-12 |
2022-09-23 |
艾利妥 |
抗cd33抗体及其使用方法
|
US10765679B2
(en)
|
2015-07-04 |
2020-09-08 |
Emory University |
Use of TREM-1 inhibitors for treatment, elimination and eradication of HIV-1 infection
|
US20180194861A1
(en)
|
2015-07-10 |
2018-07-12 |
Abbvie Inc. |
IgM- or IgE-Modified Binding Proteins and Uses Thereof
|
AU2016298227B9
(en)
|
2015-07-30 |
2019-10-31 |
Macrogenics, Inc. |
PD-1-binding molecules and methods of use thereof
|
EP3341411A1
(en)
|
2015-08-28 |
2018-07-04 |
Alector LLC |
Anti-siglec-7 antibodies and methods of use thereof
|
WO2017058866A1
(en)
|
2015-09-28 |
2017-04-06 |
Precision Immune, Inc. |
Anti-trem2 antibodies and uses thereof
|
US20190330335A1
(en)
|
2015-10-06 |
2019-10-31 |
Alector Llc |
Anti-trem2 antibodies and methods of use thereof
|
WO2017075432A2
(en)
|
2015-10-29 |
2017-05-04 |
Alector Llc |
Anti-siglec-9 antibodies and methods of use thereof
|
US20170218058A1
(en)
|
2016-01-28 |
2017-08-03 |
Alector, LLC |
Anti-apoe4 antigen-binding proteins and methods of use thereof
|
WO2017139638A1
(en)
|
2016-02-11 |
2017-08-17 |
The Johns Hopkins University |
Compositions and methods for neuralgenesis
|
WO2017147509A1
(en)
|
2016-02-25 |
2017-08-31 |
Marco Colonna |
Compositions comprising trem2 and methods of use thereof
|
JP7023853B2
(ja)
|
2016-03-04 |
2022-02-22 |
アレクトル エルエルシー |
抗trem1抗体及びその使用方法
|
US10875919B2
(en)
|
2016-04-26 |
2020-12-29 |
Alector Llc |
Chimeric receptors and methods of use thereof
|
EP3452101A2
(en)
|
2016-05-04 |
2019-03-13 |
CureVac AG |
Rna encoding a therapeutic protein
|
US11944665B2
(en)
|
2016-06-01 |
2024-04-02 |
University Of Virginia Patent Foundation |
Methods and compositions for modulating lymphatic vessels in the central nervous system
|
US10941200B2
(en)
|
2016-07-22 |
2021-03-09 |
Deutsches Zentrum Für Neurodegenerative Erkrankungen Ev |
TREM2 cleavage modulators and uses thereof
|
CN106244682B
(zh)
|
2016-07-29 |
2019-11-26 |
中山大学 |
Trem-2基因在鉴别猪对蓝耳病毒易感性中的应用
|
CN106636330B
(zh)
|
2016-09-21 |
2017-12-15 |
郁金泰 |
阿尔茨海默病的诊断和治疗药物
|
WO2018071898A1
(en)
|
2016-10-14 |
2018-04-19 |
Children's Medical Center Corporation |
Compositions and methods for treating diseases and disorders of the central nervous system
|
CN110325549B
(zh)
|
2016-12-09 |
2024-03-08 |
艾利妥 |
抗SIRPα抗体及其使用方法
|
WO2018119018A1
(en)
|
2016-12-23 |
2018-06-28 |
Genervon Biopharmaceuticals, LLC |
Methods of using gm6 in diagnosing and treating alzheimer's disease
|
WO2018132728A1
(en)
|
2017-01-12 |
2018-07-19 |
Duke University |
Compositions and methods for the treatment of demyelinating conditions
|
WO2018134815A2
(en)
|
2017-01-17 |
2018-07-26 |
Yeda Research And Development Co. Ltd. |
Methods of treating neurodegenerative diseases by inducing disease-associated microglia (dam) cells
|
WO2018136598A1
(en)
|
2017-01-18 |
2018-07-26 |
Evelo Biosciences, Inc. |
Methods of treating cancer
|
EP3574018A4
(en)
|
2017-01-27 |
2020-10-07 |
Silverback Therapeutics, Inc. |
CONJUGATES TARGETING TUMORS AND THEIR METHODS OF USE
|
US10143187B2
(en)
|
2017-02-17 |
2018-12-04 |
Denali Therapeutics Inc. |
Transferrin receptor transgenic models
|
US20210293794A1
(en)
|
2017-02-24 |
2021-09-23 |
University Of Hawii Cancer Center |
Metabolic biomarkers for the identification and characterization of alzheimers disease
|
EP3589293A4
(en)
|
2017-02-28 |
2020-12-16 |
The Regents of the University of California |
DIFFERENTIATION AND USE OF HUMAN MICROGLIA-LIKE CELLS FROM PLURIPOTENT STEM CELLS AND HEMATOPOIETIC ANALYZER CELLS
|
CA3057289A1
(en)
|
2017-03-21 |
2018-09-27 |
The Jackson Laboratory |
A genetically modified mouse expressing human apoe4 and mouse trem2 p.r47h and methods of use thereof
|
KR101936249B1
(ko)
|
2017-04-04 |
2019-01-08 |
경희대학교 산학협력단 |
쿠마타케닌을 포함하는 암의 예방, 개선 또는 치료용 조성물
|
JOP20190248A1
(ar)
|
2017-04-21 |
2019-10-20 |
Amgen Inc |
بروتينات ربط مولد ضد trem2 واستخداماته
|
US20180318379A1
(en)
|
2017-05-01 |
2018-11-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of triggering receptor expressed on myeloid cells 1 (trem1) to treat central nervous system disorders
|
WO2018213316A1
(en)
|
2017-05-16 |
2018-11-22 |
Alector Llc |
Anti-siglec-5 antibodies and methods of use thereof
|
US20180340945A1
(en)
|
2017-05-24 |
2018-11-29 |
Nanosomix, Inc. |
Detection of biomarkers on vesicles for the diagnosis and prognosis of diseases and disorders
|
US11149094B2
(en)
|
2017-06-05 |
2021-10-19 |
Janssen Biotech, Inc. |
Engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations
|
JP7356970B2
(ja)
|
2017-06-25 |
2023-10-05 |
システィミューン, インク. |
多重特異性抗体とその作製及び使用方法
|
CN109206503A
(zh)
|
2017-07-07 |
2019-01-15 |
厦门大学 |
一种蛋白用于制备防治阿尔茨海默病药物的用途
|
US20190008812A1
(en)
|
2017-07-07 |
2019-01-10 |
Washington University |
Methods for treating microglial dysfunction
|
WO2019016784A1
(en)
|
2017-07-21 |
2019-01-24 |
Universidade De Coimbra |
ANTI-NUCLEOLIN ANTIBODIES
|
WO2019021233A1
(en)
|
2017-07-27 |
2019-01-31 |
Novartis Ag |
TREM2 VARIANTS RESISTANT TO SHEDDASE
|
AU2018311055A1
(en)
|
2017-08-03 |
2019-11-14 |
Alector Llc |
Anti-TREM2 antibodies and methods of use thereof
|
CN117700548A
(zh)
|
2017-08-03 |
2024-03-15 |
艾利妥 |
抗cd33抗体及其使用方法
|
WO2019032624A1
(en)
|
2017-08-08 |
2019-02-14 |
Pionyr Immunotherapeutics, Inc. |
COMPOSITIONS AND METHODS FOR DEACTIVATING TREM1-EXPRESSING MESHLOID CELLS
|
EP3681909A1
(en)
|
2017-09-14 |
2020-07-22 |
Denali Therapeutics Inc. |
Anti-trem2 antibodies and methods of use thereof
|
WO2019068072A1
(en)
|
2017-09-29 |
2019-04-04 |
The General Hospital Corporation |
METHODS OF IDENTIFICATION AND TREATMENT OF ADRENOMYELONEUROPATHY (AMN)
|
US11364303B2
(en)
|
2017-09-29 |
2022-06-21 |
Pfizer Inc. |
Cysteine engineered antibody drug conjugates
|
KR20220015500A
(ko)
|
2017-10-03 |
2022-02-08 |
프리베일 테라퓨틱스, 인크. |
리소좀 장애를 위한 유전자 요법
|
WO2019079529A1
(en)
|
2017-10-17 |
2019-04-25 |
The Translational Genomics Research Institute |
TREM2 AGONISTS FOR STIMULATING MICROGLIA AND IDENTIFICATION METHODS
|
US10597462B1
(en)
|
2017-11-08 |
2020-03-24 |
University Of Puerto Rico |
Anti-TLT-1 antibody and uses thereof
|
CA3095354A1
(en)
|
2017-11-15 |
2019-05-23 |
Universite Laval |
Use of srsf3 agents for the treatment and/or prevention of neurological conditions, cancer, bacterial infections or viral infections
|
CN109837330A
(zh)
|
2017-11-28 |
2019-06-04 |
上海中优精准医疗科技股份有限公司 |
一种检测trem2基因多态性的探针及方法
|
US11470827B2
(en)
|
2017-12-12 |
2022-10-18 |
Alector Llc |
Transgenic mice expressing human TREM proteins and methods of use thereof
|
CN111712258B
(zh)
|
2017-12-12 |
2024-03-15 |
开拓免疫医疗公司 |
抗trem2抗体和相关方法
|
EP3746476A1
(en)
|
2018-01-31 |
2020-12-09 |
Alector LLC |
Anti-ms4a4a antibodies and methods of use thereof
|
CA3091047A1
(en)
|
2018-02-14 |
2019-08-22 |
Yale University |
Compositions for modulation of a trem or treml protein and methods of use
|
NL2020520B1
(en)
|
2018-03-02 |
2019-09-12 |
Labo Bio Medical Invest B V |
Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
|
US20210000807A1
(en)
|
2018-03-22 |
2021-01-07 |
Nsc Therapeutics Gmbh |
Compounds and methods for use in the treatment of microglia-mediated disorders
|
EP3774902A1
(en)
|
2018-04-02 |
2021-02-17 |
Bristol-Myers Squibb Company |
Anti-trem-1 antibodies and uses thereof
|
US20210059977A1
(en)
|
2018-04-09 |
2021-03-04 |
The General Hospital Corporation |
Combination therapies for the treatment of amyotrophic lateral sclerosis and related disorders
|
US11319373B2
(en)
|
2018-05-25 |
2022-05-03 |
Alector Llc |
Anti-SIRPA antibodies and methods of use thereof
|
EA202092595A1
(ru)
|
2018-06-08 |
2021-04-12 |
Алектор Ллс |
Антитела к siglec-7 и способы их применения
|
CN108752482B
(zh)
|
2018-06-12 |
2019-04-30 |
南京卡提医学科技有限公司 |
携带截短或未截短的髓样细胞触发性受体信号结构的嵌合抗原受体及其应用
|
WO2019246483A1
(en)
|
2018-06-21 |
2019-12-26 |
The Jackson Laboratory |
Genetically modified mouse models of alzheimer's disease
|
MA53015A
(fr)
|
2018-06-29 |
2021-05-05 |
Alector Llc |
Anticorps anti-sirp-bêta1 et procédés d'utilisation associés
|
US11278575B2
(en)
|
2018-07-12 |
2022-03-22 |
Duke University |
Compositions and methods for the treatment of demyelinating conditions
|
US20210255190A1
(en)
|
2018-07-12 |
2021-08-19 |
Corvus Pharmaceuticals, Inc. |
Methods for detecting and treating cancers having adenosine pathway activation
|
WO2020018461A1
(en)
|
2018-07-16 |
2020-01-23 |
The University Of Virginia Patent Foundation |
Compositions and methods of diagnosis and treatment for neurological diseases
|
CN109112214A
(zh)
|
2018-07-27 |
2019-01-01 |
复旦大学附属中山医院 |
模式识别受体trem2在肝癌预后和治疗中的应用
|
EA202190183A1
(ru)
|
2018-07-27 |
2021-05-18 |
Алектор Ллс |
Антитела к siglec-5 и способы их применения
|
EA202190235A1
(ru)
|
2018-08-31 |
2021-07-02 |
Алектор Ллс |
Антитела к cd33 и способы их применения
|
EP3846796A4
(en)
|
2018-09-05 |
2022-09-07 |
The General Hospital Corporation |
CYTOKINE RELEASE SYNDROME TREATMENT METHODS
|
EP3849598A4
(en)
|
2018-09-11 |
2022-07-06 |
Washington University |
ANTI-TREM-2 AGONIST ANTIBODIES
|
US20210315816A1
(en)
|
2018-09-12 |
2021-10-14 |
Board Of Regents Of The University Of Nebraska |
Antimicrobial compositions and methods
|
JP2022513324A
(ja)
|
2018-09-28 |
2022-02-07 |
イノトレム |
抗炎症療法に応答しやすい対象を特定するための可溶性trem-1レベルの使用
|
UY38407A
(es)
|
2018-10-15 |
2020-05-29 |
Novartis Ag |
Anticuerpos estabilizadores de trem2
|
KR102096282B1
(ko)
|
2018-10-15 |
2020-04-02 |
재단법인대구경북과학기술원 |
재조합 베큘로바이러스를 이용한 인간 trem2 세포막 단백질의 효율적인 정제방법
|
KR102156165B1
(ko)
|
2018-10-29 |
2020-09-15 |
재단법인대구경북과학기술원 |
인간 trem2 세포막 단백질에 대한 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도
|
CN111135185A
(zh)
|
2018-11-02 |
2020-05-12 |
杭州星鳌生物科技有限公司 |
天然免疫激活通过调控髓系细胞触发受体trem2抑制大脑神经慢性炎症
|
WO2020097395A1
(en)
|
2018-11-08 |
2020-05-14 |
The Regents Of The University Of California |
Systems and methods for targeting cancer cells
|
EP3887401A2
(en)
|
2018-11-26 |
2021-10-06 |
Denali Therapeutics Inc. |
Methods for treating dysregulated lipid metabolism
|
EP3898691A4
(en)
|
2018-12-10 |
2022-09-14 |
Mor Research Applications |
TREM2 ANTIBODIES AND USES THEREOF
|
EP3898667A2
(en)
|
2018-12-20 |
2021-10-27 |
F. Hoffmann-La Roche AG |
Modified antibody fcs and methods of use
|
CN113543808A
(zh)
|
2019-01-04 |
2021-10-22 |
特瑞奥制药公司 |
多特异性蛋白质分子及其用途
|
CN109646668B
(zh)
|
2019-01-04 |
2019-10-18 |
厦门大学 |
一种多肽用于制备防治阿尔茨海默病药物的用途
|
MA54752A
(fr)
|
2019-01-14 |
2021-11-24 |
Univ Virginia Patent Foundation |
Utilisation d'inhibiteurs d'intégrine pour le traitement ou la prévention d'un trouble immunitaire neurologique et/ou d'une lésion du système nerveux
|
WO2020152607A1
(en)
|
2019-01-22 |
2020-07-30 |
St. Jude Children's Research Hospital |
Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
|
EP3914071A4
(en)
|
2019-01-23 |
2022-10-19 |
The Regents of the University of California |
HUMAN GENOMIC CONSTRUCTION REPORTER CELLS AND MOUSE MODELS FOR SCREENING THERAPEUTIC AGENTS AGAINST GENES ASSOCIATED WITH MICROGLY-EXPRESSED DISEASE
|
EP3917967A4
(en)
|
2019-02-01 |
2023-02-08 |
Seattle Children's Hospital (DBA Seattle Children's Research Institute) |
MICROENVIRONMENTAL SENSORS TO REGULATE MANIPULATED GENE EXPRESSION
|
EP3917620A4
(en)
|
2019-02-01 |
2023-02-08 |
Avrobio, Inc. |
COMPOSITIONS AND METHODS FOR TREATING NEUROCOGNITIVE DISORDERS
|
MA54873A
(fr)
|
2019-02-01 |
2021-12-08 |
Avrobio Inc |
Compositions et méthodes pour le traitement de troubles neurocognitifs
|
CA3130086A1
(en)
|
2019-02-20 |
2020-08-27 |
Denali Therapeutics Inc. |
Anti-trem2 antibodies and methods of use thereof
|
WO2020194317A1
(en)
|
2019-03-28 |
2020-10-01 |
Yeda Research And Development Co. Ltd. |
Method of treating lipid-related disorders
|
CN110320368A
(zh)
|
2019-05-30 |
2019-10-11 |
广州医科大学附属第一医院(广州呼吸中心) |
基于trem2的诊断试剂盒及其在帕金森病诊断产品上的应用
|
CN110241208A
(zh)
|
2019-08-02 |
2019-09-17 |
辽宁中医药大学 |
Trem2作为早期诊断冠心病的分子标志物的应用
|
CN110511240B
(zh)
|
2019-08-27 |
2022-03-08 |
南京医科大学 |
一种髓细胞触发受体2的内源性配体及其应用
|
CN110882262A
(zh)
|
2019-11-06 |
2020-03-17 |
南京医科大学 |
一种髓细胞触发受体2的激活用药及其应用
|
CR20220228A
(es)
|
2019-11-22 |
2022-06-08 |
Lilly Co Eli |
Anticuerpos trem2 y usos de estos
|
IL293386A
(en)
|
2019-12-05 |
2022-07-01 |
Alector Llc |
Methods for using anti-trem2 antibodies
|
CN111184742B
(zh)
|
2020-02-13 |
2022-06-24 |
中山大学附属第五医院 |
Trem-2+t细胞在制备用于治疗结核病药物中的应用
|