BR112019001945A2 - composição de conjugado de fármaco aglutinante, formulação farmaceuticamente aceitável, métodos para tratar uma doença ou afecção hiperproliferativa, para inibir a multiplicação de uma célula tumoral ou célula cancerígena e para preparar uma composição de conjugado de fármaco aglutinado, e, composto - Google Patents

composição de conjugado de fármaco aglutinante, formulação farmaceuticamente aceitável, métodos para tratar uma doença ou afecção hiperproliferativa, para inibir a multiplicação de uma célula tumoral ou célula cancerígena e para preparar uma composição de conjugado de fármaco aglutinado, e, composto

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Publication number
BR112019001945A2
BR112019001945A2 BR112019001945-6A BR112019001945A BR112019001945A2 BR 112019001945 A2 BR112019001945 A2 BR 112019001945A2 BR 112019001945 A BR112019001945 A BR 112019001945A BR 112019001945 A2 BR112019001945 A2 BR 112019001945A2
Authority
BR
Brazil
Prior art keywords
drug conjugate
conjugate composition
binder drug
methods
binder
Prior art date
Application number
BR112019001945-6A
Other languages
English (en)
Inventor
Moquist Philip
Original Assignee
Seattle Genetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics, Inc. filed Critical Seattle Genetics, Inc.
Publication of BR112019001945A2 publication Critical patent/BR112019001945A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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Abstract

trata-se de compostos e composições revelados em que uma unidade de fármaco é ligada a uma unidade ligante de direcionamento através de uma unidade ligante autoestabilizante a partir da qual um composto de fármaco ou porção de fármaco ativo é liberado no sítio-alvo de ação. também são revelados métodos para o tratamento de doenças distinguidas por células-alvo anormais, tais como câncer ou uma doença autoimune com o uso dos compostos e das composições da invenção.
BR112019001945-6A 2016-08-09 2017-08-09 composição de conjugado de fármaco aglutinante, formulação farmaceuticamente aceitável, métodos para tratar uma doença ou afecção hiperproliferativa, para inibir a multiplicação de uma célula tumoral ou célula cancerígena e para preparar uma composição de conjugado de fármaco aglutinado, e, composto BR112019001945A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662372455P 2016-08-09 2016-08-09
US62/372,455 2016-08-09
PCT/US2017/046157 WO2018031690A1 (en) 2016-08-09 2017-08-09 Drug conjugates with self-stabilizing linkers having improved physiochemical properties

Publications (1)

Publication Number Publication Date
BR112019001945A2 true BR112019001945A2 (pt) 2019-05-07

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BR112019001945-6A BR112019001945A2 (pt) 2016-08-09 2017-08-09 composição de conjugado de fármaco aglutinante, formulação farmaceuticamente aceitável, métodos para tratar uma doença ou afecção hiperproliferativa, para inibir a multiplicação de uma célula tumoral ou célula cancerígena e para preparar uma composição de conjugado de fármaco aglutinado, e, composto

Country Status (15)

Country Link
US (1) US11944689B2 (pt)
EP (1) EP3496747A4 (pt)
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