SG10201608904YA - Self-Stabilizing Linker Conjugates - Google Patents

Self-Stabilizing Linker Conjugates

Info

Publication number
SG10201608904YA
SG10201608904YA SG10201608904YA SG10201608904YA SG10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA SG 10201608904Y A SG10201608904Y A SG 10201608904YA
Authority
SG
Singapore
Prior art keywords
self
linker conjugates
stabilizing linker
stabilizing
conjugates
Prior art date
Application number
SG10201608904YA
Inventor
Lyon Robert
Doronina Svetlana
Bovee Timothy
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/799,244 external-priority patent/US9504756B2/en
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of SG10201608904YA publication Critical patent/SG10201608904YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • External Artificial Organs (AREA)
  • Pyrrole Compounds (AREA)
SG10201608904YA 2012-05-15 2013-05-14 Self-Stabilizing Linker Conjugates SG10201608904YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261647373P 2012-05-15 2012-05-15
US201361770983P 2013-02-28 2013-02-28
US201361773067P 2013-03-05 2013-03-05
US13/799,244 US9504756B2 (en) 2012-05-15 2013-03-13 Self-stabilizing linker conjugates

Publications (1)

Publication Number Publication Date
SG10201608904YA true SG10201608904YA (en) 2016-12-29

Family

ID=49584442

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201608904YA SG10201608904YA (en) 2012-05-15 2013-05-14 Self-Stabilizing Linker Conjugates
SG11201406252WA SG11201406252WA (en) 2012-05-15 2013-05-14 Self-stabilizing linker conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201406252WA SG11201406252WA (en) 2012-05-15 2013-05-14 Self-stabilizing linker conjugates

Country Status (14)

Country Link
EP (1) EP2850094B1 (en)
JP (5) JP6423340B2 (en)
KR (5) KR102144069B1 (en)
CN (2) CN108465112B (en)
AU (5) AU2013263002C1 (en)
BR (1) BR112014028222A2 (en)
CA (2) CA2869777C (en)
EA (1) EA037203B1 (en)
HK (1) HK1207388A1 (en)
MX (2) MX368678B (en)
NZ (3) NZ741211A (en)
SG (2) SG10201608904YA (en)
WO (1) WO2013173337A2 (en)
ZA (1) ZA201407369B (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013031819B1 (en) 2011-06-10 2022-05-03 Mersana Therapeutics, Inc Polymeric support, pharmaceutical composition, compound and support use
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
CA2859755C (en) 2011-12-23 2021-04-20 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
NZ741211A (en) * 2012-05-15 2019-09-27 Seattle Genetics Inc Self-stabilizing linker conjugates
MX367851B (en) 2013-10-11 2019-09-09 Mersana Therapeutics Inc Protein-polymer-drug conjugates.
CN105813655B (en) 2013-10-11 2022-03-15 阿萨纳生物科技有限责任公司 Protein-polymer-drug conjugates
KR102645430B1 (en) 2013-10-15 2024-03-11 씨젠 인크. Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
JP6701077B2 (en) 2013-12-19 2020-05-27 シアトル ジェネティックス， インコーポレイテッド Methylene carbamate linker for use with targeted drug conjugates
WO2016008112A1 (en) * 2014-07-16 2016-01-21 Medshine Discovery Inc. Linkers and application towards adc thereof
SG11201701311YA (en) * 2014-09-11 2017-03-30 Seattle Genetics Inc Targeted delivery of tertiary amine-containing drug substances
RU2715905C2 (en) * 2014-10-01 2020-03-04 МЕДИММЬЮН, ЭлЭлСи Method for conjugation of a polypeptide
WO2016063959A1 (en) 2014-10-24 2016-04-28 日油株式会社 Antibody-drug complex having cyclic benzylidene acetal linker
JP6752204B2 (en) * 2014-12-03 2020-09-09 ジェネンテック， インコーポレイテッド Quadruple amine compounds and their antibodies-drug conjugates
CN111620862A (en) * 2014-12-09 2020-09-04 艾伯维公司 BCL-XL-inhibitory compounds and antibody drug conjugates including the same
RU2020123953A (en) * 2014-12-09 2020-09-18 Эббви Инк. BCL-XL INHIBITING COMPOUNDS WITH LOW CELL PERMEABILITY AND ANTIBODY-DRUG CONJUGATES INCLUDING THEM
SG11201706786UA (en) * 2015-03-18 2017-09-28 Seattle Genetics Inc Cd48 antibodies and conjugates thereof
CN106267225B (en) 2015-05-29 2020-03-06 上海新理念生物医药科技有限公司 Trimaleimide-type linker and use thereof
CN106380508A (en) * 2015-07-28 2017-02-08 上海皓元生物医药科技有限公司 Industrialized production method for antibody coupling medicine connexon
TWI726942B (en) 2015-11-30 2021-05-11 美商輝瑞股份有限公司 Site specific her2 antibody drug conjugates
TWI814699B (en) 2015-12-04 2023-09-11 美商思進公司 Conjugates of quaternized tubulysin compounds
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
MA43835A (en) 2016-03-25 2018-11-28 Seattle Genetics Inc PROCESS FOR THE PREPARATION OF PEGYLATED MEDICINAL PRODUCTS AND THEIR INTERMEDIARIES
EP3442979A4 (en) * 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey Topoisomerase poisons
WO2017196598A1 (en) * 2016-05-10 2017-11-16 Bristol-Myers Squibb Company Antibody-drug conjugates of tubulysin analogs with enhanced stability
CN109563168A (en) 2016-06-08 2019-04-02 艾伯维公司 Anti-egfr antibodies drug conjugates
EP3468615A1 (en) 2016-06-08 2019-04-17 AbbVie Inc. Anti-egfr antibody drug conjugates
CA3027181A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-egfr antibody drug conjugates
CN109562169A (en) 2016-06-08 2019-04-02 艾伯维公司 Anti-CD 98 antibody and antibody drug conjugates
CA3027046A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-cd98 antibodies and antibody drug conjugates
RU2764651C2 (en) 2016-06-08 2022-01-19 Эббви Инк. Antibodies to b7-h3 and conjugates of antibody and drug
CN109641962A (en) 2016-06-08 2019-04-16 艾伯维公司 Anti- B7-H3 antibody and antibody drug conjugates
EP3468596A2 (en) 2016-06-08 2019-04-17 AbbVie Inc. Anti-cd98 antibodies and antibody drug conjugates
SG11201900699QA (en) * 2016-08-09 2019-02-27 Seattle Genetics Inc Drug conjugates with self-stabilizing linkers having improved physiochemical properties
KR20240000650A (en) 2016-10-19 2024-01-02 인벤라 인코포레이티드 Antibody constructs
JP7244987B2 (en) 2016-12-14 2023-03-23 シージェン インコーポレイテッド Multidrug Antibody Drug Conjugates
AU2017383142A1 (en) 2016-12-22 2019-07-04 Università Degli Studi Magna Graecia Catanzaro A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of CD43
JP2020512312A (en) 2017-03-24 2020-04-23 シアトル ジェネティックス， インコーポレイテッド Process for the preparation of glucuronide drug-linker and its intermediates
CN107652219B (en) * 2017-08-14 2021-06-08 上海新理念生物医药科技有限公司 Tetramaleimide-type linker and application thereof
BR112020004495A2 (en) 2017-09-08 2020-09-08 Seattle Genetics, Inc. compound, composition, and method for preparing a composition.
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
WO2019234136A1 (en) 2018-06-05 2019-12-12 King's College London Btnl3/8 targeting constructs for delivery of payloads to the gastrointestinal system
TW202015740A (en) 2018-06-07 2020-05-01 美商西雅圖遺傳學公司 Camptothecin conjugates
CN113766933A (en) * 2019-06-28 2021-12-07 上海复旦张江生物医药股份有限公司 Antibody coupling drug, intermediate thereof, preparation method and application
EP4037717A1 (en) 2019-10-04 2022-08-10 Seagen Inc. Camptothecin peptide conjugates
WO2021226454A1 (en) * 2020-05-08 2021-11-11 Mpeg La, L.L.C. Linker compounds
WO2022068898A1 (en) * 2020-09-29 2022-04-07 迈威(上海)生物科技股份有限公司 Preparation method for bis-substituted bridging antibody-drug conjugate
UY39610A (en) 2021-01-20 2022-08-31 Abbvie Inc ANTI-EGFR ANTIBODY-DRUG CONJUGATES
TW202320857A (en) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 Linkers, drug linkers and conjugates thereof and methods of using the same
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
WO2023033129A1 (en) 2021-09-03 2023-03-09 東レ株式会社 Pharmaceutical composition for treating and/or preventing cancer
WO2023178289A2 (en) 2022-03-17 2023-09-21 Seagen Inc. Camptothecin conjugates
EP4321522A1 (en) 2022-08-12 2024-02-14 Seagen Inc. Cytotoxic compounds and conjugates thereof
WO2024092219A1 (en) * 2022-10-28 2024-05-02 Eli Lilly And Company Self-hydrolyzing maleimides for bioconjugation

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
JPS63501765A (en) 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング　インコ−ポレ−テッド Antibody gene module assembly, antibodies produced thereby, and uses
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4880935A (en) 1986-07-11 1989-11-14 Icrf (Patents) Limited Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
IL106992A (en) 1988-02-11 1994-06-24 Bristol Myers Squibb Co Acylhydrazone derivatives of anthracycline and methods for their preparation
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5091542A (en) * 1990-03-09 1992-02-25 Hybritech Incorporated Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
US5622929A (en) 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
WO1994001485A1 (en) * 1992-07-01 1994-01-20 Akzo Nobel N.V. Process for the modification of polyphenylene ether resin compositions
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
PT871490E (en) 1995-12-22 2003-07-31 Bristol Myers Squibb Co BRIDGED HIDRAZONE LIGANTS
DE69731289D1 (en) 1996-03-18 2004-11-25 Univ Texas IMMUNGLOBULIN-LIKE DOMAIN WITH INCREASED HALF-VALUE TIMES
US6130237A (en) 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
US5973166A (en) 1998-03-02 1999-10-26 The Dexter Corporation Method for the preparation of maleimides
US20030083263A1 (en) 2001-04-30 2003-05-01 Svetlana Doronina Pentapeptide compounds and uses related thereto
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US8877901B2 (en) * 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
EP2357006B1 (en) 2002-07-31 2015-09-16 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
US7432331B2 (en) * 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
EP3120861B1 (en) 2003-11-06 2018-08-15 Seattle Genetics, Inc. Intermediate for conjugate preparation comprising auristatin derivatives and a linker
RU2402548C2 (en) 2004-05-19 2010-10-27 Медарекс, Инк. Chemical linkers and conjugates thereof
CA2564076C (en) 2004-05-19 2014-02-18 Medarex, Inc. Chemical linkers and conjugates thereof
CN102973947A (en) 2004-06-01 2013-03-20 健泰科生物技术公司 Antibody-drug conjugates and methods
US8871720B2 (en) 2005-07-07 2014-10-28 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
WO2007008603A1 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
EA016577B1 (en) 2005-09-26 2012-06-29 Медарекс, Инк. Antibody-drug conjugates and use thereof
ES2374964T3 (en) 2006-01-25 2012-02-23 Sanofi CYTOTOXIC AGENTS UNDERSTANDING NEW TOMAIMYCIN DERIVATIVES.
CA2702555A1 (en) 2007-10-19 2009-04-23 Seattle Genetics, Inc. Cd19 binding agents and uses thereof
ES2647927T3 (en) 2008-03-18 2017-12-27 Seattle Genetics, Inc. Auriestatin drug linker conjugates
MX2010011807A (en) 2008-04-30 2011-03-04 Immunogen Inc Cross-linkers and their uses.
CN102348723A (en) * 2008-12-05 2012-02-08 安吉奥开米公司 Peptide therapeutic conjugates and uses thereof
WO2010091150A1 (en) 2009-02-05 2010-08-12 Immunogen, Inc. Novel benzodiazepine derivatives
CN102448494B (en) * 2009-02-13 2016-02-03 免疫医疗公司 There is the immune conjugates of the key of cleavable in born of the same parents
FR2949469A1 (en) 2009-08-25 2011-03-04 Sanofi Aventis ANTICANCER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
BR112012026213B1 (en) 2010-04-15 2021-12-28 Medimmune Limited PYRROLOBENZODIAZEPINE COMPOUNDS, CONJUGATE THEREOF, PHARMACEUTICAL COMPOSITION INCLUDING CONJUGATE AND USE THEREOF FOR TREATMENT OF A PROLIFERATIVE DISEASE
CA2815363C (en) * 2010-10-22 2020-07-14 Seattle Genetics, Inc. Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway
EP3053600B1 (en) 2011-02-15 2020-01-29 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
NZ741211A (en) 2012-05-15 2019-09-27 Seattle Genetics Inc Self-stabilizing linker conjugates
JP2016516035A (en) * 2013-03-15 2016-06-02 ノバルティス アーゲー Cell growth inhibitors and their conjugates

Also Published As

Publication number Publication date
WO2013173337A3 (en) 2015-06-11
NZ630870A (en) 2016-10-28
EA037203B1 (en) 2021-02-18
NZ724892A (en) 2018-04-27
SG11201406252WA (en) 2014-10-30
CN104822656A (en) 2015-08-05
CN104822656B (en) 2018-05-01
MX2014013807A (en) 2015-02-04
KR20220166877A (en) 2022-12-19
KR20200097000A (en) 2020-08-14
JP2022044690A (en) 2022-03-17
KR102433686B1 (en) 2022-08-19
AU2013263002A1 (en) 2014-09-25
AU2021201636A1 (en) 2021-04-08
AU2013263002C1 (en) 2018-05-31
KR102557309B1 (en) 2023-07-20
JP2020122023A (en) 2020-08-13
ZA201407369B (en) 2020-02-26
KR20230113821A (en) 2023-08-01
AU2018201190B2 (en) 2020-01-30
EP2850094A4 (en) 2016-07-06
AU2013263002B2 (en) 2017-11-30
EP2850094B1 (en) 2024-04-17
EP2850094A2 (en) 2015-03-25
JP2015521187A (en) 2015-07-27
JP7014856B2 (en) 2022-02-01
JP2018162251A (en) 2018-10-18
JP6709247B2 (en) 2020-06-10
KR102475777B1 (en) 2022-12-09
KR20150009991A (en) 2015-01-27
CA3131619A1 (en) 2013-11-21
AU2021201636B2 (en) 2023-02-16
WO2013173337A2 (en) 2013-11-21
JP7431261B2 (en) 2024-02-14
NZ741211A (en) 2019-09-27
CN108465112A (en) 2018-08-31
AU2020202805B2 (en) 2020-12-17
CN108465112B (en) 2022-04-29
JP6423340B2 (en) 2018-11-14
CA2869777C (en) 2021-11-16
AU2018201190A1 (en) 2018-03-08
HK1207388A1 (en) 2016-01-29
KR102144069B1 (en) 2020-08-13
AU2023203005A1 (en) 2023-06-01
MX368678B (en) 2019-10-11
JP2024032941A (en) 2024-03-12
BR112014028222A2 (en) 2017-06-27
EA201401254A1 (en) 2015-09-30
KR20210094150A (en) 2021-07-28
MX2019012201A (en) 2019-11-28
AU2020202805A1 (en) 2020-05-21
CA2869777A1 (en) 2013-11-21

Similar Documents

Publication Publication Date Title
HUS2300020I1 (en) Pyrrolobenzodiazepine-antibody conjugates
HK1207388A1 (en) Self-stabilizing linker conjugates
IL268420A (en) Oligonucleotide conjugates
HRP20180870T1 (en) Antibody-drug conjugate
ZA201502523B (en) Pyrrolobenzodiazepine-anitbody conjugates
ZA201501996B (en) Drug-protein conjugates
IL237672B (en) Drug-protein conjugates
IL233701A0 (en) Binding molecule conjugates
ZA201409119B (en) Polymer-nsaid conjugate
EP2836238A4 (en) Co-polymer conjugates