BR112019000610A2 - fator vii de coagulação de longa ação e métodos de produção do mesmo - Google Patents

fator vii de coagulação de longa ação e métodos de produção do mesmo

Info

Publication number
BR112019000610A2
BR112019000610A2 BR112019000610A BR112019000610A BR112019000610A2 BR 112019000610 A2 BR112019000610 A2 BR 112019000610A2 BR 112019000610 A BR112019000610 A BR 112019000610A BR 112019000610 A BR112019000610 A BR 112019000610A BR 112019000610 A2 BR112019000610 A2 BR 112019000610A2
Authority
BR
Brazil
Prior art keywords
coagulation factor
long
production methods
factor vii
acting coagulation
Prior art date
Application number
BR112019000610A
Other languages
English (en)
Inventor
Moschcovich Laura
Hershkovitz Oren
Original Assignee
Opko Biologics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opko Biologics Ltd filed Critical Opko Biologics Ltd
Publication of BR112019000610A2 publication Critical patent/BR112019000610A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

são divulgados polipeptídeos compreendendo pelo menos um peptídeo carboxi-terminal (ctp) de gonadotrofina coriônica ligado ao terminal carboxi, mas não ao terminal amino de um fator de coagulação e polinucleótideos que o codificam. composições farmacêuticas e formulações farmacêuticas compreendendo os polipeptídeos e polinucleotídeos da divulgação e métodos de utilização e produção dos mesmos são também divulgados.
BR112019000610A 2016-07-11 2017-07-11 fator vii de coagulação de longa ação e métodos de produção do mesmo BR112019000610A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662360767P 2016-07-11 2016-07-11
PCT/IL2017/050784 WO2018011799A1 (en) 2016-07-11 2017-07-11 Long-acting coagulation factor vii and methods of producing same

Publications (1)

Publication Number Publication Date
BR112019000610A2 true BR112019000610A2 (pt) 2019-07-02

Family

ID=59656113

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019000610A BR112019000610A2 (pt) 2016-07-11 2017-07-11 fator vii de coagulação de longa ação e métodos de produção do mesmo

Country Status (18)

Country Link
US (1) US11976106B2 (pt)
EP (2) EP4303228A3 (pt)
JP (1) JP7319187B2 (pt)
KR (2) KR20240006077A (pt)
CN (2) CN118085104A (pt)
AU (3) AU2017296352A1 (pt)
BR (1) BR112019000610A2 (pt)
CA (1) CA3030533A1 (pt)
CL (1) CL2019000099A1 (pt)
EA (1) EA201990255A1 (pt)
ES (1) ES2963725T3 (pt)
HU (1) HUE064463T2 (pt)
IL (1) IL264208A (pt)
MX (1) MX2019000554A (pt)
PT (1) PT3481855T (pt)
SG (2) SG11201900279UA (pt)
TW (1) TW201808988A (pt)
WO (1) WO2018011799A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019000554A (es) 2016-07-11 2019-09-19 Opko Biologics Ltd Factor vii de coagulación de acción prolongada y métodos para producir el mismo.

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