BR112018015590A2 - modulação de receptor acoplado à proteína g (gpcr) por imipridonas - Google Patents

modulação de receptor acoplado à proteína g (gpcr) por imipridonas

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Publication number
BR112018015590A2
BR112018015590A2 BR112018015590A BR112018015590A BR112018015590A2 BR 112018015590 A2 BR112018015590 A2 BR 112018015590A2 BR 112018015590 A BR112018015590 A BR 112018015590A BR 112018015590 A BR112018015590 A BR 112018015590A BR 112018015590 A2 BR112018015590 A2 BR 112018015590A2
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BR
Brazil
Prior art keywords
imipridones
modulation
gpcr
coupled receptor
protein coupled
Prior art date
Application number
BR112018015590A
Other languages
English (en)
Inventor
E Allen Joshua
Stogniew Martin
Vijay PRABHU Varun
Original Assignee
Oncoceutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2016/015817 external-priority patent/WO2016123571A1/en
Application filed by Oncoceutics Inc filed Critical Oncoceutics Inc
Publication of BR112018015590A2 publication Critical patent/BR112018015590A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • G01N2800/00—Detection or diagnosis of diseases
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Abstract

?modulação de receptor acoplado à proteína g (gpcr) por imipridonas? constatou-se que imipridonas modulam, de maneira seletiva, receptores acoplados à proteína g da classe a (gpcrs), tal como a subfamília semelhante a d2 de receptores de dopamina, e que são úteis para o tratamento de condições e distúrbios necessitando de tal modulação, tais como cânceres, distúrbios psiquiátricos e infecções bacterianas. em adição, são fornecidos métodos de identificação do fato de se um indivíduo, apresentando essas condições, provavelmente responderá a um regime de tratamento, tal como a administração de uma imipridona. além disso, são também fornecidos métodos de avaliação da eficácia de um regime de tratamento, tal como a administração de uma imipridona, de monitoramento ou de fornecimento de um prognóstico para um indivíduo com essas condições.
BR112018015590A 2016-01-29 2017-01-30 modulação de receptor acoplado à proteína g (gpcr) por imipridonas BR112018015590A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy
US201662308325P 2016-03-15 2016-03-15
US201662425403P 2016-11-22 2016-11-22
PCT/US2017/015608 WO2017132661A2 (en) 2016-01-29 2017-01-30 G protein-coupled receptor (gpcr) modulation by imipridones

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BR112018015590A2 true BR112018015590A2 (pt) 2019-10-01

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US (2) US11116771B2 (pt)
EP (1) EP3408298A4 (pt)
JP (2) JP7030701B2 (pt)
KR (1) KR20180125460A (pt)
CN (2) CN115844895A (pt)
AU (2) AU2017211423B2 (pt)
BR (1) BR112018015590A2 (pt)
CA (1) CA3013044A1 (pt)
IL (2) IL260815B (pt)
MA (1) MA43879A (pt)
MX (2) MX2018009227A (pt)
NZ (1) NZ745425A (pt)
SG (2) SG11201806401YA (pt)
WO (1) WO2017132661A2 (pt)

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US10172862B2 (en) 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas

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AU2017211423A1 (en) 2018-09-06
WO2017132661A2 (en) 2017-08-03
US11116771B2 (en) 2021-09-14
US20220072001A1 (en) 2022-03-10
SG10202108306UA (en) 2021-08-30
AU2022200583A1 (en) 2022-02-24
MX2018009227A (es) 2018-11-09
WO2017132661A3 (en) 2017-08-31
IL286923A (en) 2021-10-31
CN109311980A (zh) 2019-02-05
EP3408298A2 (en) 2018-12-05
JP2019511460A (ja) 2019-04-25
CN115844895A (zh) 2023-03-28
AU2017211423B2 (en) 2021-10-28
JP2022046528A (ja) 2022-03-23
MX2023004443A (es) 2023-05-08
CA3013044A1 (en) 2017-08-03
AU2022200583B2 (en) 2024-05-02
JP7030701B2 (ja) 2022-03-07
MA43879A (fr) 2018-12-05
KR20180125460A (ko) 2018-11-23
IL260815B (en) 2021-10-31
CN109311980B (zh) 2023-01-17
EP3408298A4 (en) 2019-09-04
NZ745425A (en) 2023-03-31
SG11201806401YA (en) 2018-08-30
US20190307751A1 (en) 2019-10-10

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