BR112018011780A2 - ?processo para preparar um composto? - Google Patents

?processo para preparar um composto?

Info

Publication number
BR112018011780A2
BR112018011780A2 BR112018011780A BR112018011780A BR112018011780A2 BR 112018011780 A2 BR112018011780 A2 BR 112018011780A2 BR 112018011780 A BR112018011780 A BR 112018011780A BR 112018011780 A BR112018011780 A BR 112018011780A BR 112018011780 A2 BR112018011780 A2 BR 112018011780A2
Authority
BR
Brazil
Prior art keywords
phospholipidation
imidazoquinolines
preparing
compound
oxoadenines
Prior art date
Application number
BR112018011780A
Other languages
English (en)
Inventor
A Johnson David
G Bazin-Lee Helene
S Bess Laura
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of BR112018011780A2 publication Critical patent/BR112018011780A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Abstract

a presente invenção refere-se a um processo para fosfolipidação de imidazoquinolinas e oxoadeninas. mais particularmente, a presente invenção refere-se a um processo escalonável e de alto rendimento para a fosfolipidação de imidazoquinolinas e oxoadeninas que previne a necessidade de isolar intermediários de fosforamidita instáveis. esse processo pode ser usado para a fosfolipidação de imidazoquinolinas e oxoadeninas ativas de receptor do tipo toll 7 (tlr7) e ativas de receptor ativo e tipo toll (tlr8).
BR112018011780A 2015-12-14 2016-12-12 ?processo para preparar um composto? BR112018011780A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562266858P 2015-12-14 2015-12-14
PCT/EP2016/080647 WO2017102654A1 (en) 2015-12-14 2016-12-12 Phospholipidation of imidazoquinolines and oxoadenines

Publications (1)

Publication Number Publication Date
BR112018011780A2 true BR112018011780A2 (pt) 2018-12-04

Family

ID=57629576

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018011780A BR112018011780A2 (pt) 2015-12-14 2016-12-12 ?processo para preparar um composto?

Country Status (10)

Country Link
US (3) US10774099B2 (pt)
EP (1) EP3390416B1 (pt)
JP (1) JP2019505489A (pt)
CN (1) CN108368138A (pt)
BE (1) BE1024380B1 (pt)
BR (1) BR112018011780A2 (pt)
CA (1) CA3008054A1 (pt)
ES (1) ES2831162T3 (pt)
MX (1) MX2018007321A (pt)
WO (1) WO2017102654A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10774099B2 (en) * 2015-12-14 2020-09-15 Glaxosmithkline Biologicals Sa Phospholipidation of imidazoquinolines and oxoadenines
BE1024865B1 (fr) * 2016-09-07 2018-07-31 Glaxosmithkline Biologicals Sa Derives d'imidazoquinoleine
WO2020162705A1 (ko) * 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
EP3922266A4 (en) * 2019-02-08 2023-02-01 Progeneer Inc. TOLL-LIKE RECEPTOR 7 OR 8 AGONIST CHOLESTEROL COMPLEX AND USE THEREOF
BR112021023292A2 (pt) * 2019-05-23 2022-02-08 The Univ Of Montana Composto, formulação, composição de vacina, composição farmacêutica, e, método para modular uma resposta imune em um indivíduo
CN112778372A (zh) * 2019-11-11 2021-05-11 苏州泽璟生物制药股份有限公司 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用
WO2022031057A1 (ko) * 2020-08-04 2022-02-10 성균관대학교산학협력단 활성화 부위가 일시적으로 비활성화된 톨-유사 수용체 7 또는 8 작용자와 기능성 약물의 결합체 및 그 용도
JP2023536953A (ja) * 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 動力学的制御が可能なアジュバントを含むｍＲＮＡワクチン
EP4194008A1 (en) * 2020-08-04 2023-06-14 Progeneer Inc. Kinetically acting adjuvant ensemble

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2341933B1 (en) * 2008-10-24 2017-11-22 GlaxoSmithKline Biologicals SA Lipidated imidazoquinoline derivatives
CN102469790B (zh) 2009-08-07 2014-12-03 葛兰素史密丝克莱恩生物有限公司 脂质化氧代腺嘌呤衍生物
CN102372711B (zh) * 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
US20140242112A1 (en) * 2012-11-30 2014-08-28 Glaxosmithkline Biologicals S.A. Novel vaccine
US10774099B2 (en) * 2015-12-14 2020-09-15 Glaxosmithkline Biologicals Sa Phospholipidation of imidazoquinolines and oxoadenines
ES2848648T3 (es) 2015-12-14 2021-08-11 Glaxosmithkline Biologicals Sa Imidazoquinolinas pegiladas como agonistas de TLR7 y TLR8

Also Published As

Publication number Publication date
US11248012B2 (en) 2022-02-15
US20210024553A1 (en) 2021-01-28
BE1024380A1 (fr) 2018-02-05
ES2831162T3 (es) 2021-06-07
US20220119428A1 (en) 2022-04-21
BE1024380B1 (fr) 2018-02-12
US20180273560A1 (en) 2018-09-27
EP3390416B1 (en) 2020-08-19
CN108368138A (zh) 2018-08-03
EP3390416A1 (en) 2018-10-24
CA3008054A1 (en) 2017-06-22
US10774099B2 (en) 2020-09-15
MX2018007321A (es) 2018-09-06
WO2017102654A1 (en) 2017-06-22
JP2019505489A (ja) 2019-02-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]