BR112017025262A2 - processo aperfeiçoado para preparação de apremilast e seus novos polimorfos - Google Patents

processo aperfeiçoado para preparação de apremilast e seus novos polimorfos

Info

Publication number
BR112017025262A2
BR112017025262A2 BR112017025262A BR112017025262A BR112017025262A2 BR 112017025262 A2 BR112017025262 A2 BR 112017025262A2 BR 112017025262 A BR112017025262 A BR 112017025262A BR 112017025262 A BR112017025262 A BR 112017025262A BR 112017025262 A2 BR112017025262 A2 BR 112017025262A2
Authority
BR
Brazil
Prior art keywords
apremilast
improved process
polymorphs
provides
novel
Prior art date
Application number
BR112017025262A
Other languages
English (en)
Inventor
Pundlik Sapdhare Ananda
Digambar Patil Arunkumar
Pal Singh Girij
Dnyanoba Ausekar GOVIND
Pal Singh Gurvinder
Mahadeorao Lande Hemraj
Dasharath Surwase Mithun
Baban Bhise Nandu
Sanphui Palash
Chandra Ray Purna
Bhikaji SHIVDAVKAR Radhakrishna
Gokuldas Varade SHANTANU
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of BR112017025262A2 publication Critical patent/BR112017025262A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção provê um processo aperfeiçoado para a preparação de um intermediário de apremilast. a presente invenção também provê um processo aperfeiçoado para a preparação de apremilast. esta invenção também provê novos polimorfos de apremilast. a presente invenção provê ainda composições farmacêuticas de novos polimorfos de apremilast. esta invenção também provê um processo para a preparação de novos polimorfos de apremilast, que são rentáveis, robustos, e viáveis em escala de fabricação industrial.
BR112017025262A 2015-05-26 2016-05-26 processo aperfeiçoado para preparação de apremilast e seus novos polimorfos BR112017025262A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2048MU2015 2015-05-26
IN2046MU2015 2015-05-26
PCT/IB2016/053083 WO2016189486A1 (en) 2015-05-26 2016-05-26 An improved process for preparation of apremilast and novel polymorphs thereof

Publications (1)

Publication Number Publication Date
BR112017025262A2 true BR112017025262A2 (pt) 2018-07-31

Family

ID=56121137

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017025262A BR112017025262A2 (pt) 2015-05-26 2016-05-26 processo aperfeiçoado para preparação de apremilast e seus novos polimorfos

Country Status (5)

Country Link
US (1) US10377712B2 (pt)
JP (1) JP2018516912A (pt)
BR (1) BR112017025262A2 (pt)
MX (1) MX2017015151A (pt)
WO (1) WO2016189486A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104761484B (zh) * 2014-11-24 2018-03-27 上海优拓医药科技有限公司 一种稳定的不含溶剂化物的阿普司特晶型ii及其制备方法
US10544097B2 (en) * 2015-08-27 2020-01-28 Msn Laboratories Private Limited Solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide and process for preparation thereof
US9765026B2 (en) 2015-08-28 2017-09-19 Scinopharm Taiwan, Ltd. Forms of apremilast and the process of making the same
US10919855B2 (en) 2017-05-04 2021-02-16 Unichem Laboratories Ltd Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide
CN108440381A (zh) * 2018-03-15 2018-08-24 威海迪素制药有限公司 一种阿普斯特新晶型h及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893101B2 (en) * 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
US7256300B2 (en) * 2004-03-30 2007-08-14 Boehringer Ingelheim Pharmaceuticals, Inc. Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
CA2736171A1 (en) 2008-09-10 2010-03-18 Celgene Corporation Processes for the preparation of aminosulfone compounds
US9126906B2 (en) * 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds

Also Published As

Publication number Publication date
WO2016189486A1 (en) 2016-12-01
JP2018516912A (ja) 2018-06-28
MX2017015151A (es) 2018-08-15
US10377712B2 (en) 2019-08-13
US20180230097A1 (en) 2018-08-16

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 209/48 , C07C 315/04 , C07C 317/28

Ipc: C07D 209/48 (2006.01), C07C 315/04 (2006.01), C07C

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements