BR112015024859A2 - processo e intermediários para a preparação de pregabalina - Google Patents

processo e intermediários para a preparação de pregabalina

Info

Publication number
BR112015024859A2
BR112015024859A2 BR112015024859A BR112015024859A BR112015024859A2 BR 112015024859 A2 BR112015024859 A2 BR 112015024859A2 BR 112015024859 A BR112015024859 A BR 112015024859A BR 112015024859 A BR112015024859 A BR 112015024859A BR 112015024859 A2 BR112015024859 A2 BR 112015024859A2
Authority
BR
Brazil
Prior art keywords
pregabalin
intermediates
preparation
compound
formula
Prior art date
Application number
BR112015024859A
Other languages
English (en)
Inventor
Thomas Erdam David
John Karmilowicz Michael
Mary O'neill Padraig
Kumar Rajesh
Debarge Sebastien
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Priority to BR122017006144A priority Critical patent/BR122017006144A2/pt
Publication of BR112015024859A2 publication Critical patent/BR112015024859A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/74—Unsaturated compounds containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)

Abstract

resumo “processo e intermediários para a preparação de pregabalina” a invenção fornece processos para a fabricação de um composto da fórmula (ia). a invenção ainda fornece métodos aperfeiçoados para a conversão do composto da fórmula (ia) em pregabalina.
BR112015024859A 2013-03-27 2014-03-25 processo e intermediários para a preparação de pregabalina BR112015024859A2 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122017006144A BR122017006144A2 (pt) 2013-03-27 2014-03-25 enzima transaminase e processo para a fabricação de ácido (s)-3-aminometil-5-metil-hexanoico

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361805786P 2013-03-27 2013-03-27
PCT/IB2014/060140 WO2014155291A1 (en) 2013-03-27 2014-03-25 Process and intermediates for the preparation of pregabalin

Publications (1)

Publication Number Publication Date
BR112015024859A2 true BR112015024859A2 (pt) 2017-10-10

Family

ID=50483187

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122017006144A BR122017006144A2 (pt) 2013-03-27 2014-03-25 enzima transaminase e processo para a fabricação de ácido (s)-3-aminometil-5-metil-hexanoico
BR112015024859A BR112015024859A2 (pt) 2013-03-27 2014-03-25 processo e intermediários para a preparação de pregabalina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122017006144A BR122017006144A2 (pt) 2013-03-27 2014-03-25 enzima transaminase e processo para a fabricação de ácido (s)-3-aminometil-5-metil-hexanoico

Country Status (22)

Country Link
US (1) US20160024540A1 (pt)
EP (2) EP3216863A1 (pt)
JP (1) JP2016516744A (pt)
KR (1) KR20150121202A (pt)
CN (3) CN105051022B (pt)
AU (2) AU2014240833B2 (pt)
BR (2) BR122017006144A2 (pt)
CA (1) CA2905411A1 (pt)
CY (1) CY1118945T1 (pt)
DK (1) DK2978748T3 (pt)
ES (1) ES2630128T3 (pt)
HK (1) HK1213882A1 (pt)
HU (1) HUE034834T2 (pt)
IL (1) IL241438A0 (pt)
MX (1) MX2015013589A (pt)
PL (1) PL2978748T3 (pt)
PT (1) PT2978748T (pt)
RU (2) RU2017125261A (pt)
SG (1) SG11201506998XA (pt)
SI (1) SI2978748T1 (pt)
WO (1) WO2014155291A1 (pt)
ZA (1) ZA201506798B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE052297T2 (hu) 2009-01-08 2021-04-28 Codexis Inc Transzamináz polipeptidek
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
EP3761036A1 (en) * 2015-03-03 2021-01-06 ARK Diagnostics, Inc. Pregabalin immunoassays
US11359183B2 (en) 2017-06-14 2022-06-14 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
CN111004102B (zh) * 2019-12-23 2022-11-04 万华化学集团股份有限公司 一种制备光学活性香茅醛的方法及用于该方法的催化剂

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB834100A (en) 1957-10-26 1960-05-04 Eastman Kodak Co Improvements in the preparation of mixed aldols
US4239636A (en) * 1978-10-23 1980-12-16 Exxon Research & Engineering Co. Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
JPH06107597A (ja) * 1992-03-12 1994-04-19 Noguchi Kenkyusho （Ｒ）−α−ヒドロキシ−β，γ−不飽和エステルの製造法
US5268387A (en) * 1992-04-24 1993-12-07 Allergan, Inc. Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss
AU7250596A (en) * 1995-11-07 1997-05-29 Minnesota Mining And Manufacturing Company Initiator system and adhesive composition made therewith
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
SE9801992D0 (sv) * 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
US20030225149A1 (en) * 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
US20070066846A1 (en) * 2005-04-11 2007-03-22 Asher Maymon Process for making (S)-Pregabalin
RU2008109031A (ru) * 2005-08-11 2009-09-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы муковисцидозного трансмембранного регулятора проводимости
WO2008127646A2 (en) * 2007-04-11 2008-10-23 Dsm Ip Assets B.V. Transaminase-based processes for preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
CN101362696A (zh) * 2008-09-27 2009-02-11 开原亨泰精细化工厂 3-氨甲基-5-甲基己酸即混旋普瑞巴林的制备新方法
HUE052297T2 (hu) * 2009-01-08 2021-04-28 Codexis Inc Transzamináz polipeptidek
WO2011086565A1 (en) 2010-01-15 2011-07-21 Lupin Limited Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids

Also Published As

Publication number Publication date
SG11201506998XA (en) 2015-10-29
US20160024540A1 (en) 2016-01-28
EP2978748A1 (en) 2016-02-03
HK1213882A1 (zh) 2016-07-15
HUE034834T2 (en) 2018-03-28
DK2978748T3 (en) 2017-07-24
RU2015138545A (ru) 2017-05-03
IL241438A0 (en) 2015-11-30
BR122017006144A2 (pt) 2019-09-03
CA2905411A1 (en) 2014-10-02
SI2978748T1 (sl) 2017-07-31
JP2016516744A (ja) 2016-06-09
EP2978748B1 (en) 2017-05-10
WO2014155291A1 (en) 2014-10-02
RU2017125261A (ru) 2019-01-31
CN105051022A (zh) 2015-11-11
PL2978748T3 (pl) 2017-09-29
AU2014240833A1 (en) 2015-10-01
ZA201506798B (en) 2019-05-29
AU2016203782B2 (en) 2017-06-01
EP3216863A1 (en) 2017-09-13
AU2014240833B2 (en) 2016-07-07
CN105051022B (zh) 2017-10-27
ES2630128T3 (es) 2017-08-18
KR20150121202A (ko) 2015-10-28
CN107746834A (zh) 2018-03-02
RU2628298C2 (ru) 2017-08-15
AU2016203782A1 (en) 2016-06-23
PT2978748T (pt) 2017-07-06
CY1118945T1 (el) 2018-01-10
CN107556273A (zh) 2018-01-09
MX2015013589A (es) 2016-06-23

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2559 DE 21/01/2020.