BR112018006189A2 - compostos da fórmula, composição farmacêutica, métodos de tratamento de uma doença, de diminuição do fluxo de íons e de tratamento de prurido em um mamífero, método para tratamento de dores em um mamífero e uso de um composto - Google Patents

compostos da fórmula, composição farmacêutica, métodos de tratamento de uma doença, de diminuição do fluxo de íons e de tratamento de prurido em um mamífero, método para tratamento de dores em um mamífero e uso de um composto

Info

Publication number
BR112018006189A2
BR112018006189A2 BR112018006189A BR112018006189A BR112018006189A2 BR 112018006189 A2 BR112018006189 A2 BR 112018006189A2 BR 112018006189 A BR112018006189 A BR 112018006189A BR 112018006189 A BR112018006189 A BR 112018006189A BR 112018006189 A2 BR112018006189 A2 BR 112018006189A2
Authority
BR
Brazil
Prior art keywords
treating
mammal
compounds
compound
formula
Prior art date
Application number
BR112018006189A
Other languages
English (en)
Inventor
Hasan Abid
Safina Brian
Martin Dehnhardt Christoph
Sutherlin Daniel
Burford Kristen
Wah Lai Kwong
Edward Grimwood Michael
Bergeron Phillipe
Mckerrall Steven
Chowdhury Sultan
Wang Tao
Phuongtram Nguyen Teresa
Focken Thilo
Liu Zhiguo
Original Assignee
Genentech Inc
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Xenon Pharmaceuticals Inc filed Critical Genentech Inc
Publication of BR112018006189A2 publication Critical patent/BR112018006189A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

a presente invenção fornece um composto de fórmula: ou um sal do mesmo, em que as variáveis raa, n, anel a, anel b, r1a, r1b, r2, r3, r4, r5, r6, r7, r8 e r9 têm o significado conforme descrito neste documento, e composições contendo tais compostos e métodos de uso de tais compostos e composições.
BR112018006189A 2015-09-28 2016-09-27 compostos da fórmula, composição farmacêutica, métodos de tratamento de uma doença, de diminuição do fluxo de íons e de tratamento de prurido em um mamífero, método para tratamento de dores em um mamífero e uso de um composto BR112018006189A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562233863P 2015-09-28 2015-09-28
US201662298817P 2016-02-23 2016-02-23
CN2016096659 2016-08-25
PCT/US2016/054011 WO2017058821A1 (en) 2015-09-28 2016-09-27 Therapeutic compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112018006189A2 true BR112018006189A2 (pt) 2018-10-09

Family

ID=57137267

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018006189A BR112018006189A2 (pt) 2015-09-28 2016-09-27 compostos da fórmula, composição farmacêutica, métodos de tratamento de uma doença, de diminuição do fluxo de íons e de tratamento de prurido em um mamífero, método para tratamento de dores em um mamífero e uso de um composto

Country Status (21)

Country Link
US (2) US10787446B2 (pt)
EP (1) EP3356360A1 (pt)
JP (1) JP6987746B2 (pt)
KR (1) KR20180067561A (pt)
CN (1) CN108290881B (pt)
AU (1) AU2016330503B2 (pt)
BR (1) BR112018006189A2 (pt)
CA (1) CA2999769A1 (pt)
CL (1) CL2018000805A1 (pt)
CO (1) CO2018003909A2 (pt)
CR (1) CR20180242A (pt)
HK (1) HK1258056A1 (pt)
IL (1) IL258192A (pt)
MX (1) MX2018003828A (pt)
PE (1) PE20181003A1 (pt)
PH (1) PH12018500668A1 (pt)
RU (1) RU2018115718A (pt)
SG (1) SG10202007787RA (pt)
TW (1) TWI726916B (pt)
WO (1) WO2017058821A1 (pt)
ZA (1) ZA201802134B (pt)

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CA2999769A1 (en) 2017-04-06
AU2016330503B2 (en) 2021-04-08
SG10202007787RA (en) 2020-09-29
RU2018115718A3 (pt) 2019-12-27
IL258192A (en) 2018-05-31
AU2016330503A1 (en) 2018-04-12
US20180291014A1 (en) 2018-10-11
AU2016330503A8 (en) 2018-04-19
PE20181003A1 (es) 2018-06-26
CL2018000805A1 (es) 2018-07-06
RU2018115718A (ru) 2019-10-28
KR20180067561A (ko) 2018-06-20
WO2017058821A1 (en) 2017-04-06
JP6987746B2 (ja) 2022-01-05
EP3356360A1 (en) 2018-08-08
CN108290881B (zh) 2021-12-07
HK1258056A1 (zh) 2019-11-01
US20210171516A1 (en) 2021-06-10
PH12018500668A1 (en) 2018-10-01
MX2018003828A (es) 2018-06-22
CR20180242A (es) 2018-08-10
TW201718556A (zh) 2017-06-01
CN108290881A (zh) 2018-07-17
CO2018003909A2 (es) 2018-07-19
US10787446B2 (en) 2020-09-29
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TWI726916B (zh) 2021-05-11
ZA201802134B (en) 2020-08-26

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