BR112018005822A2 - focagem em tempo real em imageamento de varredura de linha - Google Patents

focagem em tempo real em imageamento de varredura de linha

Info

Publication number
BR112018005822A2
BR112018005822A2 BR112018005822A BR112018005822A BR112018005822A2 BR 112018005822 A2 BR112018005822 A2 BR 112018005822A2 BR 112018005822 A BR112018005822 A BR 112018005822A BR 112018005822 A BR112018005822 A BR 112018005822A BR 112018005822 A2 BR112018005822 A2 BR 112018005822A2
Authority
BR
Brazil
Prior art keywords
objective lens
field
real
line scan
view
Prior art date
Application number
BR112018005822A
Other languages
English (en)
Inventor
Olson Allen
Crandall Greg
Saligrama Kiran
Najmabadi Peyman
Chen Ruby
Zou Yunlu
Original Assignee
Leica Biosystems Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leica Biosystems Imaging Inc filed Critical Leica Biosystems Imaging Inc
Publication of BR112018005822A2 publication Critical patent/BR112018005822A2/pt

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/40—Optical focusing aids
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/02—Objectives
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/245—Devices for focusing using auxiliary sources, detectors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/26—Stages; Adjusting means therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361—Optical details, e.g. image relay to the camera or image sensor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/28—Systems for automatic generation of focusing signals
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/28—Systems for automatic generation of focusing signals
    • G02B7/36—Systems for automatic generation of focusing signals using image sharpness techniques, e.g. image processing techniques for generating autofocus signals
    • G02B7/38—Systems for automatic generation of focusing signals using image sharpness techniques, e.g. image processing techniques for generating autofocus signals measured at different points on the optical axis, e.g. focussing on two or more planes and comparing image data
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
    • G03B13/00—Viewfinders; Focusing aids for cameras; Means for focusing for cameras; Autofocus systems for cameras
    • G03B13/32—Means for focusing
    • G03B13/34—Power focusing
    • G03B13/36—Autofocus systems
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/60—Control of cameras or camera modules
    • H04N23/67—Focus control based on electronic image sensor signals

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Multimedia (AREA)
  • Signal Processing (AREA)
  • Microscoopes, Condenser (AREA)
  • Automatic Focus Adjustment (AREA)
  • Studio Devices (AREA)

Abstract

sistema para adquirir uma imagem digital de uma amostra em uma lâmina de microscópio. numa modalidade, o sistema compreende um suporte configurado para suportar uma amostra, uma lente objetiva com um único eixo óptico que é ortogonal ao suporte, um sensor de imageamento e um sensor de focagem. o sistema ainda compreende pelo menos um divisor de feixe acoplado opticamente à lente objetiva e configurado para receber um campo de visão correspondente ao eixo óptico da lente objetiva e simultaneamente fornecer ao menos uma primeira porção do campo de visão ao sensor de imageamento e pelo menos uma segunda porção do campo de visão para o sensor de focagem. o sensor de focagem pode adquirir simultaneamente imagem(ns) em uma pluralidade de distâncias focais diferentes e/ou adquirir simultaneamente um par de imagens espelhadas, cada uma compreendendo pixels adquiridos em uma pluralidade de distâncias focais diferentes.
BR112018005822A 2015-09-24 2016-09-23 focagem em tempo real em imageamento de varredura de linha BR112018005822A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562232229P 2015-09-24 2015-09-24
PCT/US2016/053581 WO2017053891A1 (en) 2015-09-24 2016-09-23 Real-time focusing in line scan imaging

Publications (1)

Publication Number Publication Date
BR112018005822A2 true BR112018005822A2 (pt) 2018-10-09

Family

ID=58387414

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018005822A BR112018005822A2 (pt) 2015-09-24 2016-09-23 focagem em tempo real em imageamento de varredura de linha

Country Status (9)

Country Link
US (2) US10634894B2 (pt)
EP (1) EP3353601A4 (pt)
JP (1) JP6865740B2 (pt)
KR (1) KR20180058730A (pt)
CN (1) CN108139650B (pt)
AU (1) AU2016326723B2 (pt)
BR (1) BR112018005822A2 (pt)
CA (1) CA3000053C (pt)
WO (1) WO2017053891A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10634894B2 (en) 2015-09-24 2020-04-28 Leica Biosystems Imaging, Inc. Real-time focusing in line scan imaging
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
JP2019062462A (ja) * 2017-09-27 2019-04-18 キヤノン株式会社 表示装置およびその制御装置、ならびにそれらの制御方法
JP6985506B2 (ja) 2017-09-29 2021-12-22 ライカ バイオシステムズ イメージング インコーポレイテッドLeica Biosystems Imaging, Inc. リアルタイムオートフォーカス合焦アルゴリズム
ES2928577T3 (es) * 2017-09-29 2022-11-21 Leica Biosystems Imaging Inc Barrido en Z fijo bidimensional y tridimensional
CN114779459A (zh) * 2017-09-29 2022-07-22 徕卡生物***成像股份有限公司 实时自动聚焦扫描
JP6945737B2 (ja) * 2017-11-28 2021-10-06 ライカ バイオシステムズ イメージング インコーポレイテッドＬｅｉｃａ Ｂｉｏｓｙｓｔｅｍｓ Ｉｍａｇｉｎｇ， Ｉｎｃ． デュアルプロセッサ画像処理
US11055105B2 (en) * 2018-08-31 2021-07-06 Micron Technology, Inc. Concurrent image measurement and execution
EP3988988A4 (en) 2018-09-28 2023-09-13 Evident Corporation MICROSCOPE SYSTEM, PROJECTION UNIT AND IMAGE PROJECTION METHOD
EP3988987A4 (en) * 2018-09-28 2023-09-20 Evident Corporation MICROSCOPE SYSTEM, PROJECTION UNIT AND IMAGE PROJECTION METHOD
WO2020066043A1 (ja) 2018-09-28 2020-04-02 オリンパス株式会社 顕微鏡システム、投影ユニット、及び、画像投影方法
CN109342322A (zh) * 2018-10-23 2019-02-15 南京光声超构材料研究院有限公司 时域热反射谱测量中的自动聚焦方法
CN109905618B (zh) * 2019-03-26 2021-03-16 中国科学院长春光学精密机械与物理研究所 夹心成像单元结构及一步正样的设计方法
EP4010791A1 (en) 2019-08-06 2022-06-15 Leica Biosystems Imaging, Inc. Graphical user interface for slide-scanner control
WO2021026278A1 (en) * 2019-08-06 2021-02-11 Leica Biosystems Imaging, Inc. Real-time focusing in a slide-scanning system
US11053540B1 (en) 2020-01-17 2021-07-06 Element Biosciences, Inc. High performance fluorescence imaging module for genomic testing assay
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
CN111866387B (zh) * 2020-07-27 2021-11-02 支付宝(杭州)信息技术有限公司 深度图像成像***和方法
JP2022049808A (ja) * 2020-09-17 2022-03-30 オリンパス株式会社 撮影装置、撮影システム、及び、制御方法
CN111932542B (zh) * 2020-10-14 2021-02-02 深圳市瑞图生物技术有限公司 一种基于多焦距的图像识别方法及装置、存储介质
JP2022127536A (ja) * 2021-02-19 2022-08-31 株式会社キーエンス 拡大観察装置、拡大画像観察方法、拡大画像観察プログラム及びコンピュータで読み取り可能な記録媒体並びに記憶した機器
CN113031243B (zh) * 2021-03-26 2021-08-31 杭州辰景光电科技有限公司 一种基于波导片的反射式片上数字全息显微装置
CN113281874A (zh) * 2021-06-30 2021-08-20 成都易迅光电科技有限公司 一种伸缩多镜头模组
CN117908219A (zh) * 2024-03-06 2024-04-19 东莞市沃德普自动化科技有限公司 一种对焦模组、自动对焦显微成像***及方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3967110A (en) * 1973-09-21 1976-06-29 Corning Glass Works Automatic focusing system
US4636627A (en) 1983-01-17 1987-01-13 Canon Kabushiki Kaisha Focus detecting apparatus
US5756307A (en) 1991-09-20 1998-05-26 The United States Of America As Represented By The Department Of Health And Human Services Sequence of human dopamine transporter cDNA
JP2966311B2 (ja) * 1995-03-10 1999-10-25 科学技術振興事業団 顕微測光装置
JPH08320430A (ja) 1995-05-23 1996-12-03 Nikon Corp 自動焦点検出装置
JPH09189850A (ja) * 1996-01-09 1997-07-22 Olympus Optical Co Ltd オートフォーカス顕微鏡
JPH1152224A (ja) 1997-06-04 1999-02-26 Hitachi Ltd 自動焦点検出方法およびその装置並びに検査装置
US6091075A (en) 1997-06-04 2000-07-18 Hitachi, Ltd. Automatic focus detection method, automatic focus detection apparatus, and inspection apparatus
US20060060781A1 (en) 1997-08-11 2006-03-23 Masahiro Watanabe Charged-particle beam apparatus and method for automatically correcting astigmatism and for height detection
US6640014B1 (en) * 1999-01-22 2003-10-28 Jeffrey H. Price Automatic on-the-fly focusing for continuous image acquisition in high-resolution microscopy
US6839469B2 (en) * 2000-01-21 2005-01-04 Lam K. Nguyen Multiparallel three dimensional optical microscopy system
US6724489B2 (en) 2000-09-22 2004-04-20 Daniel Freifeld Three dimensional scanning camera
AU2002213157A1 (en) 2000-10-12 2002-04-22 Amnis Corporation System and method for high numeric aperture imaging systems
DE10127284A1 (de) 2001-06-05 2002-12-12 Zeiss Carl Jena Gmbh Autofokussiereinrichtung für ein optisches Gerät
JP2004046132A (ja) 2002-05-17 2004-02-12 Olympus Corp 自動焦点調節装置
US6760154B1 (en) 2002-06-04 2004-07-06 Biotechs, Inc. Microscope system with continuous autofocus
JP4370554B2 (ja) 2002-06-14 2009-11-25 株式会社ニコン オートフォーカス装置およびオートフォーカス付き顕微鏡
DE10319182B4 (de) 2003-04-29 2008-06-12 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur Bestimmung der Fokusposition bei der Abbildung einer Probe
US7330574B2 (en) 2003-05-08 2008-02-12 Ometrix, Inc. Best-focus estimation by lateral scanning
US20050089208A1 (en) 2003-07-22 2005-04-28 Rui-Tao Dong System and method for generating digital images of a microscope slide
JP2005070225A (ja) 2003-08-21 2005-03-17 Tokyo Seimitsu Co Ltd 表面画像投影装置及び表面画像投影方法
JP2005114859A (ja) * 2003-10-03 2005-04-28 Nikon Corp 顕微鏡
WO2005057193A1 (en) 2003-11-18 2005-06-23 Applied Materials Israel, Ltd Inspection system with auto-focus
US7813579B2 (en) * 2004-05-24 2010-10-12 Hamamatsu Photonics K.K. Microscope system
US7232980B2 (en) 2004-05-24 2007-06-19 Hamamatsu Photonics K.K. Microscope system
US8164622B2 (en) * 2005-07-01 2012-04-24 Aperio Technologies, Inc. System and method for single optical axis multi-detector microscope slide scanner
JP4680052B2 (ja) 2005-12-22 2011-05-11 シスメックス株式会社 標本撮像装置及びこれを備える標本分析装置
JP2009526272A (ja) 2006-02-10 2009-07-16 モノジェン インコーポレイテッド 顕微鏡媒体ベースの標本からデジタル画像データを収集するための方法および装置およびコンピュータプログラム製品
JP5094048B2 (ja) 2006-06-09 2012-12-12 株式会社日立ハイテクノロジーズ 外観検査装置
DE102006027836B4 (de) * 2006-06-16 2020-02-20 Carl Zeiss Microscopy Gmbh Mikroskop mit Autofokuseinrichtung
US7769219B2 (en) 2006-12-11 2010-08-03 Cytyc Corporation Method for assessing image focus quality
DE102007017598A1 (de) * 2007-04-13 2008-10-16 Carl Zeiss Microimaging Gmbh Verfahren und Anordnung zum Positionieren eines Lichtblattes in der Fokusebene einer Detektionsoptik
US8179432B2 (en) 2007-04-30 2012-05-15 General Electric Company Predictive autofocusing
US7576307B2 (en) 2007-04-30 2009-08-18 General Electric Company Microscope with dual image sensors for rapid autofocusing
US8878923B2 (en) 2007-08-23 2014-11-04 General Electric Company System and method for enhanced predictive autofocusing
JP4885156B2 (ja) 2008-02-07 2012-02-29 株式会社日立製作所 フォーカス制御装置及び方法
WO2010067256A1 (en) 2008-12-09 2010-06-17 Koninklijke Philips Electronics N.V. Autofocus for a microscope system.
EP2244484B1 (en) 2009-04-22 2012-03-28 Raytrix GmbH Digital imaging method for synthesizing an image using data recorded with a plenoptic camera
US8304704B2 (en) 2009-07-27 2012-11-06 Sensovation Ag Method and apparatus for autofocus using a light source pattern and means for masking the light source pattern
CA2842723C (en) 2009-10-19 2016-02-16 Ventana Medical Systems, Inc. Imaging system and techniques
RU2567295C2 (ru) 2009-12-30 2015-11-10 Конинклейке Филипс Электроникс Н.В. Датчик для микроскопии
WO2011145016A1 (en) 2010-05-18 2011-11-24 Koninklijke Philips Electronics N.V. Autofocus imaging
BR112012032713A2 (pt) 2010-06-24 2016-09-13 Koninkl Philips Electronics Nv sistema de representação de imagem de autofoco para um sistema de microscópio, sistema de microscópio, método para representação de imagem de autofoco para um sistema de microscópio e elemento de programa para representação de imagem de autofoco de um sistema de microscópio
US8175452B1 (en) 2010-10-26 2012-05-08 Complete Genomics, Inc. Method and system for imaging high density biochemical arrays with sub-pixel alignment
EP2715321A4 (en) 2011-05-25 2014-10-29 Huron Technologies Internat Inc 3D DISEASE GLEITSCANNER
GB201113071D0 (en) * 2011-07-29 2011-09-14 Ffei Ltd Method and apparatus for image scanning
CA2849330C (en) 2011-09-21 2020-11-03 Huron Technologies International Inc. Slide scanner with a tilted image
US9402036B2 (en) 2011-10-17 2016-07-26 Rudolph Technologies, Inc. Scanning operation with concurrent focus and inspection
US10298833B2 (en) 2011-12-19 2019-05-21 Hamamatsu Photonics K.K. Image capturing apparatus and focusing method thereof
US9971140B2 (en) 2011-12-19 2018-05-15 Hamamatsu Photonics K.K. Image capturing apparatus and focusing method thereof
US9860437B2 (en) 2011-12-19 2018-01-02 Hamamatsu Photonics K.K. Image capturing apparatus and focusing method thereof
JP6019998B2 (ja) 2012-02-17 2016-11-02 ソニー株式会社 撮像装置、撮像制御プログラム及び撮像方法
WO2013165576A1 (en) * 2012-05-02 2013-11-07 Aperio Technologies, Inc. Real-time focusing in line scan imaging
GB2505691B (en) 2012-09-07 2018-02-21 Ffei Ltd Method and apparatus for image scanning
JP2014178474A (ja) 2013-03-14 2014-09-25 Sony Corp デジタル顕微鏡装置、その合焦位置探索方法およびプログラム
HUE051846T2 (hu) 2013-04-26 2021-03-29 Hamamatsu Photonics Kk Képfelvevõ berendezés és fókuszáló eljárás képfelvevõ berendezés számára
JP6010505B2 (ja) 2013-06-11 2016-10-19 浜松ホトニクス株式会社 画像取得装置及び画像取得装置のフォーカス方法
JP6394850B2 (ja) 2013-09-20 2018-09-26 大学共同利用機関法人自然科学研究機構 補償光学系及び光学装置
TWI515503B (zh) 2013-12-09 2016-01-01 聯詠科技股份有限公司 自動對焦影像擷取裝置與影像擷取方法
US10634894B2 (en) * 2015-09-24 2020-04-28 Leica Biosystems Imaging, Inc. Real-time focusing in line scan imaging

Also Published As

Publication number Publication date
EP3353601A1 (en) 2018-08-01
US10634894B2 (en) 2020-04-28
KR20180058730A (ko) 2018-06-01
JP6865740B2 (ja) 2021-04-28
CN108139650A (zh) 2018-06-08
US11422350B2 (en) 2022-08-23
JP2018534610A (ja) 2018-11-22
US20200218053A1 (en) 2020-07-09
EP3353601A4 (en) 2019-10-02
AU2016326723B2 (en) 2021-11-11
WO2017053891A1 (en) 2017-03-30
CN108139650B (zh) 2020-10-30
CA3000053A1 (en) 2017-03-30
US20180275388A1 (en) 2018-09-27
AU2016326723A1 (en) 2018-04-12
CA3000053C (en) 2023-07-04

Similar Documents

Publication Publication Date Title
BR112018005822A2 (pt) focagem em tempo real em imageamento de varredura de linha
BR112016029565A2 (pt) sistema de múltiplas câmeras livre de paralaxe com capacidade para capturar imagens esféricas completas
ES2615643T3 (es) Aparato para la tomografía de coherencia óptica de un ojo y método para la tomografía de coherencia óptica de un ojo
BR112016029714A2 (pt) sistema de câmeras múltiplas que usa óptica dobrada livre de artefatos de inclinação e paralaxe
JP2018534610A5 (pt)
WO2014018584A8 (en) Partitioned aperture wavefront imaging method and system
EP3499404A3 (en) Dual-imaging vision system camera, aimer and method for using the same
BR112018000076A2 (pt) sistemas e métodos para engatilhar o foco automático
EP3127475A3 (en) Wide-field retinal imaging system
ES2535126B1 (es) Instrumento miniaturizado simulador de visión simultánea
RU2010140046A (ru) Оптическая когерентная томография
CO7250123A1 (es) Microscopio, método y programa de ordenador para la obtención de imágenes cuantitativas de fase por medio de microscopía holográfica digital y kit para adaptar un microscopio óptico
BR112017015375A2 (pt) sistema de lentes para aquisição de imagem visível e aquisição de imagem de íris infravermelha de alta qualidade
BR112019008251A2 (pt) imagens de mapa de profundidade aprimorado para dispositivos móveis
RU2017118114A (ru) Стереоскопическое визуализирующее устройство
BR112022011354A2 (pt) Geração artificial de uma imagem colorida de esfregaço sanguíneo
EP2902796A3 (en) Two axis interferometric tracking device and method
EP3081926A3 (en) System and method for acquiring images of surface texture
BR112021026607A2 (pt) Sistemas e métodos para fotografia de alta ampliação de alta resolução usando um pequeno sistema de imagem
BR112016029776A2 (pt) sistema multicâmeras fino livre de paralaxe capaz de capturar campo amplo total de imagens de visão
JP2019500607A5 (pt)
BR112023001071A2 (pt) Sistemas e métodos para realizar análise microscópica de uma amostra
WO2014179269A3 (en) Apparatus and method for generating in-focus images using parallel imaging in a microscopy system
ES2622458B1 (es) Microscopio integral, usos del mismo y sistema de microscopía integral
BR112018003900A2 (pt) dispositivo receptor de feixes, dispositivo de inspeção para determinação da qualidade de um objeto, e, separador.

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements