BR112018005284A2 - ácido nucleico interligado guna, método para produzir o mesmo, e composto intermediário - Google Patents

ácido nucleico interligado guna, método para produzir o mesmo, e composto intermediário

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Publication number
BR112018005284A2
BR112018005284A2 BR112018005284-1A BR112018005284A BR112018005284A2 BR 112018005284 A2 BR112018005284 A2 BR 112018005284A2 BR 112018005284 A BR112018005284 A BR 112018005284A BR 112018005284 A2 BR112018005284 A2 BR 112018005284A2
Authority
BR
Brazil
Prior art keywords
nucleic acid
intermediate compound
manufacturing
type nucleic
crosslinked type
Prior art date
Application number
BR112018005284-1A
Other languages
English (en)
Japanese (ja)
Inventor
Obika Satoshi
Kawanishi Eiji
Sawamoto Hiroaki
Yamakoshi Shuhei
Arai Yuuki
Kumagai Shinji
Original Assignee
Mitsubishi Tanabe Pharma Corporation
Osaka University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corporation, Osaka University filed Critical Mitsubishi Tanabe Pharma Corporation
Publication of BR112018005284A2 publication Critical patent/BR112018005284A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a presente invenção refere-se a um método para produzir ácido nucleico artificial interligado de guanidina (abreviado a seguir como guna), e um composto intermediário para a produção do mesmo. especificamente, a presente invenção fornece um método para produzir um composto representado pela fórmula geral i: (na fórmula, r1, r2, r3, r4, r5, r6, m e anel a são como definidos no relatório) ou um sal do mesmo em que um agente de redução é reagido com um composto representado pela fórmula geral ii: (na fórmula, r1, r2, r3, r4, r5, r6, m, e anel a' são como definidos na especificação).
BR112018005284-1A 2015-09-18 2016-09-20 ácido nucleico interligado guna, método para produzir o mesmo, e composto intermediário BR112018005284A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015-185730 2015-09-18
JP2015185730 2015-09-18
JP2016039351 2016-03-01
JP2016-039351 2016-03-01
PCT/JP2016/077748 WO2017047816A1 (ja) 2015-09-18 2016-09-20 架橋型核酸ＧｕＮＡ、その製造方法および中間体化合物

Publications (1)

Publication Number Publication Date
BR112018005284A2 true BR112018005284A2 (pt) 2018-12-11

Family

ID=58289462

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018005284-1A BR112018005284A2 (pt) 2015-09-18 2016-09-20 ácido nucleico interligado guna, método para produzir o mesmo, e composto intermediário

Country Status (14)

Country Link
US (1) US10961269B2 (pt)
EP (2) EP3974436A1 (pt)
JP (3) JP6994197B2 (pt)
KR (1) KR20180057651A (pt)
CN (1) CN108137638B (pt)
AU (1) AU2016324126A1 (pt)
BR (1) BR112018005284A2 (pt)
HK (1) HK1251577A1 (pt)
MX (1) MX2018003311A (pt)
PH (1) PH12018500582A1 (pt)
RU (1) RU2018113811A (pt)
SG (1) SG11201802190UA (pt)
TW (1) TW201718618A (pt)
WO (1) WO2017047816A1 (pt)

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* Cited by examiner, † Cited by third party
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TW201718618A (zh) * 2015-09-18 2017-06-01 田邊三菱製藥股份有限公司 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物
KR102131898B1 (ko) * 2017-10-31 2020-07-08 주식회사 노벨티노빌리티 Scf 및 갈렉틴-1을 표적으로 하는 이중표적항체 및 그 용도
JP2019119739A (ja) * 2017-12-28 2019-07-22 国立大学法人岐阜大学 ヌクレオシド誘導体の製造方法
CN112996522A (zh) * 2018-11-12 2021-06-18 田边三菱制药株式会社 桥连型人工核酸alna
KR20210142699A (ko) 2019-03-29 2021-11-25 미쓰비시 타나베 파마 코퍼레이션 Dux4의 발현을 조절하기 위한 화합물, 방법 및 의약조성물
JPWO2021230286A1 (pt) 2020-05-12 2021-11-18
JP2023130528A (ja) * 2020-06-24 2023-09-21 田辺三菱製薬株式会社 Ｐｌｐ１発現を調節するための化合物、方法及び医薬組成物
WO2022250072A1 (ja) * 2021-05-26 2022-12-01 ルクサナバイオテク株式会社 心疾患治療薬
US20230383296A1 (en) * 2022-03-17 2023-11-30 Aligos Therapeutics, Inc. Modified gapmer oligomers and methods of use thereof
WO2024101446A1 (ja) * 2022-11-10 2024-05-16 ルクサナバイオテク株式会社 架橋部にグアニジノ構造を有する修飾ヌクレオシドおよびそれを用いたオリゴヌクレオチドの製造方法
WO2024135721A1 (ja) * 2022-12-21 2024-06-27 田辺三菱製薬株式会社 製造中間体の製造方法、その製造中間体及びそれらを用いた架橋型人工核酸中間体の製造方法

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JPH09328497A (ja) 1996-04-12 1997-12-22 Yamasa Shoyu Co Ltd ４’−フルオロメチルヌクレオシド
JP3756313B2 (ja) * 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ／エス オリゴヌクレオチド類似体
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AR088140A1 (es) * 2011-07-19 2014-05-14 Univ Idaho Sonda y metodo para direccionar acidos nucleicos
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Also Published As

Publication number Publication date
PH12018500582A1 (en) 2018-09-10
CN108137638A (zh) 2018-06-08
TW201718618A (zh) 2017-06-01
HK1251577A1 (zh) 2019-02-01
EP3351548A4 (en) 2019-06-12
US20180251488A1 (en) 2018-09-06
EP3351548A1 (en) 2018-07-25
JPWO2017047816A1 (ja) 2018-07-05
JP2022033869A (ja) 2022-03-02
SG11201802190UA (en) 2018-04-27
CN108137638B (zh) 2022-05-03
AU2016324126A1 (en) 2018-05-10
JP2023075302A (ja) 2023-05-30
KR20180057651A (ko) 2018-05-30
WO2017047816A1 (ja) 2017-03-23
JP6994197B2 (ja) 2022-01-14
US10961269B2 (en) 2021-03-30
MX2018003311A (es) 2019-02-07
EP3974436A1 (en) 2022-03-30
RU2018113811A (ru) 2019-10-18

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]