WO2016014864A8 - Hydroxy-(r),(r)-2,2'-bismethylnaltrexones and uses thereof - Google Patents

Hydroxy-(r),(r)-2,2'-bismethylnaltrexones and uses thereof Download PDF

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Publication number
WO2016014864A8
WO2016014864A8 PCT/US2015/041848 US2015041848W WO2016014864A8 WO 2016014864 A8 WO2016014864 A8 WO 2016014864A8 US 2015041848 W US2015041848 W US 2015041848W WO 2016014864 A8 WO2016014864 A8 WO 2016014864A8
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
bismethylnaltrexones
synthesis
methods
well
Prior art date
Application number
PCT/US2015/041848
Other languages
French (fr)
Other versions
WO2016014864A1 (en
Inventor
Cameron S. GIBB
Preston J. ABSHER
Darryl A. LEBLANC
Original Assignee
Salix Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salix Pharmaceuticals, Inc. filed Critical Salix Pharmaceuticals, Inc.
Publication of WO2016014864A1 publication Critical patent/WO2016014864A1/en
Publication of WO2016014864A8 publication Critical patent/WO2016014864A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Abstract

The present application relates to compounds of Formula (I): wherein R1 and X are as defined herein, as well as methods for synthesis and use thereof. The present application also relates to 10'-hydroxy-(R),(R)-2,2'-bismethylnaltrexone, as well as methods for synthesis and use thereof.
PCT/US2015/041848 2014-07-23 2015-07-23 Hydroxy-(r)-2,2'-bismethylnal trexones and uses thereof WO2016014864A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462027852P 2014-07-23 2014-07-23
US62/027,852 2014-07-23

Publications (2)

Publication Number Publication Date
WO2016014864A1 WO2016014864A1 (en) 2016-01-28
WO2016014864A8 true WO2016014864A8 (en) 2016-03-24

Family

ID=55163804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/041848 WO2016014864A1 (en) 2014-07-23 2015-07-23 Hydroxy-(r)-2,2'-bismethylnal trexones and uses thereof

Country Status (1)

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WO (1) WO2016014864A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008233129B2 (en) * 2007-03-29 2014-03-20 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
CN101959892B (en) * 2008-02-06 2014-01-08 普罗热尼奇制药公司 Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone

Also Published As

Publication number Publication date
WO2016014864A1 (en) 2016-01-28

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