BR112018002172A2 - promotores para intensificar a expressão em poxvírus - Google Patents
promotores para intensificar a expressão em poxvírusInfo
- Publication number
- BR112018002172A2 BR112018002172A2 BR112018002172A BR112018002172A BR112018002172A2 BR 112018002172 A2 BR112018002172 A2 BR 112018002172A2 BR 112018002172 A BR112018002172 A BR 112018002172A BR 112018002172 A BR112018002172 A BR 112018002172A BR 112018002172 A2 BR112018002172 A2 BR 112018002172A2
- Authority
- BR
- Brazil
- Prior art keywords
- enhance
- promoters
- expression
- poxvirus expression
- poxvirus
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/863—Poxviral vectors, e.g. entomopoxvirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
a presente invenção diz respeito a um ou mais promotores e/ou cassetes de expressão que podem ser utilizados para intensificar a expressão de um gene heterólogo, tal como brachyury. em particular, o um ou mais promotores e/ou cassetes de expressão intensificam a expressão de genes heterólogos como parte de um vetor viral, tal como um poxvírus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562199681P | 2015-07-31 | 2015-07-31 | |
PCT/IB2016/001183 WO2017021776A1 (en) | 2015-07-31 | 2016-07-28 | Promoters for enhancing expression in poxviruses |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018002172A2 true BR112018002172A2 (pt) | 2018-09-18 |
BR112018002172A8 BR112018002172A8 (pt) | 2024-02-15 |
Family
ID=57068152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018002172A BR112018002172A8 (pt) | 2015-07-31 | 2016-07-28 | Promotores para intensificar a expressão em poxvírus |
Country Status (17)
Country | Link |
---|---|
US (1) | US11753652B2 (pt) |
EP (1) | EP3329016B1 (pt) |
JP (1) | JP6851364B2 (pt) |
KR (1) | KR102565284B1 (pt) |
CN (1) | CN107922981B (pt) |
AU (1) | AU2016303378B2 (pt) |
BR (1) | BR112018002172A8 (pt) |
CA (1) | CA2990549A1 (pt) |
DK (1) | DK3329016T3 (pt) |
ES (1) | ES2901468T3 (pt) |
HK (1) | HK1254405A1 (pt) |
IL (1) | IL256869B (pt) |
MX (1) | MX2018001055A (pt) |
RU (1) | RU2753884C2 (pt) |
SG (1) | SG10202000447YA (pt) |
WO (1) | WO2017021776A1 (pt) |
ZA (1) | ZA201800104B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019038388A1 (en) | 2017-08-24 | 2019-02-28 | Bavarian Nordic A/S | POLYTHERAPY FOR THE TREATMENT OF CANCER BY INTRAVENOUS ADMINISTRATION OF RECOMBINANT MVA AND ANTIBODY |
MX2020006471A (es) | 2017-12-19 | 2020-09-22 | Janssen Sciences Ireland Unlimited Co | Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv). |
JP2022512595A (ja) | 2018-10-05 | 2022-02-07 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えmva、及び免疫チェックポイントアンタゴニストまたは免疫チェックポイントアゴニストの静脈内投与によって、がんを治療する併用療法 |
EP3883599A1 (en) | 2018-11-20 | 2021-09-29 | Bavarian Nordic A/S | Therapy for treating cancer with an intratumoral and/or intravenous administration of a recombinant mva encoding 4-1bbl (cd137l) and/or cd40l |
EP4061406A1 (en) | 2019-11-20 | 2022-09-28 | Bavarian Nordic A/S | Recombinant mva viruses for intratumoral and/or intravenous administration for treating cancer |
WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
CA3240596A1 (en) | 2021-12-23 | 2023-06-29 | Cigdem ATAY LANGBEIN | Therapy for modulating immune response with recombinant mva encoding il-12 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5766598A (en) | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
EP0538496B1 (en) * | 1991-08-26 | 2003-10-29 | Baxter Healthcare S.A. | Recombinant fowlpox virus with intact FPV-tk-gene |
CA2261989C (en) | 1996-07-25 | 2008-09-30 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
RU2180352C2 (ru) | 1999-11-24 | 2002-03-10 | Государственный научный центр вирусологии и биотехнологии "Вектор" | ФРАГМЕНТ ГЕНОМА ВИРУСА ОСПЫ КУР ШТАММА "К", СОДЕРЖАЩИЙ ГЕН ТИМИДИНКИНАЗЫ, РЕКОМБИНАНТНЫЕ ПЛАЗМИДНЫЕ ДНК pTK1FPV И pTK2FPV, СОДЕРЖАЩИЕ ЭТУ ПОСЛЕДОВАТЕЛЬНОСТЬ, И РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pINTFPV1, ОБЛАДАЮЩАЯ СПОСОБНОСТЬЮ ИНТЕГРИРОВАТЬСЯ В ГЕНОМ ВИРУСА ОСПЫ КУР |
WO2005048957A2 (en) | 2003-02-20 | 2005-06-02 | Therion Biologics Corporation | Novel insertion sites in pox vectors |
EP1673458A4 (en) * | 2003-10-15 | 2007-12-12 | Virax Dev Pty Ltd | FOR RETROVIRUS (e.g., HIV) AND CYTOKIN-CODING POXVIRUS VECTOR |
DK2918598T3 (en) * | 2007-02-28 | 2019-04-29 | The Govt Of U S A As Represented By The Secretary Of The Dept Of Health And Human Services | Brachyury polypeptides and methods of use |
CN101775410B (zh) | 2009-01-09 | 2011-11-16 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种鸡痘病毒载体穿梭质粒及其应用 |
CA2759013C (en) | 2009-04-17 | 2021-10-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy compositions against cancer and methods |
CN102321637A (zh) | 2011-09-09 | 2012-01-18 | 中国人民解放军军事医学科学院军事兽医研究所 | 中国鸡痘病毒282e4弱毒株全基因组序列及其应用 |
WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
-
2016
- 2016-07-28 KR KR1020187000086A patent/KR102565284B1/ko active IP Right Grant
- 2016-07-28 IL IL256869A patent/IL256869B/en unknown
- 2016-07-28 EP EP16775852.3A patent/EP3329016B1/en active Active
- 2016-07-28 BR BR112018002172A patent/BR112018002172A8/pt active IP Right Grant
- 2016-07-28 JP JP2018500943A patent/JP6851364B2/ja active Active
- 2016-07-28 RU RU2018106643A patent/RU2753884C2/ru active
- 2016-07-28 ES ES16775852T patent/ES2901468T3/es active Active
- 2016-07-28 WO PCT/IB2016/001183 patent/WO2017021776A1/en active Application Filing
- 2016-07-28 DK DK16775852.3T patent/DK3329016T3/da active
- 2016-07-28 CN CN201680042251.3A patent/CN107922981B/zh active Active
- 2016-07-28 CA CA2990549A patent/CA2990549A1/en active Pending
- 2016-07-28 US US15/747,844 patent/US11753652B2/en active Active
- 2016-07-28 AU AU2016303378A patent/AU2016303378B2/en active Active
- 2016-07-28 MX MX2018001055A patent/MX2018001055A/es unknown
- 2016-07-28 SG SG10202000447YA patent/SG10202000447YA/en unknown
-
2018
- 2018-01-05 ZA ZA2018/00104A patent/ZA201800104B/en unknown
- 2018-10-22 HK HK18113484.6A patent/HK1254405A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP6851364B2 (ja) | 2021-03-31 |
US20180216134A1 (en) | 2018-08-02 |
BR112018002172A8 (pt) | 2024-02-15 |
AU2016303378A1 (en) | 2018-01-25 |
ES2901468T3 (es) | 2022-03-22 |
DK3329016T3 (da) | 2022-01-10 |
KR102565284B1 (ko) | 2023-08-08 |
RU2018106643A (ru) | 2019-08-28 |
KR20180033498A (ko) | 2018-04-03 |
CN107922981B (zh) | 2022-02-25 |
CN107922981A (zh) | 2018-04-17 |
RU2018106643A3 (pt) | 2020-01-30 |
MX2018001055A (es) | 2018-05-17 |
EP3329016A1 (en) | 2018-06-06 |
JP2018521651A (ja) | 2018-08-09 |
EP3329016B1 (en) | 2021-10-20 |
HK1254405A1 (zh) | 2019-07-19 |
CA2990549A1 (en) | 2017-02-09 |
SG10202000447YA (en) | 2020-03-30 |
AU2016303378B2 (en) | 2021-12-23 |
RU2753884C2 (ru) | 2021-08-24 |
ZA201800104B (en) | 2022-04-28 |
WO2017021776A1 (en) | 2017-02-09 |
IL256869A (en) | 2018-03-29 |
IL256869B (en) | 2022-07-01 |
US11753652B2 (en) | 2023-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/07/2016, OBSERVADAS AS CONDICOES LEGAIS |