BR112017015661A2 - anticorpo anti-alk2 - Google Patents
anticorpo anti-alk2Info
- Publication number
- BR112017015661A2 BR112017015661A2 BR112017015661-0A BR112017015661A BR112017015661A2 BR 112017015661 A2 BR112017015661 A2 BR 112017015661A2 BR 112017015661 A BR112017015661 A BR 112017015661A BR 112017015661 A2 BR112017015661 A2 BR 112017015661A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- alk2
- alk2 antibody
- dipg
- anemia
- Prior art date
Links
- 208000013558 Developmental Bone disease Diseases 0.000 abstract 1
- 206010049811 Extraskeletal ossification Diseases 0.000 abstract 1
- 208000034970 Heterotopic Ossification Diseases 0.000 abstract 1
- 206010072610 Skeletal dysplasia Diseases 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 208000028919 diffuse intrinsic pontine glioma Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
a presente invenção refere-se a um anticorpo que se liga especificamente a uma proteína alk2 e tem uma atividade de inibição da transdução de sinal de bmp mediada por alk2; um método para produzir o anticorpo; e uma composição farmacêutica compreendendo o anticorpo, para tratar e/ou prevenir a ossificação ectópica e/ou displasia óssea, anemia ou glioma pontino intrínseco difuso (dipg).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015-017882 | 2015-01-30 | ||
JP2015017882 | 2015-01-30 | ||
PCT/JP2016/052602 WO2016121908A1 (ja) | 2015-01-30 | 2016-01-29 | 抗alk2抗体 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017015661A2 true BR112017015661A2 (pt) | 2018-03-20 |
Family
ID=56543512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017015661-0A BR112017015661A2 (pt) | 2015-01-30 | 2016-01-29 | anticorpo anti-alk2 |
Country Status (9)
Country | Link |
---|---|
US (3) | US10428148B2 (pt) |
EP (1) | EP3252074A4 (pt) |
JP (2) | JP6763783B2 (pt) |
KR (1) | KR20170105558A (pt) |
CN (2) | CN107207604B (pt) |
BR (1) | BR112017015661A2 (pt) |
CA (1) | CA2975376A1 (pt) |
TW (2) | TWI774028B (pt) |
WO (1) | WO2016121908A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016121908A1 (ja) * | 2015-01-30 | 2016-08-04 | 学校法人埼玉医科大学 | 抗alk2抗体 |
GB201510758D0 (en) * | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
US20190254264A1 (en) * | 2016-10-31 | 2019-08-22 | National University Corporation Tottori University | Human antibody-producing non-human animal and method for preparing human antibodies using same |
GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
CA3048376A1 (en) | 2016-12-27 | 2018-07-05 | Riken | Bmp-signal-inhibiting compound |
US11859006B2 (en) | 2018-03-05 | 2024-01-02 | Saitama Medical University | Method of treating ectopic ossification or diffuse intrinsic pontine glioma in a subject by administering an anti-ALK2 antibody |
CN109438572A (zh) * | 2018-10-15 | 2019-03-08 | 上海药明生物技术有限公司 | 连续应用亲和层析和陶瓷羟基磷灰石层析分离抗体药物的方法 |
EP3870613A4 (en) * | 2018-10-23 | 2022-08-03 | Keros Therapeutics, Inc. | ALK2 ANTIBODIES AND METHODS OF USE THEREOF |
WO2020118011A1 (en) * | 2018-12-06 | 2020-06-11 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
JP2021017416A (ja) * | 2019-07-19 | 2021-02-15 | 国立大学法人京都大学 | Alk2の変異を有する疾患の治療または予防用医薬組成物 |
JPWO2021020282A1 (pt) | 2019-07-26 | 2021-02-04 | ||
WO2021163170A1 (en) * | 2020-02-11 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | Anti-acvr1 antibodies and uses thereof |
IL295980A (en) * | 2020-02-28 | 2022-10-01 | Brigham & Womens Hospital Inc | Selective modulation of transforming growth factor beta superfamily signaling using multispecific antibodies |
EP4047955A1 (en) | 2021-02-17 | 2022-08-24 | Oticon A/s | A hearing aid comprising a feedback control system |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007123896A2 (en) | 2006-04-18 | 2007-11-01 | The Trustees Of The University Of Pennsylvania | Mutated acvr1 for diagnosis and treatment of fibrodyplasia ossificans progressiva (fop) |
US20110182904A1 (en) | 2006-09-05 | 2011-07-28 | Deborah Zimmerman | Antibodies to bone morphogenic proteins and receptors therefor and methods for their use |
IE20090514A1 (en) | 2009-07-06 | 2011-02-16 | Opsona Therapeutics Ltd | Humanised antibodies and uses therof |
EP2332995A1 (en) | 2009-12-10 | 2011-06-15 | Bayer Schering Pharma Aktiengesellschaft | Neutralizing prolactin receptor antibodies and their therapeutic use |
WO2011112671A2 (en) * | 2010-03-09 | 2011-09-15 | President And Fellows Of Harvard College | Conversion of vascular endothelial cells into multipotent stem-like cells |
TR201802772T4 (tr) * | 2010-11-17 | 2018-03-21 | Chugai Pharmaceutical Co Ltd | Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül. |
US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
JPWO2014051109A1 (ja) * | 2012-09-28 | 2016-08-25 | 協和発酵キリン株式会社 | 抗ヒトbmp9抗体および該抗体を有効成分とする異所性骨化疾患の治療剤 |
WO2014078306A1 (en) | 2012-11-13 | 2014-05-22 | Regeneron Pharmaceuticals, Inc. | Anti-prokineticin receptor (prokr) antibodies and uses thereof |
WO2016121908A1 (ja) * | 2015-01-30 | 2016-08-04 | 学校法人埼玉医科大学 | 抗alk2抗体 |
CN107488625B (zh) | 2017-08-31 | 2018-12-21 | 广州蕊特生物科技有限公司 | 一种胎牛血清替代物及其制备方法和应用 |
US11859006B2 (en) | 2018-03-05 | 2024-01-02 | Saitama Medical University | Method of treating ectopic ossification or diffuse intrinsic pontine glioma in a subject by administering an anti-ALK2 antibody |
-
2016
- 2016-01-29 WO PCT/JP2016/052602 patent/WO2016121908A1/ja active Application Filing
- 2016-01-29 CN CN201680007605.0A patent/CN107207604B/zh active Active
- 2016-01-29 KR KR1020177022490A patent/KR20170105558A/ko not_active Application Discontinuation
- 2016-01-29 TW TW109125515A patent/TWI774028B/zh active
- 2016-01-29 US US15/547,231 patent/US10428148B2/en active Active
- 2016-01-29 EP EP16743511.4A patent/EP3252074A4/en active Pending
- 2016-01-29 CN CN202111192884.1A patent/CN113980131A/zh active Pending
- 2016-01-29 CA CA2975376A patent/CA2975376A1/en active Pending
- 2016-01-29 TW TW105102791A patent/TWI703156B/zh active
- 2016-01-29 JP JP2016572167A patent/JP6763783B2/ja active Active
- 2016-01-29 BR BR112017015661-0A patent/BR112017015661A2/pt active Search and Examination
-
2019
- 2019-08-19 US US16/543,991 patent/US11312776B2/en active Active
-
2020
- 2020-09-10 JP JP2020151717A patent/JP7101732B2/ja active Active
-
2021
- 2021-10-26 US US17/511,357 patent/US11447554B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP7101732B2 (ja) | 2022-07-15 |
JP2021006535A (ja) | 2021-01-21 |
US20180118835A1 (en) | 2018-05-03 |
TWI703156B (zh) | 2020-09-01 |
CA2975376A1 (en) | 2016-08-04 |
CN107207604A (zh) | 2017-09-26 |
EP3252074A4 (en) | 2018-07-11 |
CN113980131A (zh) | 2022-01-28 |
TW202110894A (zh) | 2021-03-16 |
US10428148B2 (en) | 2019-10-01 |
JP6763783B2 (ja) | 2020-09-30 |
US11312776B2 (en) | 2022-04-26 |
JPWO2016121908A1 (ja) | 2017-11-09 |
CN107207604B (zh) | 2021-10-26 |
US20220041738A1 (en) | 2022-02-10 |
US11447554B2 (en) | 2022-09-20 |
WO2016121908A1 (ja) | 2016-08-04 |
EP3252074A1 (en) | 2017-12-06 |
TW201636368A (zh) | 2016-10-16 |
TWI774028B (zh) | 2022-08-11 |
US20200002427A1 (en) | 2020-01-02 |
KR20170105558A (ko) | 2017-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |