BR112017014771A2 - ?anticorpo, polinucleotídeo, unidade de expressão, célula hospedeira, métodos para produção de um anticorpo e para tratamento de um indivíduo, composição, uso de um anticorpo em um método de diagnóstico, e, vetor de expressão? - Google Patents

?anticorpo, polinucleotídeo, unidade de expressão, célula hospedeira, métodos para produção de um anticorpo e para tratamento de um indivíduo, composição, uso de um anticorpo em um método de diagnóstico, e, vetor de expressão?

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Publication number
BR112017014771A2
BR112017014771A2 BR112017014771-8A BR112017014771A BR112017014771A2 BR 112017014771 A2 BR112017014771 A2 BR 112017014771A2 BR 112017014771 A BR112017014771 A BR 112017014771A BR 112017014771 A2 BR112017014771 A2 BR 112017014771A2
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BR
Brazil
Prior art keywords
antibody
polynucleotide
treating
individual
producing
Prior art date
Application number
BR112017014771-8A
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English (en)
Inventor
Van Eenennaam Hans
Van Elsas Andrea
Paul Medema Jan
Lutje Hulsik David
Original Assignee
Aduro Biotech Holdings, Europe B.V.
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Publication date
Application filed by Aduro Biotech Holdings, Europe B.V. filed Critical Aduro Biotech Holdings, Europe B.V.
Publication of BR112017014771A2 publication Critical patent/BR112017014771A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Abstract

a divulgação diz respeito a anticorpos de ligação a april, que se ligam ao mesmo epitopo de april humano como um anticorpo possuindo um local de ligação de antígeno de hapril.01a. os anticorpos da presente divulgação compreendem seleções específicas de sequências estruturais dos domínios vh e vl e têm características inesperadas em comparação com hapril.01a. a divulgação diz respeito ainda a composições que compreendem um anticorpo da invenção e ao uso médico e diagnóstico dos anticorpos e composições.
BR112017014771-8A 2015-01-09 2016-01-08 ?anticorpo, polinucleotídeo, unidade de expressão, célula hospedeira, métodos para produção de um anticorpo e para tratamento de um indivíduo, composição, uso de um anticorpo em um método de diagnóstico, e, vetor de expressão? BR112017014771A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2014108 2015-01-09
NL2014108A NL2014108B1 (en) 2015-01-09 2015-01-09 Altered april binding antibodies.
PCT/EP2016/050314 WO2016110587A1 (en) 2015-01-09 2016-01-08 Altered april binding antibodies

Publications (1)

Publication Number Publication Date
BR112017014771A2 true BR112017014771A2 (pt) 2018-01-23

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ID=53783809

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017014771-8A BR112017014771A2 (pt) 2015-01-09 2016-01-08 ?anticorpo, polinucleotídeo, unidade de expressão, célula hospedeira, métodos para produção de um anticorpo e para tratamento de um indivíduo, composição, uso de um anticorpo em um método de diagnóstico, e, vetor de expressão?

Country Status (20)

Country Link
US (4) US9969808B2 (pt)
EP (2) EP3242892B1 (pt)
JP (2) JP6824190B2 (pt)
KR (2) KR102612373B1 (pt)
CN (1) CN107207602B (pt)
AU (1) AU2016205977B2 (pt)
BR (1) BR112017014771A2 (pt)
CA (1) CA2973286A1 (pt)
DK (1) DK3242892T3 (pt)
EA (1) EA201791270A1 (pt)
ES (1) ES2902901T3 (pt)
HK (1) HK1243435A1 (pt)
IL (1) IL253306B (pt)
MA (1) MA41313A (pt)
MX (2) MX2017009052A (pt)
NL (1) NL2014108B1 (pt)
PL (1) PL3242892T3 (pt)
SG (1) SG11201705589UA (pt)
WO (1) WO2016110587A1 (pt)
ZA (2) ZA201704920B (pt)

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Also Published As

Publication number Publication date
US20210221900A1 (en) 2021-07-22
JP2018502918A (ja) 2018-02-01
MA41313A (fr) 2021-05-12
CA2973286A1 (en) 2016-07-14
MX2017009052A (es) 2018-04-11
EP3242892B1 (en) 2021-10-20
JP2021072801A (ja) 2021-05-13
KR102612373B1 (ko) 2023-12-13
EP4029879A1 (en) 2022-07-20
US10961316B2 (en) 2021-03-30
HK1243435A1 (zh) 2018-07-13
PL3242892T3 (pl) 2022-02-21
NL2014108B1 (en) 2016-09-30
EA201791270A1 (ru) 2017-12-29
DK3242892T3 (da) 2022-01-24
EP3242892A1 (en) 2017-11-15
WO2016110587A1 (en) 2016-07-14
KR20170099992A (ko) 2017-09-01
CN107207602A (zh) 2017-09-26
US9969808B2 (en) 2018-05-15
JP7060728B2 (ja) 2022-04-26
KR20230170120A (ko) 2023-12-18
US10377830B2 (en) 2019-08-13
NL2014108A (en) 2016-09-23
ZA201704920B (en) 2018-11-28
CN107207602B (zh) 2021-05-25
SG11201705589UA (en) 2017-08-30
IL253306B (en) 2021-06-30
JP6824190B2 (ja) 2021-02-03
US20160264674A1 (en) 2016-09-15
AU2016205977A1 (en) 2017-08-31
ES2902901T3 (es) 2022-03-30
US20200079859A1 (en) 2020-03-12
MX2022007774A (es) 2022-08-10
IL253306A0 (en) 2017-09-28
US20180258176A1 (en) 2018-09-13
ZA201804317B (en) 2019-09-25
AU2016205977B2 (en) 2021-11-04

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