MA41313A - Anticorps de liaison de la protéine april modifiés - Google Patents
Anticorps de liaison de la protéine april modifiésInfo
- Publication number
- MA41313A MA41313A MA041313A MA41313A MA41313A MA 41313 A MA41313 A MA 41313A MA 041313 A MA041313 A MA 041313A MA 41313 A MA41313 A MA 41313A MA 41313 A MA41313 A MA 41313A
- Authority
- MA
- Morocco
- Prior art keywords
- protein binding
- binding antibodies
- april protein
- modified april
- modified
- Prior art date
Links
- 102000013081 Tumor Necrosis Factor Ligand Superfamily Member 13 Human genes 0.000 title 1
- 108010065323 Tumor Necrosis Factor Ligand Superfamily Member 13 Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2014108A NL2014108B1 (en) | 2015-01-09 | 2015-01-09 | Altered april binding antibodies. |
Publications (1)
Publication Number | Publication Date |
---|---|
MA41313A true MA41313A (fr) | 2021-05-12 |
Family
ID=53783809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA041313A MA41313A (fr) | 2015-01-09 | 2016-01-08 | Anticorps de liaison de la protéine april modifiés |
Country Status (20)
Country | Link |
---|---|
US (4) | US9969808B2 (fr) |
EP (2) | EP3242892B1 (fr) |
JP (2) | JP6824190B2 (fr) |
KR (2) | KR102612373B1 (fr) |
CN (1) | CN107207602B (fr) |
AU (1) | AU2016205977B2 (fr) |
BR (1) | BR112017014771A2 (fr) |
CA (1) | CA2973286A1 (fr) |
DK (1) | DK3242892T3 (fr) |
EA (1) | EA201791270A1 (fr) |
ES (1) | ES2902901T3 (fr) |
HK (1) | HK1243435A1 (fr) |
IL (1) | IL253306B (fr) |
MA (1) | MA41313A (fr) |
MX (2) | MX2017009052A (fr) |
NL (1) | NL2014108B1 (fr) |
PL (1) | PL3242892T3 (fr) |
SG (1) | SG11201705589UA (fr) |
WO (1) | WO2016110587A1 (fr) |
ZA (2) | ZA201704920B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2011406C2 (en) | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
DK3380522T3 (da) | 2015-11-25 | 2024-01-22 | Visterra Inc | Antistofmolekyler til april og anvendelser deraf |
IL259931B2 (en) | 2015-12-16 | 2024-02-01 | Gritstone Bio Inc | Identification of neo-antigens, preparation, and use |
CA3064632A1 (fr) * | 2017-06-20 | 2018-12-27 | Dana-Farber Cancer Institute, Inc. | Procedes de modulation de lymphocytes t regulateurs, de lymphocytes b regulateurs et de reponses immunitaires a l'aide de modulateurs de l'interaction avril-taci |
AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
KR20200090855A (ko) | 2017-11-22 | 2020-07-29 | 그릿스톤 온콜로지, 인코포레이티드 | 신생항원에 대한 접합 에피토프 제시 감소 |
US20200190163A1 (en) * | 2018-10-26 | 2020-06-18 | Lijun Wu | Humanized bcma-car-t cells |
WO2020144535A1 (fr) | 2019-01-08 | 2020-07-16 | Aduro Biotech Holdings, Europe B.V. | Méthodes et compositions de traitement de myélome multiple |
WO2021076554A1 (fr) * | 2019-10-15 | 2021-04-22 | Dragonfly Therapeutics, Inc. | Anticorps ciblant les flt3 et leur utilisation |
MX2022004430A (es) * | 2019-10-15 | 2022-07-19 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), al cumulo de diferenciacion 16 (cd16) y a la tirosina cinasa 3 similar a fms (flt3). |
BR112022024262A2 (pt) * | 2020-05-29 | 2023-02-23 | Chinook Therapeutics Inc | Métodos de tratamento de nefropatia por iga com um anticorpo de ligação a april |
US11883432B2 (en) | 2020-12-18 | 2024-01-30 | Century Therapeutics, Inc. | Chimeric antigen receptor system with adaptable receptor specificity |
KR20240019124A (ko) | 2021-05-07 | 2024-02-14 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Taci-fc 융합 면역조절 단백질의 투여 및 치료 방법 |
US20240092921A1 (en) | 2022-04-25 | 2024-03-21 | Visterra, Inc. | Antibody molecules to april and uses thereof |
WO2024077018A2 (fr) | 2022-10-04 | 2024-04-11 | Alpine Immune Sciences, Inc. | Procédés et utilisations d'une protéine immunomodulatrice de fusion taci-fc |
WO2024092240A1 (fr) * | 2022-10-28 | 2024-05-02 | Chinook Therapeutics, Inc. | Traitement de la néphropathie à iga à l'aide d'un antagoniste du récepteur de l'endothéline et d'un anticorps de liaison à april |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US778A (en) | 1838-06-12 | Thomas wright | ||
US4946A (en) | 1847-01-26 | Improvement in carriage-wheels | ||
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DD272023A3 (de) | 1985-12-04 | 1989-09-27 | Ilmenau Tech Hochschule | Vorrichtung, insbesondere zur praezisionslichtstrahlablenkung |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
ATE87659T1 (de) | 1986-09-02 | 1993-04-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
WO1988007089A1 (fr) | 1987-03-18 | 1988-09-22 | Medical Research Council | Anticorps alteres |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
ATE297465T1 (de) | 1991-11-25 | 2005-06-15 | Enzon Inc | Verfahren zur herstellung von multivalenten antigenbindenden proteinen |
EP0792278B1 (fr) | 1994-11-07 | 2007-06-13 | Human Genome Sciences, Inc. | Polypeptide gamma appartenant a la famille des facteurs de necrose tumorale (fnt) |
US6171787B1 (en) | 1997-06-26 | 2001-01-09 | Abbott Laboratories | Member of the TNF family useful for treatment and diagnosis of disease |
CA2303615A1 (fr) | 1997-09-12 | 1999-03-18 | Jurg Tschopp | Nouveaux ligands de la famille des tnf |
WO2001060397A1 (fr) * | 2000-02-16 | 2001-08-23 | Genentech, Inc. | Utilisation d'agonistes ou d'antagonistes pour moduler l'activite de molecules associees au tnf |
WO2001096528A2 (fr) | 2000-06-15 | 2001-12-20 | Human Genome Sciences, Inc. | Facteur de necrose tumorale humain delta et epsilon |
US7189820B2 (en) | 2001-05-24 | 2007-03-13 | Human Genome Sciences, Inc. | Antibodies against tumor necrosis factor delta (APRIL) |
WO2003086310A2 (fr) | 2002-04-12 | 2003-10-23 | Ramot At Tel Aviv University Ltd. | Prevention de l'inflammation du cerveau en tant que resultat d'une reponse auto-immune induite |
US7410483B2 (en) | 2003-05-23 | 2008-08-12 | Novare Surgical Systems, Inc. | Hand-actuated device for remote manipulation of a grasping tool |
WO2005120571A2 (fr) | 2004-06-07 | 2005-12-22 | Ramot At Tel Aviv University Ltd. | Procede d'immunisation passive contre des maladies ou des troubles caracterise(e)s par agregation amyloide a risque diminue de neuroinflammation |
UY30776A1 (es) * | 2006-12-21 | 2008-07-03 | Medarex Inc | Anticuerpos cd44 |
EA201170028A1 (ru) | 2008-07-02 | 2011-12-30 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ TNF-α |
CN102239180B (zh) * | 2008-08-18 | 2014-12-31 | 辉瑞大药厂 | 抗ccr2抗体 |
MX2011002838A (es) * | 2008-09-19 | 2011-07-29 | Medimmune Llc | Anticuerpos contra homologos sonic hedgehog y usos de los mismos. |
EP2403528B1 (fr) | 2009-03-02 | 2016-04-20 | Aduro Biotech Holdings, Europe B.V. | Anticorps contre le ligand a induisant la prolifération (april) |
CN101928345B (zh) * | 2010-06-21 | 2012-08-29 | 中国科学技术大学 | 一种人源化抗体及其人源化改造方法 |
NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
DK3380522T3 (da) * | 2015-11-25 | 2024-01-22 | Visterra Inc | Antistofmolekyler til april og anvendelser deraf |
-
2015
- 2015-01-09 NL NL2014108A patent/NL2014108B1/en active
-
2016
- 2016-01-08 WO PCT/EP2016/050314 patent/WO2016110587A1/fr active Application Filing
- 2016-01-08 US US14/991,708 patent/US9969808B2/en active Active
- 2016-01-08 KR KR1020177020607A patent/KR102612373B1/ko active IP Right Grant
- 2016-01-08 MA MA041313A patent/MA41313A/fr unknown
- 2016-01-08 JP JP2017554648A patent/JP6824190B2/ja active Active
- 2016-01-08 EP EP16700803.6A patent/EP3242892B1/fr active Active
- 2016-01-08 ES ES16700803T patent/ES2902901T3/es active Active
- 2016-01-08 AU AU2016205977A patent/AU2016205977B2/en active Active
- 2016-01-08 DK DK16700803.6T patent/DK3242892T3/da active
- 2016-01-08 PL PL16700803T patent/PL3242892T3/pl unknown
- 2016-01-08 KR KR1020237041391A patent/KR20230170120A/ko active Application Filing
- 2016-01-08 EP EP21203559.6A patent/EP4029879A1/fr active Pending
- 2016-01-08 MX MX2017009052A patent/MX2017009052A/es unknown
- 2016-01-08 SG SG11201705589UA patent/SG11201705589UA/en unknown
- 2016-01-08 EA EA201791270A patent/EA201791270A1/ru unknown
- 2016-01-08 BR BR112017014771-8A patent/BR112017014771A2/pt active Search and Examination
- 2016-01-08 CN CN201680006375.6A patent/CN107207602B/zh active Active
- 2016-01-08 CA CA2973286A patent/CA2973286A1/fr active Pending
-
2017
- 2017-07-04 IL IL253306A patent/IL253306B/en active IP Right Grant
- 2017-07-07 MX MX2022007774A patent/MX2022007774A/es unknown
- 2017-07-19 ZA ZA2017/04920A patent/ZA201704920B/en unknown
-
2018
- 2018-02-28 HK HK18102920.1A patent/HK1243435A1/zh unknown
- 2018-05-14 US US15/978,699 patent/US10377830B2/en active Active
- 2018-06-27 ZA ZA2018/04317A patent/ZA201804317B/en unknown
-
2019
- 2019-08-12 US US16/538,526 patent/US10961316B2/en active Active
-
2021
- 2021-01-12 JP JP2021002780A patent/JP7060728B2/ja active Active
- 2021-03-29 US US17/301,201 patent/US20210221900A1/en active Pending
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