BR112017011798A2 - 4,6-substituído-pirazolo[1,5-a] pirazinas como inibidores janus cinase - Google Patents

4,6-substituído-pirazolo[1,5-a] pirazinas como inibidores janus cinase

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Publication number
BR112017011798A2
BR112017011798A2 BR112017011798A BR112017011798A BR112017011798A2 BR 112017011798 A2 BR112017011798 A2 BR 112017011798A2 BR 112017011798 A BR112017011798 A BR 112017011798A BR 112017011798 A BR112017011798 A BR 112017011798A BR 112017011798 A2 BR112017011798 A2 BR 112017011798A2
Authority
BR
Brazil
Prior art keywords
pyrazines
pyrazolo
substituted
kinase inhibitors
janus kinase
Prior art date
Application number
BR112017011798A
Other languages
English (en)
Inventor
L Bennett Brydon
F Kraser Christopher
Laird Ellen
James Hicken Erik
Bradford Fell Jay
Pheneger Jed
e robinson John
Gaudino John
P Fischer John
Leftheris Katerina
E Burgess Laurence
J Chicarelli Mark
Laurence Boys Mark
K Raheja Raj
Andrew RIEGER Robert
Jay Hinklin Ronald
Allen Shelley
p tang Tony
Satoh Yoshitaka
Original Assignee
Array Biopharma Inc
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Celgene Corp filed Critical Array Biopharma Inc
Publication of BR112017011798A2 publication Critical patent/BR112017011798A2/pt

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
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    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

a presente invenção refere-se a compostos de fórmula i: e estereoisômeros e sais e solvatos farmaceuticamente aceitáveis dos mesmos em que r1, r2, r3 e r4 têm os mesmos significados apresentados na especificação, são inibidores de uma ou mais jak cinases e são úteis no tratamento de distúrbios e doenças associados com jak cinase, como doenças autoimunes, doenças inflamatórias, rejeição de órgãos, tecidos e células transplantados, bem como distúrbios e malignidades hematológicas e suas comorbidades.
BR112017011798A 2014-12-05 2015-12-04 4,6-substituído-pirazolo[1,5-a] pirazinas como inibidores janus cinase BR112017011798A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462088068P 2014-12-05 2014-12-05
PCT/US2015/064062 WO2016090285A1 (en) 2014-12-05 2015-12-04 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
BR112017011798A2 true BR112017011798A2 (pt) 2017-12-26

Family

ID=55069089

Family Applications (1)

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BR112017011798A BR112017011798A2 (pt) 2014-12-05 2015-12-04 4,6-substituído-pirazolo[1,5-a] pirazinas como inibidores janus cinase

Country Status (29)

Country Link
US (3) US10189845B2 (pt)
EP (2) EP3227297B1 (pt)
JP (2) JP6641373B2 (pt)
KR (1) KR20170090476A (pt)
CN (1) CN107278203B (pt)
AU (1) AU2015357585B2 (pt)
BR (1) BR112017011798A2 (pt)
CA (1) CA2969709A1 (pt)
CL (1) CL2017001422A1 (pt)
CO (1) CO2017006674A2 (pt)
CR (1) CR20170309A (pt)
DK (1) DK3227297T3 (pt)
ES (1) ES2865483T3 (pt)
HR (1) HRP20210501T1 (pt)
HU (1) HUE054371T2 (pt)
IL (1) IL252656A0 (pt)
MX (1) MX2017007284A (pt)
MY (1) MY191016A (pt)
PH (1) PH12017501032A1 (pt)
PL (1) PL3227297T3 (pt)
PT (1) PT3227297T (pt)
RS (1) RS61693B1 (pt)
RU (2) RU2742938C2 (pt)
SG (1) SG11201704542SA (pt)
SI (1) SI3227297T1 (pt)
TW (1) TWI725004B (pt)
UA (1) UA120065C2 (pt)
WO (1) WO2016090285A1 (pt)
ZA (1) ZA201704494B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3227297T (pt) 2014-12-05 2021-04-09 Array Biopharma Inc Pirazol[1,5-a]pirazinas, substituídas nas posições 4 e 6, como inibidores de cinases janus
NZ744349A (en) 2016-02-24 2023-06-30 Pfizer Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors
US11028080B2 (en) 2016-03-11 2021-06-08 Denali Therapeutics Inc. Substituted pyrimidines as LRKK2 inhibitors
CR20220182A (es) 2016-06-16 2022-06-15 Denali Therapeutics Inc Pirimidin-2-ilamino-1h-pirazoles como inhibidores de lrrk2 para el uso en el tratamiento de trastornos neurodegenerativos (divisional 2018-592)
GB201617758D0 (en) * 2016-10-20 2016-12-07 Almac Discovery Limited Pharmaceutical compounds
JP6888101B2 (ja) * 2017-01-18 2021-06-16 アレイ バイオファーマ インコーポレイテッド RETキナーゼ阻害剤としての置換ピラゾロ[1,5−a]ピラジン化合物
US20200157081A1 (en) * 2017-05-24 2020-05-21 Denali Therapeutics Inc. Compounds, compositions and methods
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
WO2019143991A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CA3087972C (en) 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
US11964988B2 (en) 2018-09-10 2024-04-23 Array Biopharma Inc. Fused heterocyclic compounds as RET kinase inhibitors
WO2020207476A1 (zh) * 2019-04-12 2020-10-15 北京普祺医药科技有限公司 一种吡唑并吡嗪衍生的化合物、药物组合物以及其用途
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を予防するための方法および組成物
CN113150012B (zh) * 2020-01-22 2023-03-24 浙江海正药业股份有限公司 吡唑并[1,5-a]吡嗪类衍生物及其制备方法和用途
CA3177852A1 (en) 2020-04-04 2021-10-07 Pfizer Inc. Methods of treating coronavirus disease 2019
WO2023083200A1 (zh) * 2021-11-12 2023-05-19 南京明德新药研发有限公司 吡唑并环化合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2342503A1 (en) 1998-08-21 2000-03-02 Parker Hughes Institute Quinazoline derivatives
DE102007032349A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung
SI2516434T1 (sl) 2009-12-23 2015-10-30 Takeda Pharmaceutical Company Limited Zliti heteroaromatski pirolidinoni kot inhibitorji SYK
EP2526102B1 (en) * 2010-01-22 2017-03-08 Fundación Centro Nacional de Investigaciones Oncológicas Carlos III Inhibitors of PI3 kinase
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
US20110241987A1 (en) * 2010-04-01 2011-10-06 Smart Technologies Ulc Interactive input system and information input method therefor
NZ603446A (en) * 2010-04-14 2014-05-30 Array Biopharma Inc 5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases
WO2013055645A1 (en) * 2011-10-12 2013-04-18 Array Biopharma Inc. 5,7-substituted-imidazo[1,2-c]pyrimidines
CN104169284B (zh) * 2012-03-28 2017-03-29 默克专利股份公司 双环吡嗪酮衍生物
PT3227297T (pt) 2014-12-05 2021-04-09 Array Biopharma Inc Pirazol[1,5-a]pirazinas, substituídas nas posições 4 e 6, como inibidores de cinases janus

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Publication number Publication date
ZA201704494B (en) 2022-03-30
PT3227297T (pt) 2021-04-09
EP3227297B1 (en) 2021-01-20
AU2015357585B2 (en) 2020-07-02
JP2020055859A (ja) 2020-04-09
JP6641373B2 (ja) 2020-02-05
IL252656A0 (en) 2017-07-31
RU2742938C2 (ru) 2021-02-11
MY191016A (en) 2022-05-28
US10189845B2 (en) 2019-01-29
UA120065C2 (uk) 2019-09-25
MX2017007284A (es) 2017-08-25
HRP20210501T1 (hr) 2021-05-14
SI3227297T1 (sl) 2021-04-30
PH12017501032A1 (en) 2017-11-27
RU2021102805A (ru) 2021-02-12
EP3878451A1 (en) 2021-09-15
EP3227297A1 (en) 2017-10-11
DK3227297T3 (da) 2021-04-06
RU2017123387A (ru) 2019-01-11
US11028093B2 (en) 2021-06-08
TW201632523A (zh) 2016-09-16
RU2017123387A3 (pt) 2019-06-03
CN107278203B (zh) 2020-05-19
KR20170090476A (ko) 2017-08-07
JP2018507167A (ja) 2018-03-15
CL2017001422A1 (es) 2018-01-05
US20200291039A1 (en) 2020-09-17
TWI725004B (zh) 2021-04-21
PL3227297T3 (pl) 2021-10-25
US20170362240A1 (en) 2017-12-21
SG11201704542SA (en) 2017-07-28
US20190177328A1 (en) 2019-06-13
RS61693B1 (sr) 2021-05-31
CN107278203A (zh) 2017-10-20
AU2015357585A1 (en) 2017-07-13
CA2969709A1 (en) 2016-06-09
CO2017006674A2 (es) 2017-10-20
WO2016090285A1 (en) 2016-06-09
CR20170309A (es) 2018-02-02
HUE054371T2 (hu) 2021-09-28
ES2865483T3 (es) 2021-10-15
US10730880B2 (en) 2020-08-04

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