BR112017007144A2 - ácido valproico ou um sal farmaceuticamente aceitável do mesmo, composto, composição farmacêutica, e, composto ou composição para uso, uso, método ou composição. - Google Patents

ácido valproico ou um sal farmaceuticamente aceitável do mesmo, composto, composição farmacêutica, e, composto ou composição para uso, uso, método ou composição.

Info

Publication number
BR112017007144A2
BR112017007144A2 BR112017007144A BR112017007144A BR112017007144A2 BR 112017007144 A2 BR112017007144 A2 BR 112017007144A2 BR 112017007144 A BR112017007144 A BR 112017007144A BR 112017007144 A BR112017007144 A BR 112017007144A BR 112017007144 A2 BR112017007144 A2 BR 112017007144A2
Authority
BR
Brazil
Prior art keywords
composition
compound
pharmaceutically acceptable
acceptable salt
valproic acid
Prior art date
Application number
BR112017007144A
Other languages
English (en)
Inventor
Faijerson SÄLJÖ Jonas
Bergh Niklas
Jern Sverker
Original Assignee
Cereno Scient Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cereno Scient Ab filed Critical Cereno Scient Ab
Publication of BR112017007144A2 publication Critical patent/BR112017007144A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

a presente invenção se refere a ácido valproico, ou um sal farmaceuticamente aceitável do mesmo, para uso no tratamento ou na prevenção de uma afecção patológica associada ao excesso de deposição de fibrina e/ou formação de trombo, em que o dito tratamento compreende tratar um paciente com ácido valproico, ou um sal farmaceuticamente aceitável do mesmo, de uma maneira específica, e formulações para uso ou projetadas para uso em tais tratamentos.
BR112017007144A 2014-10-08 2015-10-08 ácido valproico ou um sal farmaceuticamente aceitável do mesmo, composto, composição farmacêutica, e, composto ou composição para uso, uso, método ou composição. BR112017007144A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1417828.9A GB201417828D0 (en) 2014-10-08 2014-10-08 New methods and compositions
PCT/GB2015/052950 WO2016055797A2 (en) 2014-10-08 2015-10-08 Compounds and compositions for the treatment or prevention of pathological conditions associated with excess fibrin deposition and/or thrombus formation

Publications (1)

Publication Number Publication Date
BR112017007144A2 true BR112017007144A2 (pt) 2017-12-19

Family

ID=51947070

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017007144A BR112017007144A2 (pt) 2014-10-08 2015-10-08 ácido valproico ou um sal farmaceuticamente aceitável do mesmo, composto, composição farmacêutica, e, composto ou composição para uso, uso, método ou composição.

Country Status (21)

Country Link
US (3) US10111845B2 (pt)
EP (2) EP3203997B1 (pt)
JP (2) JP6787901B2 (pt)
KR (1) KR20170063857A (pt)
CN (3) CN115721635A (pt)
AU (1) AU2015329795B2 (pt)
BR (1) BR112017007144A2 (pt)
CA (2) CA3234641A1 (pt)
CL (1) CL2017000866A1 (pt)
DK (1) DK3203997T3 (pt)
ES (1) ES2913225T3 (pt)
GB (1) GB201417828D0 (pt)
HU (1) HUE058316T2 (pt)
IL (1) IL251142B (pt)
MX (2) MX2017004558A (pt)
MY (1) MY192055A (pt)
NZ (1) NZ730307A (pt)
PL (1) PL3203997T3 (pt)
RU (1) RU2732761C2 (pt)
SG (1) SG11201702058XA (pt)
WO (1) WO2016055797A2 (pt)

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TWI664164B (zh) 2014-02-13 2019-07-01 美商英塞特控股公司 作為ｌｓｄ１抑制劑之環丙胺
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
GB201417828D0 (en) 2014-10-08 2014-11-19 Cereno Scient Ab New methods and compositions
JP6995623B2 (ja) 2015-04-03 2022-01-14 インサイト・コーポレイション Ｌｓｄ１阻害剤としてのヘテロ環式化合物
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US20230069590A1 (en) * 2020-01-16 2023-03-02 The Regents Of The University Of Michigan Concentrated sodium valproate for rapid delivery
CN111450072B (zh) * 2020-05-07 2022-07-15 江苏艾立康医药科技有限公司 一种替格瑞洛控释片及其制备方法
GB2613900B (en) * 2021-12-20 2024-01-17 Cereno Scient Ab Novel compounds and methods of use thereof

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US20200179381A1 (en) 2016-04-08 2020-06-11 Cereno Scientific Ab Compounds and compositions for the treatment or prevention of pathological conditions associated with excess fibrin deposition and/or thrombus formation
CN109414423A (zh) 2016-04-08 2019-03-01 赛伦诺科技有限公司 包含丙戊酸的延迟释放药物制剂和其用途

Also Published As

Publication number Publication date
JP2021008523A (ja) 2021-01-28
JP2017532376A (ja) 2017-11-02
HUE058316T2 (hu) 2022-07-28
CN115581691A (zh) 2023-01-10
RU2017114933A3 (pt) 2019-05-16
EP4066825A1 (en) 2022-10-05
US20180177751A1 (en) 2018-06-28
AU2015329795A1 (en) 2017-04-13
EP3203997A2 (en) 2017-08-16
GB201417828D0 (en) 2014-11-19
MX2017004558A (es) 2017-12-14
CA3234641A1 (en) 2016-04-14
ES2913225T3 (es) 2022-06-01
KR20170063857A (ko) 2017-06-08
CA2964041C (en) 2024-04-09
IL251142A0 (en) 2017-04-30
US10111845B2 (en) 2018-10-30
SG11201702058XA (en) 2017-04-27
JP6787901B2 (ja) 2020-11-18
WO2016055797A2 (en) 2016-04-14
PL3203997T3 (pl) 2022-05-16
RU2017114933A (ru) 2018-11-12
AU2015329795B2 (en) 2021-03-25
DK3203997T3 (da) 2022-05-23
US20190015360A1 (en) 2019-01-17
US20220401393A1 (en) 2022-12-22
JP7305605B2 (ja) 2023-07-10
RU2732761C2 (ru) 2020-09-22
NZ730307A (en) 2024-01-26
CL2017000866A1 (es) 2017-11-24
MX2022007221A (es) 2022-07-12
CN115721635A (zh) 2023-03-03
CN107205975A (zh) 2017-09-26
IL251142B (en) 2022-07-01
US11400064B2 (en) 2022-08-02
CA2964041A1 (en) 2016-04-14
EP3203997B1 (en) 2022-03-02
WO2016055797A3 (en) 2016-06-09
MY192055A (en) 2022-07-25

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
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