BR112016006232A2 - derivados de 3-(1h-pirazol-4-il)-1h-pirrolo[2,3-c]piridina como inibidores de nik - Google Patents
derivados de 3-(1h-pirazol-4-il)-1h-pirrolo[2,3-c]piridina como inibidores de nikInfo
- Publication number
- BR112016006232A2 BR112016006232A2 BR112016006232A BR112016006232A BR112016006232A2 BR 112016006232 A2 BR112016006232 A2 BR 112016006232A2 BR 112016006232 A BR112016006232 A BR 112016006232A BR 112016006232 A BR112016006232 A BR 112016006232A BR 112016006232 A2 BR112016006232 A2 BR 112016006232A2
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- pyrrolo
- pyrazol
- compounds
- pyridine derivatives
- Prior art date
Links
- BMZWBEHLBROZOP-UHFFFAOYSA-N c1n[nH]cc1-c1c[nH]c2cnccc12 Chemical class c1n[nH]cc1-c1c[nH]c2cnccc12 BMZWBEHLBROZOP-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 208000030159 metabolic disease Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
Abstract
a presente invenção refere-se a agentes farmacêuticos úteis para terapia e/ou profilaxia em um mamífero, e em particular a inibidores de quinase indutora de nf-¿b (nik - também conhecida como map3k14) úteis para o tratamento de doenças tais como câncer, distúrbios inflamatórios, distúrbios metabólicos e distúrbios autoimunes. a invenção está também dirigida a composições farmacêuticas compreendendo tais compostos, a processos para preparar tais compostos e composições, e ao uso de tais compostos ou composições farmacêuticas para a prevenção ou o tratamento de doenças tais como câncer, distúrbios inflamatórios, distúrbios metabólicos incluindo obesidade e diabetes, e distúrbios autoimunes.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13186148 | 2013-09-26 | ||
EP13186148.6 | 2013-09-26 | ||
EP14176125.4 | 2014-07-08 | ||
EP14176125 | 2014-07-08 | ||
PCT/EP2014/070489 WO2015044269A1 (en) | 2013-09-26 | 2014-09-25 | NEW 3-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112016006232A2 true BR112016006232A2 (pt) | 2017-08-01 |
BR112016006232B1 BR112016006232B1 (pt) | 2022-11-29 |
Family
ID=51626028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016006232-9A BR112016006232B1 (pt) | 2013-09-26 | 2014-09-25 | Derivados de 3-(1h-pirazol-4-il)-1h-pirrolo[2,3-c]piridina como inibidores de nik e composição farmacêutica que os compreende |
Country Status (14)
Country | Link |
---|---|
US (1) | US9981963B2 (pt) |
EP (1) | EP3049412B1 (pt) |
JP (1) | JP6404332B2 (pt) |
KR (1) | KR102317335B1 (pt) |
CN (1) | CN105579452B (pt) |
AU (1) | AU2014327235B2 (pt) |
BR (1) | BR112016006232B1 (pt) |
CA (1) | CA2922633C (pt) |
EA (1) | EA028101B1 (pt) |
ES (1) | ES2643070T3 (pt) |
IL (1) | IL244702B (pt) |
MX (1) | MX365739B (pt) |
TW (1) | TWI627173B (pt) |
WO (1) | WO2015044269A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為NIK抑制劑的新穎3-(1H-吡唑-4-基)-1H-吡咯并[2,3-c]吡啶衍生物 |
TWI704146B (zh) * | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作NIK抑制劑之新的1-(4-嘧啶基)-1H-吡唑並[3,2-c]吡啶衍生物 |
MX371151B (es) | 2014-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK). |
CN107074818B (zh) * | 2014-10-23 | 2020-04-17 | 詹森药业有限公司 | 作为nik抑制剂的吡唑衍生物 |
ES2715104T3 (es) | 2014-10-23 | 2019-05-31 | Janssen Pharmaceutica Nv | Nuevos derivados de pirazolopirimidina como inhibidores de nik |
WO2016062792A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New compounds as nik inhibitors |
US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
EP3383390A4 (en) * | 2015-12-02 | 2019-11-20 | Astraea Therapeutics, LLC | PIPERIDINYL COMPOUNDS FOR NOCICEPTIN RECEPTOR |
BR112018014675B1 (pt) | 2016-01-22 | 2023-12-19 | Janssen Pharmaceutica Nv | Derivados de cianoindolina substituída como inibidores de nik e composição farmacêutica que os compreende |
EP3405464B1 (en) | 2016-01-22 | 2019-12-04 | Janssen Pharmaceutica NV | New 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors |
EP3478675B1 (en) | 2016-06-30 | 2020-04-22 | Janssen Pharmaceutica NV | Heteroaromatic derivatives as nik inhibitors |
AU2017289317B2 (en) * | 2016-06-30 | 2021-04-01 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as NIK inhibitors |
JPWO2020162638A1 (ja) * | 2019-02-08 | 2021-12-16 | 学校法人近畿大学 | 悪性腫瘍改善用組成物 |
CN114222737B (zh) | 2019-05-31 | 2024-07-26 | 詹森药业有限公司 | NF-κB诱导激酶的小分子抑制剂 |
CN110156766A (zh) * | 2019-06-04 | 2019-08-23 | 南京工业大学 | 一种银催化的氘代五元芳香杂环化合物的制备方法 |
WO2022138735A1 (ja) | 2020-12-22 | 2022-06-30 | 学校法人近畿大学 | 悪性腫瘍疾患の改善用医薬組成物 |
TW202402269A (zh) * | 2022-05-26 | 2024-01-16 | 大陸商迪哲(江蘇)醫藥股份有限公司 | ROCK(Rho相關激酶)抑制劑及其用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3990061B2 (ja) * | 1998-01-05 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プリン誘導体および糖尿病の予防・治療剤としてのアデノシンa2受容体拮抗剤 |
DE19948417A1 (de) * | 1999-10-07 | 2001-04-19 | Morphochem Ag | Imidazol-Derivate und ihre Verwendung als Arzneimittel |
CA2564356A1 (en) | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
TW200736260A (en) * | 2005-11-10 | 2007-10-01 | Smithkline Beecham Corp | Inhibitors of Akt activity |
DE102008005493A1 (de) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
CA2728767A1 (en) * | 2008-06-26 | 2009-12-30 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
EP2320895A2 (en) | 2008-07-03 | 2011-05-18 | Exelixis, Inc. | Cdk modulators |
WO2010042337A1 (en) * | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
CN103476768B (zh) * | 2011-03-16 | 2015-07-08 | 弗·哈夫曼-拉罗切有限公司 | 6,5-杂环炔丙醇化合物及其用途 |
TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
TWI704146B (zh) * | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作NIK抑制劑之新的1-(4-嘧啶基)-1H-吡唑並[3,2-c]吡啶衍生物 |
TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為NIK抑制劑的新穎3-(1H-吡唑-4-基)-1H-吡咯并[2,3-c]吡啶衍生物 |
WO2016062792A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New compounds as nik inhibitors |
MX371151B (es) | 2014-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK). |
CN107074818B (zh) | 2014-10-23 | 2020-04-17 | 詹森药业有限公司 | 作为nik抑制剂的吡唑衍生物 |
ES2715104T3 (es) | 2014-10-23 | 2019-05-31 | Janssen Pharmaceutica Nv | Nuevos derivados de pirazolopirimidina como inhibidores de nik |
-
2014
- 2014-09-24 TW TW103132895A patent/TWI627173B/zh not_active IP Right Cessation
- 2014-09-25 MX MX2016003863A patent/MX365739B/es active IP Right Grant
- 2014-09-25 EA EA201690657A patent/EA028101B1/ru not_active IP Right Cessation
- 2014-09-25 JP JP2016516870A patent/JP6404332B2/ja active Active
- 2014-09-25 KR KR1020167007902A patent/KR102317335B1/ko active IP Right Grant
- 2014-09-25 AU AU2014327235A patent/AU2014327235B2/en not_active Ceased
- 2014-09-25 WO PCT/EP2014/070489 patent/WO2015044269A1/en active Application Filing
- 2014-09-25 CA CA2922633A patent/CA2922633C/en active Active
- 2014-09-25 CN CN201480052798.2A patent/CN105579452B/zh active Active
- 2014-09-25 BR BR112016006232-9A patent/BR112016006232B1/pt not_active IP Right Cessation
- 2014-09-25 EP EP14776635.6A patent/EP3049412B1/en active Active
- 2014-09-25 ES ES14776635.6T patent/ES2643070T3/es active Active
- 2014-09-25 US US15/024,724 patent/US9981963B2/en active Active
-
2016
- 2016-03-22 IL IL244702A patent/IL244702B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EA201690657A1 (ru) | 2016-08-31 |
KR20160060054A (ko) | 2016-05-27 |
IL244702A0 (en) | 2016-04-21 |
JP6404332B2 (ja) | 2018-10-10 |
KR102317335B1 (ko) | 2021-10-26 |
CA2922633A1 (en) | 2015-04-02 |
ES2643070T3 (es) | 2017-11-21 |
BR112016006232B1 (pt) | 2022-11-29 |
EA028101B1 (ru) | 2017-10-31 |
CN105579452A (zh) | 2016-05-11 |
EP3049412B1 (en) | 2017-07-12 |
WO2015044269A1 (en) | 2015-04-02 |
CA2922633C (en) | 2022-07-26 |
IL244702B (en) | 2019-07-31 |
TWI627173B (zh) | 2018-06-21 |
CN105579452B (zh) | 2018-01-23 |
US20160229851A1 (en) | 2016-08-11 |
AU2014327235B2 (en) | 2018-02-08 |
AU2014327235A1 (en) | 2016-03-17 |
MX2016003863A (es) | 2016-08-04 |
JP2016531858A (ja) | 2016-10-13 |
MX365739B (es) | 2019-06-12 |
EP3049412A1 (en) | 2016-08-03 |
US9981963B2 (en) | 2018-05-29 |
TW201602103A (zh) | 2016-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/09/2014, OBSERVADAS AS CONDICOES LEGAIS |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 10A ANUIDADE. |