BR112016006129A2 - preparação de 3-fluoropropil-nor-beta-cit radioiodado - Google Patents
preparação de 3-fluoropropil-nor-beta-cit radioiodadoInfo
- Publication number
- BR112016006129A2 BR112016006129A2 BR112016006129A BR112016006129A BR112016006129A2 BR 112016006129 A2 BR112016006129 A2 BR 112016006129A2 BR 112016006129 A BR112016006129 A BR 112016006129A BR 112016006129 A BR112016006129 A BR 112016006129A BR 112016006129 A2 BR112016006129 A2 BR 112016006129A2
- Authority
- BR
- Brazil
- Prior art keywords
- fluoropropyl
- radioiodinated
- cit
- preparation
- beta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. ***e
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
a presente invenção refere-se, em linhas gerais, aos processos para a preparação de 3-fluoropropil-nor-ß-cit radioiodado. particularmente, o processo usa um intermediário de arilsilano, evitando, portanto, o uso de hexametildiestanho, e reduzindo o número de etapas necessárias anteriormente para a preparação de 3-fluoropropil-nor-ß-cit radioiodado a partir de éster metilanidroecgonina. a invenção refere-se também à alquilação de um nortropano para o análogo correspondente de n-(3-fluoropropil), utilizando 3-fluoropropanal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361882039P | 2013-09-25 | 2013-09-25 | |
| PCT/US2014/057404 WO2015048250A1 (en) | 2013-09-25 | 2014-09-25 | Preparation of radioiodinated 3-fluoropropyl-nor-beta-cit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016006129A2 true BR112016006129A2 (pt) | 2017-08-01 |
Family
ID=52691501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016006129A BR112016006129A2 (pt) | 2013-09-25 | 2014-09-25 | preparação de 3-fluoropropil-nor-beta-cit radioiodado |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9339565B2 (pt) |
| EP (1) | EP3049378B1 (pt) |
| JP (2) | JP6224256B2 (pt) |
| AU (1) | AU2014326601B2 (pt) |
| BR (1) | BR112016006129A2 (pt) |
| CA (1) | CA2922723C (pt) |
| ES (1) | ES2711122T3 (pt) |
| MX (1) | MX2016003035A (pt) |
| PL (1) | PL3049378T3 (pt) |
| TR (1) | TR201901758T4 (pt) |
| WO (1) | WO2015048250A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX343345B (es) | 2010-05-12 | 2016-11-01 | Nestec Sa | Soporte y cápsula para preparar una bebida por centrifugación, sistema y método para preparar una bebida por centrifugación. |
| US9513907B2 (en) * | 2013-08-06 | 2016-12-06 | Intel Corporation | Methods, apparatus, instructions and logic to provide vector population count functionality |
| CA3025145A1 (en) | 2015-05-22 | 2016-12-01 | Translational Drug Development Llc | Benzamide and active compound compositions and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4190601A (en) * | 1978-05-31 | 1980-02-26 | Union Carbide Corporation | Production of tertiary amines by reductive alkylation |
| US6123917A (en) * | 1990-08-09 | 2000-09-26 | Research Triangle Institute | Method for making ***e receptor binding ligands and intermediates therefor |
| US5698179A (en) * | 1992-02-25 | 1997-12-16 | Neuro Imaging Technologies, Llc | Iodinated neuroprobe for mapping monoamine reuptake sites |
| AU5194798A (en) * | 1996-10-29 | 1998-05-22 | Guilford Pharmaceuticals Inc. | Process for the preparation of radiopharmaceuticals |
| FI104048B (fi) * | 1997-06-16 | 1999-11-15 | Map Medical Technologies Oy | Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön |
| CA2285516C (en) * | 1999-05-12 | 2010-12-07 | President And Fellows Of Harvard College | Dopamine transporter imaging agents |
| JP2001213881A (ja) * | 2000-02-02 | 2001-08-07 | Nihon Medi Physics Co Ltd | アンヒドロエクゴニン誘導体の合成法 |
| US7309790B2 (en) * | 2003-10-03 | 2007-12-18 | Pfizer Inc | Chemical compounds |
| KR100789847B1 (ko) * | 2004-12-15 | 2007-12-28 | (주)퓨쳐켐 | 알코올 용매하에서 유기플루오로 화합물의 제조방법 |
| AU2008324186B2 (en) * | 2007-11-07 | 2014-02-13 | Ge Healthcare Bv | Stabilization of radiopharmaceuticals |
| JP5778042B2 (ja) * | 2009-02-17 | 2015-09-16 | マリンクロッド エルエルシー | ノルモルフィナンの還元的アルキル化のためのプロセス |
| GB0922023D0 (en) * | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Preparation of n-monofluoroalkyl compounds |
-
2014
- 2014-09-25 AU AU2014326601A patent/AU2014326601B2/en active Active
- 2014-09-25 EP EP14849233.3A patent/EP3049378B1/en active Active
- 2014-09-25 CA CA2922723A patent/CA2922723C/en active Active
- 2014-09-25 MX MX2016003035A patent/MX2016003035A/es unknown
- 2014-09-25 WO PCT/US2014/057404 patent/WO2015048250A1/en active Application Filing
- 2014-09-25 US US14/496,376 patent/US9339565B2/en active Active
- 2014-09-25 PL PL14849233T patent/PL3049378T3/pl unknown
- 2014-09-25 JP JP2016545225A patent/JP6224256B2/ja active Active
- 2014-09-25 ES ES14849233T patent/ES2711122T3/es active Active
- 2014-09-25 TR TR2019/01758T patent/TR201901758T4/tr unknown
- 2014-09-25 BR BR112016006129A patent/BR112016006129A2/pt not_active Application Discontinuation
-
2017
- 2017-09-22 JP JP2017182197A patent/JP6423936B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015048250A1 (en) | 2015-04-02 |
| JP2016533390A (ja) | 2016-10-27 |
| AU2014326601A1 (en) | 2016-03-17 |
| JP6224256B2 (ja) | 2017-11-01 |
| US20150087838A1 (en) | 2015-03-26 |
| TR201901758T4 (tr) | 2019-03-21 |
| EP3049378B1 (en) | 2018-12-05 |
| EP3049378A1 (en) | 2016-08-03 |
| JP2017218460A (ja) | 2017-12-14 |
| MX2016003035A (es) | 2016-06-10 |
| CA2922723C (en) | 2022-04-19 |
| PL3049378T3 (pl) | 2019-06-28 |
| AU2014326601B2 (en) | 2018-01-18 |
| ES2711122T3 (es) | 2019-04-30 |
| CA2922723A1 (en) | 2015-04-02 |
| US9339565B2 (en) | 2016-05-17 |
| EP3049378A4 (en) | 2017-04-19 |
| JP6423936B2 (ja) | 2018-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |