BR112015030208A2 - Métodos para produzir um produto de fermentação e um micro-organismo, e, micro-organismo recombinante - Google Patents
Métodos para produzir um produto de fermentação e um micro-organismo, e, micro-organismo recombinanteInfo
- Publication number
- BR112015030208A2 BR112015030208A2 BR112015030208A BR112015030208A BR112015030208A2 BR 112015030208 A2 BR112015030208 A2 BR 112015030208A2 BR 112015030208 A BR112015030208 A BR 112015030208A BR 112015030208 A BR112015030208 A BR 112015030208A BR 112015030208 A2 BR112015030208 A2 BR 112015030208A2
- Authority
- BR
- Brazil
- Prior art keywords
- microorganism
- fermentation
- producing
- recombinant
- fermentation product
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
- C12Y102/07001—Pyruvate synthase (1.2.7.1), i.e. pyruvate ferredoxin oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
- C12Y102/07005—Aldehyde ferredoxin oxidoreductase (1.2.7.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01196—Cobalt-precorrin-7 (C15)-methyltransferase (decarboxylating) (2.1.1.196)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
MÉTODO PARA PRODUZIR UM PRODUTO DE FERMENTAÇÃO E UM MICRO-ORGANISMO E MICRO-ORGANISMO RECOMBINANTE. A invenção fornece métodos para aumentar a produção de produtos de fermentação através do aumento do fluxo através de uma via de fermentação pela otimização de reações enzimáticas. Em particular, a invenção se refere a identificação de enzimas e/ou fatores envolvidos em congestionamentos metabólicos em vias de fermentação e a fermentação de um substrato que compreende CO com um micro-organismo Clostridia carboxitrófico recombinante adaptada para exibir atividade aumentada das uma ou mais das ditas enzimas ou disponibilidade aumentada dos um ou mais dos ditos cofatores em comparação a um micro-organismo parental.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361831591P | 2013-06-05 | 2013-06-05 | |
PCT/US2014/041188 WO2014197746A1 (en) | 2013-06-05 | 2014-06-05 | Recombinant microorganisms exhibiting increased flux through a fermentation pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015030208A2 true BR112015030208A2 (pt) | 2017-08-22 |
Family
ID=52008601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015030208A BR112015030208A2 (pt) | 2013-06-05 | 2014-06-05 | Métodos para produzir um produto de fermentação e um micro-organismo, e, micro-organismo recombinante |
Country Status (10)
Country | Link |
---|---|
US (1) | US20150079650A1 (pt) |
EP (1) | EP3004362A4 (pt) |
JP (1) | JP2016520325A (pt) |
KR (1) | KR20160018568A (pt) |
CN (1) | CN105283554A (pt) |
AU (2) | AU2014274838A1 (pt) |
BR (1) | BR112015030208A2 (pt) |
CA (1) | CA2914003C (pt) |
EA (1) | EA201592169A1 (pt) |
WO (1) | WO2014197746A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2816119A1 (en) * | 2013-06-18 | 2014-12-24 | Johann Wolfgang Goethe-Universität | Method for storing gaseous hydrogen through producing methanoate (formate) |
HUE052810T2 (hu) * | 2014-12-08 | 2021-05-28 | Lanzatech New Zealand Ltd | Rekombináns mikroorganizmusok, amelyek megnövekedett fluxust mutatnak fermetációs útvonalon keresztül |
CN104515851B (zh) * | 2015-01-08 | 2016-09-14 | 河南农业大学 | 一种直接测定厌氧微生物内氢化酶或一氧化碳脱氢酶活性的方法与装置 |
CN105624182A (zh) * | 2015-12-15 | 2016-06-01 | 重庆大学 | 生产四氢叶酸的重组质粒、基因工程菌株构建及应用 |
US10240170B2 (en) * | 2016-01-06 | 2019-03-26 | C1Chem Co., Ltd. | CO hydratase and method for producing formate using the same |
KR20230044031A (ko) * | 2016-05-14 | 2023-03-31 | 란자테크, 인크. | 알데히드:페레독신 옥시도리덕타제 활성이 변경된 미생물 및 관련 방법 |
CN108330094B (zh) * | 2018-01-10 | 2020-04-21 | 上海晶诺生物科技有限公司 | 一种产烟酸的游离型重组耻垢分枝杆菌及其构建方法 |
CN109810991B (zh) * | 2019-03-02 | 2021-11-12 | 昆明理工大学 | 二氢蝶酸合酶基因folP的用途 |
WO2020188033A1 (en) | 2019-03-20 | 2020-09-24 | Global Bioenergies | Improved means and methods for producing isobutene from acetyl-coa |
CN111089914A (zh) * | 2019-11-07 | 2020-05-01 | 河北首朗新能源科技有限公司 | 微生物发酵生产乙醇中代谢物的高效液相检测方法 |
CN111235169A (zh) * | 2020-02-03 | 2020-06-05 | 昆明理工大学 | 一种GTP环化水解酶I基因folE及应用 |
CN114480562B (zh) * | 2022-01-27 | 2023-09-19 | 西南医科大学附属医院 | 一种基于pfor酶活性导向的fmt供体筛选方法及其应用 |
Family Cites Families (22)
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US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
JPH07155184A (ja) * | 1993-12-08 | 1995-06-20 | Ajinomoto Co Inc | 発酵法によるl−リジンの製造法 |
UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
DE60121335T2 (de) | 2000-07-25 | 2007-08-02 | Emmaus Foundation, Inc., Fayetteville | Verfahren zur steigerung der ethanolproduktion bei der mikrobiellen fermentation |
WO2002012528A2 (en) * | 2000-08-04 | 2002-02-14 | Genencor International, Inc. | Enhanced 2-keto-l-gulonic acid production |
ATE543873T1 (de) * | 2003-12-04 | 2012-02-15 | Novozymes As | Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase |
JP4633519B2 (ja) * | 2005-03-31 | 2011-02-16 | 明治製菓株式会社 | ミデカマイシン高生産菌 |
US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
CN102876609A (zh) | 2007-11-13 | 2013-01-16 | 兰扎泰克新西兰有限公司 | 新型菌及其使用方法 |
KR20130084704A (ko) * | 2008-03-12 | 2013-07-25 | 란자테크 뉴질랜드 리미티드 | 미생물 알콜 생산 방법 |
KR101643429B1 (ko) * | 2008-06-09 | 2016-07-27 | 란자테크 뉴질랜드 리미티드 | 혐기성 미생물 발효에 의한 부탄디올의 생산 방법 |
US8039239B2 (en) * | 2008-12-16 | 2011-10-18 | Coskata, Inc. | Recombinant microorganisms having modified production of alcohols and acids |
BRPI0922276A2 (pt) * | 2008-12-16 | 2015-08-04 | Genomatica Inc | "organismo microbiano de ocorrência não-natural, e , método para produzir isopropanol, 4-hidroxibutirato,e, 1,4-butanodiol." |
CN102625845A (zh) * | 2009-09-09 | 2012-08-01 | 基因组股份公司 | 协同产生异丙醇与伯醇,二元醇和酸的微生物和方法 |
US8143037B2 (en) | 2010-03-19 | 2012-03-27 | Coskata, Inc. | Ethanologenic Clostridium species, Clostridium coskatii |
WO2011155954A1 (en) * | 2010-06-09 | 2011-12-15 | Coskata, Inc. | Cloning and expression of the genes encoding key clostridial catalyzing mechanisms for syngas to ethanol production and functional characterization thereof |
US20110236941A1 (en) * | 2010-10-22 | 2011-09-29 | Lanzatech New Zealand Limited | Recombinant microorganism and methods of production thereof |
KR101840899B1 (ko) * | 2010-12-03 | 2018-03-21 | 이네오스 바이오 에스에이 | 수소를 포함하는 가스 기질의 발효의 수행 방법 |
US8993303B2 (en) * | 2011-02-24 | 2015-03-31 | South Dakota State University | Genetically engineered cyanobacteria |
CN108486169B (zh) * | 2011-02-25 | 2022-08-12 | 朗泽科技新西兰有限公司 | 重组微生物及其用途 |
WO2012177599A2 (en) * | 2011-06-22 | 2012-12-27 | Genomatica, Inc. | Microorganisms for producing n-propanol 1, 3-propanediol, 1,2-propanediol or glycerol and methods related thereto |
-
2014
- 2014-06-05 CN CN201480031665.7A patent/CN105283554A/zh active Pending
- 2014-06-05 EA EA201592169A patent/EA201592169A1/ru unknown
- 2014-06-05 CA CA2914003A patent/CA2914003C/en not_active Expired - Fee Related
- 2014-06-05 EP EP14807846.2A patent/EP3004362A4/en not_active Withdrawn
- 2014-06-05 WO PCT/US2014/041188 patent/WO2014197746A1/en active Application Filing
- 2014-06-05 AU AU2014274838A patent/AU2014274838A1/en not_active Abandoned
- 2014-06-05 US US14/297,577 patent/US20150079650A1/en not_active Abandoned
- 2014-06-05 KR KR1020157035934A patent/KR20160018568A/ko not_active Application Discontinuation
- 2014-06-05 JP JP2016518016A patent/JP2016520325A/ja active Pending
- 2014-06-05 BR BR112015030208A patent/BR112015030208A2/pt not_active Application Discontinuation
-
2018
- 2018-06-08 AU AU2018204112A patent/AU2018204112A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20150079650A1 (en) | 2015-03-19 |
AU2018204112A1 (en) | 2018-06-28 |
JP2016520325A (ja) | 2016-07-14 |
WO2014197746A1 (en) | 2014-12-11 |
KR20160018568A (ko) | 2016-02-17 |
CA2914003C (en) | 2018-01-02 |
EP3004362A1 (en) | 2016-04-13 |
EA201592169A1 (ru) | 2016-04-29 |
CA2914003A1 (en) | 2014-12-11 |
EP3004362A4 (en) | 2017-01-11 |
CN105283554A (zh) | 2016-01-27 |
AU2014274838A1 (en) | 2015-12-24 |
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