BR112015010498A2 - sistemas e métodos para contagem de plaquetas com ajuste de aglomerações - Google Patents
sistemas e métodos para contagem de plaquetas com ajuste de aglomeraçõesInfo
- Publication number
- BR112015010498A2 BR112015010498A2 BR112015010498A BR112015010498A BR112015010498A2 BR 112015010498 A2 BR112015010498 A2 BR 112015010498A2 BR 112015010498 A BR112015010498 A BR 112015010498A BR 112015010498 A BR112015010498 A BR 112015010498A BR 112015010498 A2 BR112015010498 A2 BR 112015010498A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- systems
- platelet
- cluster adjustment
- platelet counting
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000012472 biological sample Substances 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/018—Platelets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1493—Particle size
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4915—Blood using flow cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
Abstract
resumo patente de invenção: "sistemas e métodos para contagem de plaquetas com ajuste de aglomerações". as modalidades da presente invenção abrangem sistemas e métodos automatizados para analisar os parâmetros das plaquetas em um indivíduo com base em uma amostra biológica obtida a partir do sangue do indivíduo. as técnicas exemplificadoras envolvem correlacionar aspectos de dados da impedância de corrente contínua (cc) e/ou de medição de luz obtidos a partir da amostra biológica com uma avaliação das condições das plaquetas no indivíduo.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261747655P | 2012-12-31 | 2012-12-31 | |
US61/747,655 | 2012-12-31 | ||
US14/145,608 | 2013-12-31 | ||
US14/145,608 US9176112B2 (en) | 2012-12-31 | 2013-12-31 | Systems and methods for platelet count with clump adjustment |
PCT/US2013/078543 WO2014106270A1 (en) | 2012-12-31 | 2013-12-31 | Systems and methods for platelet count with clump adjustment |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015010498A2 true BR112015010498A2 (pt) | 2017-07-11 |
BR112015010498B1 BR112015010498B1 (pt) | 2020-09-29 |
Family
ID=51016868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015010498-3A BR112015010498B1 (pt) | 2012-12-31 | 2013-12-31 | Sistema de hematologia para determinar uma contagem de plaquetas em uma amostra biológica, e método automatizado para determinar uma contagem de plaquetas em uma amostra biológica |
Country Status (9)
Country | Link |
---|---|
US (1) | US9176112B2 (pt) |
EP (1) | EP2939001B1 (pt) |
JP (2) | JP6427108B2 (pt) |
KR (1) | KR101991989B1 (pt) |
CN (1) | CN104755905B (pt) |
BR (1) | BR112015010498B1 (pt) |
ES (1) | ES2772453T3 (pt) |
IN (1) | IN2015DN02927A (pt) |
WO (1) | WO2014106270A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9612221B2 (en) * | 2014-10-14 | 2017-04-04 | Chem-Aqua, Inc. + Pyxis Lab, Inc. | Opto-electrochemical sensing system for monitoring and controlling industrial fluids |
CN108463722B (zh) * | 2016-03-30 | 2021-09-21 | 西门子医疗保健诊断公司 | 用于处理血小板细胞数据的***、方法和设备 |
KR101895760B1 (ko) * | 2016-06-27 | 2018-09-06 | (주)뉴옵틱스 | 혈구 분석 시스템 및 그의 제어방법 |
EP3630342B1 (en) * | 2017-05-25 | 2022-03-30 | Abbott Laboratories | Methods and systems for sample analysis |
CN114302761A (zh) * | 2019-05-09 | 2022-04-08 | 特鲁维安科学公司 | 逆转血小板聚集的方法和组合物 |
CN113015903B (zh) * | 2019-06-11 | 2024-05-14 | 深圳迈瑞生物医疗电子股份有限公司 | 样本检测方法及样本分析仪 |
CN112683743B (zh) * | 2021-03-12 | 2021-06-18 | 杭州晟视科技有限公司 | 血小板状态分析方法、装置、电子设备和存储介质 |
Family Cites Families (29)
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US4325706A (en) * | 1980-08-15 | 1982-04-20 | Ortho Diagnostic Systems Inc. | Automated detection of platelets and reticulocytes in whole blood |
KR970007077B1 (ko) | 1987-03-13 | 1997-05-02 | 코울터 일렉트로닉스 인커퍼레이티드 | 광산란 기술을 이용한 다중-부분식별 분석 방법 |
US5540494A (en) * | 1994-06-03 | 1996-07-30 | Purvis, Jr.; Norman B. | Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry |
US5891734A (en) * | 1994-08-01 | 1999-04-06 | Abbott Laboratories | Method for performing automated analysis |
US6025201A (en) * | 1995-12-28 | 2000-02-15 | Bayer Corporation | Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
US6133995A (en) | 1997-05-09 | 2000-10-17 | Sysmex Corporation | Particle measuring apparatus |
JP4817270B2 (ja) * | 1997-05-13 | 2011-11-16 | シスメックス株式会社 | 粒子測定装置 |
US6235536B1 (en) * | 1998-03-07 | 2001-05-22 | Robert A. Levine | Analysis of quiescent anticoagulated whole blood samples |
US6228652B1 (en) | 1999-02-16 | 2001-05-08 | Coulter International Corp. | Method and apparatus for analyzing cells in a whole blood sample |
EP1425696A2 (en) | 2001-09-12 | 2004-06-09 | Burstein Technologies, Inc. | Methods for differential cell counts including related apparatus and software for performing same |
CN100468058C (zh) * | 2001-12-11 | 2009-03-11 | 株式会社奈特克 | 血细胞分离体系 |
JP4134043B2 (ja) * | 2002-12-02 | 2008-08-13 | 旭化成メディカル株式会社 | 白血球除去方法、白血球除去フィルター及びその使用 |
US7008792B2 (en) * | 2004-02-10 | 2006-03-07 | Beckman Coulter, Inc. | Method of measurement of nucleated red blood cells |
US7208319B2 (en) * | 2004-02-10 | 2007-04-24 | Beckman Coulter, Inc. | Method of measurement of nucleated red blood cells |
US7390662B2 (en) * | 2005-11-09 | 2008-06-24 | Beckman Coulter, Inc. | Method and apparatus for performing platelet measurement |
US7796797B2 (en) | 2005-09-28 | 2010-09-14 | Sysmex Corporation | Apparatus for obtaining an image of a blood cell and method for obtaining an image of a blood cell |
US7344890B2 (en) * | 2005-11-09 | 2008-03-18 | Beckman Coulter, Inc. | Method for discriminating platelets from red blood cells |
JP4976038B2 (ja) * | 2006-03-29 | 2012-07-18 | シスメックス株式会社 | 血液学的試料の測定方法 |
US8293524B2 (en) | 2006-03-31 | 2012-10-23 | Fluxion Biosciences Inc. | Methods and apparatus for the manipulation of particle suspensions and testing thereof |
JP4829716B2 (ja) * | 2006-08-18 | 2011-12-07 | シスメックス株式会社 | 血液凝固分析装置 |
US7674622B2 (en) * | 2006-12-22 | 2010-03-09 | Abbott Laboratories, Inc. | Method for determination of nucleated red blood cells and leukocytes in a whole blood sample in an automated hematology analyzer |
WO2009058876A1 (en) | 2007-10-29 | 2009-05-07 | Beckman Coulter, Inc. | Method for a rapid antibody-based analysis of platelet populations |
EP2271937B1 (en) * | 2008-03-21 | 2016-01-13 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
US8094299B2 (en) | 2008-07-24 | 2012-01-10 | Beckman Coulter, Inc. | Transducer module |
CN102150042B (zh) * | 2008-08-11 | 2014-12-10 | 藤森工业株式会社 | 血小板检验方法和血小板检验装置 |
US8417012B2 (en) | 2008-11-04 | 2013-04-09 | Beckman Coulter, Inc. | Non-linear histogram segmentation for particle analysis |
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ES2961409T3 (es) * | 2011-04-15 | 2024-03-11 | Roche Diagnostics Hematology Inc | Sistema y procedimiento para determinar un volumen plaquetario para una muestra de sangre, programa informático y medio legible por ordenador |
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2013
- 2013-12-31 CN CN201380055039.7A patent/CN104755905B/zh active Active
- 2013-12-31 IN IN2927DEN2015 patent/IN2015DN02927A/en unknown
- 2013-12-31 EP EP13824578.2A patent/EP2939001B1/en active Active
- 2013-12-31 KR KR1020157013097A patent/KR101991989B1/ko active IP Right Grant
- 2013-12-31 JP JP2015551070A patent/JP6427108B2/ja active Active
- 2013-12-31 US US14/145,608 patent/US9176112B2/en active Active
- 2013-12-31 ES ES13824578T patent/ES2772453T3/es active Active
- 2013-12-31 BR BR112015010498-3A patent/BR112015010498B1/pt active IP Right Grant
- 2013-12-31 WO PCT/US2013/078543 patent/WO2014106270A1/en active Application Filing
-
2018
- 2018-01-09 JP JP2018001240A patent/JP2018077247A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20150100634A (ko) | 2015-09-02 |
CN104755905B (zh) | 2018-07-03 |
EP2939001A1 (en) | 2015-11-04 |
US9176112B2 (en) | 2015-11-03 |
WO2014106270A1 (en) | 2014-07-03 |
JP2018077247A (ja) | 2018-05-17 |
KR101991989B1 (ko) | 2019-06-21 |
JP2016508224A (ja) | 2016-03-17 |
US20140185031A1 (en) | 2014-07-03 |
BR112015010498B1 (pt) | 2020-09-29 |
IN2015DN02927A (pt) | 2015-09-18 |
CN104755905A (zh) | 2015-07-01 |
EP2939001B1 (en) | 2019-12-04 |
JP6427108B2 (ja) | 2018-11-21 |
ES2772453T3 (es) | 2020-07-07 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/12/2013, OBSERVADAS AS CONDICOES LEGAIS. |