BR112013027124A2 - método e sistema para analisar características de tecido - Google Patents

método e sistema para analisar características de tecido

Info

Publication number
BR112013027124A2
BR112013027124A2 BR112013027124A BR112013027124A BR112013027124A2 BR 112013027124 A2 BR112013027124 A2 BR 112013027124A2 BR 112013027124 A BR112013027124 A BR 112013027124A BR 112013027124 A BR112013027124 A BR 112013027124A BR 112013027124 A2 BR112013027124 A2 BR 112013027124A2
Authority
BR
Brazil
Prior art keywords
biomarkers
association
tissue characteristics
analyzing tissue
moments
Prior art date
Application number
BR112013027124A
Other languages
English (en)
Inventor
Colin Craig Mcculloch
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Electric filed Critical Gen Electric
Publication of BR112013027124A2 publication Critical patent/BR112013027124A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/211—Selection of the most significant subset of features
    • G06F18/2115—Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/771—Feature selection, e.g. selecting representative features from a multi-dimensional feature space
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Data Mining & Analysis (AREA)
  • Artificial Intelligence (AREA)
  • Multimedia (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Software Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Hospice & Palliative Care (AREA)
  • Computing Systems (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)

Abstract

método e sistema para analisar características de tecido um conjunto de dados armazenados compreende dados do perfil celular incluindo dados de imagem biométrica multiplexada descrevendo a expressão de biomarcadores. o conjunto de dados inclui uma associação dos dados de perfil celular com um nível de campo de visão ou uma avaliação do nível de paciente. características das células são calculadas com base na expressão da célula de cada um dos biomarcadores. momentos de características celulares são calculados a partir do conjunto de dados, e combinações são examinadas para uma associação com uma avaliação. um conjunto preditivo de momentos é selecionado com base no desempenho da combinação.
BR112013027124A 2011-04-22 2012-04-23 método e sistema para analisar características de tecido BR112013027124A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161478224P 2011-04-22 2011-04-22
US13/252,078 US20120269419A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with moments
US13/252,080 US20120271553A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,072 US20120269418A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,069 US20120270752A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with moments
PCT/EP2012/057390 WO2012143558A2 (en) 2011-04-22 2012-04-23 Analyzing the expression of biomarkers in cells with moments

Publications (1)

Publication Number Publication Date
BR112013027124A2 true BR112013027124A2 (pt) 2017-01-10

Family

ID=47021377

Family Applications (4)

Application Number Title Priority Date Filing Date
BR112013027123A BR112013027123A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células
BR112013027125A BR112013027125A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit
BR112013027124A BR112013027124A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido
BR112013027122A BR112013027122A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BR112013027123A BR112013027123A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células
BR112013027125A BR112013027125A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112013027122A BR112013027122A2 (pt) 2011-04-22 2012-04-23 método e sistema para analisar características de tecido, e, kit

Country Status (8)

Country Link
US (5) US20120271553A1 (pt)
EP (4) EP2700037A2 (pt)
JP (4) JP6063446B2 (pt)
BR (4) BR112013027123A2 (pt)
CA (4) CA2833804A1 (pt)
RU (3) RU2013145154A (pt)
SG (4) SG194588A1 (pt)
WO (4) WO2012143561A2 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201111594D0 (en) * 2011-07-06 2011-08-24 Equateq Ltd New improved process
CN105122114B (zh) * 2012-12-06 2018-07-27 通用电气医疗集团生物科学公司 用于生物样本的分屏显示和用于捕捉其记录的***和方法
US9488639B2 (en) * 2013-02-25 2016-11-08 Flagship Biosciences, Inc. Cell-based tissue analysis
US8995740B2 (en) 2013-04-17 2015-03-31 General Electric Company System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue
US20160146789A1 (en) * 2013-07-03 2016-05-26 Coyne Scientific, Llc Methods for Predicting Responses to Chemical or Biological Substances
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
US9298968B1 (en) * 2014-09-12 2016-03-29 Flagship Biosciences, Inc. Digital image analysis of inflammatory cells and mediators of inflammation
WO2016118860A1 (en) 2015-01-22 2016-07-28 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for determining proportions of distinct cell subsets
US10672505B2 (en) 2015-06-03 2020-06-02 General Electric Company Biological data annotation and visualization
US9953133B2 (en) 2015-06-03 2018-04-24 General Electric Company Biological data annotation and visualization
EP3395937A4 (en) * 2015-12-22 2019-08-21 Nikon Corporation IMAGE PROCESSING APPARATUS
US20180032681A1 (en) * 2016-07-29 2018-02-01 General Electric Company Biological feature analysis technique
US11436719B2 (en) 2017-02-16 2022-09-06 Kyoto University Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program
US10127696B2 (en) * 2017-03-22 2018-11-13 Sas Institute Inc. Computer system to generate scalable plots using clustering
EP3616213A2 (en) 2017-04-28 2020-03-04 4D Path Inc. Apparatus, systems, and methods for rapid cancer detection
KR101990430B1 (ko) * 2017-06-22 2019-06-18 한국과학기술원 암의 재발 예후 예측을 위한 바이오마커 발굴 시스템 및 방법
US10706328B2 (en) 2018-05-07 2020-07-07 Google Llc Focus-weighted, machine learning disease classifier error prediction for microscope slide images
US10971255B2 (en) * 2018-09-14 2021-04-06 Zasti Inc. Multimodal learning framework for analysis of clinical trials
WO2020068684A2 (en) 2018-09-24 2020-04-02 Krishnan Ramanathan Hybrid analysis framework for prediction of outcomes in clinical trials
US11128667B2 (en) * 2018-11-29 2021-09-21 Rapid7, Inc. Cluster detection and elimination in security environments
SG11202105063QA (en) * 2018-11-29 2021-06-29 Somalogic Inc Methods for determining disease risk combining downsampling of class-imbalanced sets with survival analysis
CN113158982A (zh) * 2021-05-17 2021-07-23 广东中卡云计算有限公司 一种半介入式的目标关键点标注方法
JP7368679B2 (ja) * 2021-09-01 2023-10-25 イミュニティリサーチ株式会社 細胞集団同定システム、方法、およびプログラム
IT202200001817A1 (it) 2022-02-02 2023-08-02 Aizoon S R L Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico
IT202200005861A1 (it) 2022-03-24 2023-09-24 Aizoon S R L Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico
US20240028964A1 (en) 2022-07-25 2024-01-25 Aizoon S.r.l. Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6463438B1 (en) * 1994-06-03 2002-10-08 Urocor, Inc. Neural network for cell image analysis for identification of abnormal cells
US5740269A (en) * 1994-09-20 1998-04-14 Neopath, Inc. Method and apparatus for robust biological specimen classification
US6996549B2 (en) * 1998-05-01 2006-02-07 Health Discovery Corporation Computer-aided image analysis
US6282305B1 (en) * 1998-06-05 2001-08-28 Arch Development Corporation Method and system for the computerized assessment of breast cancer risk
US6337472B1 (en) * 1998-10-19 2002-01-08 The University Of Texas System Board Of Regents Light imaging microscope having spatially resolved images
EP1425302A2 (en) * 2001-01-24 2004-06-09 Protein Design Labs Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
WO2004013658A2 (en) * 2002-07-30 2004-02-12 Deutsches Krebsforschungszentrum Method and apparatus for multiple labeling detection and evaluation of a plurality of particles
US20040121413A1 (en) * 2002-12-20 2004-06-24 Aebersold Rudolf H. Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions
US20050265588A1 (en) * 2004-02-03 2005-12-01 Bioimagene, Inc. Method and system for digital image based flourescent in situ hybridization (FISH) analysis
EP2386854A1 (en) * 2005-04-19 2011-11-16 Prediction Sciences LLC Diagnostic markers of breast cancer treatment and progression and methods of use thereof
US8041090B2 (en) * 2005-09-10 2011-10-18 Ge Healthcare Uk Limited Method of, and apparatus and computer software for, performing image processing
US7933435B2 (en) * 2005-11-21 2011-04-26 Vala Sciences, Inc. System, method, and kit for processing a magnified image of biological material to identify components of a biological object
JP5406019B2 (ja) * 2006-05-17 2014-02-05 セルーメン、インコーポレイテッド 自動化組織分析のための方法
US8019134B2 (en) * 2006-11-16 2011-09-13 Definiens Ag Automatic image analysis and quantification for fluorescence in situ hybridization
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
EP2132327A2 (en) * 2007-03-27 2009-12-16 Rosetta Genomics Ltd Gene expression signature for classification of cancers
WO2008137912A1 (en) * 2007-05-07 2008-11-13 Ge Healthcare Bio-Sciences Corp. System and method for the automated analysis of cellular assays and tissues
WO2008143849A2 (en) * 2007-05-14 2008-11-27 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
CN102395682B (zh) * 2007-09-06 2015-09-30 生物治疗诊断股份有限公司 肿瘤分级和癌症预后
CA3074969C (en) * 2008-07-25 2023-06-13 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
US9779213B2 (en) * 2008-07-25 2017-10-03 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud System for evaluating a pathological stage of prostate cancer
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
US8320655B2 (en) * 2009-10-16 2012-11-27 General Electric Company Process and system for analyzing the expression of biomarkers in cells
WO2011087778A1 (en) * 2009-12-22 2011-07-21 The Children's Hospital Of Philadelphia Automated quantitative multidimensional volumetric analysis and visualization

Also Published As

Publication number Publication date
JP2014516413A (ja) 2014-07-10
WO2012143561A2 (en) 2012-10-26
US20120270752A1 (en) 2012-10-25
EP2700042A2 (en) 2014-02-26
RU2013145154A (ru) 2015-05-27
JP6163152B2 (ja) 2017-07-12
SG194594A1 (en) 2013-12-30
US20120271553A1 (en) 2012-10-25
WO2012143562A3 (en) 2013-02-28
US20140185905A1 (en) 2014-07-03
EP2700037A2 (en) 2014-02-26
EP2700042B1 (en) 2021-03-17
WO2012143562A2 (en) 2012-10-26
CA2833804A1 (en) 2012-10-26
WO2012143561A3 (en) 2013-05-23
JP2014521925A (ja) 2014-08-28
JP6143743B2 (ja) 2017-06-07
BR112013027123A2 (pt) 2017-01-10
EP2700038B1 (en) 2021-04-21
BR112013027122A2 (pt) 2017-01-10
JP2014521926A (ja) 2014-08-28
CA2833295A1 (en) 2012-10-26
WO2012143558A2 (en) 2012-10-26
EP2700038A2 (en) 2014-02-26
WO2012143558A3 (en) 2012-12-20
US20120269419A1 (en) 2012-10-25
SG194590A1 (en) 2013-12-30
WO2012143556A2 (en) 2012-10-26
US20120269418A1 (en) 2012-10-25
WO2012143556A3 (en) 2013-05-30
JP6063446B2 (ja) 2017-01-18
JP6063447B2 (ja) 2017-01-18
JP2014517954A (ja) 2014-07-24
SG194592A1 (en) 2013-12-30
EP2700036A2 (en) 2014-02-26
RU2013145151A (ru) 2015-05-27
RU2013145162A (ru) 2015-05-27
CA2833497A1 (en) 2012-10-26
SG194588A1 (en) 2013-12-30
BR112013027125A2 (pt) 2017-01-10
CA2833428A1 (en) 2012-10-26

Similar Documents

Publication Publication Date Title
BR112013027124A2 (pt) método e sistema para analisar características de tecido
BR112013006764A2 (pt) método para avaliar um paciente, kit, meio legível por computador, método para avaliar um tratamento, método para avaliar o risco de um paciente, método para monitorar, método de diagnosticar, sistema de teste, método para classificar ou agrupar uma população de indivíduos, método para avaliar um desfecho substituto, método para tratar, uso de pelo menos um biomarcador, uso de um agente
ES2656962T3 (es) Métodos para evaluar la receptividad del endometrio de una paciente
MX2018012580A (es) Métodos y kits para el diagnóstico y la estratificación de riesgo en pacientes con isquemia.
BR112014031365A2 (pt) métodos de detectar doenças ou condições
EA201390150A1 (ru) Способы выявления сигнатур заболевания или патологических состояний в текучих средах организма
BR112014000965A2 (pt) método, e aparelho
BR112015015400A2 (pt) métodos e sistemas de enumeração de plaquetas imaturas
EA201270020A1 (ru) Определение риска развития атеросклеротической болезни сердца
BR112018015698A2 (pt) ?métodos diagnósticos e prognósticos para doenças cardiovasculares e eventos?
BR112012030587A2 (pt) métodos para diagnóstico de câncer pancreático, para identificar se um indivíduo precisa ou não de uma terapia contra câncer pancreático e para determinar se uma terapia contra câncer pancreático obtém sucesso, dispositivo para diagnóstico de câncer pancreático e uso de pelo menos um biomarcador
BR112014014841A2 (pt) sistema para suporte clínico para o monitoramento de um ou mais pacientes, método para o monitoramento de um ou mais pacientes, um ou mais processadores programados para realizarem o método, e, sistema para a avaliação da estabilidade de uma condição fisiológica de um paciente
NZ620799A (en) Molecular diagnostic test for cancer
BR112019006004A2 (pt) método e sistema para criação de um intervalo de referência personalizado, e, método para analisar associações clínicas.
BR112013003391A2 (pt) biomarcadores de câncer pancreático e usos dos mesmos
BR112015017767A2 (pt) sistema para detectar estágios do sono de um indivíduo, método para detectar estágios do sono de um indivíduo, e, sistema configurado para detectar estágios do sono de um indivíduo
BR112016010322A2 (pt) Método computadorizado de avaliação de risco de câncer de pulmão, meio legível por computador, sistema de avaliação de câncer de pulmão, e método de geração de um classificador para avaliação de risco de câncer de pulmão
DK2885641T3 (da) Fremgangsmådeer til forudsigelse af risiko for udvikling af hypertension
BR112015031729A2 (pt) sistema de classificação, métodos e kit para classificação, prognóstico e tratamento de câncer de mama
WO2012061510A3 (en) Methods of predicting cancer cell response to therapeutic agents
BR112015018213A2 (pt) método para determinar a síndrome da angústia respiratória aguda (ards) relacionada aos biomarcadores, um método para monitorar o desenvolvimento e o tratamento da ards em um paciente
BR112015030287A2 (pt) ensaios, métodos e kits para analisar a sensibilidade e resistência a fármacos anti-câncer, prevendo o prognóstico de um paciente oncológico e estratégias de tratamento personalizadas
PE20180930A1 (es) Composiciones y metodos para la vigilancia activa del cancer de prostata
BR112018008905A8 (pt) método, e sistema
BR112016006583A2 (pt) método e aparelho para prever sinal de excitação de alta banda, e decodificador

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]