BR112013027124A2 - método e sistema para analisar características de tecido - Google Patents
método e sistema para analisar características de tecidoInfo
- Publication number
- BR112013027124A2 BR112013027124A2 BR112013027124A BR112013027124A BR112013027124A2 BR 112013027124 A2 BR112013027124 A2 BR 112013027124A2 BR 112013027124 A BR112013027124 A BR 112013027124A BR 112013027124 A BR112013027124 A BR 112013027124A BR 112013027124 A2 BR112013027124 A2 BR 112013027124A2
- Authority
- BR
- Brazil
- Prior art keywords
- biomarkers
- association
- tissue characteristics
- analyzing tissue
- moments
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F18/00—Pattern recognition
- G06F18/20—Analysing
- G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
- G06F18/211—Selection of the most significant subset of features
- G06F18/2115—Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
- G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
- G06V10/771—Feature selection, e.g. selecting representative features from a multi-dimensional feature space
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
- G06V20/698—Matching; Classification
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Theoretical Computer Science (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Evolutionary Computation (AREA)
- Data Mining & Analysis (AREA)
- Artificial Intelligence (AREA)
- Multimedia (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Software Systems (AREA)
- General Engineering & Computer Science (AREA)
- Databases & Information Systems (AREA)
- Hospice & Palliative Care (AREA)
- Computing Systems (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Physiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Image Processing (AREA)
Abstract
método e sistema para analisar características de tecido um conjunto de dados armazenados compreende dados do perfil celular incluindo dados de imagem biométrica multiplexada descrevendo a expressão de biomarcadores. o conjunto de dados inclui uma associação dos dados de perfil celular com um nível de campo de visão ou uma avaliação do nível de paciente. características das células são calculadas com base na expressão da célula de cada um dos biomarcadores. momentos de características celulares são calculados a partir do conjunto de dados, e combinações são examinadas para uma associação com uma avaliação. um conjunto preditivo de momentos é selecionado com base no desempenho da combinação.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161478224P | 2011-04-22 | 2011-04-22 | |
US13/252,078 US20120269419A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with moments |
US13/252,080 US20120271553A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with clusters |
US13/252,072 US20120269418A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with clusters |
US13/252,069 US20120270752A1 (en) | 2011-04-22 | 2011-10-03 | Analyzing the expression of biomarkers in cells with moments |
PCT/EP2012/057390 WO2012143558A2 (en) | 2011-04-22 | 2012-04-23 | Analyzing the expression of biomarkers in cells with moments |
Publications (1)
Publication Number | Publication Date |
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BR112013027124A2 true BR112013027124A2 (pt) | 2017-01-10 |
Family
ID=47021377
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027123A BR112013027123A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células |
BR112013027125A BR112013027125A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, kit |
BR112013027124A BR112013027124A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido |
BR112013027122A BR112013027122A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, kit |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027123A BR112013027123A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, método de análise de características de agrupamento de células |
BR112013027125A BR112013027125A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, kit |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013027122A BR112013027122A2 (pt) | 2011-04-22 | 2012-04-23 | método e sistema para analisar características de tecido, e, kit |
Country Status (8)
Country | Link |
---|---|
US (5) | US20120271553A1 (pt) |
EP (4) | EP2700037A2 (pt) |
JP (4) | JP6063446B2 (pt) |
BR (4) | BR112013027123A2 (pt) |
CA (4) | CA2833804A1 (pt) |
RU (3) | RU2013145154A (pt) |
SG (4) | SG194588A1 (pt) |
WO (4) | WO2012143561A2 (pt) |
Families Citing this family (26)
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GB201111594D0 (en) * | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
CN105122114B (zh) * | 2012-12-06 | 2018-07-27 | 通用电气医疗集团生物科学公司 | 用于生物样本的分屏显示和用于捕捉其记录的***和方法 |
US9488639B2 (en) * | 2013-02-25 | 2016-11-08 | Flagship Biosciences, Inc. | Cell-based tissue analysis |
US8995740B2 (en) | 2013-04-17 | 2015-03-31 | General Electric Company | System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue |
US20160146789A1 (en) * | 2013-07-03 | 2016-05-26 | Coyne Scientific, Llc | Methods for Predicting Responses to Chemical or Biological Substances |
US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
US9298968B1 (en) * | 2014-09-12 | 2016-03-29 | Flagship Biosciences, Inc. | Digital image analysis of inflammatory cells and mediators of inflammation |
WO2016118860A1 (en) | 2015-01-22 | 2016-07-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for determining proportions of distinct cell subsets |
US10672505B2 (en) | 2015-06-03 | 2020-06-02 | General Electric Company | Biological data annotation and visualization |
US9953133B2 (en) | 2015-06-03 | 2018-04-24 | General Electric Company | Biological data annotation and visualization |
EP3395937A4 (en) * | 2015-12-22 | 2019-08-21 | Nikon Corporation | IMAGE PROCESSING APPARATUS |
US20180032681A1 (en) * | 2016-07-29 | 2018-02-01 | General Electric Company | Biological feature analysis technique |
US11436719B2 (en) | 2017-02-16 | 2022-09-06 | Kyoto University | Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program |
US10127696B2 (en) * | 2017-03-22 | 2018-11-13 | Sas Institute Inc. | Computer system to generate scalable plots using clustering |
EP3616213A2 (en) | 2017-04-28 | 2020-03-04 | 4D Path Inc. | Apparatus, systems, and methods for rapid cancer detection |
KR101990430B1 (ko) * | 2017-06-22 | 2019-06-18 | 한국과학기술원 | 암의 재발 예후 예측을 위한 바이오마커 발굴 시스템 및 방법 |
US10706328B2 (en) | 2018-05-07 | 2020-07-07 | Google Llc | Focus-weighted, machine learning disease classifier error prediction for microscope slide images |
US10971255B2 (en) * | 2018-09-14 | 2021-04-06 | Zasti Inc. | Multimodal learning framework for analysis of clinical trials |
WO2020068684A2 (en) | 2018-09-24 | 2020-04-02 | Krishnan Ramanathan | Hybrid analysis framework for prediction of outcomes in clinical trials |
US11128667B2 (en) * | 2018-11-29 | 2021-09-21 | Rapid7, Inc. | Cluster detection and elimination in security environments |
SG11202105063QA (en) * | 2018-11-29 | 2021-06-29 | Somalogic Inc | Methods for determining disease risk combining downsampling of class-imbalanced sets with survival analysis |
CN113158982A (zh) * | 2021-05-17 | 2021-07-23 | 广东中卡云计算有限公司 | 一种半介入式的目标关键点标注方法 |
JP7368679B2 (ja) * | 2021-09-01 | 2023-10-25 | イミュニティリサーチ株式会社 | 細胞集団同定システム、方法、およびプログラム |
IT202200001817A1 (it) | 2022-02-02 | 2023-08-02 | Aizoon S R L | Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico |
IT202200005861A1 (it) | 2022-03-24 | 2023-09-24 | Aizoon S R L | Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico |
US20240028964A1 (en) | 2022-07-25 | 2024-01-25 | Aizoon S.r.l. | Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product |
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CN102395682B (zh) * | 2007-09-06 | 2015-09-30 | 生物治疗诊断股份有限公司 | 肿瘤分级和癌症预后 |
CA3074969C (en) * | 2008-07-25 | 2023-06-13 | Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition |
US9779213B2 (en) * | 2008-07-25 | 2017-10-03 | Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | System for evaluating a pathological stage of prostate cancer |
US20110091081A1 (en) * | 2009-10-16 | 2011-04-21 | General Electric Company | Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin |
US8320655B2 (en) * | 2009-10-16 | 2012-11-27 | General Electric Company | Process and system for analyzing the expression of biomarkers in cells |
WO2011087778A1 (en) * | 2009-12-22 | 2011-07-21 | The Children's Hospital Of Philadelphia | Automated quantitative multidimensional volumetric analysis and visualization |
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2011
- 2011-10-03 US US13/252,080 patent/US20120271553A1/en not_active Abandoned
- 2011-10-03 US US13/252,078 patent/US20120269419A1/en not_active Abandoned
- 2011-10-03 US US13/252,072 patent/US20120269418A1/en not_active Abandoned
- 2011-10-03 US US13/252,069 patent/US20120270752A1/en not_active Abandoned
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2012
- 2012-04-23 BR BR112013027123A patent/BR112013027123A2/pt not_active IP Right Cessation
- 2012-04-23 JP JP2014505669A patent/JP6063446B2/ja active Active
- 2012-04-23 SG SG2013078688A patent/SG194588A1/en unknown
- 2012-04-23 BR BR112013027125A patent/BR112013027125A2/pt not_active IP Right Cessation
- 2012-04-23 BR BR112013027124A patent/BR112013027124A2/pt not_active IP Right Cessation
- 2012-04-23 EP EP12716028.1A patent/EP2700037A2/en not_active Withdrawn
- 2012-04-23 SG SG2013078712A patent/SG194590A1/en unknown
- 2012-04-23 RU RU2013145154/15A patent/RU2013145154A/ru not_active Application Discontinuation
- 2012-04-23 BR BR112013027122A patent/BR112013027122A2/pt not_active IP Right Cessation
- 2012-04-23 WO PCT/EP2012/057394 patent/WO2012143561A2/en unknown
- 2012-04-23 SG SG2013078753A patent/SG194594A1/en unknown
- 2012-04-23 EP EP12717662.6A patent/EP2700038B1/en active Active
- 2012-04-23 RU RU2013145151/15A patent/RU2013145151A/ru not_active Application Discontinuation
- 2012-04-23 CA CA2833804A patent/CA2833804A1/en not_active Abandoned
- 2012-04-23 EP EP12716027.3A patent/EP2700036A2/en not_active Withdrawn
- 2012-04-23 WO PCT/EP2012/057387 patent/WO2012143556A2/en unknown
- 2012-04-23 SG SG2013078738A patent/SG194592A1/en unknown
- 2012-04-23 JP JP2014505668A patent/JP6163152B2/ja active Active
- 2012-04-23 CA CA2833497A patent/CA2833497A1/en not_active Abandoned
- 2012-04-23 WO PCT/EP2012/057395 patent/WO2012143562A2/en unknown
- 2012-04-23 RU RU2013145162/15A patent/RU2013145162A/ru not_active Application Discontinuation
- 2012-04-23 EP EP12719316.7A patent/EP2700042B1/en active Active
- 2012-04-23 JP JP2014505671A patent/JP6063447B2/ja active Active
- 2012-04-23 CA CA2833428A patent/CA2833428A1/en not_active Abandoned
- 2012-04-23 CA CA2833295A patent/CA2833295A1/en not_active Abandoned
- 2012-04-23 JP JP2014505670A patent/JP6143743B2/ja active Active
- 2012-04-23 WO PCT/EP2012/057390 patent/WO2012143558A2/en unknown
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2014
- 2014-03-05 US US14/197,558 patent/US20140185905A1/en not_active Abandoned
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |