BR112015003459A2 - moléculas com atividade de ligação ao antígeno e de ligação ao receptor fc gama polivalente - Google Patents
moléculas com atividade de ligação ao antígeno e de ligação ao receptor fc gama polivalenteInfo
- Publication number
- BR112015003459A2 BR112015003459A2 BR112015003459A BR112015003459A BR112015003459A2 BR 112015003459 A2 BR112015003459 A2 BR 112015003459A2 BR 112015003459 A BR112015003459 A BR 112015003459A BR 112015003459 A BR112015003459 A BR 112015003459A BR 112015003459 A2 BR112015003459 A2 BR 112015003459A2
- Authority
- BR
- Brazil
- Prior art keywords
- stradobodies
- polyvalent
- molecules
- antigen binding
- stradobody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Abstract
title (en) molecules with antigen binding and polyvalent fc gamma receptor binding activity abstract: front page image (en)the current invention involves biologically active proteins termed stradobodies. the stradobodies have two or more domains that create stradobody multimers. the stradobodies have both antigen-binding capacity and the ability to bind fc receptors (fcr), and are useful in the treatment and prevention of disease. tradução do resumo resumo "moléculas com atividade de ligação ao antígeno e de ligação ao receptor fc gama polivalente" a presente inveção envolve proteínas ativas biologicamente denominadas stradobodies. os stradobodies possuem dois ou mais domínios que criam multímeros de stradobody. os stradobodies possuem ambos capacidade de ligação ao antígeno e a habilidade de ligar receptores fc (fcr), e são úteis no tratamento e prevenção de doença.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261691057P | 2012-08-20 | 2012-08-20 | |
US201361785144P | 2013-03-14 | 2013-03-14 | |
PCT/US2013/055800 WO2014031646A2 (en) | 2012-08-20 | 2013-08-20 | Molecules with antigen binding and polyvalent fc gamma receptor binding activity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015003459A2 true BR112015003459A2 (pt) | 2017-09-26 |
Family
ID=50150476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015003459A BR112015003459A2 (pt) | 2012-08-20 | 2013-08-20 | moléculas com atividade de ligação ao antígeno e de ligação ao receptor fc gama polivalente |
Country Status (13)
Country | Link |
---|---|
US (2) | US9683044B2 (pt) |
EP (1) | EP2885320A4 (pt) |
JP (1) | JP2015527366A (pt) |
KR (1) | KR20150058236A (pt) |
CN (1) | CN104718223A (pt) |
AU (1) | AU2013305885B2 (pt) |
BR (1) | BR112015003459A2 (pt) |
CA (1) | CA2882296A1 (pt) |
HK (1) | HK1210792A1 (pt) |
IL (1) | IL237307A0 (pt) |
MX (1) | MX2015002269A (pt) |
RU (1) | RU2015109591A (pt) |
WO (1) | WO2014031646A2 (pt) |
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MX2009013004A (es) | 2007-06-01 | 2010-01-20 | Univ Maryland | Agentes de union al receptor de la region constante fc de inmunoglobulina. |
TWI542597B (zh) | 2010-07-28 | 2016-07-21 | 吉林尼克公司 | 產生依序多聚體化免疫球蛋白fc組合物之天然人類蛋白質片段之融合蛋白 |
US9683044B2 (en) * | 2012-08-20 | 2017-06-20 | Gliknik Inc. | Molecules with antigen binding and polyvalent FC gamma receptor binding activity |
AU2015226100B2 (en) | 2014-03-05 | 2020-05-07 | UCB Biopharma SRL | Multimeric Fc proteins |
AU2015252866B2 (en) * | 2014-05-02 | 2021-01-28 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc constructs |
WO2016073917A1 (en) * | 2014-11-06 | 2016-05-12 | Gliknik Inc. | Molecules with bimodal activity depleting target at low dose and increasing immunosuppression at higher dose |
EP3268048B1 (en) * | 2015-03-10 | 2019-05-08 | Bristol-Myers Squibb Company | Antibodies conjugatable by transglutaminase and conjugates made therefrom |
FI3325011T6 (fi) * | 2015-07-24 | 2023-05-11 | Ihmisen proteiinifragmenttien fuusioproteiineja järjestyksenmukaisesti multimerisoitujen, paremmin komplementtia sitovien immunoglobuliini-fc-koostumusten muodostamiseksi | |
WO2017019949A1 (en) * | 2015-07-29 | 2017-02-02 | Ntercept, Llc | Modular compositions for scavenging soluble biomolecules and methods related thereto |
CN106554968A (zh) * | 2015-09-29 | 2017-04-05 | 中国农业科学院上海兽医研究所 | 日本血吸虫重组蛋白及其制备方法和应用 |
EP3423572B1 (en) * | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Methods related to engineered fc constructs |
CN110699371A (zh) * | 2016-03-18 | 2020-01-17 | 江苏普瑞康生物医药科技有限公司 | 一种基于FcγRⅢa的嵌合基因及其用途 |
EA201891999A1 (ru) * | 2016-03-30 | 2019-08-30 | Аб Биосайенсиз, Инк. | КОМПОЗИЦИИ РЕКОМБИНАНТНЫХ ВНУТРИВЕННЫХ ИММУНОГЛОБУЛИНОВ (rIVIG) И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
KR102590061B1 (ko) * | 2016-05-23 | 2023-10-18 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
WO2017214321A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
JP7277363B2 (ja) | 2016-11-01 | 2023-05-18 | ジェンマブ ビー.ブイ. | ポリペプチド変異体およびその使用 |
CA3043261A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Manufacturing optimization of gl-2045, a multimerizing stradomer |
WO2018107082A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent fc compounds |
CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
CN110945021A (zh) | 2017-02-10 | 2020-03-31 | 根马布私人有限公司 | 多肽变体及其用途 |
KR20200079536A (ko) * | 2017-11-09 | 2020-07-03 | 메디뮨 엘엘씨 | 이중 특이성 융합 폴리펩티드 및 이의 사용 방법 |
MA51666A (fr) | 2018-01-24 | 2020-12-02 | Genmab Bv | Variants polypeptidiques et leurs utilisations |
CN112839958A (zh) | 2018-05-03 | 2021-05-25 | 根马布私人有限公司 | 抗体变体组合及其用途 |
CN113101364B (zh) * | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技(成都)有限公司 | 一种自免疫抑制剂的开发和应用 |
WO2019243636A1 (en) | 2018-06-22 | 2019-12-26 | Genmab Holding B.V. | Anti-cd37 antibodies and anti-cd20 antibodies, compositions and methods of use thereof |
JP2021530992A (ja) * | 2018-07-11 | 2021-11-18 | モメンタ ファーマシューティカルズ インコーポレイテッド | 改変されたFc抗原結合ドメイン構築体に関する組成物および方法 |
JP2021531268A (ja) * | 2018-07-11 | 2021-11-18 | モメンタ ファーマシューティカルズ インコーポレイテッド | 改変されたFc抗原結合ドメイン構築体に関する組成物および方法 |
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-
2013
- 2013-08-20 US US13/971,584 patent/US9683044B2/en active Active
- 2013-08-20 AU AU2013305885A patent/AU2013305885B2/en active Active
- 2013-08-20 KR KR1020157006960A patent/KR20150058236A/ko not_active Application Discontinuation
- 2013-08-20 CN CN201380053362.0A patent/CN104718223A/zh active Pending
- 2013-08-20 EP EP13830394.6A patent/EP2885320A4/en not_active Withdrawn
- 2013-08-20 CA CA2882296A patent/CA2882296A1/en not_active Abandoned
- 2013-08-20 MX MX2015002269A patent/MX2015002269A/es unknown
- 2013-08-20 BR BR112015003459A patent/BR112015003459A2/pt not_active IP Right Cessation
- 2013-08-20 RU RU2015109591A patent/RU2015109591A/ru not_active Application Discontinuation
- 2013-08-20 JP JP2015528591A patent/JP2015527366A/ja active Pending
- 2013-08-20 WO PCT/US2013/055800 patent/WO2014031646A2/en active Application Filing
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2015
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- 2015-11-24 HK HK15111563.7A patent/HK1210792A1/xx unknown
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US20140072582A1 (en) | 2014-03-13 |
US20180094061A1 (en) | 2018-04-05 |
WO2014031646A3 (en) | 2014-05-01 |
JP2015527366A (ja) | 2015-09-17 |
HK1210792A1 (en) | 2016-05-06 |
RU2015109591A (ru) | 2016-10-20 |
US9683044B2 (en) | 2017-06-20 |
CA2882296A1 (en) | 2014-02-27 |
CN104718223A (zh) | 2015-06-17 |
AU2013305885B2 (en) | 2017-12-21 |
MX2015002269A (es) | 2015-07-06 |
AU2013305885A1 (en) | 2015-03-05 |
EP2885320A2 (en) | 2015-06-24 |
IL237307A0 (en) | 2015-04-30 |
WO2014031646A2 (en) | 2014-02-27 |
KR20150058236A (ko) | 2015-05-28 |
EP2885320A4 (en) | 2016-04-06 |
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