BR112014016223A2 - combinações adjuvantes de proteínas de ligação de fator h meningocócico - Google Patents
combinações adjuvantes de proteínas de ligação de fator h meningocócicoInfo
- Publication number
- BR112014016223A2 BR112014016223A2 BR112014016223A BR112014016223A BR112014016223A2 BR 112014016223 A2 BR112014016223 A2 BR 112014016223A2 BR 112014016223 A BR112014016223 A BR 112014016223A BR 112014016223 A BR112014016223 A BR 112014016223A BR 112014016223 A2 BR112014016223 A2 BR 112014016223A2
- Authority
- BR
- Brazil
- Prior art keywords
- fhbp
- meningococcal
- family
- binding proteins
- factor binding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
resumo combinações adjuvantes de proteínas de ligação de fator h meningocócico a sequência m01573 de fhbp de meningococo oferece fraca cobertura em uma vacina. a invenção aborda esta fraca cobertura de duas maneiras. em um primeiro aspecto, uma vacina baseada em fhbp inclui duas sequências de fhbp de família i, uma que está mais intimamente relacionada com mc58 do que m01573, e vice-versa. em um segundo aspecto, uma vacina baseada em fhbp multi-família utiliza uma sequência de fhbp de família i que é mais estreitamente relacionada com mc58 do que m01573, em combinação com uma sequência de fhbp de família iii. as composições são adjuvadas com um adjuvante de fosfato de alumínio.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2011/056006 WO2013098589A1 (en) | 2011-12-29 | 2011-12-29 | Adjuvanted combinations of meningococcal factor h binding proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014016223A2 true BR112014016223A2 (pt) | 2017-06-13 |
BR112014016223A8 BR112014016223A8 (pt) | 2017-07-04 |
Family
ID=45529152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014016223A BR112014016223A8 (pt) | 2011-12-29 | 2011-12-29 | combinações adjuvantes de proteínas de ligação de fator h meningocócico |
Country Status (7)
Country | Link |
---|---|
US (1) | US10596246B2 (pt) |
EP (1) | EP2797624A1 (pt) |
JP (1) | JP2015505309A (pt) |
AU (1) | AU2011384634A1 (pt) |
BR (1) | BR112014016223A8 (pt) |
CA (1) | CA2862247A1 (pt) |
WO (1) | WO2013098589A1 (pt) |
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WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
RU2707251C2 (ru) | 2011-10-03 | 2019-11-25 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
EP2833892A4 (en) | 2012-04-02 | 2016-07-20 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS AND PEPTIDES ASSOCIATED WITH ONCOLOGY |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
JP6144355B2 (ja) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 化学修飾mRNA |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
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-
2011
- 2011-12-29 US US14/368,957 patent/US10596246B2/en active Active
- 2011-12-29 CA CA2862247A patent/CA2862247A1/en not_active Abandoned
- 2011-12-29 JP JP2014549542A patent/JP2015505309A/ja active Pending
- 2011-12-29 BR BR112014016223A patent/BR112014016223A8/pt not_active IP Right Cessation
- 2011-12-29 AU AU2011384634A patent/AU2011384634A1/en not_active Abandoned
- 2011-12-29 EP EP11811574.0A patent/EP2797624A1/en not_active Withdrawn
- 2011-12-29 WO PCT/IB2011/056006 patent/WO2013098589A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20150209419A1 (en) | 2015-07-30 |
JP2015505309A (ja) | 2015-02-19 |
US10596246B2 (en) | 2020-03-24 |
BR112014016223A8 (pt) | 2017-07-04 |
AU2011384634A1 (en) | 2014-06-19 |
EP2797624A1 (en) | 2014-11-05 |
WO2013098589A1 (en) | 2013-07-04 |
CA2862247A1 (en) | 2013-07-04 |
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