BR112014014767A2 - novos compostos de benzopirano, composições e usos dos mesmos - Google Patents
novos compostos de benzopirano, composições e usos dos mesmosInfo
- Publication number
- BR112014014767A2 BR112014014767A2 BR112014014767A BR112014014767A BR112014014767A2 BR 112014014767 A2 BR112014014767 A2 BR 112014014767A2 BR 112014014767 A BR112014014767 A BR 112014014767A BR 112014014767 A BR112014014767 A BR 112014014767A BR 112014014767 A2 BR112014014767 A2 BR 112014014767A2
- Authority
- BR
- Brazil
- Prior art keywords
- phenyl
- compositions
- benzopyran compounds
- compounds
- chromen
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 3
- 229940046836 anti-estrogen Drugs 0.000 abstract 2
- 239000000328 estrogen antagonist Substances 0.000 abstract 2
- KDVXAPCZVZMPMU-XBBWARJSSA-N (2s)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-[(3r)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-2h-chromen-7-ol Chemical compound C1[C@H](C)CCN1CCOC1=CC=C([C@H]2C(=C(C)C3=CC=C(O)C=C3O2)C=2C=CC(O)=CC=2)C=C1 KDVXAPCZVZMPMU-XBBWARJSSA-N 0.000 abstract 1
- KDVXAPCZVZMPMU-COBFLCELSA-N 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-[(3r)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-2h-chromen-7-ol Chemical compound C1[C@H](C)CCN1CCOC1=CC=C(C2C(=C(C)C3=CC=C(O)C=C3O2)C=2C=CC(O)=CC=2)C=C1 KDVXAPCZVZMPMU-COBFLCELSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo novos compostos de benzopirano, composições e usos dos mesmos compostos de benzopirano com forte atividade antiestrogênica e essencial-mente nenhuma atividade estrogênica são fornecidos, que são op-1038, que é 3-(4-hidróxi-fenil)-4-metil-2-(4-{2-[(3r)-3-metilpirrolidin-1-il]etóxi}fenil)-2h-cromen-7-ol, e op-1074, que é (2s)-3-(4-hidróxi-fenil)-4-metil-2-(4-{2-[(3r)-3-metilpirrolidin-1-il]etóxi}fenil)-2h-cromen-7-ol. op-1074 é um antiestrogênio puro quando testado no modo agonista e um antiestrogênio completo quando testado no modo antagonista. estes compostos são úteis para o tratamento ou prevenção de uma variedade de condições que são moduladas através do receptor de estrogênio em mamíferos, in-cluindo os humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161576890P | 2011-12-16 | 2011-12-16 | |
PCT/US2012/070168 WO2013090921A1 (en) | 2011-12-16 | 2012-12-17 | Novel benzopyran compounds, compositions and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014014767A2 true BR112014014767A2 (pt) | 2017-06-13 |
Family
ID=48613277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014014767A BR112014014767A2 (pt) | 2011-12-16 | 2012-12-17 | novos compostos de benzopirano, composições e usos dos mesmos |
Country Status (27)
Country | Link |
---|---|
US (2) | US9018244B2 (pt) |
EP (1) | EP2791128A4 (pt) |
JP (1) | JP2015505856A (pt) |
KR (1) | KR20140103335A (pt) |
CN (1) | CN104169266A (pt) |
AP (1) | AP2014007657A0 (pt) |
AU (1) | AU2012353660A1 (pt) |
BR (1) | BR112014014767A2 (pt) |
CA (1) | CA2857061A1 (pt) |
CL (1) | CL2014001533A1 (pt) |
CR (1) | CR20140259A (pt) |
CU (1) | CU20140066A7 (pt) |
DO (1) | DOP2014000135A (pt) |
EA (1) | EA201490897A1 (pt) |
EC (1) | ECSP14009619A (pt) |
HK (1) | HK1199246A1 (pt) |
IL (1) | IL233118A0 (pt) |
MA (1) | MA35722B1 (pt) |
MD (1) | MD20140054A2 (pt) |
MX (1) | MX2014007198A (pt) |
NI (1) | NI201400057A (pt) |
PE (1) | PE20150099A1 (pt) |
PH (1) | PH12014501237A1 (pt) |
SG (1) | SG11201402564QA (pt) |
TN (1) | TN2014000243A1 (pt) |
WO (1) | WO2013090921A1 (pt) |
ZA (1) | ZA201404733B (pt) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2627692T3 (es) | 2010-06-10 | 2017-07-31 | Aragon Pharmaceuticals, Inc. | Moduladores de receptores de estrógenos y usos de los mismos |
SG11201403002RA (en) | 2011-12-14 | 2014-07-30 | Seragon Pharmaceuticals Inc | Fluorinated estrogen receptor modulators and uses thereof |
WO2014203129A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Combinations of benzopyran compounds, compositions and uses thereof |
WO2014203132A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Substituted benzopyran compounds, compositions and uses thereof |
CN104725333A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种新的氮杂环庚烷衍生物的制备方法 |
CA2940576A1 (en) * | 2014-03-13 | 2015-09-17 | F. Hoffmann-La Roche Ag | Therapeutic combinations with estrogen receptor modulators |
EP3116496A1 (en) * | 2014-03-13 | 2017-01-18 | F. Hoffmann-La Roche AG | Methods and compositions for modulating estrogen receptor mutants |
WO2017024318A1 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses |
JP6776348B2 (ja) | 2015-10-01 | 2020-10-28 | オレマ ファーマシューティカルズ インク. | テトラヒドロ−1H−ピリド[3,4−b]インドール抗エストロゲン薬物 |
SG11201803119XA (en) | 2015-10-27 | 2018-05-30 | Sun Pharma Advanced Res Co Ltd | Novel heterocyclic antiestrogens |
AU2016366680B2 (en) | 2015-12-09 | 2021-06-24 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective estrogen receptor downregulators |
CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
EP3454856A4 (en) | 2016-05-10 | 2019-12-25 | C4 Therapeutics, Inc. | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
EP3858835A1 (en) | 2016-07-01 | 2021-08-04 | G1 Therapeutics, Inc. | Pyrimidine-based antiproliferative agents |
KR102623130B1 (ko) | 2016-10-11 | 2024-01-10 | 듀크 유니버시티 | Er+ 유방암의 라소폭시펜 치료 |
WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
CN110177554B (zh) | 2017-01-06 | 2023-06-02 | G1治疗公司 | 用于治疗癌症的组合疗法 |
CN111386263A (zh) | 2017-02-08 | 2020-07-07 | 达纳-法伯癌症研究所有限公司 | 调节嵌合抗原受体 |
US10208011B2 (en) | 2017-02-10 | 2019-02-19 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
CA3067873A1 (en) | 2017-06-29 | 2019-01-03 | G1 Therapeutics, Inc. | Morphic forms of g1t38 and methods of manufacture thereof |
WO2019079569A1 (en) | 2017-10-18 | 2019-04-25 | Novartis Ag | COMPOSITIONS AND METHODS FOR SELECTIVE DEGRADATION OF A PROTEIN |
TW202000658A (zh) | 2018-02-16 | 2020-01-01 | 美商星座製藥公司 | P300/cbp hat 抑制劑及其使用方法 |
US11414384B2 (en) | 2018-02-16 | 2022-08-16 | Constellation Pharmaceuticals, Inc. | P300/CBP hat inhibitors |
CN117771239A (zh) | 2018-04-10 | 2024-03-29 | 杜克大学 | 乳腺癌的拉索昔芬治疗 |
EP3897631A4 (en) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | TARGETED PROTEIN DEGRADATION |
TW202045492A (zh) | 2019-02-27 | 2020-12-16 | 美商星座製藥公司 | P300/cbp hat抑制劑及其使用方法 |
WO2020219742A1 (en) | 2019-04-24 | 2020-10-29 | Novartis Ag | Compositions and methods for selective protein degradation |
KR20220046586A (ko) | 2019-07-22 | 2022-04-14 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | 선택적 에스트로겐 수용체 분해제 |
JP2022542421A (ja) | 2019-07-29 | 2022-10-03 | コンステレーション・ファーマシューティカルズ・インコーポレイテッド | 神経障害の治療に使用するための化合物 |
CN113045546A (zh) * | 2021-03-25 | 2021-06-29 | 浙江天宇药业股份有限公司 | 一种吡咯替尼杂质、其制备方法及用途 |
WO2024030968A1 (en) | 2022-08-03 | 2024-02-08 | Brystol-Myers Squibb Company | Compounds for modulating ret protein |
WO2024097980A1 (en) | 2022-11-04 | 2024-05-10 | Bristol-Myers Squibb Company | Ret-ldd protein inhibitors |
WO2024097989A1 (en) | 2022-11-04 | 2024-05-10 | Bristol-Myers Squibb Company | Ret-ldd protein degraders |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
US5686465A (en) | 1988-10-31 | 1997-11-11 | Endorecherche Inc. | Sex steroid activity inhibitors |
US5395842A (en) | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
US5254568A (en) | 1990-08-09 | 1993-10-19 | Council Of Scientific & Industrial Research | Benzopyrans as antiestrogenic agents |
US6060503A (en) | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
US5407947A (en) | 1993-11-05 | 1995-04-18 | Eli Lilly And Company | Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans |
US5446061A (en) | 1993-11-05 | 1995-08-29 | Eli Lilly And Company | Methods for lowering serum cholesterol |
US5416098A (en) | 1993-12-30 | 1995-05-16 | Zymogenetics, Inc. | Method for treating dermatitis and related conditions |
US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
US5446071A (en) | 1994-11-18 | 1995-08-29 | Eli Lilly And Company | Methods for lowering serum cholesterol |
US5637598A (en) | 1994-11-18 | 1997-06-10 | Eli Lilly And Company | Methods of inhibiting bone loss |
US5980938A (en) | 1996-07-15 | 1999-11-09 | Eli Lilly And Company | Effect of compounds that suppress induction of plasminogen activator inhibitor 1 (PAI-1) |
AU8102398A (en) | 1997-07-09 | 1999-02-08 | Central Drug Research Institute | (dl)-2,3-diaryl-2h-1-benzopyrans |
US6326392B1 (en) | 1997-11-06 | 2001-12-04 | American Home Products Corporation | Anti-estrogen plus progestin containing oral contraceptives |
WO1999028344A2 (en) | 1997-11-28 | 1999-06-10 | Innogenetics N.V. | Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment |
US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
DE69905376T2 (de) | 1998-08-14 | 2003-10-09 | Schering Corp | Enanthioauswählende synthese |
US6262270B1 (en) | 1998-08-14 | 2001-07-17 | Schering Corporation | Enantioselective synthesis |
WO2000037083A1 (en) | 1998-12-18 | 2000-06-29 | Schering Corporation | Oral antiestrogen pharmaceutical composition |
US6638727B1 (en) | 1999-01-26 | 2003-10-28 | Cytyc Health Corporation | Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer |
AU5957500A (en) | 1999-07-06 | 2001-01-22 | Endorecherche Inc. | Methods of treating and/or suppressing weight gain |
WO2001026651A2 (en) | 1999-10-14 | 2001-04-19 | Endorecherche, Inc. | Selective estrogen receptor modulators in the treatment or reduction of the risk of acquiring hypertension, cardiovascular diseases, and insulin resistance |
GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
WO2001054699A1 (en) | 2000-01-28 | 2001-08-02 | Endorecherche, Inc. | Selective estrogen receptor modulators in combination with estrogens |
DE10013782A1 (de) * | 2000-03-15 | 2001-10-18 | Schering Ag | 4-Fluoralkyl-2H-benzopyrane mit antiestrogener Wirksamkeit, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
WO2003041654A2 (en) | 2001-11-14 | 2003-05-22 | Sirbasku David A | Anti-estrogen and immune modulator combinations for treating breast cancer |
JP4554219B2 (ja) | 2002-04-24 | 2010-09-29 | メルク・シャープ・エンド・ドーム・コーポレイション | エストロゲン受容体調節剤 |
WO2004091488A2 (en) | 2003-04-14 | 2004-10-28 | Merck & Co., Inc. | Estrogen receptor modulators |
CN102357248A (zh) | 2004-10-20 | 2012-02-22 | 恩多研究公司 | 单独的性甾体前体或与选择性***受体调节剂联合用于防治绝经后女性的***疾病和病症 |
BRPI0703735A2 (pt) | 2007-08-29 | 2009-09-15 | Endorech Inc | aperfeiçoamento em composto opticamente ativo ou sal farmaceuticamente aceitável do mesmo e composição contendo o referido composto |
US20090082467A1 (en) | 2007-09-21 | 2009-03-26 | Harry Fisch | Treatment of migraine headaches using antiestrogens |
US20100317635A1 (en) | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
PT3124481T (pt) | 2010-02-16 | 2018-06-18 | Aragon Pharmaceuticals Inc | Moduladores do receptor de androgénios e suas utilizações |
ES2627692T3 (es) * | 2010-06-10 | 2017-07-31 | Aragon Pharmaceuticals, Inc. | Moduladores de receptores de estrógenos y usos de los mismos |
US11576891B2 (en) | 2010-06-16 | 2023-02-14 | Endorecherche, Inc. | Methods of treating or preventing estrogen-related diseases |
US8853423B2 (en) | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
SG11201403002RA (en) | 2011-12-14 | 2014-07-30 | Seragon Pharmaceuticals Inc | Fluorinated estrogen receptor modulators and uses thereof |
SG10201610249TA (en) | 2012-06-07 | 2017-02-27 | Aragon Pharmaceuticals Inc | Crystalline forms of an androgen receptor modulator |
BR122017017921A2 (pt) | 2012-07-27 | 2019-09-10 | Aragon Pharmaceuticals Inc | métodos e sistema para determinar a resistência à terapia de receptor de androgênio |
NZ744456A (en) | 2012-09-26 | 2019-09-27 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
-
2012
- 2012-12-17 CN CN201280062009.4A patent/CN104169266A/zh active Pending
- 2012-12-17 AP AP2014007657A patent/AP2014007657A0/xx unknown
- 2012-12-17 CA CA2857061A patent/CA2857061A1/en not_active Abandoned
- 2012-12-17 SG SG11201402564QA patent/SG11201402564QA/en unknown
- 2012-12-17 MD MDA20140054A patent/MD20140054A2/ro not_active Application Discontinuation
- 2012-12-17 EP EP20120858374 patent/EP2791128A4/en not_active Withdrawn
- 2012-12-17 US US13/717,326 patent/US9018244B2/en not_active Expired - Fee Related
- 2012-12-17 JP JP2014547552A patent/JP2015505856A/ja active Pending
- 2012-12-17 MX MX2014007198A patent/MX2014007198A/es unknown
- 2012-12-17 PE PE2014000963A patent/PE20150099A1/es not_active Application Discontinuation
- 2012-12-17 KR KR1020147019676A patent/KR20140103335A/ko not_active Application Discontinuation
- 2012-12-17 BR BR112014014767A patent/BR112014014767A2/pt not_active IP Right Cessation
- 2012-12-17 WO PCT/US2012/070168 patent/WO2013090921A1/en active Application Filing
- 2012-12-17 AU AU2012353660A patent/AU2012353660A1/en not_active Abandoned
- 2012-12-17 EA EA201490897A patent/EA201490897A1/ru unknown
-
2014
- 2014-05-28 CR CR20140259A patent/CR20140259A/es unknown
- 2014-06-02 MA MA37096A patent/MA35722B1/fr unknown
- 2014-06-02 PH PH12014501237A patent/PH12014501237A1/en unknown
- 2014-06-03 TN TNP2014000243A patent/TN2014000243A1/fr unknown
- 2014-06-11 CU CU2014000066A patent/CU20140066A7/es unknown
- 2014-06-11 CL CL2014001533A patent/CL2014001533A1/es unknown
- 2014-06-12 IL IL233118A patent/IL233118A0/en unknown
- 2014-06-13 NI NI201400057A patent/NI201400057A/es unknown
- 2014-06-16 DO DO2014000135A patent/DOP2014000135A/es unknown
- 2014-06-26 ZA ZA2014/04733A patent/ZA201404733B/en unknown
- 2014-07-16 EC ECIEPI20149619A patent/ECSP14009619A/es unknown
- 2014-12-19 HK HK14112731.3A patent/HK1199246A1/xx unknown
-
2015
- 2015-03-17 US US14/660,248 patent/US20150197506A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AP2014007657A0 (en) | 2014-05-31 |
ZA201404733B (en) | 2016-04-28 |
MD20140054A2 (ro) | 2014-10-31 |
CU20140066A7 (es) | 2014-10-02 |
ECSP14009619A (es) | 2015-09-30 |
CR20140259A (es) | 2014-08-21 |
TN2014000243A1 (fr) | 2015-09-30 |
CA2857061A1 (en) | 2013-06-20 |
US20130178445A1 (en) | 2013-07-11 |
JP2015505856A (ja) | 2015-02-26 |
EP2791128A4 (en) | 2015-04-22 |
IL233118A0 (en) | 2014-08-03 |
MA35722B1 (fr) | 2014-12-01 |
EA201490897A1 (ru) | 2015-03-31 |
PH12014501237A1 (en) | 2014-09-08 |
NI201400057A (es) | 2014-10-01 |
WO2013090921A1 (en) | 2013-06-20 |
HK1199246A1 (en) | 2015-06-26 |
KR20140103335A (ko) | 2014-08-26 |
DOP2014000135A (es) | 2014-08-31 |
US9018244B2 (en) | 2015-04-28 |
CN104169266A (zh) | 2014-11-26 |
MX2014007198A (es) | 2014-10-13 |
AU2012353660A1 (en) | 2014-06-12 |
SG11201402564QA (en) | 2014-09-26 |
CL2014001533A1 (es) | 2014-10-17 |
US20150197506A1 (en) | 2015-07-16 |
PE20150099A1 (es) | 2015-01-30 |
EP2791128A1 (en) | 2014-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014014767A2 (pt) | novos compostos de benzopirano, composições e usos dos mesmos | |
UY31806A (es) | Compuestos de tiazole y oxazole de sulfonamida de benceno | |
BR112013011949A2 (pt) | "indóis, composição farmacêutica que os compreende, seus processos de preparação e uso dos ditos indóis" | |
BR112013009789A2 (pt) | inibidores do vírus da hepatite c | |
CL2007002971A1 (es) | Compuestos derivados de aminometil-4-imidazol; procedimiento de preparacion; composicion farmaceutica que los contiene; y su uso para tratar depresion, ansiedad, trastorno bipolar, entre otras. | |
BRPI0914606A2 (pt) | Mistura para controlar fungos nocivos fitopatogênicos, composição, método para controlar fungos nocivos fitopatogênicos, semente, e, uso dos componentes. | |
TW200943187A (en) | Virtual machine manager system and methods | |
BR112014030944A2 (pt) | composição auxiliar de moagem para moer a escória de cimento, mistura de cimento e método para aumentar a eficiência de moagem e melhorar a área superficial específica de um cimento | |
CL2008000703A1 (es) | Compuestos derivados de pirimidinas sustituidas; procedimiento para la preparacion de dichos compuestos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar transtornos hematologicos. | |
BRPI0823407A2 (pt) | Novos compostos de metaloceno, catalisadores que os compreendem, processo para produção de um polímero de olefina por uso dos catalisadores e homo- e copolímeros de olefina | |
BRPI0918586A2 (pt) | compostos, composições e métodos de uso dos mesmos para a modulação dos níveis de ácido úrico | |
ECSP10010296A (es) | Derivados de alcanos azabiciclicos sustituidos con biarilo como moduladores de la actividad de los receptores nicotinicos de acetilcolina | |
CL2009001247A1 (es) | Compuestos derivados de 5-oxi/amino-indazol; moduladores del receptor de glucocorticoides; el proceso de preparacion de dichos compuestos; composiciones farmaceuticas que los contienen; combinacion farmaceutica; y su uso en el tratamiento de afecciones inflamatorias, trastornos respiratorios, asma y epoc. | |
CL2012000921A1 (es) | Compuestos derivados de espiropiperidina-metilbenciloxifenil, activadores del receptor rpg-40; composicion farmaceutica que los comprende; y uso del compuesto para tratar diabetes. | |
NO20083057L (no) | Sulfonyl substituerte 1H-indoler som ligander til 5-hydroksytryptamin reseptorer | |
NO20083553L (no) | Indolsulfonamidmodulatorer av progrestonreseptorer | |
CL2007002970A1 (es) | Compuestos derivados de aminometil-4-imidazol; procedimiento de preparacion; composicion farmaceutica que los contiene; y su uso para tratar depresion, ansiedad, trastorno bipolar, entre otras. | |
BRPI0916069C1 (pt) | composto, usos de um composto, composição farmacêutica, composição cosmética e usos cosméticos de uma composição | |
BRPI0512395A (pt) | composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou a profilaxia de condições ou distúrbios associadas(os) com a modulação de receptor de estrogênio seletiva, e para o tratamento ou a profilaxia relacionado(a) com condições ou distúrbios | |
BR112013003041A2 (pt) | éter de celulose, composição, uso de um éter de celulose e método para modificar a viscosidade de uma composição | |
BRPI0923291A2 (pt) | processo para a destilação de uma mistura aquosa de polimetilol, composição, e, uso de um polimetilol. | |
CL2009001298A1 (es) | Compuestos derivados de n-ciclohexil-2-fenoxinicotinamida; composición farmcéutica que los comprende; combinación farmacéutica que los comprende; y su uso para tratar una enfermedad mediada por la pde4. | |
CL2013000733A1 (es) | Compuestos derivados de arilalquilimidazol, moduladores selectivos de receptores alfa 2 adrenergicos; y composicion farmaceutica que los comprende. | |
BR112015007879A2 (pt) | inibidores do vírus da hepatite c | |
MA52424A (fr) | Compositions pharmaceutiques comprenant du (2s)--((1s)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl)-1,4-oxazepane-2-carboxamide |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |