BR112014012429A2 - rocesso para a purificação de poliaminocarboxilatos como dota, dtpa, do3a-butrol, bopta; e poliaminopolicarboxilato substancialmente puro - Google Patents

rocesso para a purificação de poliaminocarboxilatos como dota, dtpa, do3a-butrol, bopta; e poliaminopolicarboxilato substancialmente puro

Info

Publication number
BR112014012429A2
BR112014012429A2 BR112014012429A BR112014012429A BR112014012429A2 BR 112014012429 A2 BR112014012429 A2 BR 112014012429A2 BR 112014012429 A BR112014012429 A BR 112014012429A BR 112014012429 A BR112014012429 A BR 112014012429A BR 112014012429 A2 BR112014012429 A2 BR 112014012429A2
Authority
BR
Brazil
Prior art keywords
butrol
bopta
do3a
dota
dtpa
Prior art date
Application number
BR112014012429A
Other languages
English (en)
Inventor
Babu Rangisetty Jagadeesh
Reddy Pullagurla Manik
Bhudeti Rajesh
Original Assignee
Biophore India Pharmaceuticals Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biophore India Pharmaceuticals Pvt Ltd filed Critical Biophore India Pharmaceuticals Pvt Ltd
Publication of BR112014012429A2 publication Critical patent/BR112014012429A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

resumo processo para a purificação de poliaminocarboxilatos como dota, dtpa, do3a-butrol, bopta; e poliaminopolicarboxilato substancialmente puro a presente invenção revela um processo melhorado para a purificação de poliaminocarboxilatos como dota, dtpa, do3a-butrol, bopta.
BR112014012429A 2011-11-25 2012-11-26 rocesso para a purificação de poliaminocarboxilatos como dota, dtpa, do3a-butrol, bopta; e poliaminopolicarboxilato substancialmente puro BR112014012429A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4068CH2011 2011-11-25
PCT/IN2012/000768 WO2013076743A2 (en) 2011-11-25 2012-11-26 Process for the purification of polyaminocarboxylates

Publications (1)

Publication Number Publication Date
BR112014012429A2 true BR112014012429A2 (pt) 2017-06-06

Family

ID=48470389

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014012429A BR112014012429A2 (pt) 2011-11-25 2012-11-26 rocesso para a purificação de poliaminocarboxilatos como dota, dtpa, do3a-butrol, bopta; e poliaminopolicarboxilato substancialmente puro

Country Status (11)

Country Link
US (1) US10106489B2 (pt)
EP (1) EP2782900B1 (pt)
JP (1) JP6096798B2 (pt)
KR (1) KR101832027B1 (pt)
CN (1) CN104169252B (pt)
AU (1) AU2012342016C1 (pt)
BR (1) BR112014012429A2 (pt)
CA (1) CA2857014C (pt)
IL (1) IL232735A (pt)
RU (1) RU2621896C2 (pt)
WO (1) WO2013076743A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3102566B1 (en) * 2014-02-06 2018-09-12 T2Pharma GmbH Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
CN106279220B (zh) * 2015-06-05 2018-10-30 四川科伦药物研究院有限公司 一种适于产业化的钆弗塞胺的纯化方法
DE102015013939A1 (de) 2015-09-15 2017-03-16 be imaging GmbH Verfahren zur Herstellung von Gadotersäure (Gd-DOTA)- Komplexen
GB201522412D0 (en) * 2015-12-18 2016-02-03 Ge Healthcare As Dota synthesis
CN108264491B (zh) 2016-12-30 2022-09-16 威智医药有限公司 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3043867A (en) 1959-10-16 1962-07-10 Dow Chemical Co Method for the purification of aminocarboxylic acids
US5334729A (en) * 1989-06-29 1994-08-02 Associated Universities, Inc. Stable radiometal antibody immunoconjugates
US5491259A (en) 1994-09-13 1996-02-13 The Dow Chemical Company Process to produce aminocarboxylic acids containing low residual salt
IT1275426B (it) * 1995-05-16 1997-08-07 Bracco Spa Recupero del gadolinio e dei suoi agenti complessanti da soluzioni acquose contenenti i loro complessi
IT1293777B1 (it) * 1997-07-25 1999-03-10 Bracco Spa Processo per la preparazione di tetraazamacrocicli
EP1762563A1 (en) * 2005-09-13 2007-03-14 BRACCO IMAGING S.p.A. Process for the preparation of contrast agents
RU2425831C2 (ru) * 2005-12-02 2011-08-10 Джи-И Хелткер АС Мультимерные контрастные агенты для магнитного резонанса
US9580457B2 (en) 2012-10-29 2017-02-28 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of (1-{9-[(4S, 2R, 3R, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide

Also Published As

Publication number Publication date
AU2012342016C1 (en) 2016-09-01
RU2014125548A (ru) 2015-12-27
CN104169252A (zh) 2014-11-26
KR101832027B1 (ko) 2018-04-04
IL232735A (en) 2017-05-29
EP2782900A2 (en) 2014-10-01
EP2782900B1 (en) 2018-01-10
JP2015501807A (ja) 2015-01-19
KR20140097411A (ko) 2014-08-06
US20140323719A1 (en) 2014-10-30
AU2012342016A1 (en) 2014-06-26
WO2013076743A2 (en) 2013-05-30
EP2782900A4 (en) 2015-08-12
IL232735A0 (en) 2014-08-03
CN104169252B (zh) 2017-03-22
JP6096798B2 (ja) 2017-03-15
CA2857014C (en) 2018-08-14
US10106489B2 (en) 2018-10-23
WO2013076743A3 (en) 2014-05-30
AU2012342016B2 (en) 2016-05-19
RU2621896C2 (ru) 2017-06-08
CA2857014A1 (en) 2013-05-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements