BR112014008932A2 - bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associados - Google Patents
bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associadosInfo
- Publication number
- BR112014008932A2 BR112014008932A2 BR112014008932A BR112014008932A BR112014008932A2 BR 112014008932 A2 BR112014008932 A2 BR 112014008932A2 BR 112014008932 A BR112014008932 A BR 112014008932A BR 112014008932 A BR112014008932 A BR 112014008932A BR 112014008932 A2 BR112014008932 A2 BR 112014008932A2
- Authority
- BR
- Brazil
- Prior art keywords
- protocells
- cancer
- charge
- cells
- hepatocellular
- Prior art date
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- Communicable Diseases (AREA)
Abstract
resumo "bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associados", por tratar-se a presente invenção de protocélulas para direcionamento específico para células hepatocelulares e outras células cancerígenas, que compreendem um núcleo de sílica nanoporosa com uma bicamada lipídica suportada; pelo menos um agente que facilita a morte da célula cancerígena (tal como uma molécula pequena tradicional, uma carga macromolecular (por exemplo, siarn ou uma toxina protéica, como, por exemplo, toxina ricina de cadeia a ou toxina difteria de cadeia a) e/ou um dna plasmídeo empacotado com uma histona disposta no interior do núcleo de sílica nanoporosa (de preferência, super-enrolado, de modo a empacotar de forma mais eficiente o dna nas protocélulas), que é opcionalmente modificado por uma sequência de localização nuclear, para auxiliar na localização das protocélulas dentro do núcleo da célula cancerígena e a capacidade de expressar os peptídeos envolvidos na terapia (apoptose/morte celular) das células cancerígenas ou como repórter, um peptídeo de direcionamento que tem como alvo as células cancerígenas no tecido a ser tratado, de tal modo que a ligação da protocélula às células-alvo é específica e aprimorada e um peptídeo fusogênico que promove o escape endossomal das protocélulas e do dna encapsulado. as protocélulas, de acordo com a presente invenção, podem ser utilizadas para tratar o câncer, incluindo, especialmente, o câncer hepatocelular (câncer de fígado), por meio do uso dos novos peptídeos de ligação (peptídeos c-met), que se ligam seletivamente a um tecido hepatocelular, ou para funcionar no diagnóstico do câncer, incluindo o tratamento do câncer e a descoberta de medicamentos. 1/1
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PCT/US2012/060072 WO2013056132A2 (en) | 2011-10-14 | 2012-10-12 | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof |
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BR112014008932A BR112014008932A2 (pt) | 2011-10-14 | 2012-10-12 | bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associados |
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EP (1) | EP2765997A4 (pt) |
JP (1) | JP2014532071A (pt) |
KR (1) | KR20140103914A (pt) |
CN (1) | CN104023711A (pt) |
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- 2012-10-12 EP EP12840155.1A patent/EP2765997A4/en not_active Withdrawn
- 2012-10-12 SG SG11201401499XA patent/SG11201401499XA/en unknown
- 2012-10-12 BR BR112014008932A patent/BR112014008932A2/pt not_active IP Right Cessation
- 2012-10-12 CN CN201280061866.2A patent/CN104023711A/zh active Pending
- 2012-10-12 AU AU2012323937A patent/AU2012323937A1/en not_active Abandoned
-
2016
- 2016-12-15 US US15/380,962 patent/US20170232115A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2765997A2 (en) | 2014-08-20 |
WO2013056132A2 (en) | 2013-04-18 |
EP2765997A4 (en) | 2015-06-24 |
US20150272885A1 (en) | 2015-10-01 |
WO2013056132A3 (en) | 2013-06-13 |
MX2014004415A (es) | 2015-06-05 |
SG11201401499XA (en) | 2014-09-26 |
CA2852064A1 (en) | 2013-04-18 |
US20170232115A1 (en) | 2017-08-17 |
CN104023711A (zh) | 2014-09-03 |
JP2014532071A (ja) | 2014-12-04 |
KR20140103914A (ko) | 2014-08-27 |
AU2012323937A1 (en) | 2014-06-05 |
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