SG11201401499XA - Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereof - Google Patents
Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery including transdermal delivery of cargo and methods thereofInfo
- Publication number
- SG11201401499XA SG11201401499XA SG11201401499XA SG11201401499XA SG11201401499XA SG 11201401499X A SG11201401499X A SG 11201401499XA SG 11201401499X A SG11201401499X A SG 11201401499XA SG 11201401499X A SG11201401499X A SG 11201401499XA SG 11201401499X A SG11201401499X A SG 11201401499XA
- Authority
- SG
- Singapore
- Prior art keywords
- protocells
- cargo
- methods
- lipid bilayers
- including transdermal
- Prior art date
Links
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161547402P | 2011-10-14 | 2011-10-14 | |
US201161577410P | 2011-12-19 | 2011-12-19 | |
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Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8992984B1 (en) | 2009-10-21 | 2015-03-31 | Stc.Unm | Protocells and their use for targeted delivery of multicomponent cargos to cancer cells |
US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
JP2014511687A (en) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | Engineered nucleic acid delivery and formulation |
CN103687590A (en) | 2011-04-28 | 2014-03-26 | Stc·Unm公司 | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
BR112014001346A8 (en) | 2011-07-19 | 2018-05-08 | Stc Unm | nanotransport compound, method, pharmaceutical compound and use of a |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
HUE057725T2 (en) | 2011-10-03 | 2022-06-28 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
HRP20220717T1 (en) | 2011-12-16 | 2022-07-22 | Modernatx, Inc. | Modified mrna compositions |
AU2013243947A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
US9273305B1 (en) | 2012-04-25 | 2016-03-01 | Sandia Corporation | Cell-based composite materials with programmed structures and functions |
JP2015537029A (en) | 2012-11-14 | 2015-12-24 | ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn | Composition containing biologically active substance and irregular inorganic oxide |
SG10201510324YA (en) | 2012-11-16 | 2016-01-28 | Univ Cardiff | Process for preparing nucleoside prodrugs |
ES2921623T3 (en) | 2012-11-26 | 2022-08-30 | Modernatx Inc | terminally modified RNA |
US10828255B2 (en) | 2013-03-05 | 2020-11-10 | The Regents Of The University Of California | Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents |
EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
WO2014201276A1 (en) * | 2013-06-12 | 2014-12-18 | The Methodist Hospital | Polycation-functionalized nanoporous silicon carrier for systemic delivery of gene silencing agents |
WO2015013352A2 (en) * | 2013-07-25 | 2015-01-29 | Patel Hasmukh B | Nucleoside phosphoramidates and phosphoramidites |
WO2015034928A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
EP3046547A4 (en) * | 2013-09-18 | 2017-05-24 | Stc.Unm | Core and surface modification of mesoporous silica nanoparticles to achieve cell specific targeting in vivo |
US9855217B2 (en) | 2013-09-18 | 2018-01-02 | Stc. Unm | Toroidal mesoporous silica nanoparticles (TMSNPs) and related protocells |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
WO2015066717A1 (en) | 2013-11-04 | 2015-05-07 | BioPharmX, Inc. | Dosage form comprising an active ingredient and a plurality of solid porous microcarriers |
JP6628226B2 (en) * | 2014-01-17 | 2020-01-08 | 洋孝 松尾 | Evaluation method for gout predisposition |
US20170204152A1 (en) | 2014-07-16 | 2017-07-20 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
CN107072951A (en) | 2014-07-22 | 2017-08-18 | 雷莫内克斯生物制药有限公司 | Composition for delivering bioactive substance or protein and application thereof |
US20170210788A1 (en) | 2014-07-23 | 2017-07-27 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
WO2016054225A1 (en) * | 2014-09-30 | 2016-04-07 | Stc.Unm | Plasmid delivery in the treatment of cancer and other disease states |
EP3906918B1 (en) | 2014-11-05 | 2024-01-03 | Selecta Biosciences, Inc. | Methods and compositions related to synthetic nanocarriers with rapamycin in a stable, super-saturated state |
WO2016145031A1 (en) * | 2015-03-09 | 2016-09-15 | Stc.Unm | Cd 47 containing porous nanoparticle supported lipid bilayers (protocells) |
US11643445B2 (en) * | 2015-04-24 | 2023-05-09 | Colgate-Palmolive Company | Porous protein particles as carriers for actives |
WO2017008059A1 (en) * | 2015-07-09 | 2017-01-12 | The Regents Of The University Of California | Fusogenic liposome-coated porous silicon nanoparticles |
EP3324979B1 (en) | 2015-07-21 | 2022-10-12 | ModernaTX, Inc. | Infectious disease vaccines |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
US10624949B1 (en) | 2015-07-27 | 2020-04-21 | National Technology & Engineering Solutions Of Sandia, Llc | Methods for treating diseases related to the wnt pathway |
ES2910425T3 (en) | 2015-09-17 | 2022-05-12 | Modernatx Inc | Compounds and compositions for the intracellular delivery of therapeutic agents |
US11219694B2 (en) * | 2015-09-24 | 2022-01-11 | The University Of North Carolina At Chapel Hill | Methods and compositions for reducing metastases |
CN105174211B (en) * | 2015-10-12 | 2017-02-01 | 海南大学 | Preparation method of silver-based composite nanomaterial with surface-enhanced Raman activity, product obtained with preparation method and application of silver-based composite nanomaterial |
JP6925688B2 (en) | 2015-10-22 | 2021-08-25 | モデルナティーエックス, インコーポレイテッド | Nucleic acid vaccine for varicella-zoster virus (VZV) |
DK3718565T3 (en) | 2015-10-22 | 2022-06-20 | Modernatx Inc | VACCINES AGAINST RESPIRATORY VIRUS |
JP2018531290A (en) | 2015-10-22 | 2018-10-25 | モデルナティーエックス, インコーポレイテッド | Sexually transmitted disease vaccine |
WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
JP6667896B2 (en) * | 2015-11-06 | 2020-03-18 | 国立研究開発法人産業技術総合研究所 | Ribonucleic acid-immobilized carrier and method for separating and recovering ribonucleic acid using the same |
SI3386484T1 (en) | 2015-12-10 | 2022-06-30 | Modernatx, Inc. | Compositions and methods for delivery of therapeutic agents |
RS63051B1 (en) | 2015-12-22 | 2022-04-29 | Modernatx Inc | Compounds and compositions for intracellular delivery of agents |
SI3394093T1 (en) | 2015-12-23 | 2022-05-31 | Modernatx, Inc. | Methods of using ox40 ligand encoding polynucleotides |
WO2017120504A1 (en) * | 2016-01-08 | 2017-07-13 | Durfee Paul N | Osteotropic nanoparticles for prevention or treatment of bone metastases |
WO2017120537A1 (en) * | 2016-01-08 | 2017-07-13 | The Regents Of The University Of California | Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery |
US20190241658A1 (en) | 2016-01-10 | 2019-08-08 | Modernatx, Inc. | Therapeutic mRNAs encoding anti CTLA-4 antibodies |
CA3021001A1 (en) * | 2016-04-14 | 2017-10-19 | Spinnaker Biosciences, Inc. | Porous silicon materials comprising a metal silicate for delivery of therapeutic agents |
EP3235908A1 (en) * | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
EP3269444A1 (en) * | 2016-07-14 | 2018-01-17 | Base4 Innovation Ltd | Method of identifying droplets in a stack and an associated sequencer |
US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
US10925958B2 (en) | 2016-11-11 | 2021-02-23 | Modernatx, Inc. | Influenza vaccine |
US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
LU100023B1 (en) * | 2017-01-20 | 2018-07-30 | Luxembourg Inst Science & Tech List | Nanocapsules and method for manufacturing thereof |
CN106822916B (en) * | 2017-01-25 | 2020-02-28 | 浙江大学 | Preparation method of pH-sensitive nano Bcl-2 selective inhibitor, product and application |
US11382964B2 (en) * | 2017-01-27 | 2022-07-12 | The Methodist Hospital | Core/shell structure platform for immunotherapy |
EP3578171A4 (en) | 2017-02-06 | 2020-12-30 | Lemonex Inc. | Physiologically active substance carrier |
US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
WO2018170336A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
AU2018234814B2 (en) | 2017-03-15 | 2022-06-30 | Modernatx, Inc. | Crystal forms of amino lipids |
EP3609534A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Broad spectrum influenza virus vaccine |
KR20190132405A (en) | 2017-03-15 | 2019-11-27 | 모더나티엑스, 인크. | Compounds and Compositions for Intracellular Delivery of Therapeutic Agents |
WO2018170256A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Herpes simplex virus vaccine |
WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
WO2018170260A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | Rna formulations |
US11007516B1 (en) | 2017-06-19 | 2021-05-18 | National Technology & Engineering Solutions Of Sandia, Llc | Tunable metal-organic framework compositions and methods thereof |
EP3689355A4 (en) * | 2017-07-28 | 2021-09-08 | Lemonex Inc. | Pharmaceutical composition for preventing or treating liver cancer |
AU2018326799A1 (en) | 2017-08-31 | 2020-02-27 | Modernatx, Inc. | Methods of making lipid nanoparticles |
KR102152348B1 (en) | 2017-09-05 | 2020-09-08 | 주식회사 레모넥스 | Composition for modulating cell fate |
WO2019050283A1 (en) * | 2017-09-05 | 2019-03-14 | 주식회사 레모넥스 | Composition for regulating cell fate |
EP3681514A4 (en) | 2017-09-14 | 2021-07-14 | ModernaTX, Inc. | Zika virus rna vaccines |
US10933027B1 (en) * | 2017-09-25 | 2021-03-02 | National Technology & Engineering Solutions Of Sandia, Llc | Expanded pore particles and delivery methods thereof |
CN107952076A (en) * | 2017-11-07 | 2018-04-24 | 徐州医科大学 | A kind of multivesicular liposome/porous carbon nano-complex, preparation method and application |
US20200330616A1 (en) * | 2017-11-13 | 2020-10-22 | POLITECNICO Dl TORINO | Biomimetic non-immunogenic nanoassembly for the antitumor therapy |
US11661599B1 (en) | 2017-12-14 | 2023-05-30 | National Technology & Engineering Solutions Of Sandia, Llc | CRISPR-Cas based system for targeting single-stranded sequences |
MA54676A (en) | 2018-01-29 | 2021-11-17 | Modernatx Inc | RSV RNA VACCINES |
KR102017110B1 (en) | 2018-03-08 | 2019-09-02 | 한국화학연구원 | Microfabricated platform for mimicking the liver zonation and evaluating method of zonal toxicity using thereof |
WO2019204666A1 (en) * | 2018-04-18 | 2019-10-24 | Oisin Biotechnologies, Inc. | Fusogenic lipid nanoparticles and methods for the manufacture and use thereof for the target cell-specific production of a therapeutic protein and for the treatment of a disease, condition, or disorder associated with a target cell |
AU2019255725A1 (en) * | 2018-04-18 | 2020-12-10 | Ligandal, Inc. | Methods and compositions for genome editing |
US11045554B1 (en) | 2018-06-22 | 2021-06-29 | National Technology & Engineering Solutions Of Sandia, Llc | Lipid-coated particles for treating viral infections |
US20210177988A1 (en) * | 2018-08-06 | 2021-06-17 | Lemonex Inc. | Immunoreactant carrier |
WO2020037530A1 (en) * | 2018-08-22 | 2020-02-27 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Crystalline form of compound and uses thereof in medicine |
KR20200051916A (en) * | 2018-11-05 | 2020-05-14 | 주식회사 메디포럼제약 | Silica hydrogel composition containing goserelin |
US20220049216A1 (en) * | 2018-12-24 | 2022-02-17 | Korea University Research And Business Foundation | Manufacture of structure capable of forming three-dimensional neuronal spheroid and generating neurite through various surface processes |
IT201900001009A1 (en) | 2019-01-23 | 2020-07-23 | Torino Politecnico | Biomimetic nanoporous vector comprising an inhibitor directed towards the native form of the IDH2 protein |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
WO2020171680A1 (en) * | 2019-02-22 | 2020-08-27 | 주식회사 레모넥스 | Pharmaceutical composition for immune activity or for preventing or treating cancer |
EP3714879A1 (en) * | 2019-03-28 | 2020-09-30 | Sisaf Ltd | Structured encapsulated silicon-containing particles |
GB201904337D0 (en) * | 2019-03-28 | 2019-05-15 | Sisaf Ltd | A delivery system |
WO2020200472A1 (en) * | 2019-04-05 | 2020-10-08 | Biontech Rna Pharmaceuticals Gmbh | Preparation and storage of liposomal rna formulations suitable for therapy |
US20210038633A1 (en) * | 2019-08-09 | 2021-02-11 | Case Western Reserve University | Nanoparticle constructs for systemic co-delivery of anti-tumor agents |
CA3154618A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
TW202322824A (en) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | Antiviral compounds |
BR112022018070A2 (en) | 2020-03-11 | 2022-10-25 | Selecta Biosciences Inc | METHODS AND COMPOSITIONS RELATED TO SYNTHETIC NANOVEHICLES |
EP4125816A4 (en) * | 2020-04-01 | 2024-01-10 | Univ Cincinnati | Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy |
US11433121B1 (en) * | 2020-04-03 | 2022-09-06 | National Technology & Engineering Solutions Of Sandia, Llc | Lipid composition for the delivery of therapeutic cargos |
CN113713115B (en) * | 2020-05-22 | 2023-11-24 | 青岛科技大学 | Method for constructing anticancer drug carrying system by adopting carbon porous material |
GB2600704A (en) * | 2020-11-04 | 2022-05-11 | Sumitomo Chemical Co | Nanoparticle |
WO2022115075A1 (en) * | 2020-11-30 | 2022-06-02 | Ege Üni̇versi̇tesi̇ | Targeted nanoparticles carrying dual drugs in the treatment of melanoma |
US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
CN112870387B (en) * | 2021-02-26 | 2023-08-29 | 中山大学孙逸仙纪念医院 | Magnetic nano-drug carrier and preparation method and application thereof |
CN113149023B (en) * | 2021-03-11 | 2023-05-02 | 昆明理工大学 | Preparation method of mesoporous silica nanoparticle transdermal delivery eutectic system |
WO2022192674A1 (en) * | 2021-03-11 | 2022-09-15 | The Trustees Of The University Of Pennsylvania | Targeted therapeutic lipid nanoparticles and methods of use |
CA3216162A1 (en) | 2021-04-16 | 2022-10-20 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
CN113082226B (en) * | 2021-04-27 | 2023-12-15 | 山东中医药大学 | Preparation method of drug-loaded nanocage and application of drug-loaded nanocage in targeting circulating tumor cells to release triptolide |
CN113735350B (en) * | 2021-09-23 | 2023-01-24 | 深圳市水务规划设计院股份有限公司 | Black and odorous water body treatment process and experimental device thereof |
CN114129718B (en) * | 2021-10-19 | 2024-05-03 | 华东师范大学 | Nanometer delivery system for in-vivo self-assembly CAR-T, and preparation method and application thereof |
WO2023161350A1 (en) | 2022-02-24 | 2023-08-31 | Io Biotech Aps | Nucleotide delivery of cancer therapy |
CN116327985A (en) * | 2023-02-21 | 2023-06-27 | 武汉工程大学 | Hollow vesicle drug-loaded delivery system with targeted ultrasound contrast imaging function, and preparation method and application thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7514530B2 (en) * | 2004-04-26 | 2009-04-07 | Centre National De La Recherche Scientifique | Peptide carrier for delivering siRNA into mammalian cells |
WO2009078924A2 (en) * | 2007-12-06 | 2009-06-25 | The Regents Of The University Of California | Mesoporous silica nanoparticles for biomedical applications |
WO2010048572A1 (en) * | 2008-10-23 | 2010-04-29 | Cornell University | A novel anti-viral method |
US8734816B2 (en) * | 2009-01-05 | 2014-05-27 | Stc.Unm | Porous nanoparticle supported lipid bilayer nanostructures |
CN103687590A (en) * | 2011-04-28 | 2014-03-26 | Stc·Unm公司 | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
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BR112014008932A2 (en) | 2019-09-24 |
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AU2012323937A1 (en) | 2014-06-05 |
KR20140103914A (en) | 2014-08-27 |
WO2013056132A2 (en) | 2013-04-18 |
WO2013056132A3 (en) | 2013-06-13 |
US20150272885A1 (en) | 2015-10-01 |
MX2014004415A (en) | 2015-06-05 |
CA2852064A1 (en) | 2013-04-18 |
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