BR112014003063A2 - "3,4-di-hidro-1h-[1,8]naftiridinonas substituídas com ciclopenta[c]pirrol antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso". - Google Patents

"3,4-di-hidro-1h-[1,8]naftiridinonas substituídas com ciclopenta[c]pirrol antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso".

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Publication number
BR112014003063A2
BR112014003063A2 BR112014003063A BR112014003063A BR112014003063A2 BR 112014003063 A2 BR112014003063 A2 BR 112014003063A2 BR 112014003063 A BR112014003063 A BR 112014003063A BR 112014003063 A BR112014003063 A BR 112014003063A BR 112014003063 A2 BR112014003063 A2 BR 112014003063A2
Authority
BR
Brazil
Prior art keywords
compounds
naphthyridinones
dihydro
substituted
pyrrol
Prior art date
Application number
BR112014003063A
Other languages
English (en)
Other versions
BR112014003063B1 (pt
Inventor
Koul Anil
Francis Alain Lançois David
Pierre Alexandre Arnoult Eric
Emile Georges Guillemont Jerôme
Madeleine Simone Motte Magali
Mia Albert Balemans Wendy
Original Assignee
Janssen R&D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46650549&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014003063(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen R&D Ireland filed Critical Janssen R&D Ireland
Publication of BR112014003063A2 publication Critical patent/BR112014003063A2/pt
Publication of BR112014003063B1 publication Critical patent/BR112014003063B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

abstract antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1h-[1,8]naphthyridinones the present invention is related to novel compounds of formula (i) that inhibit the activity of the fabi enzyme which are therefore useful in the treatment of bacterial infections. it further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds. ________________________________________________________________________________ tradução resumo resumo patente de invenção: "3,4-dihidro-1h-[1,8]naftiridinonas substituídas com ciclopenta[c]pirrol antibacterianas". a presente invenção refere-se a novos compostos da fórmula (i), que inibem a atividade da enzima fabi que portanto são úteis no tratamento de infecções bacterianas. também se refere a composições farmacêuticas compreendendo esses compostos, e a processos químicos de preparação desses compostos.
BR112014003063-4A 2011-08-10 2012-08-10 3,4-DI-HIDRO-lH-[l,8]NAFTIRIDINONAS SUBSTITUÍDAS COM CICLOPENTA[C]PIRROL ANTIBACTERIANAS, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS REFERIDOS COMPOSTOS, PROCESSOS PARA PREPARAÇÃO DESTES E USO BR112014003063B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11177119.2 2011-08-10
EP11177119 2011-08-10
PCT/EP2012/065733 WO2013021054A1 (en) 2011-08-10 2012-08-10 Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1h-[1,8]naphthyridinones

Publications (2)

Publication Number Publication Date
BR112014003063A2 true BR112014003063A2 (pt) 2017-02-21
BR112014003063B1 BR112014003063B1 (pt) 2020-11-17

Family

ID=46650549

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014003063-4A BR112014003063B1 (pt) 2011-08-10 2012-08-10 3,4-DI-HIDRO-lH-[l,8]NAFTIRIDINONAS SUBSTITUÍDAS COM CICLOPENTA[C]PIRROL ANTIBACTERIANAS, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO OS REFERIDOS COMPOSTOS, PROCESSOS PARA PREPARAÇÃO DESTES E USO

Country Status (24)

Country Link
US (7) US8906923B2 (pt)
EP (1) EP2742045B1 (pt)
JP (2) JP5921687B2 (pt)
KR (1) KR101996862B1 (pt)
CN (2) CN103874698B (pt)
AR (1) AR087508A1 (pt)
AU (1) AU2012293621B2 (pt)
BR (1) BR112014003063B1 (pt)
CA (1) CA2842518C (pt)
CL (1) CL2014000289A1 (pt)
DK (1) DK2742045T3 (pt)
EA (1) EA201490438A1 (pt)
ES (1) ES2721658T3 (pt)
HK (2) HK1199243A1 (pt)
HU (1) HUE042978T2 (pt)
IL (1) IL230549A (pt)
JO (1) JO3611B1 (pt)
MX (1) MX348128B (pt)
PE (1) PE20141410A1 (pt)
TR (1) TR201905537T4 (pt)
TW (1) TWI568731B (pt)
UA (1) UA111210C2 (pt)
UY (1) UY34253A (pt)
WO (1) WO2013021054A1 (pt)

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BR112014002958B1 (pt) 2011-08-10 2020-10-06 Janssen Sciences Ireland Uc 3,4-dihidro-1h-[1,8]naftiridinonas substituídas com piperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
MX367309B (es) * 2012-08-10 2019-08-14 Janssen Sciences Ireland Uc Nuevos compuestos antibacterianos.
EP3036221B1 (en) 2013-09-26 2018-11-07 Cadent Therapeutics, Inc. Selective octahydro-cyclopenta[c]pyrrole negative modulators of nr2b
JO3579B1 (ar) 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
CN109311897B (zh) 2017-03-20 2021-07-20 福马治疗股份有限公司 作为丙酮酸激酶(pkr)活化剂的吡咯并吡咯组合物
US11691967B2 (en) 2018-03-12 2023-07-04 The Board Of Trustees Of The University Of Illinois Antibiotics effective for gram-negative pathogens
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
US20230055923A1 (en) 2018-09-19 2023-02-23 Forma Therapeutics, Inc. Activating pyruvate kinase r
CN113272302A (zh) 2018-11-12 2021-08-17 德彪药业国际股份公司 抗生素化合物、其制造方法、包含其的药物组合物及其用途

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AU1192501A (en) 1999-10-08 2001-04-23 Smithkline Beecham Corporation Fab i inhibitors
PE20010635A1 (es) 1999-10-08 2001-08-15 Smithkline Beecham Corp Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas
WO2001026652A1 (en) 1999-10-08 2001-04-19 Smithkline Beecham Corporation Fab i inhibitors
ES2320984T3 (es) 2001-04-06 2009-06-01 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
ES2515101T3 (es) * 2004-06-04 2014-10-29 Debiopharm International Sa Derivados de acrilamida como agentes antibióticos
US7732612B2 (en) 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7973060B2 (en) 2005-10-13 2011-07-05 Crystalgenomics, Inc. Fab I inhibitor and process for preparing same
EP2054422B1 (en) * 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
US8263613B2 (en) 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
KR20130010456A (ko) * 2009-11-18 2013-01-28 에프에이비 파마 에스에이에스 신규의 헤테로사이클릭 아크릴아미드 및 약제로서 이의 용도
US8766017B2 (en) 2011-07-29 2014-07-01 Eastman Chemical Company Integrated process for the preparation of 1,4-cyclohexanedimethanol from terephthalic acid
AU2012290261A1 (en) 2011-07-29 2014-02-20 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of HIV
JO3611B1 (ar) * 2011-08-10 2020-08-27 Janssen Sciences Ireland Uc سايكلو بنتا (سي (بيرول 4,3 ثاني هيدرو 1 hمستبدله [8,1] نافثيريدينونات مضادة للجراثيم
EP2742044B1 (en) 2011-08-10 2019-12-04 Janssen Sciences Ireland Unlimited Company Antibacterial homopiperidinyl substituted 3,4-dihydro-1h-[1,8]naphthyridinones
BR112014002958B1 (pt) 2011-08-10 2020-10-06 Janssen Sciences Ireland Uc 3,4-dihidro-1h-[1,8]naftiridinonas substituídas com piperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso

Also Published As

Publication number Publication date
US20160194324A1 (en) 2016-07-07
US20170174683A1 (en) 2017-06-22
AU2012293621A1 (en) 2014-02-13
US20190194194A1 (en) 2019-06-27
KR20140072034A (ko) 2014-06-12
MX2014001600A (es) 2014-04-25
JP2016190843A (ja) 2016-11-10
CN105461684A (zh) 2016-04-06
BR112014003063B1 (pt) 2020-11-17
US20140171451A1 (en) 2014-06-19
US20190084982A1 (en) 2019-03-21
TR201905537T4 (tr) 2019-05-21
HK1223352A1 (zh) 2017-07-28
DK2742045T3 (en) 2019-04-23
US10155759B2 (en) 2018-12-18
US8906923B2 (en) 2014-12-09
MX348128B (es) 2017-05-26
UA111210C2 (uk) 2016-04-11
CN105461684B (zh) 2018-09-25
TWI568731B (zh) 2017-02-01
ES2721658T3 (es) 2019-08-02
JP5921687B2 (ja) 2016-05-24
IL230549A (en) 2017-07-31
PE20141410A1 (es) 2014-10-13
US10501463B2 (en) 2019-12-10
WO2013021054A1 (en) 2013-02-14
US20150080413A1 (en) 2015-03-19
EP2742045B1 (en) 2019-01-23
NZ620212A (en) 2015-10-30
EA201490438A1 (ru) 2014-06-30
CN103874698B (zh) 2016-03-23
AR087508A1 (es) 2014-03-26
JP2014531404A (ja) 2014-11-27
KR101996862B1 (ko) 2019-07-05
AU2012293621B2 (en) 2016-07-21
CL2014000289A1 (es) 2014-07-11
US9617262B2 (en) 2017-04-11
HUE042978T2 (hu) 2019-07-29
EP2742045A1 (en) 2014-06-18
HK1199243A1 (zh) 2015-06-26
US20180105525A1 (en) 2018-04-19
CN103874698A (zh) 2014-06-18
CA2842518A1 (en) 2013-02-14
US9290493B2 (en) 2016-03-22
IL230549A0 (en) 2014-03-31
JO3611B1 (ar) 2020-08-27
UY34253A (es) 2013-02-28
US9884864B2 (en) 2018-02-06
TW201313714A (zh) 2013-04-01
US10526331B2 (en) 2020-01-07
CA2842518C (en) 2019-07-23

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: JANSSEN SCIENCES IRELAND UC (IE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/08/2012, OBSERVADAS AS CONDICOES LEGAIS.