BR112013024059A2 - compostos de bis(fluoroalquil)-1,4-benzodiazepinona - Google Patents

compostos de bis(fluoroalquil)-1,4-benzodiazepinona

Info

Publication number
BR112013024059A2
BR112013024059A2 BR112013024059A BR112013024059A BR112013024059A2 BR 112013024059 A2 BR112013024059 A2 BR 112013024059A2 BR 112013024059 A BR112013024059 A BR 112013024059A BR 112013024059 A BR112013024059 A BR 112013024059A BR 112013024059 A2 BR112013024059 A2 BR 112013024059A2
Authority
BR
Brazil
Prior art keywords
compounds
fluoroalkyl
bis
ch2ch2cf3
ch2cf3
Prior art date
Application number
BR112013024059A
Other languages
English (en)
Other versions
BR112013024059B1 (pt
Inventor
Ashvinikumar Gavai
Claude Quesnelle
Francis Y Lee
Soong-Hoon Kim
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR112013024059A2 publication Critical patent/BR112013024059A2/pt
Publication of BR112013024059B1 publication Critical patent/BR112013024059B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

resumo patente de invenção: "compostos de bis(fluoroalquil)-1,4-benzodiazepinona". a invenção refere-se a compostos de fórmula (i) ou profármacos dos mesmos; (i) em que: r1 é -ch2cf3 ou -ch2ch2cf3; r2 é -ch2cf3, -ch2ch2cf3, ou -ch2ch2ch2cf3; r3 é h ou -ch3; cada ra é independentemente f, cl, -cn, -och3, e/ou -nhch2ch2och3; e z é zero, 1, ou 2. da mesma forma refere-se aos métodos de usar tal composto para inibir o receptor de notch, e composições farmacêuticas compreendendo tais compostos. estes compostos são úteis no tratamento, prevenção, ou retardo do progresso de doenças ou distúrbios em uma variedade de áreas terapêuticas, tal como câncer.
BR112013024059-8A 2011-03-22 2012-03-22 Compostos de bis(fluoroalquil)-1,4-benzodiazepinona, combinação e uso de ditos compostos BR112013024059B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161466238P 2011-03-22 2011-03-22
US61/466,238 2011-03-22
PCT/US2012/030021 WO2012129353A1 (en) 2011-03-22 2012-03-22 Bis(fluoroalkyl)-1,4-benzodiazepinone compounds

Publications (2)

Publication Number Publication Date
BR112013024059A2 true BR112013024059A2 (pt) 2016-12-06
BR112013024059B1 BR112013024059B1 (pt) 2022-01-25

Family

ID=45894701

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013024059-8A BR112013024059B1 (pt) 2011-03-22 2012-03-22 Compostos de bis(fluoroalquil)-1,4-benzodiazepinona, combinação e uso de ditos compostos

Country Status (32)

Country Link
US (2) US8629136B2 (pt)
EP (1) EP2688873B1 (pt)
JP (1) JP5873923B2 (pt)
KR (1) KR101948347B1 (pt)
CN (1) CN103717576B (pt)
AR (1) AR085471A1 (pt)
AU (1) AU2012230904B2 (pt)
BR (1) BR112013024059B1 (pt)
CA (1) CA2830902C (pt)
CL (1) CL2013002690A1 (pt)
CO (1) CO6771446A2 (pt)
CY (1) CY1116423T1 (pt)
DK (1) DK2688873T3 (pt)
EA (1) EA022530B1 (pt)
ES (1) ES2534080T3 (pt)
HK (1) HK1189218A1 (pt)
HR (1) HRP20150273T1 (pt)
IL (1) IL228534A (pt)
MA (1) MA35036B1 (pt)
MX (1) MX2013010420A (pt)
MY (1) MY161233A (pt)
PE (1) PE20140626A1 (pt)
PL (1) PL2688873T3 (pt)
PT (1) PT2688873E (pt)
RS (1) RS53843B1 (pt)
SG (1) SG193555A1 (pt)
SI (1) SI2688873T1 (pt)
SM (1) SMT201500091B (pt)
TN (1) TN2013000372A1 (pt)
TW (1) TWI530489B (pt)
UY (1) UY33961A (pt)
WO (1) WO2012129353A1 (pt)

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US20140100365A1 (en) 2014-04-10
DK2688873T3 (en) 2015-04-27
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PL2688873T3 (pl) 2015-06-30
CL2013002690A1 (es) 2014-02-14
KR20140027956A (ko) 2014-03-07
SI2688873T1 (sl) 2015-04-30
BR112013024059B1 (pt) 2022-01-25
JP5873923B2 (ja) 2016-03-01
WO2012129353A1 (en) 2012-09-27
RS53843B1 (en) 2015-08-31
UY33961A (es) 2012-09-28
KR101948347B1 (ko) 2019-02-14
HK1189218A1 (en) 2014-05-30
AU2012230904A1 (en) 2013-11-07
TN2013000372A1 (en) 2015-01-20
IL228534A0 (en) 2013-12-31
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MA35036B1 (fr) 2014-04-03
EA201391324A1 (ru) 2014-03-31
PE20140626A1 (es) 2014-05-30
AR085471A1 (es) 2013-10-02
EP2688873B1 (en) 2015-01-21
PT2688873E (pt) 2015-04-14
JP2014511840A (ja) 2014-05-19
HRP20150273T1 (hr) 2015-06-19
ES2534080T3 (es) 2015-04-17
CN103717576A (zh) 2014-04-09
NZ616876A (en) 2014-08-29
CA2830902C (en) 2019-10-29
AU2012230904B2 (en) 2016-03-31
US20120245151A1 (en) 2012-09-27
MX2013010420A (es) 2013-10-01
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EA022530B1 (ru) 2016-01-29
CO6771446A2 (es) 2013-10-15
TW201309656A (zh) 2013-03-01
US8629136B2 (en) 2014-01-14
SMT201500091B (it) 2015-05-05
US8822454B2 (en) 2014-09-02

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