PE20140626A1 - Compuestos de bis(fluoroalquil)-1,4-benzodiazepinona - Google Patents

Compuestos de bis(fluoroalquil)-1,4-benzodiazepinona

Info

Publication number
PE20140626A1
PE20140626A1 PE2013002083A PE2013002083A PE20140626A1 PE 20140626 A1 PE20140626 A1 PE 20140626A1 PE 2013002083 A PE2013002083 A PE 2013002083A PE 2013002083 A PE2013002083 A PE 2013002083A PE 20140626 A1 PE20140626 A1 PE 20140626A1
Authority
PE
Peru
Prior art keywords
bis
benzodiazepinone
fluoroalkyl
compounds
benzodiazepin
Prior art date
Application number
PE2013002083A
Other languages
English (en)
Inventor
Claude Quesnelle
Soong-Hoon Kim
Francis Lee
Ashvinikumar Gaval
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20140626A1 publication Critical patent/PE20140626A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE BIS(FLUOROALQUIL)-1,4-BENZODIAZEPINONA DE FORMULA (I) DONDE R1 ES -CH2CF3 O -CH2CH2CF3; R2 ES -CH2CF3, -CH2CH2CF3 O -CH2CH2CH2CF3; R3 ES H O -CH3; Ra ES F, Cl, -CN, ENTRE OTROS; z ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: (2R,3S)-N-((3S)-1-METIL-2-OXO-5-FENIL-2,3-DIHIDRO-1H-1,4-BENZODIAZEPIN-3-IL)-2,3-BIS(3,3,3-TRIFLUOROPROPIL)SUCCINAMIDA; (2R,3S)-N-((3S)-2-OXO-5-FENIL-2,3-DIHIDRO-1H-1,4-BENZODIAZEPIN-3-IL)-2,3-BIS(3,3,3-TRIFLUOROPROPIL)SUCCINAMIDA; (2R,3S)-N-((3S)-1-METIL-2-OXO-5-FENIL-2,3-DIHIDRO-1H-1,4-BENZODIAZEPIN-3-IL)-2-(2,2,2-TRIFLUOROETIL)-3-(3,3,3-TRIFLUOROPROPIL)SUCCINAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMA CRISTALINA Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE NOTCH SIENDO UTILES EN EL TRATAMIENTO DE CANCER
PE2013002083A 2011-03-22 2012-03-22 Compuestos de bis(fluoroalquil)-1,4-benzodiazepinona PE20140626A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161466238P 2011-03-22 2011-03-22

Publications (1)

Publication Number Publication Date
PE20140626A1 true PE20140626A1 (es) 2014-05-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013002083A PE20140626A1 (es) 2011-03-22 2012-03-22 Compuestos de bis(fluoroalquil)-1,4-benzodiazepinona

Country Status (32)

Country Link
US (2) US8629136B2 (es)
EP (1) EP2688873B1 (es)
JP (1) JP5873923B2 (es)
KR (1) KR101948347B1 (es)
CN (1) CN103717576B (es)
AR (1) AR085471A1 (es)
AU (1) AU2012230904B2 (es)
BR (1) BR112013024059B1 (es)
CA (1) CA2830902C (es)
CL (1) CL2013002690A1 (es)
CO (1) CO6771446A2 (es)
CY (1) CY1116423T1 (es)
DK (1) DK2688873T3 (es)
EA (1) EA022530B1 (es)
ES (1) ES2534080T3 (es)
HK (1) HK1189218A1 (es)
HR (1) HRP20150273T1 (es)
IL (1) IL228534A (es)
MA (1) MA35036B1 (es)
MX (1) MX2013010420A (es)
MY (1) MY161233A (es)
PE (1) PE20140626A1 (es)
PL (1) PL2688873T3 (es)
PT (1) PT2688873E (es)
RS (1) RS53843B1 (es)
SG (1) SG193555A1 (es)
SI (1) SI2688873T1 (es)
SM (1) SMT201500091B (es)
TN (1) TN2013000372A1 (es)
TW (1) TWI530489B (es)
UY (1) UY33961A (es)
WO (1) WO2012129353A1 (es)

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AU2012230904B2 (en) 2016-03-31
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EP2688873A1 (en) 2014-01-29
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