BR112012018022A2 - inibição de sinalização axl em terapia antimetastática. - Google Patents

inibição de sinalização axl em terapia antimetastática.

Info

Publication number
BR112012018022A2
BR112012018022A2 BR112012018022A BR112012018022A BR112012018022A2 BR 112012018022 A2 BR112012018022 A2 BR 112012018022A2 BR 112012018022 A BR112012018022 A BR 112012018022A BR 112012018022 A BR112012018022 A BR 112012018022A BR 112012018022 A2 BR112012018022 A2 BR 112012018022A2
Authority
BR
Brazil
Prior art keywords
inhibition
axl
axl signaling
antimetastatic
therapy
Prior art date
Application number
BR112012018022A
Other languages
English (en)
Inventor
Amato J Giacci
Douglas Jones
Erinn Bruno Rankin
Jennifer R Cochran
Katherine Fuh
Mihalis Kariolis
Yu Miao
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of BR112012018022A2 publication Critical patent/BR112012018022A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

inibição de sinalização axl em terapia antimetastática. composições e métodos são fornecidos para aliviar câncer em um mamífero administrando uma dose terapêutica de uma composição farmacêutica que inibe a atividade de proteína axl, por exemplo, por inibição competitiva ou não competitiva da interação de ligação entre axl e seu ligando gas6.
BR112012018022A 2010-01-22 2011-01-21 inibição de sinalização axl em terapia antimetastática. BR112012018022A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33647810P 2010-01-22 2010-01-22
PCT/US2011/022125 WO2011091305A2 (en) 2010-01-22 2011-01-21 Inhibition of axl signaling in anti-metastatic therapy

Publications (1)

Publication Number Publication Date
BR112012018022A2 true BR112012018022A2 (pt) 2017-01-10

Family

ID=44307615

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012018022A BR112012018022A2 (pt) 2010-01-22 2011-01-21 inibição de sinalização axl em terapia antimetastática.

Country Status (15)

Country Link
US (2) US8618254B2 (pt)
EP (2) EP2525824B1 (pt)
JP (1) JP5965322B2 (pt)
KR (3) KR101951410B1 (pt)
CN (2) CN107082805A (pt)
AU (2) AU2011207381B2 (pt)
BR (1) BR112012018022A2 (pt)
CA (2) CA3056999A1 (pt)
DK (2) DK2525824T3 (pt)
ES (2) ES2632345T3 (pt)
HK (1) HK1245806A1 (pt)
PT (2) PT2525824T (pt)
RU (1) RU2556822C2 (pt)
WO (1) WO2011091305A2 (pt)
ZA (2) ZA201204866B (pt)

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Also Published As

Publication number Publication date
KR101951410B1 (ko) 2019-02-26
RU2556822C2 (ru) 2015-07-20
KR20190019220A (ko) 2019-02-26
EP2525824A2 (en) 2012-11-28
CA2786149C (en) 2019-11-12
RU2012136113A (ru) 2014-02-27
EP2525824A4 (en) 2013-11-13
PT2525824T (pt) 2017-07-13
CA2786149A1 (en) 2011-07-28
EP3241840B1 (en) 2022-07-27
KR20130004568A (ko) 2013-01-11
ZA201307676B (en) 2015-09-30
WO2011091305A3 (en) 2013-02-21
US9266947B2 (en) 2016-02-23
DK2525824T3 (en) 2017-07-17
CN103154020A (zh) 2013-06-12
CN103154020B (zh) 2017-03-15
US20130017205A1 (en) 2013-01-17
ES2632345T3 (es) 2017-09-12
US20140065143A1 (en) 2014-03-06
AU2011207381A1 (en) 2012-07-26
ES2928111T3 (es) 2022-11-15
EP3241840A2 (en) 2017-11-08
CN107082805A (zh) 2017-08-22
JP5965322B2 (ja) 2016-08-03
US8618254B2 (en) 2013-12-31
PT3241840T (pt) 2022-10-13
CA3056999A1 (en) 2011-07-28
EP3241840A3 (en) 2018-02-07
ZA201204866B (en) 2014-01-29
AU2011207381B2 (en) 2016-06-09
AU2016213693A1 (en) 2016-08-25
WO2011091305A2 (en) 2011-07-28
KR20200100866A (ko) 2020-08-26
DK3241840T3 (da) 2022-10-03
HK1245806A1 (zh) 2018-08-31
EP2525824B1 (en) 2017-04-26
JP2013518055A (ja) 2013-05-20

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B25G Requested change of headquarter approved

Owner name: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US)

Owner name: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL