BR112012017393A2 - derivados de 2,5,7-oxazolpirimidina substituída - Google Patents

derivados de 2,5,7-oxazolpirimidina substituída

Info

Publication number
BR112012017393A2
BR112012017393A2 BR112012017393A BR112012017393A BR112012017393A2 BR 112012017393 A2 BR112012017393 A2 BR 112012017393A2 BR 112012017393 A BR112012017393 A BR 112012017393A BR 112012017393 A BR112012017393 A BR 112012017393A BR 112012017393 A2 BR112012017393 A2 BR 112012017393A2
Authority
BR
Brazil
Prior art keywords
oxazolpyrimidine
derivatives
substituted
compounds
formula
Prior art date
Application number
BR112012017393A
Other languages
English (en)
Inventor
Gille Andreas
Dietrich Axel
Kadereit Dieter
Hiss Katrin
Schaefer Matthias
Hachtel Stephanie
Huebschle Thomas
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112012017393A2 publication Critical patent/BR112012017393A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

derivados de 2,5,7-oxazolpirimidina substituída. a presente invenção refere-se a compostos de oxazolpirimidina da fórmula (i) onde a, r ^1^, r ^2^ e r ^3^ são definidos como citados nas reivindicações. os compostos da fórmula (i) são adequados, por exemplos, para cicatrização de ferida.
BR112012017393A 2010-01-13 2011-01-12 derivados de 2,5,7-oxazolpirimidina substituída BR112012017393A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10305035 2010-01-13
PCT/EP2011/050295 WO2011086075A1 (de) 2010-01-13 2011-01-12 2,5,7-substituierte oxazolopyrimidinderivate

Publications (1)

Publication Number Publication Date
BR112012017393A2 true BR112012017393A2 (pt) 2017-12-12

Family

ID=41820512

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012017393A BR112012017393A2 (pt) 2010-01-13 2011-01-12 derivados de 2,5,7-oxazolpirimidina substituída

Country Status (21)

Country Link
US (1) US8785439B2 (pt)
EP (1) EP2523961B1 (pt)
JP (1) JP5844276B2 (pt)
KR (1) KR101759126B1 (pt)
CN (1) CN102791716B (pt)
AR (1) AR079980A1 (pt)
AU (1) AU2011206611B2 (pt)
BR (1) BR112012017393A2 (pt)
CA (1) CA2791445C (pt)
DK (1) DK2523961T3 (pt)
ES (1) ES2448645T3 (pt)
HK (1) HK1178884A1 (pt)
IL (1) IL220707A (pt)
MX (1) MX2012007835A (pt)
MY (1) MY156525A (pt)
PT (1) PT2523961E (pt)
RU (1) RU2557246C2 (pt)
SG (1) SG183101A1 (pt)
TW (1) TWI485153B (pt)
UY (1) UY33176A (pt)
WO (1) WO2011086075A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR079884A1 (es) * 2010-01-14 2012-02-29 Sanofi Aventis Derivados de acido carboxilico heterociclicos que comprenden un anillo de oxazolopirimidina 2,5-sustituida
KR101764607B1 (ko) * 2010-01-14 2017-08-03 사노피 ２,５-치환된 옥사졸로피리미딘 유도체
CA2784560C (en) * 2010-01-14 2017-12-05 Sanofi Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring
US9321787B2 (en) 2011-07-07 2016-04-26 Sanofi Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring
ES2770113T3 (es) 2015-07-02 2020-06-30 Horizon Orphan Llc Análogos de la cisteamina resistentes a la ADO y sus usos
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
CN117120444A (zh) 2021-04-16 2023-11-24 吉利德科学公司 使用酰胺制备卡巴核苷的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1622913A1 (en) 2003-04-25 2006-02-08 University College Cardiff Consultants, Ltd. Heterocyclic compounds for use in the treatment of viral infections
CA2524048C (en) 2003-05-19 2013-06-25 Irm Llc Immunosuppressant compounds and compositions
FR2865208B1 (fr) * 2004-01-16 2009-01-16 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique
AU2006317689B2 (en) * 2005-11-23 2013-07-25 Epix Delaware, Inc. S1P receptor modulating compounds and use thereof
EP1900729A1 (en) * 2006-09-15 2008-03-19 Novartis AG Benzoxazoles and oxazolopyridines being useful as Janus kinases inhibitors
CA2679980A1 (en) * 2007-03-21 2007-09-27 Epix Pharmaceuticals, Inc. S1p receptor modulating compounds and use thereof
TW201000099A (en) * 2008-06-20 2010-01-01 Amgen Inc S1P1 receptor agonists and use thereof
JP5449346B2 (ja) 2008-07-15 2014-03-19 サノフイ Ｅｄｇ−１受容体アゴニストとしてのオキサゾロピリミジン類
UY33177A (es) 2010-01-13 2011-08-31 Sanofi Aventis Derivados de ácido carboxílico que comprenden un anillo de oxazolopirimidina 2, 5, 7-sustituido
AR079982A1 (es) 2010-01-13 2012-03-07 Sanofi Aventis Derivados de acido carboxilico heterociclicos que comprenden un anillo de oxazolopirimidina 2,5,7- sustituido., composiciones farmaceuticas y procesos para prepararlos.
AR079884A1 (es) 2010-01-14 2012-02-29 Sanofi Aventis Derivados de acido carboxilico heterociclicos que comprenden un anillo de oxazolopirimidina 2,5-sustituida
KR101764607B1 (ko) 2010-01-14 2017-08-03 사노피 ２,５-치환된 옥사졸로피리미딘 유도체
CA2784560C (en) 2010-01-14 2017-12-05 Sanofi Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring

Also Published As

Publication number Publication date
AU2011206611B2 (en) 2015-03-05
TWI485153B (zh) 2015-05-21
AR079980A1 (es) 2012-03-07
RU2557246C2 (ru) 2015-07-20
CN102791716B (zh) 2016-05-11
RU2012134349A (ru) 2014-02-20
MX2012007835A (es) 2012-07-30
ES2448645T3 (es) 2014-03-14
CA2791445C (en) 2017-08-29
IL220707A0 (en) 2012-08-30
AU2011206611A1 (en) 2012-08-02
WO2011086075A1 (de) 2011-07-21
PT2523961E (pt) 2014-03-20
DK2523961T3 (en) 2014-03-24
MY156525A (en) 2016-02-26
JP2013517238A (ja) 2013-05-16
CA2791445A1 (en) 2011-07-21
HK1178884A1 (pt) 2013-09-19
CN102791716A (zh) 2012-11-21
TW201141873A (en) 2011-12-01
UY33176A (es) 2011-08-31
US8785439B2 (en) 2014-07-22
JP5844276B2 (ja) 2016-01-13
EP2523961B1 (de) 2013-12-18
IL220707A (en) 2015-02-26
SG183101A1 (en) 2012-09-27
KR20120115544A (ko) 2012-10-18
US20130137685A1 (en) 2013-05-30
EP2523961A1 (de) 2012-11-21
KR101759126B1 (ko) 2017-07-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO ARQUIVAMENTO PUBLICADO NA RPI 2497 DE 13/11/2018.

B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]