BR112012015337B8 - composição farmacêutica, cartucho de aerossol, método para carregar um cartucho de aerossol, conjunto de componentes e uso de uma composição farmacêutica - Google Patents

composição farmacêutica, cartucho de aerossol, método para carregar um cartucho de aerossol, conjunto de componentes e uso de uma composição farmacêutica

Info

Publication number
BR112012015337B8
BR112012015337B8 BR112012015337A BR112012015337A BR112012015337B8 BR 112012015337 B8 BR112012015337 B8 BR 112012015337B8 BR 112012015337 A BR112012015337 A BR 112012015337A BR 112012015337 A BR112012015337 A BR 112012015337A BR 112012015337 B8 BR112012015337 B8 BR 112012015337B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
components
aerosol cartridge
aerosol
loading
Prior art date
Application number
BR112012015337A
Other languages
English (en)
Other versions
BR112012015337B1 (pt
BR112012015337A2 (pt
Inventor
Zambelli Enrico
Usberti Francesca
Bonelli Sauro
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42107420&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012015337(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of BR112012015337A2 publication Critical patent/BR112012015337A2/pt
Publication of BR112012015337B1 publication Critical patent/BR112012015337B1/pt
Publication of BR112012015337B8 publication Critical patent/BR112012015337B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B65B31/003—Adding propellants in fluid form to aerosol containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
    • B65B7/2842—Securing closures on containers
    • B65B7/285—Securing closures on containers by deformation of the closure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)

Abstract

composição farmacêutica, cartucho de aerossol, método para carregar um cartucho de aerossol, conjunto de componentes e uso de uma composição farmacêutica. a presente invenção refere-se a uma formulação aerossol adequada para ser administrada a pacientes com doença pulmonar obstrutiva crônica (dpoc) por meio de um inalador pressurizado dosimetrado (pmdi), compreendendo brometo de glicopirrônio combinado com formoterol. a formulação compreende ainda um propelente hfa, um cossolvente e uma quantidade de ácido inorgânico suficiente para estabilizar ambos componentes brometo de glicopirrônio e o formoterol. opcionalmente, a formulação compreende ainda dipropionato de beclometasona.
BR112012015337A 2009-12-23 2010-12-22 composição farmacêutica, cartucho de aerossol, método para carregar um cartucho de aerossol, conjunto de componentes e uso de uma composição farmacêutica BR112012015337B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09180671 2009-12-23
EP09180671.1 2009-12-23
PCT/EP2010/070479 WO2011076843A2 (en) 2009-12-23 2010-12-22 Combination therapy for copd

Publications (3)

Publication Number Publication Date
BR112012015337A2 BR112012015337A2 (pt) 2016-03-15
BR112012015337B1 BR112012015337B1 (pt) 2021-05-04
BR112012015337B8 true BR112012015337B8 (pt) 2021-05-25

Family

ID=42107420

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012015337A BR112012015337B8 (pt) 2009-12-23 2010-12-22 composição farmacêutica, cartucho de aerossol, método para carregar um cartucho de aerossol, conjunto de componentes e uso de uma composição farmacêutica

Country Status (39)

Country Link
US (3) US20110150782A1 (pt)
EP (1) EP2515855B3 (pt)
JP (2) JP5914354B2 (pt)
KR (2) KR101757951B1 (pt)
CN (2) CN102665679B (pt)
AR (2) AR079726A1 (pt)
AU (3) AU2010334859A1 (pt)
BR (1) BR112012015337B8 (pt)
CA (1) CA2785321C (pt)
CL (1) CL2012001705A1 (pt)
CO (1) CO6541628A2 (pt)
CY (2) CY1115116T1 (pt)
DK (1) DK2515855T6 (pt)
EA (2) EA021917B1 (pt)
ES (1) ES2468840T7 (pt)
FI (1) FI2515855T6 (pt)
GE (1) GEP20156311B (pt)
HK (2) HK1174566A1 (pt)
HR (1) HRP20140582T4 (pt)
HU (1) HUS1800001I1 (pt)
IL (1) IL260932B (pt)
LT (1) LTC2515855I2 (pt)
LU (1) LUC00060I2 (pt)
MA (1) MA33823B1 (pt)
MX (1) MX2012006878A (pt)
MY (1) MY156949A (pt)
NL (1) NL300923I2 (pt)
NZ (1) NZ600790A (pt)
PE (2) PE20121396A1 (pt)
PL (1) PL2515855T6 (pt)
PT (1) PT2515855E (pt)
RS (1) RS53391B2 (pt)
SG (1) SG181868A1 (pt)
SI (1) SI2515855T1 (pt)
TN (1) TN2012000269A1 (pt)
TW (1) TWI495468B (pt)
UA (1) UA113832C2 (pt)
WO (1) WO2011076843A2 (pt)
ZA (1) ZA201204615B (pt)

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HUE039359T2 (hu) 2013-12-30 2018-12-28 Chiesi Farm Spa Glikopirrónium-bromid és formoterol kombináció stabil, túlnyomásos aeroszol oldat készítménye
US9554992B2 (en) * 2014-06-09 2017-01-31 Chiesi Farmaceutici S.P.A. Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic
US10098837B2 (en) * 2016-07-28 2018-10-16 Chiesi Farmaceutici S.P.A. Combination therapy for COPD

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