BR112012010202A2 - molécula de nuclease hibrida polipeptideo dimerico, composição farmacêutica molécula de acido nucleico vetor de expressão recombinante célula hospedeira transformada metodo para preparar a molécula de nuclease e metodo para tratar ou previnir uma condição associada com uma imune anormal - Google Patents

molécula de nuclease hibrida polipeptideo dimerico, composição farmacêutica molécula de acido nucleico vetor de expressão recombinante célula hospedeira transformada metodo para preparar a molécula de nuclease e metodo para tratar ou previnir uma condição associada com uma imune anormal

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Publication number
BR112012010202A2
BR112012010202A2 BR112012010202A BR112012010202A BR112012010202A2 BR 112012010202 A2 BR112012010202 A2 BR 112012010202A2 BR 112012010202 A BR112012010202 A BR 112012010202A BR 112012010202 A BR112012010202 A BR 112012010202A BR 112012010202 A2 BR112012010202 A2 BR 112012010202A2
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BR
Brazil
Prior art keywords
nuclease molecule
molecule
treating
preparing
nucleic acid
Prior art date
Application number
BR112012010202A
Other languages
English (en)
Inventor
Jeffrey A Ledbetter
Keith Elkon
Xizhang Sun
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Univ Washington filed Critical Univ Washington
Publication of BR112012010202A2 publication Critical patent/BR112012010202A2/pt

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
BR112012010202A 2009-11-02 2010-11-02 molécula de nuclease hibrida polipeptideo dimerico, composição farmacêutica molécula de acido nucleico vetor de expressão recombinante célula hospedeira transformada metodo para preparar a molécula de nuclease e metodo para tratar ou previnir uma condição associada com uma imune anormal BR112012010202A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25745809P 2009-11-02 2009-11-02
US37075210P 2010-08-04 2010-08-04
PCT/US2010/055131 WO2011053982A2 (en) 2009-11-02 2010-11-02 Therapeutic nuclease compositions and methods

Publications (1)

Publication Number Publication Date
BR112012010202A2 true BR112012010202A2 (pt) 2015-09-22

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BR112012010202A BR112012010202A2 (pt) 2009-11-02 2010-11-02 molécula de nuclease hibrida polipeptideo dimerico, composição farmacêutica molécula de acido nucleico vetor de expressão recombinante célula hospedeira transformada metodo para preparar a molécula de nuclease e metodo para tratar ou previnir uma condição associada com uma imune anormal

Country Status (23)

Country Link
US (9) US20130089546A1 (pt)
EP (3) EP3460056B1 (pt)
JP (6) JP6199033B2 (pt)
KR (5) KR102378465B1 (pt)
CN (3) CN113528485A (pt)
AU (4) AU2010313103B2 (pt)
BR (1) BR112012010202A2 (pt)
CA (2) CA2779615C (pt)
CY (3) CY1119166T1 (pt)
DK (3) DK3202898T3 (pt)
ES (2) ES2626000T3 (pt)
HR (2) HRP20170757T1 (pt)
HU (2) HUE032166T2 (pt)
IL (4) IL297588A (pt)
LT (3) LT3460056T (pt)
MX (3) MX341084B (pt)
PL (2) PL3202898T3 (pt)
PT (2) PT3202898T (pt)
RS (1) RS55989B1 (pt)
SG (3) SG10201912571XA (pt)
SI (3) SI2496691T1 (pt)
WO (1) WO2011053982A2 (pt)
ZA (3) ZA201705246B (pt)

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US11034944B2 (en) 2011-04-29 2021-06-15 University Of Washington Therapeutic nuclease compositions and methods
US11306297B2 (en) 2009-11-02 2022-04-19 University Of Washington Therapeutic nuclease compositions and methods

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