BR112012008128B8 - processos para a preparação de um composto da fórmula | e processo para a alquilação regiosseletiva de um composto da fórmula || - Google Patents

processos para a preparação de um composto da fórmula | e processo para a alquilação regiosseletiva de um composto da fórmula ||

Info

Publication number
BR112012008128B8
BR112012008128B8 BR112012008128A BR112012008128A BR112012008128B8 BR 112012008128 B8 BR112012008128 B8 BR 112012008128B8 BR 112012008128 A BR112012008128 A BR 112012008128A BR 112012008128 A BR112012008128 A BR 112012008128A BR 112012008128 B8 BR112012008128 B8 BR 112012008128B8
Authority
BR
Brazil
Prior art keywords
compound
formula
preparation
processes
regioselective alkylation
Prior art date
Application number
BR112012008128A
Other languages
English (en)
Other versions
BR112012008128B1 (pt
BR112012008128A2 (pt
Inventor
Thomas Ebert Jefferson
Wang Lihua
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of BR112012008128A2 publication Critical patent/BR112012008128A2/pt
Publication of BR112012008128B1 publication Critical patent/BR112012008128B1/pt
Publication of BR112012008128B8 publication Critical patent/BR112012008128B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

processo para a preparação de um composto da fórmula i e processo para a alquilação regiosseletiva de um composto da fórmula ii a presente invenção refere-se a um processo para a preparação de um composto da fórmula i: em particular, em que um composto da fórmula ii: é reagido com um dialquilsulfato. r1 é c1-c4haloalquila; r2 é alquila opcionalmente substituída, arila opcionalmente substituída ou heteroarila opcionalmente substituída; e r3 é metila ou etila.
BR112012008128A 2009-07-31 2010-07-27 processos para a preparação de um composto da fórmula | e processo para a alquilação regiosseletiva de um composto da fórmula || BR112012008128B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23013409P 2009-07-31 2009-07-31
US61/230,134 2009-07-31
US36157010P 2010-07-06 2010-07-06
PCT/EP2010/060884 WO2011012620A2 (en) 2009-07-31 2010-07-27 Processes for the alkylation of pyrazoles

Publications (3)

Publication Number Publication Date
BR112012008128A2 BR112012008128A2 (pt) 2015-09-22
BR112012008128B1 BR112012008128B1 (pt) 2017-10-31
BR112012008128B8 true BR112012008128B8 (pt) 2019-07-16

Family

ID=42782270

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008128A BR112012008128B8 (pt) 2009-07-31 2010-07-27 processos para a preparação de um composto da fórmula | e processo para a alquilação regiosseletiva de um composto da fórmula ||

Country Status (12)

Country Link
US (1) US8563747B2 (pt)
EP (1) EP2459538B1 (pt)
JP (1) JP5956334B2 (pt)
CN (1) CN102471279A (pt)
AR (1) AR077332A1 (pt)
BR (1) BR112012008128B8 (pt)
DK (1) DK2459538T3 (pt)
ES (1) ES2525489T3 (pt)
IL (1) IL217387A (pt)
MX (1) MX2012001067A (pt)
TW (1) TW201107296A (pt)
WO (1) WO2011012620A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8558006B2 (en) 2009-07-28 2013-10-15 Syngenta Crop Protection, Llc Processes relating to the alkylation of pyrazoles
WO2012019950A1 (en) * 2010-08-10 2012-02-16 Syngenta Participations Ag Process for the preparation of 3-haloalkylpyrazoles
JP5140776B1 (ja) * 2012-09-05 2013-02-13 タマ化学工業株式会社 １−置換−３−フルオロアルキルピラゾール−４−カルボン酸エステルの製造方法
HUE045718T2 (hu) 2014-08-19 2020-01-28 Bayer Animal Health Gmbh Eljárás 5-fluor-1H-pirazolok elõállítására hexafluorpropénbõl kiindulva

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0759560B2 (ja) * 1987-10-19 1995-06-28 三井東圧化学株式会社 １，３−ジアルキルピラゾール−４−カルボン酸エステルの製造法
GB9405229D0 (en) * 1994-03-17 1994-04-27 Rhone Poulenc Agriculture Compositions of matter
US5498624A (en) * 1995-05-03 1996-03-12 Monsanto Company Selected pyrazolyl derivatives
JP2000044541A (ja) 1998-08-03 2000-02-15 Mitsui Chemicals Inc １，３−ジアルキルピラゾール−４−カルボン酸エステルの製造法
JP4568404B2 (ja) 2000-05-17 2010-10-27 三井化学アグロ株式会社 ピラゾールカルボン酸エステル誘導体の製造法
ATE365719T1 (de) 2002-03-05 2007-07-15 Syngenta Participations Ag O-cyclopropyl-carboxanilide und ihre verwendung als fungizide
GB0224316D0 (en) 2002-10-18 2002-11-27 Syngenta Participations Ag Chemical compounds
EP1761498A1 (de) * 2004-06-18 2007-03-14 Basf Aktiengesellschaft 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid
JP4971170B2 (ja) * 2004-10-21 2012-07-11 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト ピラゾールの調製のための方法
EP1854788B8 (en) * 2005-02-25 2012-12-26 Sagami Chemical Research Institute Method for producing 1-substituted-3-fluoroalkyl pyrazole-4-carboxylate
PL1940813T3 (pl) 2005-10-25 2011-04-29 Syngenta Participations Ag Pochodne amidowe heterocykli użyteczne jako środki mikrobiobójcze
GB0526044D0 (en) * 2005-12-21 2006-02-01 Syngenta Ltd Novel herbicides
WO2008053044A2 (de) 2006-11-03 2008-05-08 Basf Se Hetarylcarbonsäure-n-(biphen-2-yl)amid-verbindungen
ES2525797T3 (es) 2007-03-16 2014-12-30 Syngenta Limited Nueva forma sólida de un microbiocida
MX2009012126A (es) 2007-05-11 2009-11-23 Lilly Co Eli 2-[4-(pirazol-4-ilalquil)piperazin-1-il]-3-fenil-pirazinas y piridinas y 3-[4-(pirazol-4-ilalquil)piperazin-1-il]-2-fenil piridinas como antagonistas del receptor 5-ht7.
KR20100017431A (ko) 2007-05-31 2010-02-16 신젠타 파티서페이션즈 아게 피라졸의 제조 방법
AU2009245791B2 (en) 2008-05-08 2013-05-16 Basf Se Method for manufacturing aryl carboxamides
GB0812028D0 (en) 2008-07-01 2008-08-06 Syngenta Participations Ag Fungicidal compositions

Also Published As

Publication number Publication date
US8563747B2 (en) 2013-10-22
ES2525489T3 (es) 2014-12-23
US20120130085A1 (en) 2012-05-24
BR112012008128B1 (pt) 2017-10-31
EP2459538A2 (en) 2012-06-06
IL217387A0 (en) 2012-02-29
BR112012008128A2 (pt) 2015-09-22
AR077332A1 (es) 2011-08-17
MX2012001067A (es) 2012-03-16
DK2459538T3 (en) 2015-01-05
IL217387A (en) 2016-02-29
JP2013500945A (ja) 2013-01-10
TW201107296A (en) 2011-03-01
WO2011012620A3 (en) 2011-06-09
EP2459538B1 (en) 2014-10-15
JP5956334B2 (ja) 2016-07-27
CN102471279A (zh) 2012-05-23
WO2011012620A2 (en) 2011-02-03

Similar Documents

Publication Publication Date Title
BR112012007085B8 (pt) processos para a preparação de derivados de benzil-benzeno substituídos com glicopiranosila
BRPI0905147A8 (pt) processo para síntese de ivabradina e seus sais de adição com um ácido farmaceuticamente aceitável
BRPI0813284A8 (pt) Processo para a preparação de um composto da fórmula (i) e composto
BR112012032244A2 (pt) processo para preparar derivados de antranilamida com tetrazole-substituído e polimorfos cristalinos novos e derivados destes
BRPI0817747A8 (pt) Processo para a preparação de derivados de ácido 2-di-halogenoacil-3-amino-acrílico
ATE477234T1 (de) Synthese von phenolischen estern von hydroxymethylphenolen
CO6410257A2 (es) Herbicidas novedosos
BR112012021556A2 (pt) processo para a preparação de peptídeos prolila substituídos e peptidomiméticos similares
BR112014006559A2 (pt) derivados do ácido betulínico com atividade antiviral
ME00928B (me) Novi postupak za sintezu agomelatina
BR112014004210A2 (pt) processo para a preparação de derivados de diamida do ácido antranílico substituídos com tetrazole por reação de benzoxazinonas com aminas
BRPI0803636A2 (pt) processo para a sìntese de ranelato de estrÈncio e seus hidratos
BR112012008128B8 (pt) processos para a preparação de um composto da fórmula | e processo para a alquilação regiosseletiva de um composto da fórmula ||
BR112014026198A2 (pt) compostos pirazol como inibidores de sglt1
HK1168102A1 (en) Process for the preparation of a compound useful as an inhibitor of tafia
SG194727A1 (en) Method for modification of organic molecules
CO6480992A2 (es) Derivados de pirazoles, su preparacion y su aplicacion terapeutica
BR112014015430A8 (pt) formulação oftálmica
BR112013028789A2 (pt) processo
BRPI0516994A (pt) processo para preparação de pirazóis
BR112014009266A2 (pt) processo para a preparação de ácidos isoxazolil-metóxi-nicotínicos
BR112012020703A2 (pt) composição para o controle de pragas
BR102012013573A2 (pt) processo de sÍntese, e forma cristalina de cloridrato de 4-{3-[cis-hexa-hidrociclopenta[c]pirrol-2(1h)-il]propà xi}benzamida e composiÇÕes farmacÊuticas contendo o mesmo
BR112013011244A2 (pt) processo para a preparação de derivados e ácido 3-(6-amino-piridin-3il)-2-acrílico
BR112018013346A2 (pt) processo de preparação de 1,1,3-trioxo-1,2-benzotiazol-6-carboxamida

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/07/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) REF. 2443 DE 31/10/2017 QUANTO AO ITEM (30) PRIORIDADE UNIONISTA.