BR112012005869A2 - cristais da proteína a, cristais reticulados e métodos de utilização dos mesmos - Google Patents
cristais da proteína a, cristais reticulados e métodos de utilização dos mesmosInfo
- Publication number
- BR112012005869A2 BR112012005869A2 BR112012005869A BR112012005869A BR112012005869A2 BR 112012005869 A2 BR112012005869 A2 BR 112012005869A2 BR 112012005869 A BR112012005869 A BR 112012005869A BR 112012005869 A BR112012005869 A BR 112012005869A BR 112012005869 A2 BR112012005869 A2 BR 112012005869A2
- Authority
- BR
- Brazil
- Prior art keywords
- crystals
- protein
- methods
- cross
- linked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
Abstract
cristais da proteína a, cristais reticulados e métodos de utilização dos mesmos. cristais da proteína a e cristais reticulados da proteína a (clpcs) são descritos. métodos de preparação e uso são, também, revelados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24253709P | 2009-09-15 | 2009-09-15 | |
PCT/US2010/048664 WO2011034822A1 (en) | 2009-09-15 | 2010-09-13 | Protein a crystals and cross-linked crystals and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012005869A2 true BR112012005869A2 (pt) | 2017-01-31 |
Family
ID=43758972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012005869A BR112012005869A2 (pt) | 2009-09-15 | 2010-09-13 | cristais da proteína a, cristais reticulados e métodos de utilização dos mesmos |
Country Status (12)
Country | Link |
---|---|
US (2) | US8921531B2 (pt) |
EP (1) | EP2478005B1 (pt) |
JP (1) | JP5700581B2 (pt) |
KR (1) | KR101530417B1 (pt) |
CN (1) | CN102753570B (pt) |
BR (1) | BR112012005869A2 (pt) |
CA (1) | CA2774212C (pt) |
DK (1) | DK2478005T3 (pt) |
EA (1) | EA033141B1 (pt) |
ES (1) | ES2530578T3 (pt) |
HK (1) | HK1173457A1 (pt) |
WO (1) | WO2011034822A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112012005869A2 (pt) | 2009-09-15 | 2017-01-31 | Althea Tech Inc | cristais da proteína a, cristais reticulados e métodos de utilização dos mesmos |
JP5963538B2 (ja) * | 2012-02-24 | 2016-08-03 | 三井造船株式会社 | モーレラ属細菌の遺伝子組換え法 |
WO2014192877A1 (ja) * | 2013-05-29 | 2014-12-04 | Jsr株式会社 | 洗浄用組成物、タンパク質精製方法、及びタンパク質 |
US9546208B2 (en) | 2014-01-03 | 2017-01-17 | Bio-Rad Laboratories, Inc. | Removal of impurities from protein A eluates |
WO2016031932A1 (ja) * | 2014-08-27 | 2016-03-03 | 田辺三菱製薬株式会社 | アルカリ洗浄によるFc領域を有するタンパク質の製造方法 |
AR103726A1 (es) * | 2015-02-27 | 2017-05-31 | Merck Sharp & Dohme | Cristales de anticuerpos monoclonales anti-pd-1 humanos |
JP2020504172A (ja) * | 2016-12-12 | 2020-02-06 | フラー エス.アー.エール.エル. | 免疫グロブリン結合ポリペプチドおよびオリゴペプチドの免疫グロブリン結合容量を増加するための組成物および方法 |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
RU2019138507A (ru) | 2017-05-02 | 2021-06-02 | Мерк Шарп И Доум Корп. | Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1 |
CN112816700A (zh) * | 2020-12-28 | 2021-05-18 | 杭州新脉生物科技有限公司 | 一种检测尿液中hiv抗体的胶体金试纸条 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS508549A (pt) | 1973-05-21 | 1975-01-29 | ||
US5618710A (en) | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
UA27035C2 (uk) * | 1990-08-03 | 2000-02-28 | Вертекс Фармас'Ютікалс Інкорпорейтід | Кристал білка, зшитого багатофуhкціоhальhим зшивальним агеhтом (варіаhти), пристрій, що містить кристал білка та спосіб отримаhhя аспартаму |
AU628264B2 (en) | 1990-08-14 | 1992-09-10 | Oracle International Corporation | Methods and apparatus for providing a client interface to an object-oriented invocation of an application |
US6447777B1 (en) | 1996-03-29 | 2002-09-10 | David S. Terman | Polymerized staphylococcal protein a for treatment of diseases |
US6140475A (en) | 1997-04-11 | 2000-10-31 | Altus Biologics Inc. | Controlled dissolution crosslinked protein crystals |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
GB0304576D0 (en) | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
CN101120017A (zh) * | 2004-08-30 | 2008-02-06 | 英国龙沙生物医药股份有限公司 | 用于纯化抗体的亲和力加离子交换层析 |
BR112012005869A2 (pt) | 2009-09-15 | 2017-01-31 | Althea Tech Inc | cristais da proteína a, cristais reticulados e métodos de utilização dos mesmos |
-
2010
- 2010-09-13 BR BR112012005869A patent/BR112012005869A2/pt not_active Application Discontinuation
- 2010-09-13 EA EA201270425A patent/EA033141B1/ru not_active IP Right Cessation
- 2010-09-13 JP JP2012529818A patent/JP5700581B2/ja not_active Expired - Fee Related
- 2010-09-13 DK DK10817707.2T patent/DK2478005T3/en active
- 2010-09-13 WO PCT/US2010/048664 patent/WO2011034822A1/en active Application Filing
- 2010-09-13 ES ES10817707T patent/ES2530578T3/es active Active
- 2010-09-13 EP EP10817707.2A patent/EP2478005B1/en not_active Not-in-force
- 2010-09-13 CA CA2774212A patent/CA2774212C/en not_active Expired - Fee Related
- 2010-09-13 KR KR1020127009563A patent/KR101530417B1/ko active IP Right Grant
- 2010-09-13 CN CN201080051667.4A patent/CN102753570B/zh not_active Expired - Fee Related
- 2010-09-13 US US13/395,869 patent/US8921531B2/en not_active Expired - Fee Related
-
2013
- 2013-01-15 HK HK13100618.7A patent/HK1173457A1/zh not_active IP Right Cessation
-
2014
- 2014-11-21 US US14/550,807 patent/US9273123B2/en active Active - Reinstated
Also Published As
Publication number | Publication date |
---|---|
CN102753570B (zh) | 2016-01-20 |
JP2013504621A (ja) | 2013-02-07 |
HK1173457A1 (zh) | 2013-05-16 |
CN102753570A (zh) | 2012-10-24 |
CA2774212A1 (en) | 2011-03-24 |
EA033141B1 (ru) | 2019-09-30 |
US9273123B2 (en) | 2016-03-01 |
US20150239962A1 (en) | 2015-08-27 |
JP5700581B2 (ja) | 2015-04-15 |
ES2530578T3 (es) | 2015-03-03 |
US20130053548A1 (en) | 2013-02-28 |
KR20140002459A (ko) | 2014-01-08 |
DK2478005T3 (en) | 2015-02-16 |
US8921531B2 (en) | 2014-12-30 |
EP2478005A4 (en) | 2013-07-24 |
KR101530417B1 (ko) | 2015-06-19 |
WO2011034822A1 (en) | 2011-03-24 |
CA2774212C (en) | 2018-01-30 |
EP2478005B1 (en) | 2014-11-12 |
EA201270425A1 (ru) | 2013-02-28 |
EP2478005A1 (en) | 2012-07-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |