BR112012000792A2 - compostos heterocíclicos como inibidores de autotaxina - Google Patents

compostos heterocíclicos como inibidores de autotaxina

Info

Publication number: BR112012000792A2
Authority: BR; Brazil
Prior art keywords: heterocyclic compounds; autotaxin inhibitors; autotaxin; inhibitors; heterocyclic
Prior art date: 2009-07-16

Application number

BR112012000792A

Other languages

English (en)

Inventor

Kai Schiemann

Melanie Schultz

Wolfgang Staehle

Original Assignee

Merck Patent Ges Mit Beschränkter Haftung

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-16

Filing date

2010-06-17

Publication date

2016-02-23

2010-06-17 Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung

2016-02-23 Publication of BR112012000792A2 publication Critical patent/BR112012000792A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

BR112012000792A 2009-07-16 2010-06-17 compostos heterocíclicos como inibidores de autotaxina BR112012000792A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102009033392A DE102009033392A1 (de)	2009-07-16	2009-07-16	Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
PCT/EP2010/003661 WO2011006569A1 (de)	2009-07-16	2010-06-17	Heterocyclische verbindungen als autotaxin-inhibitoren

Publications (1)

Publication Number	Publication Date
BR112012000792A2 true BR112012000792A2 (pt)	2016-02-23

Family

ID=42646326

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112012000792A BR112012000792A2 (pt)	2009-07-16	2010-06-17	compostos heterocíclicos como inibidores de autotaxina

Country Status (16)

Country	Link
US (1)	US20120115852A1 (pt)
EP (1)	EP2454258A1 (pt)
JP (1)	JP2012532901A (pt)
KR (1)	KR20120090031A (pt)
CN (1)	CN102471343A (pt)
AR (1)	AR077488A1 (pt)
AU (1)	AU2010272922A1 (pt)
BR (1)	BR112012000792A2 (pt)
CA (1)	CA2768095A1 (pt)
DE (1)	DE102009033392A1 (pt)
EA (1)	EA201200119A1 (pt)
IL (1)	IL217466A0 (pt)
MX (1)	MX2012000609A (pt)
SG (1)	SG177522A1 (pt)
WO (1)	WO2011006569A1 (pt)
ZA (1)	ZA201201124B (pt)

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MA37756B1 (fr)	2012-06-13	2018-09-28	Hoffmann La Roche	Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane
EP3590940B1 (en) *	2012-09-25	2021-06-09	F. Hoffmann-La Roche AG	Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
US9409895B2 (en)	2012-12-19	2016-08-09	Novartis Ag	Autotaxin inhibitors
AU2013365742B2 (en)	2012-12-19	2016-11-24	Novartis Ag	Autotaxin inhibitors
AR095079A1 (es) *	2013-03-12	2015-09-16	Hoffmann La Roche	Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
AR095328A1 (es) *	2013-03-15	2015-10-07	Biogen Idec Inc	Agentes de modulación de s1p y/o atx
JP2016530209A (ja)	2013-09-17	2016-09-29	ファーマケア，インク．	ビニルオートタキシン阻害剤化合物
EP3046909A4 (en)	2013-09-17	2017-03-29	Pharmakea, Inc.	Heterocyclic vinyl autotaxin inhibitor compounds
JP2016531874A (ja)	2013-09-26	2016-10-13	ファーマケア，インク．	オートタキシン阻害剤化合物
BR112016010221A2 (pt)	2013-11-22	2018-05-02	Pharmakea Inc	inibidores tetracíclicos de autotaxina.
PT3071561T (pt)	2013-11-22	2021-06-25	Sabre Therapeutics Llc	Compostos inibidores de autotaxina
MA38982A1 (fr)	2013-11-26	2017-09-29	Hoffmann La Roche	Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl
MX2016010675A (es) *	2014-03-26	2016-11-10	Hoffmann La Roche	Compuestos condensados de [1,4]diazepina como inhibidores de produccion de la autotaxina (atx) y acido lisofosfatidico (lpa).
CN106103446B (zh)	2014-03-26	2019-07-30	豪夫迈·罗氏有限公司	作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
MD20160116A2 (ro)	2014-04-04	2017-04-30	X-Rx Discovery, Inc	Inhibitori spirociclici substituiţi ai autotaxinei
JP6592008B2 (ja) *	2014-04-23	2019-10-16	エックス−アールエックス，インコーポレイテッド	オートタキシンの置換ｎ−（２−アミノ）−２−オキソエチルベンズアミド阻害剤およびそれらの調製、ならびにｌｐａ依存性またはｌｐａ媒介性疾患の処置における使用
US9051320B1 (en)	2014-08-18	2015-06-09	Pharmakea, Inc.	Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
GB201501870D0 (en)	2015-02-04	2015-03-18	Cancer Rec Tech Ltd	Autotaxin inhibitors
GB201502020D0 (en)	2015-02-06	2015-03-25	Cancer Rec Tech Ltd	Autotaxin inhibitory compounds
MA41898A (fr)	2015-04-10	2018-02-13	Hoffmann La Roche	Dérivés de quinazolinone bicyclique
EP4026549A1 (en)	2015-05-27	2022-07-13	Sabre Therapeutics LLC	Autotaxin inhibitors and uses thereof
US10118904B2 (en)	2015-06-05	2018-11-06	Vertex Pharmaceuticals Incorporated	Triazoles for the treatment of Demyelinating Diseases
GB201510010D0 (en)	2015-06-09	2015-07-22	King S College London	PDD and BPD compounds
GB201514928D0 (en)	2015-08-21	2015-10-07	King S College London	PDD compounds
US20180339985A1 (en)	2015-08-21	2018-11-29	Femtogenix Limited	Pdd compounds
CN108026077B (zh)	2015-09-04	2021-11-05	豪夫迈·罗氏有限公司	苯氧基甲基衍生物
MA42923A (fr)	2015-09-24	2021-04-28	Hoffmann La Roche	Composés bicycliques comme inhibiteurs mixtes de atx/ca
MA42918A (fr)	2015-09-24	2018-08-01	Hoffmann La Roche	Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
WO2017050792A1 (en)	2015-09-24	2017-03-30	F. Hoffmann-La Roche Ag	Bicyclic compounds as atx inhibitors
JP6845230B2 (ja)	2015-09-24	2021-03-17	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
WO2018106646A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Aminotriazoles for the treatment of demyelinating diseases
WO2018106643A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106641A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Pyrazoles for the treatment of demyelinating diseases
CN110382484B (zh)	2017-03-16	2022-12-06	豪夫迈·罗氏有限公司	新的作为atx抑制剂的二环化合物
MA49879A (fr)	2017-03-16	2020-06-24	Hoffmann La Roche	Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
EP3797617A4 (en) *	2018-05-21	2022-05-18	ASICS Corporation	BRA
KR102623218B1 (ko) *	2018-08-23	2024-01-11	가천대학교 산학협력단	페닐아세트산 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물
US20210353642A1 (en) *	2018-10-02	2021-11-18	Case Western Reserve University	Compounds for treating myelin related disorders
WO2023154197A1 (en) *	2022-02-10	2023-08-17	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Fused diazepines as agonists of the insulin-like 3 (insl3) peptide receptor rxfp2 and methods of use thereof

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US5747469A (en)	1991-03-06	1998-05-05	Board Of Regents, The University Of Texas System	Methods and compositions comprising DNA damaging agents and p53
WO2000043398A2 (en) *	1999-01-19	2000-07-27	Ortho-Mcneil Pharmaceutical, Inc.	Tricyclic benzodiazepines as vasopressin receptor antagonists
GB9904387D0 (en)	1999-02-25	1999-04-21	Pharmacia & Upjohn Spa	Antitumour synergistic composition
WO2000061186A1 (en)	1999-04-08	2000-10-19	Arch Development Corporation	Use of anti-vegf antibody to enhance radiation in cancer therapy
HUP0203241A3 (en) *	1999-11-09	2006-07-28	Sod Conseils Rech Applic	Combination of product inhibiting transduction of g heterotrimeric protein signals and anti-cancer agent for use in cancer treatment

2009
- 2009-07-16 DE DE102009033392A patent/DE102009033392A1/de not_active Withdrawn
2010
- 2010-06-17 EA EA201200119A patent/EA201200119A1/ru unknown
- 2010-06-17 CA CA2768095A patent/CA2768095A1/en not_active Abandoned
- 2010-06-17 AU AU2010272922A patent/AU2010272922A1/en not_active Abandoned
- 2010-06-17 US US13/383,908 patent/US20120115852A1/en not_active Abandoned
- 2010-06-17 SG SG2012000774A patent/SG177522A1/en unknown
- 2010-06-17 MX MX2012000609A patent/MX2012000609A/es not_active Application Discontinuation
- 2010-06-17 BR BR112012000792A patent/BR112012000792A2/pt not_active Application Discontinuation
- 2010-06-17 WO PCT/EP2010/003661 patent/WO2011006569A1/de active Application Filing
- 2010-06-17 JP JP2012519902A patent/JP2012532901A/ja active Pending
- 2010-06-17 EP EP10725398A patent/EP2454258A1/de not_active Withdrawn
- 2010-06-17 CN CN2010800318870A patent/CN102471343A/zh active Pending
- 2010-06-17 KR KR1020127004105A patent/KR20120090031A/ko not_active Application Discontinuation
- 2010-07-16 AR ARP100102610A patent/AR077488A1/es unknown
2012
- 2012-01-10 IL IL217466A patent/IL217466A0/en unknown
- 2012-02-15 ZA ZA2012/01124A patent/ZA201201124B/en unknown

Also Published As

Publication number	Publication date
IL217466A0 (en)	2012-02-29
EA201200119A1 (ru)	2012-07-30
WO2011006569A1 (de)	2011-01-20
DE102009033392A1 (de)	2011-01-20
SG177522A1 (en)	2012-02-28
MX2012000609A (es)	2012-01-27
JP2012532901A (ja)	2012-12-20
EP2454258A1 (de)	2012-05-23
US20120115852A1 (en)	2012-05-10
AU2010272922A1 (en)	2012-03-08
ZA201201124B (en)	2012-11-28
CN102471343A (zh)	2012-05-23
CA2768095A1 (en)	2011-01-20
AR077488A1 (es)	2011-08-31
KR20120090031A (ko)	2012-08-16

Legal Events

Date	Code	Title	Description
2016-05-03	B11A	Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
2016-08-02	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]

Publication	Publication Date	Title
BR112012000792A2 (pt)	2016-02-23	compostos heterocíclicos como inibidores de autotaxina
BRPI1009800A2 (pt)	2016-03-15	compostos heterocíclicos como inibidores de autotaxina
BRPI0921860A2 (pt)	2015-12-29	compostos de benzonaftiridina como inibidores de autotaxina
CO6831983A2 (es)	2014-01-10	Compuestos heterocíclicos como inhibidores de cinasas
BRPI0916375A2 (pt)	2018-02-06	compostos orgânicos como inibidores de smo
BRPI1015038A2 (pt)	2016-04-12	derivados espiro azacíclicos como inibidores de hsl
BRPI0913879A2 (pt)	2019-09-24	fenilpirazinonas como inibidores de quinase
BR112012008061A2 (pt)	2016-03-01	compostos de oxima heterocíclica
BRPI0925050A2 (pt)	2015-08-04	Compostos heterocíclicos como inibidores de mek
BRPI1013614A2 (pt)	2019-09-24	compostos substituídos de espiro-amida
BR112013015449A2 (pt)	2016-09-20	compostos de bi-heteroarila como inibidores de vps23
BR112012006859A2 (pt)	2019-09-24	compostos
BRPI0920135A2 (pt)	2019-09-24	imidazopiridazinacarbonitrilos úteis como inibidores de quinase
DK2427449T3 (da)	2013-04-22	Vinylindazolylforbindelser
BR112012005616A2 (pt)	2016-06-21	compostos antivirais heterocíclicos
BRPI1005525A2 (pt)	2016-02-23	compostos de azaazuleno
BRPI1010852A2 (pt)	2019-09-24	compostos antivirais heterocíclicos
BRPI1014077A2 (pt)	2015-08-25	Derivados de tiazolilperidina como fungicidas
BRPI0906705A2 (pt)	2015-06-30	Composto heterocíclicos
BRPI0912475A8 (pt)	2018-03-20	compostos como inibidores de quinase
BRPI1016266A2 (pt)	2019-09-24	compostos antivirais heterocíclicos
SMT201600031B (it)	2016-02-25	Composti eterociclici di fenossimetile
BR112012003868A2 (pt)	2015-09-01	Compostos orgânicos
UY33155A (es)	2011-07-29	Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa
BR112012005503A2 (pt)	2016-04-19	derivados de isoxazolidina